Review
Immunology
Ran Chen, Xu Zhang, Lijuan Gu, Hua Zhu, Yi Zhong, Yingze Ye, Xiaoxing Xiong, Zhihong Jian
Summary: Ischemic stroke leads to nerve cell death and immune cell activation, with immune cell infiltration having both negative and positive effects in the central nervous system, highlighting the need for further exploration of their role in cerebral ischemia.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Endocrinology & Metabolism
Ariel Diaz, Yena Woo, Cynthia Martin-Jimenez, Paola Merino, Enrique Torre, Manuel Yepes
Summary: Ischemic tolerance is a phenomenon where exposure to a non-injurious preconditioning stimulus triggers resistance to a subsequent lethal ischemic insult. Tissue-type plasminogen activator (tPA) released from astrocytes plays a crucial role in inducing ischemic tolerance in the blood-brain barrier.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Biotechnology & Applied Microbiology
Xiang Li, Xiaoyan Tian
Summary: Pimavanserin effectively reverses neurological deficits, brain edema, increased inflammatory response, BBB permeability, and downregulation of Claudin 5 caused by cerebral ischemia injury. Its protective effects are mediated by regulating BBB integrity in a KLF6-dependent manner.
Review
Engineering, Biomedical
Xing Tian, Taojian Fan, Wentian Zhao, Ghulam Abbas, Bo Han, Ke Zhang, Nan Li, Ning Liu, Weiyuan Liang, Hao Huang, Wen Chen, Bing Wang, Zhongjian Xie
Summary: This review focuses on the potential applications of nanotechnology in stroke treatment. It discusses the main molecular pathological mechanisms of ischemic stroke, the role of the blood-brain barrier, and summarizes the challenges and future prospects of nanomedicine-based stroke treatments.
BIOACTIVE MATERIALS
(2021)
Article
Neurosciences
Xiaolong Zheng, Jun Yang, Zhou Zhu, Yongkang Fang, Yeye Tian, Minjie Xie, Wei Wang, Yang Liu
Summary: This study investigated the role of TREK-1 in focal cerebral ischemia using TREK-1-deficient mice and pharmacological inhibition. The results indicated that TREK-1 might have a detrimental effect in focal cerebral ischemia and inhibiting TREK-1 could be a strategy for treating ischemic stroke.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Clinical Neurology
Juan Zhu, Zheqi Li, Zhong Ji, Yongming Wu, Yihua He, Kewei Liu, Yuan Chang, Yuqin Peng, Zhenzhou Lin, Shengnan Wang, Dongmei Wang, Kaibin Huang, Suyue Pan
Summary: The dynamic degradation and reconstruction of GCX may explain the biphasic changes in BBB permeability in ischemic stroke, and reveal the essential role of GCX in suppressing transcellular transport in brain endothelial cells to maintain BBB integrity. Targeting GCX may provide a novel strategy for managing BBB dysfunction and central nervous system drug delivery.
Review
Pharmacology & Pharmacy
Zhizhun Mo, Zhongyi Zeng, Yuxiang Liu, Linsheng Zeng, Jiansong Fang, Yinzhong Ma
Summary: Stroke is a leading cause of death and survivors often suffer from severe neurological and motor deficits. The Wnt signaling pathway has been found to play a key role in the pathogenesis of stroke and reactivating this pathway can have significant therapeutic effects. A comprehensive understanding of the role of Wnt signaling in different cell types can help evaluate its potential value for stroke treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Caifeng Gu, Weichun Mo, Kunlun Wang, Mingqiang Gao, Junfeng Chen, Feng Zhang, Jie Shen
Summary: Ischemia/reperfusion (I/R) damage induced by stroke poses a serious hazard to human life, while the mechanism of blood-brain barrier (BBB) dysfunction is still unknown. Researchers found that cerebral I/R damage increased infarct volume and BBB permeability in a rat model of stroke. They also discovered that miR-370-3p regulates BBB permeability by targeting MAPK1.
Review
Biochemistry & Molecular Biology
Hui-min Gao, Hao Chen, Gui-Yun Cui, Jin-Xia Hu
Summary: This article briefly describes the role and mechanism of action of the blood-brain barrier (BBB), as well as the functional proteins involved. Additionally, it discusses the mechanisms of BBB damage following an ischemic stroke and presents several therapeutic strategies addressing these impairments. The article aims to provide innovative ideas for drug delivery research via the BBB.
CELL AND BIOSCIENCE
(2023)
Review
Clinical Neurology
Pan Huang
Summary: Arachidonic Acid (AA) is the precursor of cerebrovascular active substances in the human body, and its metabolites are closely associated with the pathogenesis of cerebrovascular diseases. In recent years, the cytochrome P450 (CYP) metabolic pathway of AA has become a research hotspot, which is regulated by soluble epoxide hydrolase (sEH). 1-trifluoromethoxyphenyl-3(1-propionylpiperidin-4-yl) urea (TPPU) is a novel sEH inhibitor that exerts cerebrovascular protective activity. This article reviews the mechanism of TPPU's protective effect on ischemic stroke disease.
FRONTIERS IN NEUROLOGY
(2023)
Article
Pharmacology & Pharmacy
Xuehui Fan, Hongping Chen, Chen Xu, Yingju Wang, Pengqi Yin, Meng Li, Zhanbin Tang, Fangchao Jiang, Wan Wei, Jihe Song, Guozhong Li, Di Zhong
Summary: S1PR3 is involved in the regulation of blood-brain barrier damage after cerebral ischemia/reperfusion. S1PR3 is expected to be an indicator and predictor of cerebral ischemia, and drugs targeting S1PR3 may also provide new ideas for clinical medications.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xue Yang, Jia Liang, Mengjie Jia, Tianhui Yang, Xinyang Deng, Pan Wang, Lili Ren, Shuang Gao, Zhongfu Zuo, Dan Pei, Jing Bi, Peng Wang
Summary: The study showed that B3galt2 protects mice against ischemic stroke by modulating the TGF-beta signaling pathway, reducing infarct volume, and improving neurological function. The damage to the BBB is closely related to the neuroprotective effects after cerebral ischemia.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Review
Chemistry, Multidisciplinary
Jianglong Kong, Runxuan Chu, Yi Wang
Summary: Stroke is a major cause of death and disability worldwide. Neuroprotective therapy, combined with thrombolytic therapy, is an important treatment for stroke.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Immunology
Ping-Chang Kuo, Wen-Tsan Weng, Barbara A. Scofield, Hallel C. Paraiso, Paul Bojrab, Brandon Kimes, I-Chen Ivorine Yu, Jui-Hung Jimmy Yen
Summary: This study found that interferon beta (IFN beta) extends the therapeutic window of tissue plasminogen activator (tPA) and alleviates its adverse effects in ischemic stroke. IFN beta modulates microglia (MG) phenotypes, suppressing inflammatory MG and promoting anti-inflammatory MG, which leads to reduced brain injury and blood-brain barrier disruption.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Clinical Neurology
Patrick Lyden, Alastair Buchan, Johannes Boltze, Marc Fisher
Summary: Despite years of research, ischemic stroke remains a major public health concern, and STAIR XI workshop addressed challenges such as redefining neuroprotection paradigm, using tissue window for patient selection, and proposing target window for therapies targeting elements of the neurovascular unit at different times.
Article
Health Care Sciences & Services
Bill J. Wright, Keri B. Vartanian, Hsin-Fang Li, Natalie Royal, Jennifer K. Matson
Article
Neurosciences
Sriparna Ghosal, Amy E. B. Packard, Parinaz Mahbod, Jessica M. McKlveen, Randy J. Seeley, Brent Myers, Yvonne Ulrich-Lai, Eric P. Smith, David A. D'Alessio, James P. Herman
JOURNAL OF NEUROSCIENCE
(2017)
Article
Psychology, Biological
M. L. Goodson, A. E. B. Packard, D. R. Buesing, M. Maney, B. Myers, Y. Fang, J. E. Basford, D. Y. Hui, Y. M. Ulrich-Lai, J. P. Herman, K. K. Ryan
PHYSIOLOGY & BEHAVIOR
(2017)
Article
Endocrinology & Metabolism
Amy E. B. Packard, Jintao Zhang, Brent Myers, Chih-Wei Ko, Fei Wang, Patrick Tso, Yvonne M. Ulrich-Lai
PSYCHONEUROENDOCRINOLOGY
(2017)
Article
Cardiac & Cardiovascular Systems
Heidi Allen, Bill J. Wright, Keri Vartanian, Kristen Dulacki, Hsin-Fang Li
CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES
(2019)
Article
Behavioral Sciences
Ann E. Egan, Laurel R. Seemiller, Amy E. B. Packard, Matia B. Solomon, Yvonne M. Ulrich-Lai
HORMONES AND BEHAVIOR
(2019)
Article
Health Care Sciences & Services
Keri B. Vartanian, Hannah Cohen-Cline, Sheetal Kulkarni-Rajasekhara, Heather M. Polonsky, Bill Wright
POPULATION HEALTH MANAGEMENT
(2020)
Article
Cardiac & Cardiovascular Systems
Derek Schaeuble, Amy E. B. Packard, Jessica M. McKlveen, Rachel Morano, Sarah Fourman, Brittany L. Smith, Jessie R. Scheimann, Benjamin A. Packard, Steven P. Wilson, Jeanne James, David Y. Hui, Yvonne M. Ulrich-Lai, James P. Herman, Brent Myers
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2019)
Article
Health Care Sciences & Services
Caroline Cawley, Hannelore Buckenmeyer, Trina Jellison, Joseph B. Rinaldi, Keri B. Vartanian
JMIR MHEALTH AND UHEALTH
(2020)
Article
Public, Environmental & Occupational Health
Hannah Cohen-Cline, Hsin-Fang Li, Monique Gill, Fatima Rodriguez, Tina Hernandez-Boussard, Harry Wolberg, Jacob Lippa, Keri Vartanian
Summary: The study revealed that individuals whose preferred language is not English are at a higher risk of testing positive for COVID-19, even after adjusting for age, race/ethnicity, and social factors. This highlights a significant inequity in healthcare access and outcomes for non-English speakers.
Article
Multidisciplinary Sciences
Keri B. Vartanian, Megan Holtorf, Emily J. Cox, George Diaz, Hargobind Khurana, Sherene Schlegel, Caroline Raganit, Brandon Ong, Todd Czartoski
Summary: Background Telemedicine is a crucial response to COVID-19 in the healthcare system. This study examined the engagement, experience, and utilization patterns for English and Spanish-speaking patients involved in a telemedicine home monitoring program (HMP) for COVID-19. The results showed a high level of satisfaction and comfort among participants, and the program was associated with increased outpatient care and emergency department encounters. This highlights the importance of language-concordant telemedicine.
Article
Health Care Sciences & Services
Keri Vartanian, Daniel Fish, Benjamin Gronowski, Natalie Kenton, Ari Robicsek
Summary: This study aims to understand the physical, mental, and social health outcomes of fully vaccinated individuals who contracted COVID-19. The results show that the global physical and mental health scores increased over time and remained within one standard deviation of the population mean. At least 40% of participants reported good health for all component questions, and the proportion reporting good health increased over time for all questions.
PATIENT-PATIENT CENTERED OUTCOMES RESEARCH
(2023)
Article
Family Studies
Hannah Cohen-Cline, Kyle G. Jones, Sheetal Kulkarni-Rajasekhara, Heather M. Polonsky, Keri B. Vartanian
CHILD ABUSE & NEGLECT
(2019)
Meeting Abstract
Biochemistry & Molecular Biology
Brent Myers, Derek Schaeuble, Amy E. B. Packard, Jessica M. McKlveen, Rachel L. Morano, Sarah Fourman, Brittany L. Smith, Jessie R. Scheimann, Ben A. Packard, Steven P. Wilson, Jeanne James, David Y. Hui, Yvonne M. Ulrich-Lai, James P. Herman
Article
Anatomy & Morphology
Amy E. B. Packard, Shi Di, Ann E. Egan, Sarah M. Fourman, Jeffrey G. Tasker, Yvonne M. Ulrich-Lai
BRAIN STRUCTURE & FUNCTION
(2017)
Article
Biochemistry & Molecular Biology
Pei-Yang Gao, Ya-Nan Ou, Yi-Ming Huang, Zhi-Bo Wang, Yan Fu, Ya-Hui Ma, Qiong-Yao Li, Li-Yun Ma, Rui-Ping Cui, Yin-Chu Mi, Lan Tan, Jin-Tai Yu
Summary: Liver function may play a role in the progression of Alzheimer's disease. The study found that as AD progressed, certain liver function markers increased while others decreased. The relationship between liver function and CSF AD biomarkers indicates a potential mediation effect on cognition.
JOURNAL OF NEUROCHEMISTRY
(2024)