Article
Polymer Science
Niamh Bayliss, Gokhan Yilmaz, Alexander Plucinski, C. Remzi Becer, Bernhard V. K. J. Schmidt
Summary: Aqueous two-phase systems (ATPS) have gained attention in polymer chemistry due to their biocompatibility and applications in biomaterials and biology. This study investigated ATPS formed from poly(N,N-diethylacrylamide) (PDEA) with dextran and poly(ethylene glycol), and observed a significant shift in PDEA's cloud point temperature in the ATPS compared to pure aqueous solutions. This effect on thermoresponsive behavior opens up new possibilities for water-based polymer systems in areas such as multicompartment hydrogels or biotechnology.
Article
Polymer Science
Avnish Kumar Mishra, Junsub Lim, Jaeyong Lee, Soyeong Park, Yeseong Seo, Heedong Hwang, Jin Kon Kim
Summary: pH-sensitive and stable PNVP-b-P4VP micelles with low critical micelle concentration were successfully synthesized and showed excellent drug release capabilities under different pH conditions. The release of DOX could be effectively regulated by controlling pH, demonstrating high drug loading efficiency and good biocompatibility.
Article
Chemistry, Multidisciplinary
Maria Pilo, Sylwia Baluta, Anna C. Loria, Gavino Sanna, Nadia Spano
Summary: This study presents a method for immobilizing glucose oxidase using an electrogenerated conducting film and enhancing the analytical performance of glucose detection by modifying it with graphene oxide. The biosensor with graphene oxide exhibited satisfactory values of linear dynamic range, limit of detection, and sensitivity.
Article
Biochemistry & Molecular Biology
D. V. Estrada-Osorio, Ricardo A. Escalona-Villalpando, L. G. Arriaga, A. Gutierrez, J. Ledesma-Garcia
Summary: Ferrocene-based polymers have been widely studied as redox mediators in glucose biosensors. This work successfully modified poly-L-lysine (PLL) with ferrocene carboxylate and tested its performance as a redox mediator with glucose oxidase. The results showed remarkable activity and high selectivity. Scanning electrochemical microscopy was used to analyze the charged regions of the modified polymer on the electrode surface.
BIOELECTROCHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Feng Shi, Jinming Xu, Zhongfang Hu, Chuanli Ren, Yadong Xue, Yongcai Zhang, Juan Li, Chengyin Wang, Zhanjun Yang
Summary: A novel bird nest-like zinc oxide (BN-ZnO) nanostructures were prepared and used to develop a sensitive electrochemical glucose biosensor. The biosensor showed high sensitivity and a wide linear range, benefitting from the large specific surface area of BN-ZnO and its ability to retain the native bioactivity of enzymes.
CHINESE CHEMICAL LETTERS
(2021)
Article
Polymer Science
Alexander Plucinski, Marko Pavlovic, Mairi Clarke, David Bhella, Bernhard V. K. J. Schmidt
Summary: The study investigated the aggregation behavior of high molar mass block copolymer in an organic solvent, revealing unprecedented behavior under specific conditions. Potential future applications in photonics and templating of inorganic structures were envisioned for this new thermo-responsive block copolymer.
MACROMOLECULAR RAPID COMMUNICATIONS
(2022)
Article
Chemistry, Analytical
Ema Gricar, Josip Radic, Bostjan Genorio, Mitja Kolar
Summary: A simple, sensitive, cost-effective, and reliable enzymatic glucose biosensor was developed and tested. The sensor showed good performance in detecting glucose in food and beverage samples, demonstrating its suitability for practical applications.
Article
Chemistry, Analytical
Kantapat Chansaenpak, Anyanee Kamkaew, Sireerat Lisnund, Pannaporn Prachai, Patipat Ratwirunkit, Thitichaya Jingpho, Vincent Blay, Piyanut Pinyou
Summary: This research presents a self-powered glucose sensor based on a biofuel cell, which efficiently detects glucose with high sensitivity using immobilized redox enzymes. The combination of carbon nanostructures and multi-enzyme cascade allows the sensor to operate under air-saturating conditions.
Article
Biophysics
Tianzi Xia, Guangyan Liu, Junjie Wang, Shili Hou, Shifeng Hou
Summary: The synthesized MXene exhibited biocompatibility, excellent electronic conductivity, and good dispersion in aqueous phase. The Chit/ChOx/Ti3C2Tx nanocomposite was prepared and characterized using SEM, CV, EIS, and DPV. The biosensor for cholesterol detection showed a good linear relationship with low detection limit and high sensitivity, demonstrating practicality in real samples.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Biophysics
Nicole L. Walker, Jeffrey E. Dick
Summary: The development of a new electrochemical technique - open circuit potential, has been aimed at stable and reliable monitoring of biological metabolites. By immobilizing oxidase enzyme in chitosan hydrogel, the method achieves specificity in monitoring metabolites. This approach can effectively detect metabolites such as glucose and can be extended to detect other analytes.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Polymer Science
Julie Stastna, Vladislav Ivaniuzhenkov, Lenka Hanykova
Summary: The combination of swelling experiments and NMR spectroscopy was used to investigate the sensitivity of hydrogels with a single- and double-network structure to various stimuli. The behavior of the double network was found to be significantly affected by the introduction of the second component and the formation of the interpenetrating structure.
Article
Polymer Science
Umut Bulut, Vuslat Oyku Sayin, Sevki Can Cevher, Ali Cirpan, Saniye Soylemez
Summary: In this study, a novel glucose biosensor was developed by utilizing an amino-functionalized, conjugated polymer modified glassy carbon electrode as an immobilization platform for glucose oxidase (GOx). The biosensor displayed a wide linear range and a low detection limit for glucose, and demonstrated high stability and selectivity.
EXPRESS POLYMER LETTERS
(2022)
Article
Chemistry, Analytical
Ke Quan, Yuqing Zeng, Wenke Zhang, Fengfeng Li, Mengjiao Li, Zhihe Qing, Linlin Wu
Summary: In this study, a visual and reusable biosensor was developed for detecting substrates that are closely associated with human physiological health. The immobilized oxidase showed higher stability and sensitivity under harsh conditions, enabling reliable detection of substrates in complex fluids.
ANALYTICA CHIMICA ACTA
(2024)
Article
Engineering, Electrical & Electronic
Shamo Tapdiqov, Luigi Ambrosio, Dilgam Taghiyev, Maria Grazia Raucci, Nizami Zeynalov
Summary: Amphiphilic pH-sensitive hydrogels with magnetite Fe3O4 nanoparticles were synthesized and analyzed. The incorporation of Fe3O4 improved the structure and stability of the hydrogel. The adsorption of trypsin by the hydrogels was studied, and the PVPr-so-P4VP/Fe3O4 hydrogel showed better adsorption capacity. The results can be applied to protein and drug separation and enzyme administration.
SENSORS AND ACTUATORS A-PHYSICAL
(2023)
Article
Materials Science, Multidisciplinary
Guan-Kai Huang, Shivam Gupta, Chi -Young Lee, Nyan-Hwa Tai
Summary: In this study, a noninvasive saliva glucose sensor was developed using polypyrrole (PPy) and acid-treated carbon nanotubes (acid-CNTs) deposited on a fluorine-doped tin oxide (FTO) conductive glass substrate. The sensor exhibited high sensitivity, selectivity, and stability, making it suitable for noninvasive diagnosis of diabetes.
DIAMOND AND RELATED MATERIALS
(2022)
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)