Article
Chemistry, Analytical
W. Cheuquepan, S. Hernandez, M. Perez-Estebanez, L. Romay, A. Heras, A. Colina
Summary: Electrochemistry can be used to generate SERS substrates, utilizing the plasmonic properties of nanos-tructures and the chemical mechanism, with time-resolved Raman spectroelectrochemistry providing valuable information. Comparing Au and Ag metals for folic acid detection in drugs, it was found that Ag SERS substrates outperformed Au SERS substrates in complex samples.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2021)
Review
Chemistry, Multidisciplinary
Andrea N. Giordano, Rahul Rao
Summary: The field of ultraviolet surface-enhanced Raman scattering (UV-SERS) has lagged behind its visible and near-infrared counterparts despite its potential advantages. A major challenge is the lack of accessible and reproducible UV-SERS substrates. In this review, we assess the reported UV-SERS substrates based on their composition, morphology, and performance, and discuss the challenges and opportunities in this field. We also explore potential application areas for UV-SERS, such as detecting environmentally and militarily relevant analytes, in situ experimentation, defect engineering, extreme environment materials development, and biosensing.
Article
Spectroscopy
Tong Zhang, Shunhua Zhu, Jingjing Wang, Zhiying Liu, Mingxin Wang, Shibao Li, Qingli Huang
Summary: Fabricating sensitive, stable and low-cost nanomaterials for glucose detection is crucial for disease diagnosis and monitoring. In this study, a nanocomposite (polypyrrole bridging GO@Au@MnO2) was developed as a novel surface-enhanced Raman scattering (SERS) nanoprobe for quantitative glucose detection in trace serum.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Electrochemistry
Sheila Hernandez, Juan Perales-Rondon, Aranzazu Heras, Alvaro Colina
Summary: EC-SOERS is a new phenomenon that enhances the Raman signal during the oxidation of a metal surface. Studies show that carbonyl and carboxyl groups are necessary to observe this phenomenon, with a delocated charge being important factor. Evaluating the enhancement factors for different molecules with highly delocated charge and a carboxyl group sheds more light on the interaction of molecules with the electrochemically generated SOERS substrates.
ELECTROCHIMICA ACTA
(2021)
Review
Chemistry, Multidisciplinary
Ilya A. Milekhin, Alexander G. Milekhin, Dietrich R. T. Zahn
Summary: This study presents the optical response of spherical CdSe nanocrystals using SERS and TERS techniques, achieving significant enhancement of optical phonons by selecting appropriate plasmonic substrates. Combining Raman scattering with atomic force microscopy offers nanoscale spatial resolution for investigating phonon properties. Gap-mode TERS further enhances Raman scattering of CdSe NCs' optical phonon modes with nanometer spatial resolution, providing new pathways for optical characterization and phonon spectrum details at the nanometer scale of single semiconductor nanostructures.
Article
Physics, Multidisciplinary
Guanzhou Lin, Bingquan Yang, Chenglong Zhang, Jia Zhu, Yang Wang, Liye Li, Shisong Xiong, Jinwen Zhang, Zhimei Qi, Wengang Wu
Summary: In this study, a simple composite substrate combining a metal metasurface and silver nanoparticles was developed to enhance the performance of surface-enhanced Raman scattering (SERS) sensing. The composite substrate showed high enhancement factor, good stability, and reproducibility, enabling the detection of trace substances.
Review
Chemistry, Multidisciplinary
Shanshan Lin, Ziyi Cheng, Qifu Li, Rui Wang, Fabiao Yu
Summary: Molecular imaging technologies, especially SERS imaging, offer significant advantages in clinical diagnostics, enabling accurate detection of biomarkers and cellular microenvironment. The integration of multimodal imaging helps achieve more comprehensive and accurate imaging outcomes, showing strong potential in discriminating pathological tissues and surgical navigation.
Article
Chemistry, Multidisciplinary
Myoung Gyu Kim, Miyeon Jue, Kwan Hee Lee, Eun Yeong Lee, Yeonjeong Roh, Minju Lee, Hyo Joo Lee, Sanghwa Lee, Huifang Liu, Bonhan Koo, Yoon Ok Jang, Eui Yeon Kim, Qiao Zhen, Sung-Han Kim, Jun Ki Kim, Yong Shin
Summary: The study introduces a deep learning assisted ZnO-Au-SERS-based direct amplification (ZADA) system for rapid, sensitive molecular diagnostics. The system can amplify target nucleic acids directly on the SERS surface, eliminating the need for post-amplification hybridization and Raman reporters. Clinical validation with COVID-19 samples yielded high sensitivity and specificity. The integration of a deep learning program further enhanced sensitivity and specificity to 100%.
Article
Chemistry, Analytical
Weixing Gao, Weiman Duan, Dandan Peng, Juan Li, Zhangmei Hu, Dongmei Wang, Zhengjun Gong, Meikun Fan
Summary: The complexity of substances in environmental water bodies is leading to severe ecotoxicological problems. Evaluating water quality accurately based on the species and concentration of chemicals alone is difficult due to the intricate interaction among various chemicals. Therefore, the acute toxicity evaluation of water is of significant importance in environmental monitoring, especially in emergency situations. This study proposes a SERS approach to evaluate the acute toxicity of fresh water for the first time, using indole as an indicator. It demonstrates the feasibility of using SERS-based microbial sensors to assess acute toxicity in water.
MICROCHEMICAL JOURNAL
(2023)
Article
Materials Science, Multidisciplinary
Junxiang Xiang, Yunxia Wang, Yupeng Wu, Qi Peng, Langquan Shui, Wengen Ouyang, Tao Ding, Ze Liu
Summary: A cost-effective approach for fabricating highly ordered metallic pillar arrays in centimeter scale has been developed using superplastic nanomolding and anodic aluminum oxide templates. This method enables surface-enhanced Raman scattering with an enhancement factor of approximately 10^6 and provides guidance for quantitative analysis on the sub-micrometer scale.
ADVANCED MATERIALS TECHNOLOGIES
(2022)
Review
Chemistry, Analytical
Dan Li, Ling Xia, Gongke Li
Summary: This paper reviews the classification and applications of nanozymes in surface-enhanced Raman scattering (SERS), highlighting their importance in disease diagnosis, food safety, and environmental safety. The practical shortcomings of nanozymes in SERS applications are also discussed, and suggestions for further research are provided.
Article
Spectroscopy
Mengmeng Zheng, Yamin Lin, Jianshu Xu, Jiamin Gao, Wei Gong, Shusen Xie, Yun Yu, Juqiang Lin
Summary: This study compared electroporation-assisted and ultrasound-assisted delivery methods for surface-enhanced Raman scattering (SERS) detection, finding that the two methods have different capabilities in delivering nanoparticles into living cells. Ultrasound-assisted SERS showed better sensitivity, specificity, and accuracy in discriminating and identifying drug-treated degranulated mast cells compared to electroporation-assisted SERS.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Review
Chemistry, Physical
Ryan D. Norton, Hoa T. Phan, Stephanie N. Gibbons, Amanda J. Haes
Summary: This review discusses the recent advances in quantitative SERS detection, focusing on intermolecular interactions, surface selection rules, and target molecule solubility and accessibility. The impacts of surface selection rules and enhancement mechanisms on the activation and deactivation of normal Raman modes in SERS are explored. The review also summarizes the experimental conditions that can be used to tune the molecular affinity to and density near SERS substrates.
ANNUAL REVIEW OF PHYSICAL CHEMISTRY
(2022)
Article
Chemistry, Applied
Jie He, Hongxia Li, Lulu Zhang, Xiao Zhi, Xin Li, Xin Wang, Zijian Feng, Guangxia Shen, Xianting Ding
Summary: This study demonstrated an easy-prepared and low-cost surface enhanced Raman Scattering (SERS) chip for the quantitative testing of carbendazim in Chinese tea, which offers more aggregation-induced hotspots, strong 3D synergetic effects, and reduces costs without impacting performance.
Article
Chemistry, Physical
Faezeh Mohaghegh, Alireza Mazaheri Tehrani, Arnulf Materny
Summary: The increase in inelastically scattered signal observed in Surface-enhanced Raman spectroscopy (SERS) is attributed to different mechanisms. The study revealed a transition to pure electromagnetic enhancement when molecules are separated from the metal surface. By preventing direct contact between molecules and the metal surface, the electronic (chemical) enhancement mechanism can be switched.
JOURNAL OF PHYSICAL CHEMISTRY C
(2021)