Article
Electrochemistry
Zainab Javeed, Muhammad Ibrahim, Muhammad Faisal Iqbal, Rahat Nawaz, Dilshad Hussain, Muhammad Ayub, Muhammad Naeem Ashiq, Saadat Majeed, Muahmmad Najam-ul-Haq, Batool Fatima
Summary: Early detection of xanthine levels in human blood is crucial for minimizing risks associated with metabolic disorders. A non-enzymatic xanthine sensor was fabricated using lanthanum sulfide nanoparticles, showing good conductivity, large surface area, fast electron transfer, and promising sensing capability for xanthine detection.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2023)
Article
Electrochemistry
Amoolya Chandran, K. Girish Kumar
Summary: In addition to their physiological roles, hormones and purine metabolites are recognized biomarkers for disease detection and monitoring. This article discusses the development of a voltammetric sensor for the selective determination of EP, UA, XA, and HX. The sensor utilizes a copolymer modification that allows for well-defined peaks and a wide linear range with low detection limits.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2023)
Article
Food Science & Technology
Miaomiao Peng, Zhuosheng Chen, Qiuping Deng, Shijiang Zhu, Guang Wang
Summary: The study showed that peanut hull extract enriched in luteolin has a protective effect on erythrocytes against HX-XOD-induced damage by inhibiting reactive oxygen species generation and preserving antioxidative enzymes and non-enzymatic substances.
Article
Electrochemistry
Zhengcai Guo, Guiyan Wang, Jinlian Li, Dongmei Wu, Xiaoling Guo
Summary: This paper describes a new strategy for trace determination of uric acid, xanthine, and hypoxanthine using a miniaturized electrochemical biosensor. The biosensor exhibited excellent electrocatalytic activity and good reproducability, making it suitable for practical sample analysis. The device is easily available, cost-effective, and simple to fabricate.
INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE
(2021)
Article
Chemistry, Analytical
Sevilay Erdogan Kablan, Abdulkadir Yilmaz, Umit Kervan, Nuran Ozaltin, Emirhan Nemutlu
Summary: Cardiopulmonary bypass during cardiac surgery may cause a systemic inflammatory reaction, leading to complications such as acute renal failure. This study developed an electroanalytical method for simultaneous analysis of three biomarkers in plasma samples and successfully applied it to early diagnosis of ARF after CPB.
Review
Chemistry, Applied
Diksha Garg, Minni Singh, Neelam Verma, Monika
Summary: This review discusses the importance of hypoxanthine as a marker for meat freshness and clinical diagnosis, as well as the application of sensors for hypoxanthine detection. Sensors provide a simple, rapid, and cost-effective way to detect hypoxanthine, playing a significant role in clinical and food applications.
Article
Chemistry, Analytical
Yan Wu, Rongnan Yi, Honghui Zang, Jing Li, Rong Xu, Fang Zhao, Junli Wang, Cuicui Fu, Jinyang Chen
Summary: In this study, a sensitive, simple, and reliable approach for measuring xanthine in biological liquids was developed using a ratiometric surface-enhanced Raman spectroscopy (SERS) sensing strategy. By measuring the ratio of specific Raman peaks, the xanthine concentration could be quantitatively detected. This novel sensor showed high sensitivity and reliability, providing a new direction for the analysis of other biomolecules.
Article
Chemistry, Analytical
Debin Song, Qiaowei Chen, Chunyang Zhai, Hengcong Tao, Lina Zhang, Tianbo Jia, Zhiwang Lu, Wuyang Sun, Pengxiang Yuan, Baikang Zhu
Summary: A novel electrochemical sensing platform based on ZnIn2S4/UiO-66-NH2 modified electrode was constructed for simultaneous determination of xanthine and hypoxanthine. The sensor showed wide linear ranges, low detection limits, and good recovery, indicating promising application in the marine food industry.
Review
Biochemistry & Molecular Biology
Arrigo F. G. Cicero, Federica Fogacci, Valentina Di Micoli, Cristina Angeloni, Marina Giovannini, Claudio Borghi
Summary: Purines, such as adenine and guanine, have various important roles in cells, including being found in nucleic acids, serving as structural components of coenzymes, and playing crucial roles in energy metabolism and signal transduction. They also contribute significantly to the physiology of platelets, muscles, and neurotransmission. Maintaining a balanced purine ratio is essential for cell growth, proliferation, and survival. Dysfunctions in purine metabolism, such as hyperuricemia, have been associated with certain human diseases, particularly cardiovascular ones. Investigating purine metabolism dysfunctions, the functionality of xanthine oxidoreductase, and the formation of catabolites in urine and saliva can provide insights and potential markers for oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Electrochemistry
S. Swathy, Manna Rachel Mathew, K. Girish Kumar
Summary: We have developed an electrochemical sensor based on poly L-methionine/electrochemically reduced graphene oxide composite film modified glassy carbon electrode for the simultaneous determination of 5-hydroxyindole acetic acid and tyrosine. The sensor offers sensitive and selective detection, and has been successfully applied to artificial urine and blood serum samples.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2022)
Article
Chemistry, Analytical
Kubra Turan, Ahmet Uge, Bulent Zeybek, Gozde Aydogdu Tig
Summary: In this study, a poly(N-methyl aniline)-cerium oxide-functionalized MWCNTs composite was synthesized and used as a modifier for simultaneous detection of uric acid and 5-fluorouracil. The composite exhibited excellent sensing performance with a wide linear working range and low detection limits. The effect of interfering substances on the electrochemical response was investigated, confirming the stability and anti-interference ability of the sensing platform.
ANALYTICAL METHODS
(2023)
Article
Chemistry, Multidisciplinary
Di Zhu, Xinying Li, Lili Fu, Tianshuo Bai, Qin Wang, Chunlei Ma, Xin Sun, Lixin Lin, Xuemei Li
Summary: A cost-effective and environmentally friendly method has been proposed for synthesizing a nanomaterial composed of highly dispersed cerium oxide nanoparticles anchored on sulfur-doped scaly carbon. This nanomaterial was utilized for the modification of a glassy carbon electrode to create an electrochemical sensor capable of detecting uric acid. The sensor exhibited a wide linear concentration range, low detection limit, and exceptional levels of selectivity, stability, reproducibility, and repeatability.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Nanoscience & Nanotechnology
Zhenlong Jiang, Hui Dong, Yanli Zhou, Yanan Chen, Wanqing Hao, Ziyi Zhang, Yizhao Hao, Lantao Liu, Xiaobing Wang, Maotian Xu
Summary: A ratiometric electrochemical detection platform was constructed to simultaneously determine the levels of uric acid (UA) and xanthine (XA). The cPDA-Gp electrode was prepared by in situ modification of polydopamine (PDA) on graphene paper (Gp) and subsequent carbonization. Methylene blue (MB) was used as an internal reference and coupled with cPDA-Gp. The sensing platform showed promising results for the detection of UA and XA in real samples.
ACS APPLIED NANO MATERIALS
(2023)
Article
Peripheral Vascular Disease
Masato Furuhashi, Yukimura Higashiura, Masayuki Koyama, Marenao Tanaka, Takayo Murase, Takashi Nakamura, Seigo Akari, Akiko Sakai, Kazuma Mori, Hirofumi Ohnishi, Shigeyuki Saitoh, Kazuaki Shimamoto, Tetsuji Miura
Summary: The study found that plasma XOR activity is independently associated with hypertension in nondiabetic individuals who are not taking any medications. The activity is positively correlated with mean arterial pressure and significantly higher in the hypertension group compared to the non-hypertension group.
HYPERTENSION RESEARCH
(2021)
Article
Agriculture, Multidisciplinary
Ze-Rui Sun, Hua-Rong Liu, Di Hu, Mao-Si Fan, Ming-Yue Wang, Meng-Fei An, Yun-Li Zhao, Ze-Min Xiang, Jun Sheng
Summary: Ellagic acid (EA) has been shown to effectively regulate hyperuricemia by inhibiting xanthine oxidase and superoxide anion, reducing uric acid levels through the NLRP3 signaling pathway, and improving histopathology in animal models.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)