Article
Fisheries
Yale Deng, Marc C. J. Verdegem, Ep Eding, Fotini Kokou
Summary: The establishment of early-life gut microbiota is crucial for fish development and health. Rearing fish larvae in recirculating aquaculture systems (RAS) improves survival compared to flow-through systems (FTS), and dietary probiotic supplementation modulates gut bacterial composition, promoting beneficial bacteria presence.
Article
Environmental Sciences
Dongdong Song, Lizhao Chen, Siqi Zhu, Li Zhang
Summary: The presence of gut microbiota, especially arsenic-resistant bacteria such as Stenotrophomonas maltophilia, plays an important role in the accumulation and transformation of arsenic in fish. Removing the gut microbiota through antibiotic treatment significantly reduces the levels of total arsenic and arsenobetaine in the intestines and muscles of fish. Arsenic exposure alters the composition of the fish gut microbiota, with S. maltophilia becoming the dominant species. In vitro experiments demonstrated that the gut contents of untreated fish can metabolize arsenate to arsenite and organoarsenicals, while antibiotic-treated fish lose this ability.
ENVIRONMENTAL POLLUTION
(2022)
Article
Agriculture, Dairy & Animal Science
L. Yan, Z. Z. Lv, S. An, K. Xing, Z. G. Wang, M. B. Lv, M. Choct, Y. M. Guo, G. L. Zhou
Summary: According to the study, broilers reared in the PN system had a higher body weight. The MC system led to poorer intestinal development and health condition, but with better FCR. The FL rearing system appeared to be beneficial for gastrointestinal development and health.
Article
Food Science & Technology
Andrea Osimani, Ilario Ferrocino, Maria Rita Corvaglia, Andrea Roncolini, Vesna Milanovic, Cristiana Garofalo, Lucia Aquilanti, Paola Riolo, Sara Ruschioni, Elham Jamshidi, Nunzio Isidoro, Matteo Zarantoniello, Luca Cocolin, Ike Olivotto, Francesca Clementi
Summary: This study focused on the microbial diversity in Hermetia illucens larvae reared on different substrates enriched with microalgae. Differences in microbial communities were observed, with various algae and nutrient bioactive substances potentially influencing the abundance of bacterial taxa. Further research is needed to explore the implications of these findings on insect pathogen control and food safety.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Gastroenterology & Hepatology
Zhaowei Yang, Zhong Chen, Xinliu Lin, Siyang Yao, Mo Xian, Xiaoping Ning, Wanyi Fu, Mei Jiang, Naijian Li, Xiaojun Xiao, Mulin Feng, Zexuan Lian, Wenqing Yang, Xia Ren, Zhenyu Zheng, Jiefeng Zhao, Nili Wei, Wenju Lu, Marjut Roponen, Bianca Schaub, Gary W. K. Wong, Zhong Su, Charles Wang, Jing Li
Summary: Rural environments and microbiota are linked to a reduction in the prevalence of allergies. This study found that rural children have fewer allergies and a unique gut microbiota with fewer Bacteroides and more Prevotella. Indoor dusts in rural environments have higher endotoxin levels and a greater diversity of bacteria and fungi compared to indoor urban dusts.
Article
Environmental Sciences
Miao Wang, Zijian Fan, Ziyue Zhang, Mengmeng Yi, Zhigang Liu, Xiaoli Ke, Fengying Gao, Jianmeng Cao, Maixin Lu
Summary: This study investigated the impact of diet on the dynamics of gut microbiota in Nile tilapia. The results demonstrated that different diet types have a significant effect on the intestinal microbiota of tilapia in their early life stages. These findings provide valuable information for studying the microbial community in the gut of tilapia and suggest the potential for modulating the gut microbiota in the early life stages of these fish.
FRONTIERS IN MARINE SCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Mercedes Quintanilla-Mena, Julio Vega-Arreguin, Marcela Del Rio-Garcia, Victoria Patino-Suarez, Santy Peraza-Echeverria, Carlos Puch-Hau
Summary: The study investigated the effects of BaP on the gut microbiome of Oreochromis niloticus. Dysbiosis was observed at 24 hours post-injection, followed by a slight recovery at 72 hours and stabilization at 120 hours. The gut microbiome played a significant role in PAH degradation mainly at 24 hours post-injection.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Marcel Martinez-Porchas, Aranza Preciado-Alvarez, Francisco Vargas-Albores, Martina Hilda Gracia-Valenzuela, Francesco Cicala, Luis Rafael Martinez-Cordova, Diana Medina-Felix, Estefania Garibay-Valdez
Summary: Through a meta-analysis of several projects studying the gut microbiota of tilapia exposed to feed additives, it was found that probiotics and other additives did not show significant differentiation patterns in the tilapia gut microbiota. The study also revealed that the tilapia gut microbiota is a dynamic microbial community, capable of plastically responding to feed additives.
Article
Microbiology
Junfeng Li, Siran Wang, Jie Zhao, Zhihao Dong, Tao Shao
Summary: The study found that the gut microbiota of the European corn borer plays a significant role in degrading maize cellulose, with different diets impacting the diversity and function of gut microbial communities, leading to distinct metabolomic profiles and products when maize is digested by specific gut microbes.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Environmental Sciences
Zeyang Sun, Wenwen Sun, Jiating An, Haixuan Xu, Yue Liu, Chuncai Yan
Summary: This study is the first to present the gut microbial structure of chironomid larvae and examine the microbial alterations induced by chlorpyrifos and copper. The study found that both chlorpyrifos and copper were able to generate distinct variations in the gut microbiota. Additionally, the study observed impaired complexity and stability in the microbial interactions of stressor-challenged larvae. This investigation provides a fundamental basis for further exploration of the protective roles of chironomid gut bacterial colonizers against aquatic contaminants.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Engineering, Environmental
Lei He, Shan -Shan Yang, Jie Ding, Zhi-Li He, Ji-Wei Pang, De-Feng Xing, Lei Zhao, He -Shan Zheng, Nan-Qi Ren, Wei-Min Wu
Summary: In this study, it was demonstrated that mealworms were able to rapidly biodegrade PET with high efficiency, with a reduction in mass and molecular weight. The gut microbial community of the mealworms played a crucial role in PET degradation, and various metabolic pathways were up-regulated in response to PET intake. This research provides new insights into the adaptation of gut microbes to a PET diet and their contribution to PET degradation.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Review
Immunology
Jinchen Wang, Hongfei Zhang, Jianying He, Xiaoxing Xiong
Summary: This review summarizes the studies on the gut microbiota and its relationship with various neurological diseases, focusing on ischemic stroke. The review provides novel ideas for the prevention and treatment of ischemic stroke by exploring the physiological function of the gut microbiota and gut microbiota disorders related to the central nervous system.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Roohollah Zarei Koosha, Parvindokht Fazel, Hamid Sedighian, Elham Behzadi, Mojtaba Ch Hedayati, Abbas Ali Imani Fooladi
Summary: Microbiota in the host play a crucial role in human health and disease, and understanding the principles of HostMicrobiota Interactions (HMIs) can help clarify the mechanisms of infections. The interactions between the host and microbiota can reveal new therapeutic pathways and potential microbial effects on the host.
MICROBIAL PATHOGENESIS
(2021)
Article
Ecology
Roberto Garcia-Roa, Rebeca Dominguez-Santos, Vicente Perez-Brocal, Andres Moya Amparo Latorre, Pau Carazo, Andres Moya, Amparo Latorre
Summary: Social behaviors often rely on kin recognition, and recent research suggests that altering host-associated microorganisms may provide insights into the mechanisms of kin recognition. This study investigates the effects of larval rearing environment and relatedness on gut microbiota and cuticular hydrocarbons in the fruit fly Drosophila melanogaster. The results show that rearing environment strongly influences microbiota composition and hydrocarbon profiles, while relatedness mainly affects microbiota diversity, which in turn covaries with hydrocarbon profiles.
Article
Biochemistry & Molecular Biology
Hiromi Sato, Shintaro Narita, Masanori Ishida, Yoshiko Takahashi, Huang Mingguo, Soki Kashima, Ryohei Yamamoto, Atsushi Koizumi, Taketoshi Nara, Kazuyuki Numakura, Mitsuru Saito, Toshiaki Yoshioka, Tomonori Habuchi
Summary: A diet rich in lard increases the risk of prostate cancer development and progression. Two mouse models fed with lard-enriched diets showed enhanced prostate cancer progression and weight gain compared to a fish oil diet. The composition of gut microbiota differed significantly between the two diets, with changes in bacterial species such as Clostridiales and Lactobacillales. The proportion of Lactobacillales in the gut was negatively associated with weight gain and prostate cancer progression. The study also identified genes involved in lipid metabolism and cholesterol biosynthesis that correlated with the abundance of Lactobacillales in the gut.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Toxicology
Janneke Elzinga, Menno Grouls, Guido J. E. J. Hooiveld, Meike van der Zande, Hauke Smidt, Hans Bouwmeester
Summary: There is a need for standardized in vitro models of the human intestinal tract to study intestinal health without using animals. The Caco-2 cell line is a widely accepted and characterized model for studying intestinal drug transport, host-microbe interactions, and toxicity. We investigated the effect of different experimental variables on gene expression using transcriptome analysis of Caco-2 cells grown on permeable membranes. Our analysis revealed a weak association between experimental variables and gene expression, possibly due to heterogeneity in cell culture practice and inadequate reporting. This highlights the need for improved reporting protocols and serves as a template for future comparative studies.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Engineering, Environmental
Sara N. Jimenez-Volkerink, Joaquim Vila, Maria Jordan, Cristina Minguillon, Hauke Smidt, Magdalena Grifoll
Summary: Polar biotransformation products have been found to cause an increase in genotoxicity after the bioremediation of PAH-contaminated soils. The microorganisms and mechanisms underlying their further biodegradation have not been fully understood.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Chemistry, Medicinal
Ton That Huu Dat, Georg Steinert, Nguyen Thi Kim Cuc, Pham Viet Cuong, Hauke Smidt, Detmer Sipkema
Summary: Recent reviews have shown that sponge-associated bacteria are valuable sources of structurally diverse secondary metabolites with potent biological activities, making these microbial communities promising for new drug candidates. However, accessing the overall diversity of secondary metabolite biosynthetic potential in bacteria is challenging due to the difficulty in culturing the majority of bacteria in the laboratory. This study investigates the diversity of secondary metabolite biosynthetic gene clusters in metagenomes of bacterial communities associated with three different sponge species and identifies numerous potential gene clusters for the production of novel compounds.
Article
Gastroenterology & Hepatology
D. J. M. Barnett, M. F. Endika, C. E. Klostermann, F. Gu, C. Thijs, A. Nauta, H. A. Schols, H. Smidt, I. C. W. Arts, J. Penders
Summary: The infant gut microbiota is influenced by antibiotic exposures and prebiotic oligosaccharides found in breast milk. This study analyzed the stool microbiota of 1023 one-month-old infants and found that breastfeeding and antibiotic exposure both decrease gut microbial diversity, but have different effects on microbiota composition. Other factors such as C-section, homebirth, siblings, and exposure to animals also impact microbiota composition. Understanding these factors can help protect and promote a healthy infant gut microbiota.
Article
Psychology, Developmental
Yangwenshan Ou, Clara Belzer, Hauke Smidt, Carolina de Weerth
Summary: The study investigated the development of gut microbiota in children during the first 14 years of life and its relation to mental health problems in puberty. The analysis of fecal microbiota composition revealed the presence of four distinct microbial clusters in puberty. Prevotella 9 and Faecalibacterium were found to be associated with externalizing behavior and social anxiety, respectively. Further studies are needed to validate these findings and explore the underlying mechanisms.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Review
Pediatrics
Desiree F. Baaleman, Carrie A. M. Wegh, Tessa J. M. de Leeuw, Faridi S. van Etten-Jamaludin, Elaine E. Vaughan, Margriet H. C. Schoterman, Clara Belzer, Hauke Smidt, Merit M. Tabbers, Marc A. Benninga, Ilan J. N. Koppen
Summary: A systematic review was conducted to estimate normal reference values for defecation frequency and stool consistency in healthy children up to age 4. The results showed that younger infants have a higher frequency of defecation compared to young children, and the type of feeding and age also have an impact on defecation frequency and stool consistency.
JOURNAL OF PEDIATRICS
(2023)
Article
Microbiology
Martha F. Endika, David J. M. Barnett, Cynthia E. Klostermann, Henk A. Schols, Ilja C. W. Arts, John Penders, Arjen Nauta, Hauke Smidt, Koen Venema
Summary: Antibiotic exposure disrupts infant gut microbiota, but the ability to recover from this disruption depends on the type of antibiotic. This study investigated the effect of two common infant prebiotics, 2'-fucosyllactose (2'-FL) and galacto-oligosaccharides (GOS), on the resilience of the gut microbiota after exposure to amoxicillin/clavulanate. The results showed that the prebiotics supported the recovery of the microbiota and restored the production of beneficial fatty acids.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Andrea Aldas-Vargas, Jannigje G. G. Kers, Hauke Smidt, Huub H. M. Rijnaarts, Nora B. B. Sutton
Summary: Groundwater in The Netherlands is the main source of drinking water, but pesticide presence threatens its quality. Biodegradation is a natural process that can help remove pesticides. However, the oligotrophic groundwater conditions may limit biodegradation due to the lack of microbial communities capable of degrading pesticides. In this study, bioaugmentation with enriched mixed inocula was used to enhance pesticide biodegradation, and the effect of different redox conditions on biodegradation was observed.
Article
Ecology
Asimenia Gavriilidou, Burak Avci, Anastasia Galani, Michelle A. Schorn, Colin J. Ingham, Thijs J. G. Ettema, Hauke Smidt, Detmer Sipkema
Summary: Using genome-centric metagenomics, researchers revealed the phylogenomic placement of the candidate phylum Dadabacteria and predicted the metabolism of sponge-associated members. The results showed that these strains are aerobic heterotrophs capable of synthesizing amino acids, vitamins and cofactors, degrading complex carbohydrates, and exhibiting host-specific gene adaptations. Additionally, fluorescence in situ hybridization revealed the morphology and lifestyle of a member of Ca. Desulfobacterota.
Review
Microbiology
Angela Sessitsch, Steve Wakelin, Michael Schloter, Emmanuelle Maguin, Tomislav Cernava, Marie-Christine Champomier-Verges, Trevor C. Charles, Paul D. Cotter, Ilario Ferrocino, Aicha Kriaa, Pedro Lebre, Don Cowan, Lene Lange, Seghal Kiran, Lidia Markiewicz, Annelein Meisner, Marta Olivares, Inga Sarand, Bettina Schelkle, Joseph Selvin, Hauke Smidt, Leo van Overbeek, Gabriele Berg, Luca Cocolin, Yolanda Sanz, Wilson Lemos Fernandes, S. J. Liu, Matthew Ryan, Brajesh Singh, Tanja Kostic
Summary: Microbiomes play crucial roles in ecosystem functioning, supporting planetary health through nutrient cycling, climate regulation, and water filtration. They are closely associated with complex multicellular organisms and contribute to the health of their hosts. However, there is still limited understanding of microbiome transfer and connectivity.
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
(2023)
Article
Gastroenterology & Hepatology
Taojun Wang, Nils Leibrock, Caroline M. Plugge, Hauke Smidt, Erwin G. Zoetendal
Summary: Methanogens, reductive acetogens, and sulfate-reducing bacteria interact with each other in gut ecosystems, and their interactions may vary depending on environmental conditions.
Article
Environmental Sciences
James M. Tiedje, Yuhao Fu, Zhi Mei, Andreas Schaeffer, Qingyuan Dou, Wulf Amelung, Martin Elsner, Joseph Adu-Gyamfi, Lee Heng, Marko Virta, Xin Jiang, Hauke Smidt, Edward Topp, Fang Wang
Summary: The imprudent use of antibiotics in food production contributes to the spread of antibiotic resistance. This review emphasizes the need for collaborative efforts and preventive measures to mitigate the problem. Strategies such as heightened awareness, strengthened governance, and integrated surveillance systems are proposed to alleviate the burden of antibiotic resistance.
CURRENT OPINION IN ENVIRONMENTAL SCIENCE & HEALTH
(2023)
Article
Microbiology
Caifang Wen, Mirelle Geervliet, Hugo de Vries, Lluis Faba, Petra J. Roubos-van den Hil, Kerstin Skovgaard, Huub F. J. Savelkoul, Henk A. Schols, Jerry M. Wells, Edwin Tijhaar, Hauke Smidt
Summary: The study found that adding a fermented feed additive - rye overgrown with mycelium of Agaricus subrufescens can modulate gut microbiota and immune system development in pigs. This supplementation may contribute to improving the health of piglets during the weaning transition period and reducing the use of antibiotics.
Article
Environmental Sciences
Sara N. Jimenez-Volkerink, Maria Jordan, Hauke Smidt, Cristina Minguillon, Joaquim Vila, Magdalena Grifoll
Summary: By studying a specific microbial consortium in PAH-contaminated soils, it was discovered that the degradation of the carcinogenic compound BaAQ may occur through the Baeyer-Villiger monooxygenase (BVMOs) pathway, and that horizontal gene transfer may play a significant role in this degradation process.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Gastroenterology & Hepatology
Yangwenshan Ou, Eline Rots, Clara Belzer, Hauke Smidt, Carolina de Weerth
Summary: An increasing number of studies have shown the connection between gut microbiota and mental health. This study investigated the composition of gut microbiota in low-risk children during early puberty, and explored the behavioral associations with gut microbiota composition and metabolites. The study also explored the potential role of sex in these associations.