Article
Chemistry, Multidisciplinary
Bei Zhang, Shuxing Lv, Zhonghua Qiang, Miao Guo, Xin Tan, Huiqiang Li, Yang Yu
Summary: Competitive immunoassays have advantages in detecting small molecules, but balancing sensitivity and detection range is challenging due to variations in analyte concentrations. This study developed a chemiluminescence assay using antigens with different affinities, resulting in high sensitivity and wide detection range. The method was successfully applied to detect estradiol, with a lower limit of detection and good linearity.
Article
Medicine, General & Internal
Elena Kempf, Mandy Vogel, Tim Vogel, Juergen Kratzsch, Kathrin Landgraf, Andreas Kuehnapfel, Ruth Gausche, Daniel Graefe, Elena Sergeyev, Roland Pfaeffle, Wieland Kiess, Juraj Stanik, Antje Koerner
Summary: This study found distinctive changes in linear growth dynamics in children with obesity at different developmental stages, with early emergence possibly indicating genetic, environmental, and/or endocrine factors. Children with obesity were taller than their normal-weight peers, but may exhibit slower growth during puberty.
Review
Immunology
Holly Brettle, Vivian Tran, Grant R. Drummond, Ashley E. Franks, Steve Petrovski, Antony Vinh, Maria Jelinic
Summary: Obesity is characterized by excessive body fat accumulation and is linked to increased risks of major health problems such as cardiovascular disease, diabetes, and stroke. There are notable differences between sexes in the epidemiology, pathophysiology, and consequences of obesity, with females generally having better protection than males. This protection has been attributed to sex hormone estrogen and differences in fat distribution. More recent research highlights the role of differences in gut microbiota composition and function, as well as the intestinal immune system, in the sexual dimorphisms of obesity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Physiology
Sava M. Radovic Pletikosic, Isidora M. Starovlah, Dejan Miljkovic, Dragana M. Bajic, Ivan Capo, Serge Nef, Tatjana S. Kostic, Silvana A. Andric
Summary: The study indicates that insulin resistance in Leydig cells can lead to the development of female characteristics in mice, affecting testosterone levels and fertility. Insulin resistance results in a significant decrease in the activity and function of Leydig cells, causing changes in hormone conversion rate and reduced sperm count.
Article
Pharmacology & Pharmacy
Francesco Di Pierro, Ruqqia Sultana, Amna Zia Eusaph, Saida Abrar, Mahroo Bugti, Fauzia Afridi, Umer Farooq, Somia Iqtadar, Fareeha Ghauri, Syeda Makhduma, Shazia Nourin, Ayesha Kanwal, Aasiya Bano, Ali Akbar Bugti, Shah Mureed, Ayesha Ghazal, Romana Irshad, Martino Recchia, Alexander Bertuccioli, Pietro Putignano, Antonella Riva, Luigina Guasti, Nicola Zerbinati, Amjad Khan
Summary: A multi-centric, randomized, controlled and prospective study found that supplementation with Berberine Phytosome (BP), a more easily absorbed form of berberine, can improve menstrual and ovary abnormalities in women with polycystic ovary syndrome (PCOS), with good tolerability and safety.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Ming-Jun Chen, Jing Leng, Jian-Ping Ni, Ai-Ling Xiong, Man-Yun Hu
Summary: This study examined the association between fasting plasma C-peptide levels and sarcopenia, revealing a U-shaped relationship with lower risk in the range of 774-939 pmol/L.
Article
Andrology
Xin Lv, Yu-Ting Jiang, Xin-Yue Zhang, Lei-Lei Li, Hong-Guo Zhang, Rui-Zhi Liu
Summary: Previous studies have reported an association between body mass index (BMI) and sex hormone levels. However, these studies used linear or logistic regression models, which may result in the loss of important information. Our study compared different regression models and found that BMI was associated with testosterone and estradiol levels. Importantly, quantile regression revealed that BMI was only associated with estradiol levels up to the 80th percentile.
ASIAN JOURNAL OF ANDROLOGY
(2023)
Article
Endocrinology & Metabolism
Jose Carlos Fernandez-Garcia, Rocio Barrios-Rodriguez, Maite Asenjo-Plaza, Bruno Ramos-Molina, Maria Molina-Vega, Antonio Guzman-Guzman, Luis Moreno-Leon, Elena M. Yubero-Serrano, Francisca Rius-Diaz, Sergio Valdes, Miguel Angel Martinez-Gonzalez, Jose Juan Jimenez-Moleon, Francisco J. Tinahones
Summary: Among men with obesity and low testosterone concentrations, the combination of metformin plus testosterone, metformin only, and testosterone only, compared to placebo, reduced insulin resistance with no evidence of additive benefit.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Article
Cell Biology
Seyed Amirhossein Tabatabaei Dakhili, Kunyan Yang, Cassandra A. A. Locatelli, Christina T. Saed, Amanda A. Greenwell, Jordan S. F. Chan, Jadin J. Chahade, Jared Scharff, Shahad Al-Imarah, Farah Eaton, Peter A. Crawford, Keshav Gopal, Erin E. Mulvihill, John R. Ussher
Summary: Acute elevations in circulating ketones improve glucose tolerance in obesity, independent of muscle ketone oxidation.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Review
Endocrinology & Metabolism
Weijuan Cui, Ling Zhao
Summary: Through a systematic review and meta-analysis of randomized controlled trials, we found that the co-administration of 17-beta-estradiol and norethisterone acetate has a positive impact on glycated hemoglobin, fasting glucose, insulin, and C-peptide concentrations in females. Future research is needed to confirm the potential benefits of this drug combination in the prevention and/or management of cardiometabolic disorders.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Zoya Huschtscha, Alexandra Parr, Judi Porter, Ricardo J. S. Costa
Summary: The study investigated the effects of consuming high-protein dairy milk beverage with or without progressive resistance training (PRT) on age-related sarcopenia in older adults. The results showed that while the milk beverage did not further enhance the effects of PRT on fat-free mass or physical performance, it did significantly improve maximal strength outcomes during PRT in healthy active older adults.
FRONTIERS IN NUTRITION
(2021)
Article
Endocrinology & Metabolism
Federico Oldoni, Kevin Bass, Julia Kozlitina, Hannah Hudson, Lisa M. Shihanian, Viktoria Gusarova, Jonathan C. Cohen, Helen H. Hobbs
Summary: Plasma A8 levels vary significantly across different racial/ethnic groups and are associated with BMI, fasting glucose, insulin, and TG levels. However, genetic variants in the A8 locus do not appear to have a causal relationship with the metabolic phenotypes associated with A8 levels.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Xiaohui Li, Jia Liu, Biao Zhou, Yinhui Li, Zhengyu Wu, Hua Meng, Guang Wang
Summary: Adipose tissue insulin resistance (adipose-IR) in males is higher than in females with similar BMI levels. Adipose-IR increases progressively from overweight to class III obesity in both genders, but is significantly higher in males than females in the class III obesity group. Testosterone levels are negatively correlated with adipose-IR in males, while positively correlated in females. Low testosterone levels may contribute to more severe adipose-IR in obese males.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Larissa Valadares Ramos, Teresa Helena Macedo da Costa, Sandra Fernandes Arruda
Summary: The effects of coffee on glucose metabolism in obesity are controversial. Results showed that chronic coffee consumption did not ameliorate the negative effects on glucose metabolism induced by a high-fat diet, but it did improve antioxidant and anti-inflammatory responses, increase insulin secretion, and promote muscle glycogen synthesis.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Endocrinology & Metabolism
Luigi Barrea, Ludovica Verde, Claudia Vetrani, Annamaria Docimo, Giulia de Alteriis, Silvia Savastano, Annamaria Colao, Giovanna Muscogiuri
Summary: This study investigated the prevalence of different chronotype categories in women with PCOS and their impact on hormonal and metabolic aspects. The findings showed a higher prevalence of evening chronotype in women with PCOS, which was associated with worse hormonal and metabolic profiles.
JOURNAL OF PINEAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Olexander M. Semenenko, Victoria V. Lipson, Alina O. Sadchenko, Olga V. Vashchenko, Natalia A. Kasian, Liliia Sviechnikova, Longin M. Lisetski, Mykola L. Babak, Volodymyr M. Vakula, Oleksandr Borysov, Yuliia Holota, Sergey O. Zozulya, Petro O. Borysko, Olexander Mazepa
Summary: An efficient protocol for the synthesis of novel methotrexate-betulonic acid hybrids has been developed and their structures and properties have been fully established. The hybrids showed inferior interactions with artificial lipid membranes, possibly due to their increasing lipophilicity.
Article
Biochemistry & Molecular Biology
Mohadese Yaghoobi Anzabi, Piotr Cmoch, Roman Luboradzki, Zbigniew Pakulski
Summary: Friedelin and 3-acetoxyfriedel-3-en-2-one, known as friedelane triterpenoids, have been isolated from cork smoker wash solids and used as starting materials for the synthesis of new friedelane derivatives. Reduction reactions result in the formation of friedelinol and epi-cerin derivatives.
Article
Biochemistry & Molecular Biology
Detlef Thieme, Aniko Krumbholz, Martin Bidlingmaier, Christoph Geffert, Annika Hameder, Andreas Stoever, Matthias Graw, Annekathrin M. Keiler
Summary: Ethanol can affect testosterone metabolism and potentially influence steroid biosynthesis and blood steroid profiles. The study emphasizes the importance of sufficient time interval from food and ethanol intake during blood sampling, particularly for diagnostics in doping control.
Article
Biochemistry & Molecular Biology
Masanobu Murao, Tetsuo Imano, Yoshinobu Sato, Masaaki Nakajima
Article
Biochemistry & Molecular Biology
Jingyuan Wang, Ye Feng, Brian Liu, Wen Xie
Summary: Sulfation and desulfation of steroids are opposing processes that regulate steroid homeostasis and are involved in steroid-related diseases. Cytosolic sulfotransferase and steroid sulfatase modify and regulate steroids to affect hormonal dysregulation, metabolic diseases, and cancer.
Article
Biochemistry & Molecular Biology
Noah K. Babel, Brian J. Feldman
Summary: Our research identified a previously unrecognized ADAMTS1-PTN-Wnt pathway in regulating adipose precursor cell behavior. The non-muscle myosin protein MYH9 was found to be a key target of this pathway for modulating adipogenesis. These findings offer potential for developing novel therapeutics for obesity and related metabolic disorders.
Article
Biochemistry & Molecular Biology
Martiniano Bello
Summary: This study explores the structural and thermodynamic basis of molecular recognition between ERβ and DPN and its derivatives using molecular dynamics simulations and end-point methods. The results show that the MMGBSA approach is able to reproduce experimental trends and identify eight residues that strongly interact with the ligands.