Article
Chemistry, Multidisciplinary
Valeriya S. Bolshakova, Ekaterina O. Sinegubova, Yana L. Esaulkova, Alexander S. Peregudov, Ekaterina A. Khakina, Nikita A. Slesarenko, Alexander F. Shestakov, Vladimir V. Zarubaev, Pavel A. Troshin, Olga A. Kraevaya
Summary: Here, a simple method for synthesizing water-soluble fullerene derivatives with five residues of amino acids is presented. This method allows for the use of a wide range of amino acids, including those that are unstable under traditional reaction conditions. Additionally, the nature of the sixth addend X in the precursor compounds does not affect the synthesis, allowing for the production of fullerene derivatives with various X values. These derivatives have demonstrated promising antiviral activities against a rimantadine-resistant influenza A/Puerto Rico/8/34 (H1N1) virus in vitro.
CHINESE JOURNAL OF CHEMISTRY
(2023)
Article
Engineering, Biomedical
Huan Li, Yingying Li, Yudan Wang, Lijia Liu, Hongxing Dong, Toshifumi Satoh
Summary: In this study, a series of star-shaped cationic polyetheramides derived from amino acids were synthesized and investigated for their antibacterial and anti-biofilm activities as well as biocompatibility. These star-shaped polyetheramides exhibited high-efficient and broad-spectrum antibacterial activity and showed stability in complex mammalian body fluids.
ACTA BIOMATERIALIA
(2022)
Review
Chemistry, Applied
Hao-Qiang Cao, Jun-Kuan Li, Fa-Guang Zhang, Dominique Cahard, Jun-An Ma
Summary: This review comprehensively summarizes modern synthetic methods towards asymmetric construction of chiral amino carboxylic-phosphonic acid derivatives, including phosphono-containing amino acid derivatives and catalytic enantioselective synthesis as a potent strategy. Topics such as chiral resolution protocols, chiral auxiliary-directed syntheses, and valorization of abundant chiral amino acid resources are also discussed.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Editorial Material
Chemistry, Multidisciplinary
Bao-Le Qu, Mao-Mao Zhang, Liang-Qiu Lu, Wen-Jing Xiao
Summary: The study presents an iridium-catalyzed reaction for asymmetric synthesis of Z-allyl esters, allowing for the elegant preparation of important chiral Z-olefins.
Article
Biochemistry & Molecular Biology
K. Abinaya, Subash C. B. Gopinath, Thirumananseri Kumarevel, Pachaiappan Raman
Summary: The study evaluated the anti-quorum sensing activity of selected cationic amino acids histidine, arginine, and ornithine against P. aeruginosa and C. violaceum. Results showed that histidine had a stronger inhibitory effect on both organisms at MIC and sub-MIC concentrations.
PROCESS BIOCHEMISTRY
(2023)
Article
Chemistry, Organic
Daniel Polyak, Isaac J. Krauss
Summary: An efficient multigram synthesis method for alkynyl amino acid Fmoc-L-homopropargylglycine-OH is described. The optimized Boc protection and Seyferth-Gilbert homologation resulted in high material throughput and avoidance of racemization, respectively. The enantiopure (>98% ee) noncanonical amino acid can be readily generated for solid phase synthesis of functionalized peptides.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Oluyomi Stephen Adeyemi, Kosei Ishii, Kentaro Kato
Summary: The modified titanium dioxide nanoparticles showed strong anti-Toxoplasma gondii activity and did not exhibit significant cytotoxicity to host cells. Among them, tryptophan-modified titanium dioxide nanoparticles showed the highest specificity against T. gondii and improved host biocompatibility.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Chemistry, Multidisciplinary
Tapas Ghosh, Shu Wang, Dharmendra Kashyap, Rohit G. Jadhav, Tanmay Rit, Hem Chandra Jha, Brian G. Cousins, Apurba K. Das
Summary: Self-assembled benzoselenadiazole (BSe)-capped tripeptide based nanofibrillar hydrogels have been developed that possess intrinsic anticancer and anti-inflammatory activities.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Organic
Mingming Mao, Jia Li, Kang Dong, Rui-Peng Li, Xi Chen, Jian Liu, Shouchu Tang
Summary: We present a metal-free late-stage reductive C2 alkylation method for the synthesis of structurally complex peptides, utilizing readily available 1,3-dithianes. This protocol shows a broad substrate scope and excellent tolerance toward reactive functional groups.
Article
Biochemistry & Molecular Biology
Serdar Burmaoglu, Derya Aktas Anil, Arzu Gobek, Deryanur Kilic, Derya Yetkin, Nizami Duran, Oztekin Algul
Summary: This study describes a series of new chalcones that contain fluorine atoms on the B ring and exhibit antiproliferative activity against human tumor cells. Some of these compounds showed potent antiproliferative effects on certain tumor cells without cytotoxicity towards normal cells. The antiproliferative and cytotoxic effects were mediated through apoptosis. Molecular docking study suggested that these compounds interfere with cell division.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Pharmacology & Pharmacy
Khairunisa Mohd Zamli, Fatimah Hashim, Siti Aisyah Razali, Hanis Mohd Yusoff, Habsah Mohamad, Fauziah Abdullah, Asnuzilawati Asari
Summary: This study synthesized and screened nine eugenol derivatives for their potential antiamoebic activity against Acanthamoeba infections, demonstrating their effectiveness.
SAUDI PHARMACEUTICAL JOURNAL
(2023)
Article
Multidisciplinary Sciences
Chuansheng Guo, Zhiyuan You, Hao Shi, Yu Sun, Xingrong Du, Gustavo Palacios, Cliff Guy, Sujing Yuan, Nicole M. M. Chapman, Seon Ah Lim, Xiang Sun, Jordy Saravia, Sherri Rankin, Yogesh Dhungana, Hongbo Chi
Summary: Cancer cells evade T cell-mediated killing through unknown mechanisms. Dendritic cells, especially type-1 conventional DCs, play a crucial role in T cell priming and therapeutic efficacy against tumors. The function of dendritic cells is orchestrated by pattern recognition receptors, but other signals involved are not fully defined. Nutrients have been identified as emerging mediators of adaptive immunity, but their impact on dendritic cell function and communication between innate and adaptive immune cells is still unclear.
Article
Chemistry, Multidisciplinary
Minghao Feng, Roberto Tinelli, Ricardo Meyrelles, Leticia Gonzalez, Boris Maryasin, Nuno Maulide
Summary: This study reports a practical method for the synthesis of alpha-amino acid derivatives via direct hydrative amination of activated alkynes using sulfinamides as the nitrogen source under mild conditions. Computational studies suggest that the reaction is enabled by a new type of sulfonium [2,3]-sigmatropic rearrangement.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Pharmacology & Pharmacy
Qiong Huang, Xiao Wang, An Chen, Hua Zhang, Qimeng Yu, Chenfeng Shen, Annoor Awadasseid, Xiaoyin Zhao, Xuqiong Xiong, Yanling Wu, Wen Zhang
Summary: A series of new naphthalimide derivatives have been designed and synthesized, among which compound 7c displayed the strongest anti-tumor activity with the best selectivity for HepG2 cells. It was found that 7c induced HepG2 cell apoptosis, hindered cancer cell migration, and arrested the cell cycle at the G2/M phase. Mechanism studies revealed that 7c selectively induced a G-rich HRCC DNA sequence in the mitochondria to form a G-quadruplex structure, causing mitochondrial dysfunction and ultimately leading to proliferative inhibition and apoptosis of cancer cells.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Manuel J. Mallen-Ponce, Maria Esther Perez-Perez, Jose L. Crespo
Summary: This study reveals that carbon assimilation through the Calvin-Benson-Bassham cycle regulates TOR signaling in the model microalga Chlamydomonas reinhardtii, likely through the synthesis of key amino acids.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Medicinal
Tian-Yi Zhang, Zhan-Kui Yu, Xue-Jun Jin, Ming-Yue Li, Liang-Peng Sun, Chang-Ji Zheng, Hu-Ri Piao
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2018)
Article
Chemistry, Medicinal
Zhi-Yu Wei, Ke-Qiang Chi, Ke-Si Wang, Jie Wu, Li-Ping Liu, Hu-Ri Piao
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2018)
Review
Chemistry, Medicinal
Jiachun Liu, Yanling Wu, Huri Piao, Xiaoyin Zhao, Wen Zhang, Yanli Wang, Minrui Liu
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2018)
Article
Chemistry, Medicinal
Jie Wu, Zhi-Hong Zhang, Lin-Hao Zhang, Xue-Jun Jin, Juan Ma, Hu-Ri Piao
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2019)
Article
Biochemistry & Molecular Biology
Li-Min Zhao, Zhen Guo, Yi-Jie Xue, Jun Zhe Min, Wen-Jing Zhu, Xiang-Yu Li, Hu-Ri Piao, Cheng Hua Jin
Article
Chemistry, Medicinal
Liangpeng Sun, Peipei Wang, Lili Xu, Lixin Gao, Jia Li, Huri Piao
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2019)
Article
Biochemistry & Molecular Biology
Kun Yang, Ming-Ji Jin, Zhe-Shan Quan, Hu-Ri Piao
Article
Chemistry, Medicinal
Tian-Yi Zhang, Chang-Ji Zheng, Jie Wu, Liang-Peng Sun, Hu-Ri Piao
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2019)
Article
Chemistry, Medicinal
Jie Wu, Song Ma, Tian-Yi Zhang, Zhi-Yu Wei, Hui-Min Wang, Fang-Yan Guo, Chang-Ji Zheng, Hu-Ri Piao
MEDICINAL CHEMISTRY RESEARCH
(2019)
Article
Chemistry, Medicinal
Zhen Guo, Xiaowei Song, Li-Min Zhao, Ming Guan Piao, Jishan Quan, Hu-Ri Piao, Cheng Hua Jin
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2019)
Article
Chemistry, Medicinal
Lin-Hao Zhang, Zhi-Hong Zhang, Ming-Yue Li, Zhi-Yu Wei, Xue-Jun Jin, Hu-Ri Piao
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2019)
Article
Chemistry, Medicinal
Hongyan Liu, Danwen Sun, Hang Du, Changji Zheng, Jingya Li, Huri Piao, Jia Li, Liangpeng Sun
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2019)
Article
Chemistry, Medicinal
Liyan Lv, Jincai Lu, Hongyu Zhang, Xude Wang, Guangyue Su, Huri Piao, Yuqing Zhao
Article
Chemistry, Medicinal
Wen-Jing Zhu, Ben-Wen Cui, Hui Min Wang, Ji-Xing Nan, Hu-Ri Piao, Li-Hua Lian, Cheng Hua Jin
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Ke-Qiang Chi, Zhi-Yu Wei, Ke-Si Wang, Jie Wu, Wei-Qiang Chen, Xue-Jun Jin, Hu-Ri Piao
BIOORGANIC CHEMISTRY
(2017)
Article
Biochemistry & Molecular Biology
Olexander M. Semenenko, Victoria V. Lipson, Alina O. Sadchenko, Olga V. Vashchenko, Natalia A. Kasian, Liliia Sviechnikova, Longin M. Lisetski, Mykola L. Babak, Volodymyr M. Vakula, Oleksandr Borysov, Yuliia Holota, Sergey O. Zozulya, Petro O. Borysko, Olexander Mazepa
Summary: An efficient protocol for the synthesis of novel methotrexate-betulonic acid hybrids has been developed and their structures and properties have been fully established. The hybrids showed inferior interactions with artificial lipid membranes, possibly due to their increasing lipophilicity.
Article
Biochemistry & Molecular Biology
Mohadese Yaghoobi Anzabi, Piotr Cmoch, Roman Luboradzki, Zbigniew Pakulski
Summary: Friedelin and 3-acetoxyfriedel-3-en-2-one, known as friedelane triterpenoids, have been isolated from cork smoker wash solids and used as starting materials for the synthesis of new friedelane derivatives. Reduction reactions result in the formation of friedelinol and epi-cerin derivatives.
Article
Biochemistry & Molecular Biology
Detlef Thieme, Aniko Krumbholz, Martin Bidlingmaier, Christoph Geffert, Annika Hameder, Andreas Stoever, Matthias Graw, Annekathrin M. Keiler
Summary: Ethanol can affect testosterone metabolism and potentially influence steroid biosynthesis and blood steroid profiles. The study emphasizes the importance of sufficient time interval from food and ethanol intake during blood sampling, particularly for diagnostics in doping control.
Article
Biochemistry & Molecular Biology
Masanobu Murao, Tetsuo Imano, Yoshinobu Sato, Masaaki Nakajima
Article
Biochemistry & Molecular Biology
Jingyuan Wang, Ye Feng, Brian Liu, Wen Xie
Summary: Sulfation and desulfation of steroids are opposing processes that regulate steroid homeostasis and are involved in steroid-related diseases. Cytosolic sulfotransferase and steroid sulfatase modify and regulate steroids to affect hormonal dysregulation, metabolic diseases, and cancer.
Article
Biochemistry & Molecular Biology
Noah K. Babel, Brian J. Feldman
Summary: Our research identified a previously unrecognized ADAMTS1-PTN-Wnt pathway in regulating adipose precursor cell behavior. The non-muscle myosin protein MYH9 was found to be a key target of this pathway for modulating adipogenesis. These findings offer potential for developing novel therapeutics for obesity and related metabolic disorders.
Article
Biochemistry & Molecular Biology
Martiniano Bello
Summary: This study explores the structural and thermodynamic basis of molecular recognition between ERβ and DPN and its derivatives using molecular dynamics simulations and end-point methods. The results show that the MMGBSA approach is able to reproduce experimental trends and identify eight residues that strongly interact with the ligands.
