Article
Cell Biology
Wei Pan, Liqiang Gu, Hongzhong Yang, Cong Xu, Zhengbiao Yang, Qijiong Lu, Yuhua Shi, Lili Zhang, Jinjin Shao, Yunxiang Chen, Xin Pan, Feifei Wu, Ruolang Pan, Jinfeng Liang, Lijiang Zhang
Summary: This study assessed the effects of human umbilical cord mesenchymal stem cells (hUC-MSCs) on cynomolgus monkeys in terms of toxicity, immune perturbation, and toxicokinetics. The results showed that hUC-MSCs had an immunosuppressive effect and did not cause obvious systemic toxicity in the monkeys. However, close monitoring is needed in future clinical trials to identify any potential adverse effects.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Cell Biology
Xiaobo Li, Qijing Huang, Xiangxiang Zhang, Changfeng Xie, Muyun Liu, Yueming Yuan, Jianjia Feng, Haoyu Xing, Li Ru, Zheng Yuan, Zhiyong Xu, YaoXiang Yang, Yan Long, Chengfeng Xing, Jianping Song, Xiang Hu, Qin Xu
Summary: The study evaluated the effects of intravenous injection of hUC-MSCs on reproduction and development in rats, finding no significant adverse effects within a certain dosage range, but high doses may lead to mortality in pregnant female rats, highlighting the importance of cautious use.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Engineering, Biomedical
Cheung Kwan Yeung, Yaping Yan, Li Yan, Yanchao Duan, Enqin Li, Borong Huang, Ke Lu, Koukou Li, Muya Zhou, Lei Zhang, Yaojiong Wu, Kathy Qian Luo, Weizhi Ji, Ren-He Xu, Wei Si
Summary: Previous research has shown that locally-administered MSCsp can promote wound healing and alleviate multiple sclerosis and osteoarthritis, while intravenous injection of MSCsp in cynomolgus monkeys has been found to be feasible, safe, and potentially associated with better efficacy.
Review
Cell Biology
Yuelong Zhang, Huangming Zhuang, Xunshan Ren, Fuze Jiang, Panghu Zhou
Summary: Osteoarthritis is a common and disabling disease, and surgical treatment is the main approach. Human umbilical cord mesenchymal stem cells (hUC-MSCs) are self-regenerative pluripotent cells that promote cartilage regeneration through the secretion of various trophic factors. The combination of hUC-MSCs with other substances also shows a significant synergistic effect on osteoarthritis treatment. Some scholars have suggested transplanting stem cells into damaged cartilage to slow down the progression of osteoarthritis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Cell Biology
Santhosh Kacham, Tejal Sunil Bhure, Sindhuja D. Eswaramoorthy, Gaurav Naik, Subha Narayan Rath, Sreenivasa Rao Parcha, Sayan Basu, Virender Singh Sangwan, Sachin Shukla
Summary: Umbilical cord-derived mesenchymal stem cells promote the repair of injured corneal epithelium by stimulating the proliferation of corneal epithelial cells, potentially serving as a non-ocular source of stem cells for treating injury-induced bilateral corneal diseases.
Review
Cell & Tissue Engineering
Oldouz Shareghi-oskoue, Leili Aghebati-Maleki, Mehdi Yousefi
Summary: Premature ovarian failure (POF) is a problem for women before the age of 40, characterized by symptoms such as amenorrhea and low estrogen levels. The current treatment approach involves stem cell therapy, particularly HUCMSC transplantation, which has shown to effectively improve ovarian function and treat infertility.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Su Hyeon Myeong, Hyeongseop Kim, Na Kyung Lee, Jung Won Hwang, Hee Jin Kim, Hyemin Jang, Soo Jin Choi, Duk L. Na
Summary: Transplanted hUCB-MSCs have been found to cause transient inflammatory responses and fever in patients with Alzheimer's disease, as well as in a mouse model. Increased levels of pro-inflammatory cytokines were observed in both the clinical trial and mouse study.
Article
Obstetrics & Gynecology
Shunichiro Tsuji, Takeo Mukai, Hideaki Tsuchiya, Chizuru Iwatani, Akiko Nakamura, Tokiko Nagamura-Inoue, Takashi Murakami
Summary: This study aimed to investigate the therapeutic potential of umbilical cord-derived mesenchymal stem cells (UC-MSCs) for endometriosis. In a nonhuman primate model, intraperitoneal administration of UC-MSCs exacerbated the condition, while intravenous administration decreased CA125 levels.
REPRODUCTIVE MEDICINE AND BIOLOGY
(2023)
Article
Cell Biology
Shichao Wang, Wenyue Jiang, Shuang Lv, Zhicheng Sun, Lihui Si, Jinxin Hu, Yang Yang, Dingbang Qiu, Xiaobin Liu, Siying Zhu, Lunhao Yang, Ling Qi, Guangfan Chi, Guiqing Wang, Pengdong Li, Baojian Liao
Summary: This study confirms the anti-inflammatory effects of human umbilical cord-derived mesenchymal stem cell exosomes (hUC-MSCs-Exos) in the treatment of chondrocyte inflammation, suggesting their potential as a cell-free treatment strategy for osteoarthritis.
Article
Cell & Tissue Engineering
Hsiu-Chu Chou, Chien-Hsiang Chang, Chien-Han Chen, Willie Lin, Chung-Ming Chen
Summary: The consecutive intratracheal administration of surfactant and hUC-MSCs for two days effectively attenuated hyperoxia-induced lung injury in neonatal rats, demonstrating a potential therapeutic regimen for this condition.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Thang Quoc Bui, Nguyen Trong Binh, Truc Le-Buu Pham, Trinh Le Van, Nhung Hai Truong, Dang Phu-Hai Nguyen, Thao Thi-Thu Luu, Trang Nguyen-Xuan Pham, Tu Cam Tran, Huyen Thuong-Thi Nguyen, Nhu Thuy-Trinh, Phong Anh Tran
Summary: In this study, the transplantation of human umbilical cord-derived mesenchymal stem cell (MSC) sheets was investigated as a potential treatment for myocardial infarction (MI). The findings showed that MSC sheets with higher cell density had better therapeutic effects on MI mice, with significant improvements in weight gain and ejection fraction recovery. In conclusion, hUC-MSC sheets ameliorated heart MI injury in mice and their efficacy improved with increased cell density.
Article
Chemistry, Multidisciplinary
Liming Li, Jiafu Mu, Yu Zhang, Chenyang Zhang, Teng Ma, Lu Chen, Tianchen Huang, Jiahe Wu, Jian Cao, Shiqing Feng, Youzhi Cai, Min Han, Jianqing Gao
Summary: This study found that exosomes derived from hypoxic preconditioned human umbilical vein endothelial cells can stimulate angiogenic MSCs, showing great potential in the treatment of traumatic spinal cord injury.
Article
Biotechnology & Applied Microbiology
Xiao Zhai, Kai Chen, Huan Yang, Bo Li, Tianjunke Zhou, Haojue Wang, Huipeng Zhou, Shaofeng Chen, Xiaoyi Zhou, Xiaozhao Wei, Yushu Bai, Ming Li
Summary: CD73+ hucMSC-EVs ameliorated inflammation after spinal cord injury by reducing extracellular ATP, promoting A2bR/cAMP/PKA pathway and M2/M1 polarization. They may be promising nano drugs for clinical application in SCI therapy.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Adolfo Rodriguez-Eguren, Maria Gomez-alvarez, Emilio Frances-Herrero, Monica Romeu, Hortensia Ferrero, Emre Seli, Irene Cervello
Summary: This literature review analyzes the application of human umbilical cord mesenchymal stem cells (hUC-MSCs) and blood derivatives in the treatment of female infertility. It shows that these alternative therapies have high efficacy in promoting anti-inflammatory and regenerative processes. However, further clinical trials are needed to validate their application.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yu-Hsun Chang, Kun-Chi Wu, Dah-Ching Ding
Summary: This study found that Exo(-)FBS-cultured HUCMSCs have similar characteristics to FBS-cultured HUCMSCs and showed better therapeutic effects in a mouse osteoarthritis model. These findings provide a basis for future clinical trials using Exo(-)FBS-cultured stem cells for the treatment of osteoarthritis.
Article
Biochemistry & Molecular Biology
Baoquan Song, Hairui Zhang, Lei Jiang, Ying Chi, Jianjian Tian, Wenjing Du, Bentong Yu, Zhongchao Han
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2015)
Article
Biochemistry & Molecular Biology
Wantong Wu, Weiqiang Wang, Yun Wang, Wenwen Li, Gang Yu, Zhonglong Li, Chunmin Fang, Yue Shen, Zhina Sun, Ling Han, Juan Yu, Lijun Fang, Song Chen, Kui Dong, Zhongchao Han, Hanzhi Liu, Yuechen Luo, Xiaoming Feng
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2015)
Article
Chemistry, Multidisciplinary
Wei-qiang Wang, Dan Zhao, Yu-shan Zhou, Xiao-yu Hu, Zhi-na Sun, Gang Yu, Wan-tong Wu, Song Chen, Jiu-long Kuang, Guo-gang Xu, Zhong-chao Han, Bang-mao Wang, Jing-xian Yang, Xiao-ming Feng
ACTA PHARMACOLOGICA SINICA
(2015)
Article
Hematology
Qinjun Zhao, Hongying Ren, Sizhou Feng, Ying Chi, Yi He, Donglin Yang, Fengxia Ma, Jianping Li, Shihong Lu, Fang Chen, Jianhui Xu, Shaoguang Yang, Zhongchao Han
BLOOD CELLS MOLECULES AND DISEASES
(2015)
Article
Cell & Tissue Engineering
Fengxia Ma, Dandan Chen, Fang Chen, Ying Chi, Zhibo Han, Xiaoming Feng, Xue Li, Zhongchao Han
CELL TRANSPLANTATION
(2015)
Article
Cell Biology
Chunmin Fang, Juan Yu, Yuechen Luo, Song Chen, Weiqiang Wang, Chunxiao Zhao, Zhina Sun, Wantong Wu, Wei Guo, Zhongchao Han, Xiao Hu, Fang Liao, Xiaoming Feng
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
(2015)
Article
Cell Biology
Bao-quan Song, Ying Chi, Xue Li, Wen-jing Du, Zhi-Bo Han, Jian-jian Tian, Juan-juan Li, Fang Chen, He-he Wu, Li-xin Han, Shi-hong Lu, Yi-zhou Zheng, Zhong-chao Han
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
(2015)
Article
Multidisciplinary Sciences
Xue Li, Wenjing Du, Feng Xia Ma, Xiaoming Feng, Francis Bayard, Zhong Chao Han
Article
Cell & Tissue Engineering
Lina Wang, Weijun Su, Wei Du, Yang Xu, Lijun Wang, Deling Kong, Zhongchao Han, Guoguang Zheng, Zongjin Li
STEM CELL REVIEWS AND REPORTS
(2015)
Article
Medicine, Research & Experimental
Junfeng Liu, Zhibo Han, Zhongchao Han, Zhixu He
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2015)
Article
Medicine, Research & Experimental
Junfeng Liu, Zhibo Han, Zhongchao Han, Zhixu He
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2016)
Article
Biochemical Research Methods
Hua Bai, Haiyu Li, Zhibo Han, Cheng Zhang, Junfa Zhao, Changyun Miao, Shulin Yan, Aibin Mao, Hui Zhao, Zhongchao Han
BIOMEDICAL OPTICS EXPRESS
(2015)
Article
Multidisciplinary Sciences
Ningning He, Yang Xu, Wei Du, Xin Qi, Lu Liang, Yuebing Wang, Guowei Feng, Yan Fan, Zhongchao Han, Deling Kong, Zhen Cheng, Joseph C. Wu, Zuoxiang He, Zongjin Li
SCIENTIFIC REPORTS
(2015)
Article
Cell & Tissue Engineering
Lina Wang, Weijun Su, Wei Du, Yang Xu, Lijun Wang, Deling Kong, Zhongchao Han, Guoguang Zheng, Zongjin Li
STEM CELL REVIEWS AND REPORTS
(2015)
Review
Cell & Tissue Engineering
Hongyan Tao, Zhibo Han, Zhong Chao Han, Zongjin Li
STEM CELLS INTERNATIONAL
(2016)