Article
Clinical Neurology
Rafael Pazinatto de Aguiar, Adrian Newman-Tancredi, Jos Prickaerts, Rubia Maria Weffort de Oliveira
Summary: This review focuses on the roles and mechanisms of 5-HT1A receptors in neuroprotection in experimental models of cerebral ischemia, with experimental evidence suggesting that 5-HT1A receptor agonists can prevent neuronal damage and promote functional recovery induced by ischemia.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Nutrition & Dietetics
Eduardo Sanches, Yohan van de Looij, Sadou Sow, Audrey Toulotte, Analina da Silva, Laura Modernell, Stephane Sizonenko
Summary: This study demonstrates that lactoferrin (Lf) supplementation attenuates acute and long-term cerebral injuries caused by hypoxia-ischemia in a dose-dependent manner. The optimal dose of 1 g/kg of Lf showed the best effects, reducing brain volume decreases and other detrimental effects. The research emphasizes the need for better understanding of Lf's effects and potential harmful effects on immature brains.
Review
Nutrition & Dietetics
Helene Roumes, Pierre Goudeneche, Luc Pellerin, Anne-Karine Bouzier-Sore
Summary: Polyphenols, including resveratrol, have potential neuroprotective effects against neonatal hypoxia-ischemia-induced damage due to their anti-apoptotic, anti-inflammatory, and anti-oxidative properties, and may enhance brain energy metabolism. Maternal supplementation at nutritional doses shows promising results and could be a novel prophylactic treatment for neonatal hypoxia-ischemia.
Article
Nutrition & Dietetics
Paula Garcia-Rodriguez, Feifei Ma, Carmen del Rio, Marina Romero-Bernal, Ana M. Najar, Maria de la Luz Cadiz-Gurrea, Francisco Javier Leyva-Jimenez, Laura Ramiro, Paloma Menendez-Valladares, Soledad Perez-Sanchez, Antonio Segura-Carretero, Joan Montaner
Summary: This study investigated the protective effect of Salicornia ramosissima, a plant rich in polyphenols, against hypoxia and brain ischemia. The results showed that the ethanolic extract of S. ramosissima could protect flies and mice from the harmful effects of hypoxia and reduce infarct volume. Phytochemical analysis revealed the presence of 50 compounds in the extract. These findings suggest that S. ramosissima could be developed as an effective food supplement for the prevention or treatment of neurovascular disorders.
Review
Biochemistry & Molecular Biology
Matteo Haupt, Stefan T. Gerner, Mathias Baehr, Thorsten R. Doeppner
Summary: Despite significant progress in stroke therapy, ischemic stroke still imposes a high socioeconomic burden on industrialized countries. Current treatment paradigms focus on thrombolysis or thrombectomy, which are only suitable for a fraction of patients. Therefore, there is an urgent need for adjuvant therapeutic approaches like neuroprotection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Alice McDouall, Guido Wassink, Sumudu Ranasinghe, Kelly Q. Zhou, Rashika N. Karunasinghe, Justin M. Dean, Joanne O. Davidson
Summary: This study found that blocking connexin 43 hemichannels can attenuate brain injury and promote neurodevelopment in infants with mild hypoxic-ischemic encephalopathy, without causing hypothermia.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Biochemistry & Molecular Biology
Jea-Young Lee, Vanessa Castelli, Narender Kumar, Regine Sitruk-Ware, Cesario Borlongan
Summary: This study shows that Nestorone and human amniotic fluid-derived stem cells (hAFSc) treatment alone or in combination can significantly improve behavioral function and reduce infarction and peri-infarct cell loss in adult rats with ischemic stroke. The mechanism of Nestorone's neuroprotection in stroke may involve the regulation of pro-inflammatory signals, stem cell proliferation, and differentiation, as well as the modulation of mitochondrial metabolism and oxidative protection.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Jose Martinez-Orgado, Maria Villa, Aaron del Pozo
Summary: CBD shows neuroprotective effects in newborn pigs and rodents with HIBI, modulating the major components of HIBI pathophysiology. It has the potential to be an effective treatment for neonatal HIBI.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Fan Zhang, Bingying Lin, Siyu Huang, Pengsen Wu, Min Zhou, Jing Zhao, Xiangqing Hei, Yu Ke, Yiting Zhang, Danping Huang
Summary: Retinal ischemia-reperfusion (RIR) injury caused by high intraocular pressure (IOP) leads to retinal ganglion cell (RGC) death and eventually blindness. Ferroptosis, a form of programmed cell death, is involved in RGC death. Melatonin (MT) shows neuroprotective effects against RIR injury by inhibiting p53-mediated ferroptosis.
Article
Pharmacology & Pharmacy
Kemeng Zhao, Pengwei Wang, Xiaoguang Tang, Na Chang, Haonan Shi, Longfei Guo, Bingyi Wang, Pengfei Yang, Tiantian Zhu, Xinghua Zhao
Summary: Stroke is caused by ruptured or blocked cerebral blood vessels and subsequent disruption of brain blood circulation, resulting in rapid neurological deficits. The majority of stroke cases are ischemic strokes. Current treatments for ischemic stroke, such as t-PA thrombolytic therapy and surgical thrombectomy, can paradoxically lead to ischemia-reperfusion injury, exacerbating brain damage. Minocycline, a semi-synthetic tetracycline antibiotic, has demonstrated a wide range of neuroprotective effects independent of its antibacterial activity. In this article, we summarize the mechanisms underlying the protective effects of minocycline against cerebral ischemia-reperfusion injury, including modulation of oxidative stress, inflammatory response, excitotoxicity, programmed cell death, and blood-brain barrier injury. We also discuss the role of minocycline in alleviating stroke-related complications, providing a theoretical basis for its clinical application in cerebral ischemia-reperfusion injury.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Nutrition & Dietetics
Ana M. Najar, Marina Romero-Bernal, Carmen del Rio, Joan Montaner
Summary: There is a growing interest in consuming halophytes as a healthy food. Salicornia ramosissima is a Mediterranean halophyte with a rich profile of bioactive compounds, including over 60 identified polyphenols with various biological activities. These polyphenols have shown potential protective effects against brain ischemia, mainly through reducing oxidative stress and inflammation, inhibiting cell death pathways, and preserving vascular function. Although most of these compounds have been found to be neuroprotective, human studies on their effects are still limited. Considering the safe profile of polyphenols in S. ramosissima, this halophyte could be a valuable source of bioactive compounds for the nutraceutical industry.
Editorial Material
Endocrinology & Metabolism
Di Wu, Jian Chen, Xuxiang Zhang, Roxanne Ilagan, Yuchuan Ding, Xunming Ji
Summary: Selective therapeutic cooling is a promising technique for reducing final infarct volume and improving outcomes in ischemic stroke. However, more targeted induction of brain hypothermia and mitigating potential side effects related to inducing hypothermia may be necessary to enhance the benefits of this method.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Editorial Material
Endocrinology & Metabolism
Shuaili Xu, Xunming Ji, Ming Li, Di Wu
Summary: Selective brain cooling is a promising technique to improve outcomes in ischemic stroke. A recent study showed the efficacy of a new method, active conductive head cooling, in achieving therapeutic cooling during pre-hospital transfer. However, a more comprehensive strategy is needed to prevent delay in hypothermic induction and enhance selectivity in the brain to mitigate potential side effects.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Plant Sciences
Yan Mi, Kun Jiao, Ji-kai Xu, Kun Wei, Jing-yu Liu, Qing-qi Meng, Ting-ting Guo, Xue-ni Zhang, Di Zhou, De-gang Qing, Yu Sun, Ning Li, Yue Hou
Summary: The study explored the effect of kellerin on cerebral ischemia and its possible mechanisms using MCAO model and LPS-activated microglia model. Kellerin improved neurological outcome, reduced brain infarct size, and alleviated neuron damage by inhibiting microglial activation under pathologic conditions of focal cerebral ischemia. In in vitro studies, kellerin protected neuronal cells from damage by suppressing pro-inflammatory cytokines, NF-kappa B signaling pathway, ROS generation, and NADPH oxidase activity.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Neurosciences
Jia Liu, Yakun Gu, Mengyuan Guo, Xunming Ji
Summary: The brain, as the organ with the highest oxygen demand, has poor tolerance to ischemia and hypoxia. Ischemic/hypoxic preconditioning has been studied as an effective strategy to improve tolerance and is considered significant in treating CNS diseases. It involves multiple protective mechanisms and is a research frontier in neurotherapy, with challenges in translating from basic research to clinical application.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Psychology, Biological
Abigail K. Thompson, Sarah Fourman, Amy E. B. Packard, Ann E. Egan, Karen K. Ryan, Yvonne M. Ulrich-Lai
PHYSIOLOGY & BEHAVIOR
(2015)
Article
Clinical Neurology
Raffaella Gesuete, Sara N. Christensen, Frances R. Bahjat, Amy E. B. Packard, Susan L. Stevens, Mingyue Liu, Andres M. Salazar, Mary P. Stenzel-Poore
Article
Neurosciences
Sriparna Ghosal, Amy E. B. Packard, Parinaz Mahbod, Jessica M. McKlveen, Randy J. Seeley, Brent Myers, Yvonne Ulrich-Lai, Eric P. Smith, David A. D'Alessio, James P. Herman
JOURNAL OF NEUROSCIENCE
(2017)
Article
Psychology, Biological
M. L. Goodson, A. E. B. Packard, D. R. Buesing, M. Maney, B. Myers, Y. Fang, J. E. Basford, D. Y. Hui, Y. M. Ulrich-Lai, J. P. Herman, K. K. Ryan
PHYSIOLOGY & BEHAVIOR
(2017)
Article
Endocrinology & Metabolism
Amy E. B. Packard, Jintao Zhang, Brent Myers, Chih-Wei Ko, Fei Wang, Patrick Tso, Yvonne M. Ulrich-Lai
PSYCHONEUROENDOCRINOLOGY
(2017)
Article
Endocrinology & Metabolism
Amy E. B. Packard, Philberta Y. Leung, Keri B. Vartanian, Susan L. Stevens, Frances R. Bahjat, Mary P. Stenzel-Poore
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2012)
Article
Biochemistry & Molecular Biology
Raffaella Gesuete, Amy E. B. Packard, Keri B. Vartanian, Valerie K. Conrad, Susan L. Stevens, Frances R. Bahjat, Tao Yang, Mary P. Stenzel-Poore
JOURNAL OF NEUROCHEMISTRY
(2012)
Article
Neurosciences
M. B. Solomon, A. R. Furay, K. Jones, A. E. B. Packard, B. A. Packard, A. C. Wulsin, J. P. Herman
Article
Endocrinology & Metabolism
Amy E. B. Packard, Sriparna Ghosal, James P. Herman, Stephen C. Woods, Yvonne M. Ulrich-Lai
PSYCHONEUROENDOCRINOLOGY
(2014)
Article
Behavioral Sciences
Ann E. Egan, Laurel R. Seemiller, Amy E. B. Packard, Matia B. Solomon, Yvonne M. Ulrich-Lai
HORMONES AND BEHAVIOR
(2019)
Article
Cardiac & Cardiovascular Systems
Derek Schaeuble, Amy E. B. Packard, Jessica M. McKlveen, Rachel Morano, Sarah Fourman, Brittany L. Smith, Jessie R. Scheimann, Benjamin A. Packard, Steven P. Wilson, Jeanne James, David Y. Hui, Yvonne M. Ulrich-Lai, James P. Herman, Brent Myers
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2019)
Meeting Abstract
Biochemistry & Molecular Biology
Brent Myers, Derek Schaeuble, Amy E. B. Packard, Jessica M. McKlveen, Rachel L. Morano, Sarah Fourman, Brittany L. Smith, Jessie R. Scheimann, Ben A. Packard, Steven P. Wilson, Jeanne James, David Y. Hui, Yvonne M. Ulrich-Lai, James P. Herman
Article
Anatomy & Morphology
Amy E. B. Packard, Shi Di, Ann E. Egan, Sarah M. Fourman, Jeffrey G. Tasker, Yvonne M. Ulrich-Lai
BRAIN STRUCTURE & FUNCTION
(2017)
Article
Physiology
Amy E. B. Packard, Ann E. Egan, Yvonne M. Ulrich-Lai
COMPREHENSIVE PHYSIOLOGY
(2016)
Meeting Abstract
Clinical Neurology
Raffaella Gesuete, Amy E. Packard, Keri B. Vartanian, Susan L. Stevens, Frances R. Bahjat, Tao Yang, Mary P. Stenzel-Poore