Article
Biotechnology & Applied Microbiology
Xin Chen, Jiajun Yan, Yingying Jiang, Yunshan Fan, Zhengran Ying, Shuo Tan, Zhi Zhou, Junjian Liu, Feng Chen, Shisheng He
Summary: This study presents a biomimetic strategy for developing an injectable biomaterial composed of platelets, fibrins, and biominerals to repair bone defects. The biomaterial showed high biocompatibility and promoted the osteogenic differentiation of bone marrow stem cells. In vivo studies demonstrated that the biomaterial induced the formation of new collagen and blood vessels, leading to faster bone defect regeneration. This research provides a strategy for designing new biomimetic materials and holds significant importance for the treatment of refractory bone fractures.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Anastasia Yu. Teterina, Igor V. Smirnov, Irina S. Fadeeva, Roman S. Fadeev, Polina V. Smirnova, Vladislav V. Minaychev, Margarita I. Kobyakova, Aleksandr Yu. Fedotov, Sergey M. Barinov, Vladimir S. Komlev
Summary: The study presented the synthesis of low-temperature calcium phosphate compounds with strontium substitution to improve bioactive properties, indicating the effectiveness of using strontium in OCP for enhancing biocompatibility in composite materials intended for bone repair.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Engineering, Biomedical
Oznur Demir-Oguz, Aldo R. Boccaccini, Dagnija Loca
Summary: Calcium phosphate bone cements (CPCs) have valuable properties such as bioactivity, osteoconductivity, injectability, and moldability, but their low mechanical performance limits their clinical application. Adding bioactive glasses (BGs) as a secondary powder phase can improve the injectable properties of CPCs and enhance the degradation rate, in vitro osteogenic differentiation, cell response, and tissue-material interaction.
BIOACTIVE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Min-juan Shen, Chen-yu Wang, Dong-xiao Hao, Jia-xin Hao, Yi-fei Zhu, Xiao-xiao Han, Lige Tonggu, Ji-hua Chen, Kai Jiao, Franklin R. Tay, Li-na Niu
Summary: The idea that RNA can play nonbiological roles in the nanomaterial world is revolutionary. RNA molecules can self-assemble into various nanostructures and have the potential to replicate bone healing. The development of RNA-biomineral nanomachines can mimic bone formation and create an environment conducive to rapid biomineralization and osteogenesis.
ADVANCED MATERIALS
(2022)
Article
Engineering, Biomedical
Agneta Vezenkova, Janis Locs
Summary: With the increase in global population, the demand for bone substitutes is growing. Calcium phosphate cements (CPCs) have the potential for various applications in bone regeneration due to their ability to self-set and resorb. However, finding an osteoinductive material that is suitable for injection remains a challenge.
BIOACTIVE MATERIALS
(2022)
Article
Biophysics
Yuanda Liu, Jing Wang, Ming Jiang, Xueyan Li, Qinghao Zhang, Hongyan He
Summary: In this study, a hybrid membrane with biomimetic function was developed to create an angiogenesis-inductive microenvironment through the release of calcium ions, aiming to overcome the limitations of bone tissue regeneration in diabetic patients. The results showed that the hybrid membrane can enhance vascularization and bone regeneration by recruiting, proliferating, and differentiating mesenchymal stem cells and endothelial progenitors.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Multidisciplinary Sciences
Dimitra Athanasiadou, Nadeen Meshry, Naara G. Monteiro, Ana C. Ervolino-Silva, Ryan Lee Chan, Christopher A. McCulloch, Roberta Okamoto, Karina M. M. Carneiro
Summary: DNA-based biomaterials have potential as biodegradable scaffolds for bone repair due to their ability to bind Ca2+ and promote HAP growth. This study describes the design and synthesis of DNA hydrogels, their interactions with osteogenic cell lines, and their promotion of new bone formation in rat calvarial wounds.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Materials Science, Ceramics
Hyeon Jin Kim, Kummara Madhusudana Rao, K. S. V. Krishna Rao, Sung Soo Han
Summary: Bioactive hydrogels with enhanced bone-like apatite formation were developed using a calcium-free phosphate approach. The structure and properties of the hydrogels were validated through analysis techniques. The hydrogels exhibited a porous structure with a fibrous topology, promoting cell growth and adhesion. The phosphate functionality within the hydrogels facilitated rapid biomineralization.
CERAMICS INTERNATIONAL
(2023)
Article
Engineering, Biomedical
Zhe Xu, Zhixuan Zhu, Hui Chen, Lingyu Han, Pujie Shi, Xiufang Dong, Di Wu, Ming Du, Tingting Li
Summary: The IEELEEELEAER peptide (PIE) derived from Mytilus edulis protein hydrolysate enhances osteoblast growth and differentiation and has a superior bone formation ability. It binds to calcium and facilitates calcium uptake, and when incorporated into calcium phosphate cements, it promotes calcium ion uptake, osteoblast proliferation, and inhibits bacterial growth. This study suggests that PIE-supplemented calcium phosphate cements can be used as an efficient material for bone grafts in spinal surgery.
Article
Multidisciplinary Sciences
Lijia Cheng, Tianchang Lin, Ahmad Taha Khalaf, Yamei Zhang, Hongyan He, Liming Yang, Shuo Yan, Jiang Zhu, Zheng Shi
Summary: The study developed an artificial bone material with excellent mechanical properties and good osteogenic capability, which showed better bone tissue regeneration and repair effects in mice compared to the control group. The CTC composites have proven to be a promising option for orthopedic patients.
SCIENTIFIC REPORTS
(2021)
Review
Engineering, Biomedical
Xiaodong Hou, Lei Zhang, Zifei Zhou, Xiong Luo, Tianlong Wang, Xinyu Zhao, Bingqiang Lu, Feng Chen, Longpo Zheng
Summary: This review discusses the role and properties of CaP-based biomaterials in bone regeneration, including synthesis strategies, structure control, biological behavior, and the mechanisms of CaP in promoting osteogenesis. It will be helpful for scientists and engineers to further understand CaP-based biomaterials and develop new high-performance biomaterials for bone repair.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2022)
Article
Materials Science, Biomaterials
Zhongcheng Li, Qian Ren, Sili Han, Longjiang Ding, Xi Qin, Die Hui, Ting Het, Tian Tian, Ziqian Lu, Linglin Zhang
Summary: The study demonstrated the promoting effect of ID8 on the intrafibrillar mineralization of collagen, achieved through its self-assembly ability and calcium responsiveness. It enhanced intermolecular hydrogen bonding and significantly increased the hydrophilicity of collagen. Peptides with self-assembly properties like ID8 are expected to be potential tools for biomimetic mineralization of collagen.
REGENERATIVE BIOMATERIALS
(2022)
Article
Engineering, Biomedical
M. T. Tavares, S. C. Santos, C. A. Custodio, J. P. S. Farinha, C. Baleizao, J. F. Mano
Summary: A novel PLMA-based nanocomposite was developed for bone repair and regeneration, capable of guiding the differentiation of human bone marrow-derived mesenchymal stem cells without any other osteogenic supplementation.
MATERIALS TODAY BIO
(2021)
Article
Engineering, Biomedical
Jiawei Liu, Wen Hou, Wenying Wei, Jian Peng, Xiaopei Wu, Chenxi Lian, Yanan Zhao, Rong Tu, Takashi Goto, Honglian Dai
Summary: This study proposes a strategy to develop high-performance bone cement and establishes a trimagnesium phosphate cement (TMPC) system. The TMPC exhibits high early strength, low curing temperature, neutral pH, and excellent injectability, overcoming the critical limitations of recently studied magnesium phosphate cement. By adjusting the pH of the system, the magnesium-to-phosphate ratio can manipulate the components of hydration products and their transformation, as well as influence the hydration speed and regulate the properties of TMPC. Moreover, TMPC shows outstanding biocompatibility and bone-filling capacity, making it a potential alternative to current bone cements.
BIOACTIVE MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Ahmed Salama
Summary: Researchers are increasingly focusing on the development of unique materials from sustainable and renewable resources, with chitosan and its derivatives being versatile candidates for preparing attractive materials. Various preparation strategies for chitosan/calcium phosphate composites have been discussed and are widely applied in the biomedical and environmental fields.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Polymer Science
Muhammad Ilyas, Md. Anamul Haque, Youfeng Yue, Takayuki Kurokawa, Tasuku Nakajima, Takayuki Nonoyama, Jian Ping Gong
Article
Polymer Science
Kei Mito, Md. Anamul Haque, Tasuku Nakajima, Maki Uchiumi, Takayuki Kurokawa, Takayuki Nonoyama, Jian Ping Gong
Article
Chemistry, Multidisciplinary
Ya Nan Ye, Martin Frauenlob, Lei Wang, Masumi Tsuda, Tao Lin Sun, Kunpeng Cui, Riku Takahashi, Hui Jie Zhang, Tasuku Nakajima, Takayuki Nonoyama, Takayuki Kurokawa, Shinya Tanaka, Jian Ping Gong
ADVANCED FUNCTIONAL MATERIALS
(2018)
Article
Chemistry, Multidisciplinary
Md. Tariful Islam Mredha, Yun Zhou Guo, Takayuki Nonoyama, Tasuku Nakajima, Takayuki Kurokawa, Jian Ping Gong
ADVANCED MATERIALS
(2018)
Article
Engineering, Biomedical
Ryuji Kiyama, Takayuki Nonoyama, Susumu Wada, Shingo Semba, Nobuto Kitamura, Tasuku Nakajima, Takayuki Kurokawa, Kazunori Yasuda, Shinya Tanaka, Jian Ping Gong
ACTA BIOMATERIALIA
(2018)
Article
Orthopedics
Ryosuke Hishimura, Tomohiro Onodera, Kazutoshi Hontani, Rikiya Baba, Kentaro Homan, Shinji Matsubara, Zenta Joutoku, WooYoung Kim, Takayuki Nonoyama, Takayuki Kurokawa, Jian Ping Gong, Norimasa Iwasaki
AMERICAN JOURNAL OF SPORTS MEDICINE
(2019)
Article
Chemistry, Multidisciplinary
Riku Takahashi, Kouichi Shimano, Haruka Okazaki, Takayuki Kurokawa, Tasuku Nakajima, Takayuki Nonoyama, Daniel R. King, Jian Ping Gong
ADVANCED MATERIALS INTERFACES
(2018)
Article
Medicine, General & Internal
Takeru Tsujimoto, Hideki Sudo, Masahiro Todoh, Katsuhisa Yamada, Koji Iwasaki, Takashi Ohnishi, Naoki Hirohama, Takayuki Nonoyama, Daisuke Ukeba, Katsuro Ura, Yoichi M. Ito, Norimasa Iwasaki
Article
Polymer Science
Kunpeng Cui, Ya Nan Ye, Tao Lin Sun, Liang Chen, Xueyu Li, Takayuki Kurokawa, Tasuku Nakajima, Takayuki Nonoyama, Jian Ping Gong
Article
Polymer Science
Joji Murat, Tasuku Nakajima, Takahiro Matsuda, Katsuhiko Tsunoda, Takayuki Nonoyama, Takayuki Kurokawa, Jian Ping Gong
Article
Chemistry, Multidisciplinary
Takayuki Nonoyama, Yong Woo Lee, Kumi Ota, Keigo Fujioka, Wei Hong, Jian Ping Gong
ADVANCED MATERIALS
(2020)
Article
Engineering, Biomedical
Md. Tariful Islam Mredha, Nobuto Kitamura, Takayuki Nonoyama, Susumu Wada, Keiko Goto, Xi Zhang, Tasuku Nakajima, Takayuki Kurokawa, Yasuaki Takagi, Kazunori Yasuda, Jian Ping Gong
Article
Chemistry, Multidisciplinary
Yiwan Huang, Daniel R. King, Tao Lin Sun, Takayuki Nonoyama, Takayuki Kurokawa, Tasuku Nakajima, Jian Ping Gong
ADVANCED FUNCTIONAL MATERIALS
(2017)
Article
Materials Science, Multidisciplinary
Hui Jie Zhang, Feng Luo, Yanan Ye, Tao Lin Sun, Takayuki Nonoyama, Takayuki Kurokawa, Tasuku Nakajima
ACS APPLIED POLYMER MATERIALS
(2019)
Article
Chemistry, Multidisciplinary
Md. Anamul Haque, Kei Mito, Takayuki Kurokawa, Tasuku Nakajima, Takayuki Nonoyama, Muhammad Ilyas, Jian Ping Gong
Article
Chemistry, Physical
Yiping Yin, Zhe Wang, Hua Zou
Summary: This study presents a novel method for preparing dimpled polymer-silica nanocomposite particles using interfacial swelling-based seeded polymerization. The optimized conditions allow for a relatively high percentage of dimpled particles to be achieved.
Article
Chemistry, Physical
Brenden D. Hoehn, Elizabeth A. Kellstedt, Marc A. Hillmyer
Summary: Porous materials with nanometer-scale pores have important applications as nanoporous membranes. In this study, ABA triblock copolymers were used as precursors to produce nanoporous polymeric membranes (NPMs) in thin film form by degrading the end blocks. Polycyclooctene (PCOE) NPMs with tunable pore sizes were successfully prepared using solvent casting technique. Oxygen plasma etching was employed to improve the surface porosity and hydrophilicity of the membranes. This study provides a straightforward method to produce tough NPMs with high porosity and hydrophilic surface properties.
Article
Chemistry, Physical
Vladislav S. Petrovskii, Stepan I. Zholudev, Igor I. Potemkin
Summary: This article investigates the behavior of linear and ring polypeptide chains in aqueous solution and explores the properties of the complexes formed by these chains with oppositely charged surfactants. The results demonstrate that the complexes of linear supercharged unfolded polypeptides and the corresponding surfactants exhibit impressive adhesive properties.
Article
Chemistry, Physical
Merve Cevik, Serkan Dikici
Summary: Cardiovascular diseases are a leading cause of death globally, and vascular grafts are a promising treatment option. This study focuses on tissue-engineered vascular grafts (TEVGs) using decellularized parsley stems as a potential biomaterial. The decellularized parsley stems showed suitable properties for TEVGs, providing a suitable environment for human endothelial cells to form a pseudo endothelium. This study showcases the potential of using parsley stems for TEVGs.
Article
Chemistry, Physical
Gustavo A. Vasquez-Montoya, Tadej Emersic, Noe Atzin, Antonio Tavera-Vazquez, Ali Mozaffari, Rui Zhang, Orlando Guzman, Alexey Snezhko, Paul F. Nealey, Juan J. de Pablo
Summary: The optical properties of liquid crystals are typically controlled by electric fields. In this study, we investigate the effects of microfluidic flows and acoustic fields on the molecular orientation and optical response of nematic liquid crystals. We identify several previously unknown structures and explain them through calculations and simulations. These findings hold promise for the development of new systems combining sound, flow, and confinement.
Article
Chemistry, Physical
Xinjun Wu, Xin Guan, Shushu Chen, Jiangpeng Jia, Chongyi Chen, Jiawei Zhang, Chuanzhuang Zhao
Summary: This research presents a novel shape memory hydrogel with a remodelable permanent shape and programmable cold-induced shape recovery behavior. The hydrogel is prepared using specific treatment methods to achieve shape fixation by heating and shape recovery by cooling. Additionally, deformable devices can be obtained by assembling hydrogel blocks with different concentrations.
Article
Chemistry, Physical
Rebecca Hengsbach, Gerhard Fink, Ulrich Simon
Summary: This study examines the properties of DNA functionalized pNipmam microgels and pure pNipmam microgels at different concentrations of sodium chloride and in PBS solutions using temperature dependent H-1-NMR measurements. The results show that DNA modification affects the volume phase transition temperature and the addition of salt and PBS further enhances this effect.
Article
Chemistry, Physical
Ningyi Li, Junhong Li, Lijingting Qing, Shicheng Ma, Yao Li, Baohui Li
Summary: This paper investigates the self-assembly behavior of colloids with competing interactions under spherical confinement and finds that different ordered structures can be formed under different sized spherical confinements. Moreover, more perforated structures are formed in smaller spheres.