Article
Pharmacology & Pharmacy
Guijun Wang, Guo Hou, Qi Tian, Chengli Liu, Yujia Guo, Heng Wei, Zhan Zhang, Mingchang Li
Summary: The knockout of S100A9 has a protective effect on early brain injury and neurogenic pulmonary edema (NPE) following subarachnoid hemorrhage (SAH). This effect is achieved through the regulation of inflammatory molecules, tight junction proteins, and apoptosis-associated proteins. Additionally, the use of Paquinimod also reduces inflammation and pulmonary edema.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Xinyan Wu, Yinghan Guo, Hanhai Zeng, Gao Chen
Summary: The study demonstrates the therapeutic value of DNase-1 in relieving neurogenic pulmonary edema (NPE) after subarachnoid hemorrhage (SAH), and suggests that DNase-1 has the potential to be a clinical drug for use after SAH.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Sung-Ho Ahn, Angela Burkett, Atzhiry Paz, Jude P. Savarraj, Sarah Hinds, Georgene Hergenroeder, Aaron M. Gusdon, Xuefeng Ren, Jeong-Ho Hong, Huimahn A. Choi
Summary: The study identified serum cytokines at different time points that were independently associated with persistent CE, particularly persistent elevations of Eotaxin were associated with persistent CE after SAH.
JOURNAL OF NEUROINFLAMMATION
(2022)
Review
Biochemistry & Molecular Biology
Yue Zhao, Yujie Luo, Yibo Liu, Cameron Lenahan, Qun Wu, Sheng Chen
Summary: Subarachnoid hemorrhage (SAH) is a devastating type of stroke with high mortality. Neuronal apoptosis and autophagy play crucial roles in the prognosis of SAH patients.
MOLECULAR BIOLOGY REPORTS
(2022)
Review
Neurosciences
Dengfeng Lu, Lingling Wang, Guangjie Liu, Shixin Wang, Yi Wang, Yu Wu, Jing Wang, Xiaoou Sun
Summary: Subarachnoid hemorrhage (SAH) is a common acute and severe disease worldwide, with unsatisfactory therapeutic strategies. Recent studies have shown that hydrogen sulfide (H2S) has promising neuroprotective effects in the treatment of central nervous system diseases, reducing secondary damage caused by SAH through antioxidant, anti-inflammatory, and anti-apoptosis mechanisms, as well as alleviating cerebral edema and vasospasm.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Medicine, General & Internal
Jong-Myong Lee
Summary: This study describes 7 cases of acute paraparesis caused by anterior communicating artery aneurysm rupture and evaluates the clinical and radiological factors associated with this syndrome. The results show that acute paraparesis is associated with acute hydrocephalus and global cerebral edema.
Article
Immunology
Qi Tian, Yujia Guo, Shi Feng, Chengli Liu, Peibang He, Jianfeng Wang, Wenrui Han, Chen Yang, Zhan Zhang, Mingchang Li
Summary: CCR2 expression is upregulated in both mouse models and clinical patients with subarachnoid hemorrhage. Inhibition of CCR2 can alleviate neuroinflammation and neuronal apoptosis. CCR2 levels in cerebrospinal fluid are associated with a 6-month prognosis in patients.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Biotechnology & Applied Microbiology
Ming Liu, Weiying Zhong, Chao Li, Wandong Su
Summary: The study examined the effects of Fluoxetine on apoptosis and the Notch1/ASK1/p38 MAPK signaling pathway in early brain injury after subarachnoid hemorrhage (SAH). The findings showed that Fluoxetine could reverse the effects of notch1 inhibition, suppress apoptosis, and improve brain injury after SAH.
Article
Clinical Neurology
Yong Guo, Yongmei Hu, Yi Huang, Lei Huang, Hideki Kanamaru, Yushin Takemoto, Hao Li, Dujuan Li, Jianjun Gu, John H. Zhang
Summary: This study explored the neuroprotective effects of ERR gamma activation against early brain injury (EBI) after subarachnoid hemorrhage (SAH) and its underlying mechanisms. The results showed that activating ERR gamma improved neurological deficits, reduced oxidative stress and neuronal apoptosis in SAH rats. ERR gamma may be a promising therapeutic target for ameliorating EBI after SAH.
Review
Clinical Neurology
Lei Guo, Xu Yang, Bo Yang, Guo Tang, Chunling Li
Summary: Neurogenic pulmonary edema (NPE) is a serious and life-threatening complication in patients with spontaneous subarachnoid hemorrhage (SAH). The global prevalence of NPE in patients with SAH was estimated to be 13% in this study. Female gender, WFNS class, APACHE II score ≥20, IL-6 > 40 pg/mL, Hunt and Hess grade ≥3, elevated troponin I, elevated white blood cell count, and electrocardiographic abnormalities were identified as risk factors for NPE after SAH. Early prediction of NPE onset is crucial for prevention and intervention.
NEUROSURGICAL REVIEW
(2023)
Article
Clinical Neurology
Hui Shi, Yuanjian Fang, Lei Huang, Ling Gao, Cameron Lenahan, Takeshi Okada, Zachary D. Travis, Shucai Xie, Hong Tang, Qin Lu, Rui Liu, Jiping Tang, Yuan Cheng, John H. Zhang
Summary: This study demonstrates that activation of GalR1 attenuated neuronal apoptosis after SAH through the ERK/GSK-3 beta/TIP60 pathway. GalR1 may serve as a promising therapeutic target for SAH patients.
Article
Clinical Neurology
Mario Zanaty, Lauren Allan, Edgar A. Samaniego, Anthony Piscopo, Eleanor Ryan, James C. Torner, David Hasan
Summary: The study suggests that using tirofiban in patients with aneurysmal subarachnoid hemorrhage can reduce the incidence of delayed cerebral ischemia.
Article
Biochemistry & Molecular Biology
Tongyu Zhang, Minghai Zhang
Summary: This study investigated the possible mechanism of NL-1 after subarachnoid hemorrhage (SAH) in rats. The results showed that NL-1 could improve neurological behavior, increase mitophagy, and reduce oxidative stress and apoptosis. However, liensinine may inhibit the treatment effect of NL-1.
NEUROCHEMICAL RESEARCH
(2023)
Article
Neurosciences
Chuanjing Fu, Heng Xin, Zhengting Qian, Xiang Li, Juemin Gao, Youwu Fan, Yong Tang, Yan Shi, Ding Li, Heming Wu
Summary: Microglial activation and sustained inflammation contribute to early brain injury (EBI) after subarachnoid hemorrhage (SAH). Sinomenine (SIN) has been shown to have neuroprotective effects in traumatic brain injury (TBI) models. This study aimed to investigate the effects of SIN on SAH-induced EBI and its impact on microglial inflammatory response. Results demonstrated that SIN administration improved neurobehavioral function, reduced neural apoptosis, and brain edema after SAH. Furthermore, SIN inhibited microglial activation and subsequent inflammatory response through the upregulation of HO-1 and NQO-1 via the Nrf2 pathway.
Article
Anesthesiology
Mukilan Balasubramanian, Aswini Kuberan, Amit Rawat, Sivashanmugam Dhandapani, Nidhi Panda, Ajay Kumar, Asish K. Sahoo, Munish Kumar, Tanavi Sharma, Paul S. Garcia, Hemant Bhagat
Summary: The study revealed that propofol, isoflurane, sevoflurane, or desflurane have similar effects on CSF and serum caspase-3 levels in aSAH patients, suggesting a possible role in neuroresuscitation by slowing the neuronal apoptotic pathway through reducing intraoperative CSF caspase-3 levels.
JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY
(2021)
Article
Neurosciences
Robert P. Ostrowski, John H. Zhang
JOURNAL OF NEUROSCIENCE RESEARCH
(2020)
Article
Neurosciences
Pinar Eser Ocak, Umut Ocak, Prativa Sherchan, John H. Zhang, Jiping Tang
JOURNAL OF NEUROSCIENCE RESEARCH
(2020)
Article
Neurosciences
Desislava Doycheva, Harpreet Kaur, Jiping Tang, John H. Zhang
JOURNAL OF NEUROSCIENCE RESEARCH
(2020)
Article
Endocrinology & Metabolism
Zhenhua Zhou, Ningbo Xu, Nathanael Matei, Devin W. McBride, Yan Ding, Hui Liang, Jiping Tang, John H. Zhang
Summary: The study demonstrated that intranasal administration of sodium butyrate reduced infarct volume and improved neurological function after middle cerebral artery occlusion (MCAO) in rats. The mechanism involved the activation of the PI3K/Akt pathway via GPR41/G beta gamma, leading to attenuation of neuronal apoptosis.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Review
Pharmacology & Pharmacy
Lei Huang, Cameron Lenahan, Warren Boling, Jiping Tang, John H. Zhang
Summary: Stroke is a major global health concern with limited effective treatments. Molecular hydrogen, as a novel medical gas, shows therapeutic potential for neurological diseases, including stroke. Studies have demonstrated neuroprotective effects of molecular hydrogen therapy in stroke patients and models, providing new insights for stroke treatment.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Review
Endocrinology & Metabolism
Richard Camara, Nathanael Matei, John H. Zhang
Summary: Although many patients are not eligible for reperfusion within 24 hours according to current guidelines, case studies show favorable outcomes for delayed recanalization beyond 24 hours after symptom onset. Modern imaging techniques aid in identifying penumbra and improving understanding of reperfusion risks and complications. There is an urgent need to further comprehend the pathophysiologic mechanisms and optimal conditions for delayed recanalization after 24 hours of ischemia.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Cell Biology
Shengpeng Liu, Jerry J. Flores, Bo Li, Shuixiang Deng, Gang Zuo, Jun Peng, Jiping Tang, John H. Zhang
Summary: This study found that rIL-19 treatment improved hematoma clearance and reduced neurological deficits after GMH by upregulating the IL-20R1/ERK/Nrf2 signaling pathway, suggesting a promising therapeutic strategy for GMH patients.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Cell Biology
Qin Zhang, Mei Zheng, Cristian E. Betancourt, Lifeng Liu, Albert Sitikov, Nikola Sladojevic, Qiong Zhao, John H. Zhang, James K. Liao, Rongxue Wu
Summary: The study found that MMP3 affects the permeability of the BBB through upregulation of the ERK signaling pathway, leading to a decrease in TJ and VE-cadherin proteins in BMVECs.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Review
Cell Biology
Li Li, Cameron Lenahan, Zhihui Liao, Jingdong Ke, Xiuliang Li, Fushan Xue, John H. Zhang
Summary: The immune system plays a crucial role in brain damage and recovery, but the biology of immune response in the brain is still poorly understood due to the complexity of the central nervous system and technological limitations. Novel technologies such as single-cell RNA analysis and cytometry by time-of-flight are being utilized to study brain immune response and may provide a promising future for brain repair.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Cell Biology
Shufeng Yu, Desislava Met Doycheva, Marcin Gamdzyk, Yuanyuan Gao, Yong Guo, Zackary D. Travis, Jiping Tang, Wen-Xiong Chen, John H. Zhang
Summary: The activation of MC1R with BMS-470539 attenuates oxidative stress and neuronal apoptosis in a neonatal HI rat model, improving neurological deficits. This effect is partially mediated by the MC1R/cAMP/PKA/Nurr1 signaling pathway.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Clinical Neurology
Jun Yan, Weilin Xu, Cameron Lenahan, Lei Huang, Jing Wen, Gaigai Li, Xin Hu, Wen Zheng, John H. Zhang, Jiping Tang
Summary: The study revealed that CCR5 activation can promote neuronal pyroptosis and neurological deficits after experimental intracerebral hemorrhage, partially through the CCR5/PKA/CREB/NLRP1 signaling pathway. Administration of the selective antagonist of CCR5, Maraviroc, improved neurobehavioral deficits and decreased neuronal pyroptosis, offering a promising therapeutic approach in managing patients with ICH.
Article
Cardiac & Cardiovascular Systems
Reng Ren, Qin Lu, Prativa Sherchan, Yuanjian Fang, Cameron Lenahan, Lihui Tang, Yi Huang, Rui Liu, John H. Zhang, Jianmin Zhang, Jiping Tang
Summary: The study demonstrates the crucial role of AHR in hyperglycemia-induced hematoma expansion after ICH. Inhibition of AHR can provide neurological benefits by restricting hematoma expansion and preserving BBB function. AHR may serve as a potential therapeutic target to attenuate hyperglycemia-induced complications in ICH patients.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cell Biology
Jinwei Pang, Nathanael Matei, Jianhua Peng, Wen Zheng, Jing Yu, Xu Luo, Richard Camara, Ligang Chen, Jiping Tang, John H. Zhang, Yong Jiang
Summary: Delayed recanalization at day 3 postinfarct can significantly improve neurological outcomes after ischemic stroke. Macrophages play a critical role in this process by promoting angiogenesis and reducing neurodegeneration.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Endocrinology & Metabolism
Chensheng Le, Xin Hu, Lusha Tong, Xianghua Ye, Junyi Zhang, Jun Yan, Prativa Sherchan, John H. Zhang, Feng Gao, Jiping Tang
Summary: This study investigated the role of LAR in neuroinflammation after intracerebral hemorrhage (ICH) using a mouse model. The results showed that LAR contributed to neuroinflammation after ICH via the RhoA/IRS-1 pathway, and the inhibitor ELP may be a potential therapeutic strategy to attenuate LAR-mediated neuroinflammation after ICH.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Review
Clinical Neurology
Ben Gaastra, John Zhang, Will Tapper, Diederik Bulters, Ian Galea
Summary: Sphingosine-1-phosphate (S1P) plays a role in the pathophysiology of neurological injury after aneurysmal subarachnoid haemorrhage (aSAH). The literature agrees that S1P increases in cerebrospinal fluid following aSAH and contributes to cerebral artery vasospasm. However, the role of S1P in the parenchyma is less clear, with conflicting studies suggesting both beneficial and harmful effects. This review provides a concise interpretation of the conflicting data and discusses the potential repurposing of S1P receptor modulators for aSAH.
TRANSLATIONAL STROKE RESEARCH
(2023)