Review
Biochemistry & Molecular Biology
Jaehi Kim, Min-Sup Shin, Jonghyun Shin, Hyung-Mo Kim, Xuan-Hung Pham, Seung-min Park, Dong-Eun Kim, Young Jun Kim, Bong-Hyun Jun
Summary: Rapid, accurate, and convenient diagnosis is crucial for effective disease management, and lateral flow immunoassay (LFIA) with optical nanoparticles (NPs) has emerged as a major diagnostic tool. Researchers have developed various types of optical NPs with modified optical properties to serve as probes for LFIA. This review focuses on the literature about LFIA with optical NPs for specific target detection in diagnostics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Ana Barragan, Sara Lois, Ane Sarasola, Lucia Vitali
Summary: Non-covalent bonds are crucial for designing self-assembled organic structures with high responsiveness. In this study, the synergistic action of multiple highly-directional and purely electrostatic bonds was examined in the assembly of a specific molecule on the Au surface. The research found that multiple secondary interactions strengthen the electrostatic attraction and form the building blocks of the structures.
Article
Chemistry, Multidisciplinary
Xin Zhang, Haoxuan Ding, Shu Yang, Hualin Yang, Xiaoqing Yang, Bosheng Li, Xueting Xing, Yaojie Sun, Guangxin Gu, Xiaorui Chen, Jianzhi Gao, Minghu Pan, Lifeng Chi, Quanmin Guo
Summary: Chirality transfer plays a vital role in the structure and functionality of biological systems. By adjusting the kinetic factors, such as deposition rate and heat treatment, different chiral 2D assemblies can be synthesized on the Au(111) surface from achiral molecules, resulting in enantiomeric entities. The results demonstrate that chirality transfer and induction in biological assemblies can be controlled by altering the kinetic factors, providing insights and practical approaches for the design of complex biomolecular superstructures.
Review
Chemistry, Medicinal
Yuchen Qiao, Bing Xu
Summary: Supramolecular assemblies formed by peptides have been widely applied in various fields. This review focuses on the recent progress of using peptide assemblies as supramolecular medicine for cancer therapy. The combination of peptide assemblies with anticancer drugs, as well as the use of enzyme-controlled transformation of peptide assemblies for inhibiting cancer cells and tumors, are discussed. The review also provides an outlook on the future prospects of this exciting field.
Article
Multidisciplinary Sciences
Xu-Man Chen, Xiao-Fang Hou, Hari Krishna Bisoyi, Wei-Jie Feng, Qin Cao, Shuai Huang, Hong Yang, Dongzhong Chen, Quan Li
Summary: Light-induced amphiphiles were used to construct an artificial dissipative self-assembly system, which can form dissipative supramolecular assembly in water through light irradiation. The lifetimes of the transient supramolecular nanoparticles are highly sensitive to temperature and light power, and they can function in human hepatocellular cancer cells.
NATURE COMMUNICATIONS
(2021)
Review
Chemistry, Multidisciplinary
Ayan Chatterjee, Antara Reja, Sumit Pal, Dibyendu Das
Summary: This article discusses the use of minimal peptide assemblies to emulate the structure and function of existing enzymes, aiming to understand the origins of catalytically active binding pockets in early life. Additionally, the study focuses on catalytic systems under non-equilibrium conditions to shed light on the role of bioenergetics in the chemical emergence of complex behavior.
CHEMICAL SOCIETY REVIEWS
(2022)
Article
Chemistry, Applied
Xiaofan Ruan, Fei Yu, Yuehe Lin, Dan Du, Bernard J. Van Wie
Summary: Atrazine and acetochlor are herbicides commonly used in crop production. In this study, we developed two Pd@Pt nanoparticle-based immunoassays, a colorimetric NLISA and a dual-LFIA-DPV, to quantify the presence of these herbicides in food and vegetable samples. Both immunoassays showed good overall recoveries and low limits of detection. The findings suggest that Pd@Pt-based immunoassays have potential applications in various fields.
Article
Chemistry, Multidisciplinary
Jialei Song, Chengling Wu, Yan Zhao, Min Yang, Qingxin Yao, Yuan Gao
Summary: A bioorthogonal disassembly strategy was developed to prompt clearance of supramolecular assemblies within living cells. The enzyme-instructed self-assembly process led to the disruption of pi-pi stacking and induced disassembly of the assemblies, depriving them of potency and addressing their unintended retention and cellular toxicity. This strategy leverages biosafety in developing nanomaterials for drug delivery systems.
Article
Nanoscience & Nanotechnology
Wenhao Li, Tiange Gao, Chenxi Lou, Haifang Wang, Yuanfang Liu, Aoneng Cao
Summary: This study presents a novel artificial antibody called Goldbody, which is based on gold nanoparticles and exhibits comparable specificity and improved stability compared to monoclonal antibodies. The Goldbody was successfully utilized in competitive LFIA and ELISA assays for the detection of lysozyme, demonstrating its potential as a substitute for monoclonal antibodies in immunoassays.
ACS APPLIED NANO MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Bo Kyeong Yoon, Tun Naw Sut, Ki Yeol Yoo, Seung Hwa Lee, Youngkyu Hwang, Joshua A. Jackman, Nam-Joon Cho
Summary: A streamlined ELISA strategy using lipid nanoparticles as a blocking agent was developed, showing fewer processing steps, quicker protocol time, and superior detection performance compared to conventional BSA blocking. This method has been successfully applied to COVID-19 antibody detection and is broadly applicable for rapid ELISA diagnostics development.
APPLIED MATERIALS TODAY
(2021)
Article
Biochemistry & Molecular Biology
Rongyu Tang, Yang Song, Lizhi Zhang, Ziliang Shi
Summary: In this work, we demonstrate the formation of supramolecular assemblies from a bifunctional ligand on Au(111), which enables the engineering of two-dimensional (metal-) organic multilevel nanostructures. The bifunctional ligand employed offers multiple bonding motifs that are highly self-selective and self-recognizable, resulting in the formation of subunits for multilevel self-assemblies. Scanning tunneling microscopy experiments and density functional theory calculations were used to determine the different bonding motifs dictating the levels of the assemblies. This multilevel assembly protocol provides a deliberate control over the fabrication of surface-confined (metal-) organic nanostructures, opening up new opportunities for the synthesis of complex functional nanomaterials.
Review
Engineering, Biomedical
Jiali Chen, Yan Zhao, Qingxin Yao, Yuan Gao
Summary: Peptidic self-assembly, particularly guided by pathological environment, has shown significant progress in constructing biomedical materials with integrated functions and treating diseases. Cancer and infection instructed self-assembly have demonstrated great therapeutic efficacy and potential applications, showcasing a novel targeting regime with selective assembly in pathological loci.
BIOMEDICAL MATERIALS
(2021)
Article
Chemistry, Analytical
Menglian Wei, Todd Darcie, Wenwen Xu, Yongfeng Gao, Hannah Mundel, J. Stewart Aitchison, Xueji Zhang, Michael J. Serpe
Summary: The study revealed that coating the Au film of a surface plasmon resonance sensor with microgels and depositing a layer of Au on top of the microgels can enhance the sensor's sensitivity to changes in solution properties.
ANALYTICAL CHEMISTRY
(2021)
Article
Optics
N. N. H. E. N. Mahmud, N. A. Awang, N. U. H. H. Zulkefli, F. N. M. Hanafiah
Summary: This study presents a method for optically trapping silica gel microparticles using a stable Q-switched fiber laser pulse. By fabricating gold nanoparticles as saturable absorbers, stable Q-switched fiber laser pulses with a frequency of 25.81 kHz were achieved. The microparticles exhibited different attractive trapping forces based on the viscous drag exerted by the laser field. Experimental results confirmed the validity of the numerical model and demonstrated the potential application of the proposed system for absorption microparticle trapping at 1540 nm wavelength.
OPTICS AND LASERS IN ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Cheng-Yan Wu, Shilong Su, Xi Zhang, Rui Liu, Bing Gong, Zhong-Lin Lu
Summary: This study presents a strategy for creating molecular nanotubes with defined lengths by tethering macrocyclic units and oligomer chains. The resulting tubular assemblies can form potassium and proton channels with relatively long open durations, indicating enhanced thermodynamic stability by reducing the number of molecular components. The findings demonstrate the feasibility and reliability of covalently tethering shape-persistent macrocyclic units for building molecular nanotubes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Chemistry, Analytical
Alejandra Alba-Patino, Andreu Vaquer, Enrique Baron, Steven M. Russell, Marcio Borges, Roberto de la Rica
Summary: This article reviews recent advances in diagnostic tools for managing sepsis based on micro- and nanostructured materials. It discusses popular biomarkers and detection methods for sepsis diagnosis, and highlights the role of micro- and nanostructured materials in developing biosensors to meet the specific needs of different points of sepsis care. The article also summarizes the most utilized materials and points out future challenges for development.
Article
Chemistry, Multidisciplinary
Andreu Vaquer, Enrique Baron, Roberto de la Rica
Summary: This article presents a chrono-sampling method for fabricating wearable devices made entirely of filter paper. The method uses dried polymers as valves to control the flow of liquids for sequential measurements. The concept was demonstrated with a paper multisensor capable of performing nine consecutive pH measurements and a urea biosensor. The proposed analytical platform can monitor the pH of sweat with accuracy and precision comparable to a laboratory-based method.
Article
Multidisciplinary Sciences
Aldrik H. Velders, Michel Ossendrijver, Bart J. F. Keijser, Vittorio Saggiomo
Summary: A solution to the bottlenecks of centralized testing during the pandemic is presented, with a cheap and easy-to-produce noninstrumental device for at-home SARS-CoV2 RNA detection. This device, capable of maintaining isothermal conditions for LAMP tests, has minimal environmental impact and can be deployed on a large scale in a short amount of time.
Article
Chemistry, Analytical
Steven M. Russell, Alejandra Alba-Patino, Andreu Vaquer, Antonio Clemente, Roberto de la Rica
Summary: This study introduces a minimal reader prototype composed of open-source hardware and software that can automatically measure colorimetric signals in rapid tests. It avoids interoperability issues associated with closed-source readers and utilizes an image-processing algorithm to automatically select an optimal region of interest and measure pixel intensity. The results obtained with the proposed algorithm for detecting antibodies against SARS-CoV-2 were comparable to manual methods but showed improved precision and accuracy in quantifying small spots or faint and patchy signals.
Article
Chemistry, Analytical
Maria del Mar Gonzalez del Campo, Alejandra Alba-Patino, Carlos Palomino, Marta Bauza, Estrella Rojo-Molinero, Antonio Oliver, Gemma Turnes, Roberto de la Rica
Summary: This study explored the impact of polymer modifications on the storage and release of reagents in paper-based biosensors, revealing that different polymers can enhance reagent concentration and release efficiency. By modifying polymers, the sensitivity of biosensors can be significantly improved and the detection limits can be lowered.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Review
Materials Science, Multidisciplinary
Mariadel Mar Gonzalez del Campo, Andreu Vaquer, Roberto de la Rica
Summary: In recent years, paper has become a widely used material for developing various types of sensors, and a polymer-based toolbox has emerged to enhance the functionalities of these devices. This article compiles examples from recent literature on microfluidic systems and polymer-based transducers implemented in paper-based analytical platforms. The use of printing methods to pattern polymers allows for mass production of these advanced paper-based devices without requiring specialized facilities.
ADVANCED MATERIALS TECHNOLOGIES
(2022)
Article
Chemistry, Multidisciplinary
Rebecca Kaup, Aldrik H. Velders
Summary: This study investigates the dynamics of polyamidoamine (PAMAM) dendrimer based micelles and shows that they can be manipulated by changing dendrimer generation, pH, and stoichiometry. The results reveal the exchange of dendrimers between micellar cores and demonstrate the importance of dendrimer generation, charge density, and stoichiometry in controlling the dynamics of complex coacervate core micelles.
Article
Biochemistry & Molecular Biology
Nikolas Duszenko, Danny M. van Willigen, Anton Bunschoten, Aldrik H. Velders, Meta Roestenberg, Fijs W. B. van Leeuwen
Summary: This study demonstrates that pathogen immunogenicity can be enhanced by complexing an adjuvant onto the surface of a poorly immunogenic bacterium. The adjuvanted bacteria were able to stimulate a stronger immune response and could potentially be used as a treatment modality to boost the immune system's response to pathogenic microbes.
Article
Chemistry, Physical
Laura M. I. Schijven, Vittorio Saggiomo, Aldrik H. Velders, Johannes H. Bitter, Constantinos V. Nikiforidis
Summary: Researchers have discovered that solid or hollow microparticles can be formed using proteins with different aggregate sizes. By mixing proteins with CaCl2 and Na2CO3 solutions, and then adding Au3+ ions, solid and hollow protein microparticles with embedded gold nanoparticles can be fabricated. This method has a broader range of applications, including biomaterial preparation and multimodal imaging.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Analytical
Andreu Vaquer, Cristina Adrover-Jaume, Antonio Clemente, Amanda Iglesias, Meritxell Lopez, Rocio Martinez, Isabel M. Roig, Borja G. Cosio, Roberto de la Rica
Summary: A new method for infusing porous materials with concentrated polymers is proposed, which solves the issue of high viscosity during conventional printing methods and reduces manufacturing variability of biosensors. Immunosenors for detecting cytokines IL-6 and IL-5 were developed using this method and showed promising results.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Multidisciplinary Sciences
M. Victoria Gomez, Sander Baas, Aldrik H. Velders
Summary: Nuclear Magnetic Resonance (NMR) spectroscopy is a powerful technique for molecular characterization and quantification, but is limited by poor sensitivity and expensive hardware. In this study, a microfluidic NMR-chip with a single planar-spiral microcoil and photochemically induced hyperpolarization is used for multidimensional and heteronuclear NMR experiments on picomole quantities of material. This chip significantly improves sensitivity and reduces cost and hardware complexity compared to traditional instruments.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Manuel Gutierrez-Capitan, Ana Sanchis, Estela O. Carvalho, Antonio Baldi, Lluisa Vilaplana, Vanessa F. Cardoso, Alvaro Calleja, Mingxing Wei, Roberto de la Rica, Javier Hoyo, Arnau Bassegoda, Tzanko Tzanov, Maria-Pilar Marco, Senentxu Lanceros-Mendez, Cesar Fernandez-Sanchez
Summary: This study demonstrates a unique and easily deployable multiplex device that can simultaneously measure interleukin-8, tumor necrosis factor-α, and myeloperoxidase biomarkers in sputum, aiming to facilitate the timely detection of acute exacerbations of chronic obstructive pulmonary disease.
Article
Chemistry, Analytical
David Delgado-Cano, Antonio Clemente, Cristina Adrover-Jaume, Andreu Vaquer, Meritxell Lopez, Rocio Martinez, Isabel M. Roig, Amanda Iglesias, Borja G. Cosio, Roberto de la Rica
Summary: Rapid detection and treatment of Pseudomonas aeruginosa (P. aeruginosa) infections in the respiratory tract of patients with chronic lung diseases is crucial. In this study, an alternative diagnosis approach based on analyzing breath aerosols was proposed. The use of nanoparticle immunosensors on the polypropylene layer of surgical facemasks worn by patients allowed for the detection of chronic and acute P. aeruginosa lung infections.
Article
Chemistry, Analytical
Giulia Santopolo, Antonio Clemente, Estrella Rojo-Molinero, Antonio Oliver, Camilla Noe, Roberto de la Rica
Summary: In this study, a multisensor was proposed for the rapid detection of bacterial pathogens carrying different types of β-lactamases. The sensor can generate colored spots that can be quantified and interpreted to identify the presence of specific enzymes.
ANALYTICAL CHEMISTRY
(2022)
Article
Materials Science, Biomaterials
Laura M. Schijven, Thomas D. Vogelaar, Simha Sridharan, Vittorio Saggiomo, Aldrik H. Velders, Johannes H. Bitter, Constantinos Nikiforidis
Summary: In this study, hollow microparticles (MPs) were formed by assembling lipoproteins in CaCO3 templates. The proteins interacted in the pores of the templates through hydrophobic forces, forming dense edges of the hollow MPs. Addition of Au3+ initiated a redox reaction that cross-linked the proteins, while forming gold nanoparticles (AuNPs). The resulting protein-based hollow MPs had a diameter of 6 μm and AuNPs embedded on their surface. This research suggests a new route for designing biobased Au-protein hollow MPs, enabling new possibilities for carrying functional molecules and bioimaging.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
