Article
Veterinary Sciences
Yunna Li, Hua Yang, Jing Guo, Yonglin Yang, Qian Yu, Yuanyuan Guo, Chaoxin Zhang, Zhipeng Wang, Peng Zuo
Summary: This study conducted a genome-wide association study (GWAS) using a high-density SNP chip to map loci related to weaning weight and yearling weight in sheep. The results identified significant associations of various SNPs with these weight traits and revealed potential candidate genes involved in regulating body weight. The findings highlight the value of multi-omic analysis in identifying genetic factors influencing body weight.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Multidisciplinary Sciences
Bingxin Zhao, Yue Shan, Yue Yang, Zhaolong Yu, Tengfei Li, Xifeng Wang, Tianyou Luo, Ziliang Zhu, Patrick Sullivan, Hongyu Zhao, Yun Li, Hongtu Zhu
Summary: The study found that structural variations of the human brain are highly heritable and have been linked to various complex traits. By performing cross-tissue TWAS analysis on 211 structural neuroimaging, the researchers identified 278 associated genes. Furthermore, TWAS gene-based polygenic risk scores showed significant improvement in association analysis compared to conventional variant-based GWAS PRS, explaining up to 6.97% of phenotypic variance.
NATURE COMMUNICATIONS
(2021)
Article
Allergy
Randi K. Johnson, Tonya Brunetti, Kevin Quinn, Katrina Doenges, Monica Campbell, Christopher Arehart, Margaret A. Taub, Rasika A. Mathias, Nichole Reisdorph, Kathleen C. Barnes, Michelle Daya
Summary: This study integrated metabolomics and genetics in a homogeneous population to discover new genetic effects in asthma and characterize the molecular consequences of asthma genetic risk. They identified novel metabolite quantitative trait loci with asthma associations and provided insight into the functional consequences of genetic risk factors for asthma.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Plant Sciences
Tingru Zeng, Zhaodong Meng, Runqing Yue, Shouping Lu, Wenlan Li, Wencai Li, Hong Meng, Qi Sun
Summary: Using a large-scale investigation, this study identified 59 significantly associated genetic loci related to maize yield through genome-wide association analysis. These findings are important for understanding the genetic architecture of maize yield and genetic improvement of maize.
Article
Genetics & Heredity
David Burstein, Trevor C. Griffen, Karen Therrien, Jaroslav Bendl, Sanan Venkatesh, Pengfei Dong, Amirhossein Modabbernia, Biao Zeng, Deepika Mathur, Gabriel Hoffman, Robyn Sysko, Tom Hildebrandt, Georgios Voloudakis, Panos Roussos
Summary: A genome-wide association analysis of binge eating disorder identifies three risk loci and suggests a role for iron metabolism in its etiology.
Article
Biology
Xinzhu Wei, Christopher R. Robles, Ali Pazokitoroudi, Andrea Ganna, Alexander Gusev, Arun Durvasula, Steven Gazal, Po-Ru Loh, David Reich, Sriram Sankararaman
Summary: Through analyzing the genetic data of 300,000 individuals and 96 distinct phenotypes, it is found that the genetic variants introduced from interbreeding with Neanderthals have a modest contribution to complex human traits. However, these introgressed variants tend to be depleted compared to modern human variants, possibly due to purifying selection. The significant associations between introgressed Neanderthal variants and phenotypes are likely driven by nearby modern human variants rather than the introgressed variants themselves.
Article
Nutrition & Dietetics
Jose Jaime Martinez-Magana, Sandra Hernandez, Ana Rosa Garcia, Valeria Cardoso-Barajas, Emmanuel Sarmiento, Beatriz Camarena, Alejandro Caballero, Laura Gonzalez, Jorge Ameth Villatoro-Velazquez, Maria Elena Medina-Mora, Marycarmen Bustos-Gamino, Clara Fleiz-Bautista, Carlos Alfonso Tovilla-Zarate, Isela Esther Juarez-Rojop, Humberto Nicolini, Alma Delia Genis-Mendoza
Summary: This study conducted a genome-wide association study in the Mexican population to explore the genetic factors shared between eating disorders, particularly focusing on the metabolic and immunologic domains. The results revealed significant associations between genetic variations and eating disorders, and in silico analysis suggested potential functional implications in the regulation of food intake.
Article
Genetics & Heredity
Ali Pazokitoroudi, Alec M. Chiu, Kathryn S. Burch, Bogdan Pasaniuc, Sriram Sankararaman
Summary: This study investigates the proportion of non-additive genetic effects in complex traits and presents an efficient method for estimating these effects using genotype and trait data. The research finds that in a large collection of unrelated individuals in the UK Biobank, additive heritability is 21.86% and dominance heritability is around 0.13%, indicating a limited contribution of dominance heritability to complex trait variation.
AMERICAN JOURNAL OF HUMAN GENETICS
(2021)
Article
Multidisciplinary Sciences
Marion Patxot, Daniel Trejo Banos, Athanasios Kousathanas, Etienne J. Orliac, Sven E. Ojavee, Gerhard Moser, Alexander Holloway, Julia Sidorenko, Zoltan Kutalik, Reedik Magi, Peter M. Visscher, Lars Ronnegard, Matthew R. Robinson
Summary: The authors developed a novel Bayesian approach for association analysis in large-scale genetic data, improving SNP-heritability estimation, discovery, fine-mapping, and genomic prediction. They found that genetic variation for height, body mass index, cardiovascular disease, and type 2 diabetes is mainly attributed to coding regions, introns, and distal upstream regions, highlighting new insights into genetic factors associated with these traits.
NATURE COMMUNICATIONS
(2021)
Article
Biology
Mengchao Wang, Shubo Jin, Shuai Liu, Hongtuo Fu, Yunfeng Zhao, Li Jiang
Summary: This study identified single-nucleotide polymorphisms (SNPs) that affect the growth and sex differentiation of Macrobrachium nipponense, providing assistance for genetic breeding. The study also found genetic correlations between growth and sexual traits, simplifying genetic selection for multiple traits. Significant SNPs associated with growth and sexual traits were detected through genome-wide association analysis. These results shed light on the genetic nature of growth and sex traits in Macrobrachium nipponense.
Article
Endocrinology & Metabolism
Arthur Gilly, Young-Chan Park, Emmanouil Tsafantakis, Maria Karaleftheri, George Dedoussis, Eleftheria Zeggini
Summary: Through a genome-wide association study, we identified 322 protein quantitative trait loci (pQTL) signals across 92 proteins of cardiometabolic relevance. These findings provide genetic evidence for the role of inflammation in cardiometabolic disease processes.
MOLECULAR METABOLISM
(2023)
Article
Evolutionary Biology
Jie Gong, Ji Zhao, Qiaozhen Ke, Bijun Li, Zhixiong Zhou, Jiaying Wang, Tao Zhou, Weiqiang Zheng, Peng Xu
Summary: Genomic selection has the potential to improve breeding value accuracy of economically vital growth-related traits in the O. fasciatus population. The underlying genetic architecture of body weight, total length, and body depth traits was found to be polygenic, and different statistical models showed similar performance in predicting genomic estimated breeding values. The study suggests that low SNP density is sufficient for accurate prediction in breeding populations of O. fasciatus.
EVOLUTIONARY APPLICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Zhe Zheng, Ruijuan Hao, Chuangye Yang, Yu Jiao, Qingheng Wang, Ronglian Huang, Yongshan Liao, Jianbo Jian, Yao Ming, Lixin Yin, Weiming He, Ziman Wang, Chuyi Li, Qi He, Kun Chen, Yuewen Deng, Xiaodong Du
Summary: Biomineralization-controlled growth of exo-/endoskeleton contributes to body growth and size diversity. This study used pearl oysters to investigate the genetic regulation of biomineralization-controlled growth and ectopic biomineralization. The insulin-like growth factor (IGF) endocrine signal and ancient single-copy transcription factors formed the regulatory network. Cross-phylum regulation of key long noncoding RNA (lncRNA) in bivalves and mammals suggests conserved genetic and epigenetic regulation. Thyroid hormone signal and apoptosis regulation affected ectopic biomineralization in pearl oysters.
MOLECULAR ECOLOGY RESOURCES
(2023)
Article
Biochemistry & Molecular Biology
Haonan Zeng, Wenjing Zhang, Qing Lin, Yahui Gao, Jinyan Teng, Zhiting Xu, Xiaodian Cai, Zhanming Zhong, Jun Wu, Yuqiang Liu, Shuqi Diao, Chen Wei, Wentao Gong, Xiangchun Pan, Zedong Li, Xiaoyu Huang, Xifan Chen, Jinshi Du, Fuping PigGTEx Consortium, Fuping Zhao, Yunxiang Zhao, Maria Ballester, Daniel Crespo-Piazuelo, Marcel Amills, Alex Clop, Peter Karlskov-Mortensen, Merete Fredholm, Pinghua Li, Ruihua Huang, Guoqing Tang, Mingzhou Li, Xiaohong Liu, Yaosheng Chen, Qin Zhang, Jiaqi Li, Xiaolong Yuan, Xiangdong Ding, Lingzhao Fang, Zhe Zhang
Summary: To unlock the potential of pigs in agriculture and biomedical research, the PigBiobank was created to investigate the molecular and cellular mechanisms underlying complex traits in pigs and translate the findings to other species.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Genetics & Heredity
Valentin Hivert, Julia Sidorenko, Florian Rohart, Michael E. Goddard, Jian Yang, Naomi R. Wray, Loic Yengo, Peter M. Visscher
Summary: This study introduces a method to calculate non-additive genetic variance for complex traits by analyzing unrelated individuals with genome-wide SNP data instead of traditional data on relatives. The results show that genetic variance for complex traits is predominantly additive, and large sample sizes are needed to estimate epistatic variance accurately.
AMERICAN JOURNAL OF HUMAN GENETICS
(2021)
Article
Oncology
Antonio Omuro, Alba A. Brandes, Antoine F. Carpentier, Ahmed Idbaih, David A. Reardon, Timothy Cloughesy, Ashley Sumrall, Joachim Baehring, Martin van den Bent, Oliver Bahr, Giuseppe Lombardi, Paul Mulholland, Ghazaleh Tabatabai, Ulrik Lassen, Juan Manuel Sepulveda, Mustafa Khasraw, Elodie Vauleon, Yoshihiro Muragaki, Anna Maria Di Giacomo, Nicholas Butowski, Patrick Roth, Xiaozhong Qian, Alex Z. Fu, Yanfang Liu, Von Potter, Alexandros-Georgios Chalamandaris, Kay Tatsuoka, Michael Lim, Michael Weller
Summary: This study showed that TMZ + RT had better efficacy than NIVO + RT in newly diagnosed GBM patients with unmethylated MGMT promoter. However, no new safety signals were detected with NIVO in this study.
Article
Oncology
Khe Hoang-Xuan, Martina Deckert, Andres J. M. Ferreri, Julia Furtner, Jaime Gallego Perez-Larraya, Roger Henriksson, Andreas F. Hottinger, Benjamin Kasenda, Florence Lefranc, Alexander Lossos, Catherine McBain, Matthias Preusser, Patrick Roth, Roberta Ruda, Uwe Schlegel, Riccardo Soffietti, Carole Soussain, Martin J. B. Taphoorn, Valerie Touitou, Michael Weller, Jacoline E. C. Bromberg
Summary: The management of primary central nervous system lymphoma (PCNSL) is a controversial topic in neuro-oncology. The European Association of Neuro-Oncology (EANO) formed a multidisciplinary task force to update the evidence-based guidelines and include immunosuppressed patients. The guideline provides consensus considerations and recommendations for the treatment of PCNSL, including intraocular manifestations and specific management of the elderly.
Letter
Oncology
Alice Laurenge, Renata Ursu, Emeline Tabouret, Vincent Harlay, Guido Ahle, Sylvain Choquet, Carole Soussain, Cecile Molucon-Chabrot, Bertrand Mathon, Karima Mokhtari, Valerie Pourcher, Lucia Nichelli, Stephane Marot, Mehdi Touat, Khe Hoang-Xuan, Caroline Houillier
LEUKEMIA & LYMPHOMA
(2023)
Review
Clinical Neurology
L. Nguyen-Them, A. Alentorn, G. Ahle, C. Soussain, B. Mathon, M. Le Garff Tavernier, C. Houillier, K. Hoang-Xuan
Summary: PCNSL is a highly aggressive non-Hodgkin lymphoma that affects the brain, spinal cord, eyes, and leptomeninges. Early diagnosis is crucial for effective management, but it can be challenging due to misleading radiological presentations, steroid response bias, and contraindications for brain biopsy. In this review, various CSF biomarkers for diagnosis and prognosis of PCNSL will be discussed, highlighting their advantages and limitations.
REVUE NEUROLOGIQUE
(2023)
Article
Oncology
I. Hernandez-Verdin, E. Kirasic, K. Wienand, K. Mokhtari, S. Eimer, H. Loiseau, A. Rousseau, J. Paillassa, G. Ahle, F. Lerintiu, E. Uro-Coste, L. Oberic, D. Figarella-Branger, O. Chinot, G. Gauchotte, L. Taillandier, J. -P. Marolleau, M. Polivka, C. Adam, R. Ursu, A. Schmitt, N. Barillot, L. Nichelli, F. Lozano-Sanchez, M. -J. Ibanez-Julia, M. Peyre, B. Mathon, Y. Abada, F. Charlotte, F. Davi, C. Stewart, A. de Reynies, S. Choquet, C. Soussain, C. Houillier, B. Chapuy, K. Hoang-Xuan, A. Alenorn
Summary: Through comprehensive multi-omic analysis, we identified and characterized four molecular patterns in PCNSL, which have a distinct prognostic impact and can guide future clinical stratification and targeted interventions.
ANNALS OF ONCOLOGY
(2023)
Article
Hematology
Aikaterini Panopoulou, David A. Cairns, Amy Holroyd, Isabel Nichols, Nikita Cray, Charlotte Pawlyn, Gordon Cook, Mark Drayson, Kevin Boyd, Faith E. Davies, Matthew Jenner, Gareth J. Morgan, Roger Owen, Richard Houlston, Graham Jackson, Martin F. Kaiser
Summary: Through extended molecular profiling, we investigated outcome prediction in patients in the Myeloma XI trial, and found that single hit multiple myeloma patients derived the highest progression-free survival benefit from lenalidomide maintenance.
Letter
Oncology
Rachel H. Horton, Malcolm G. Dunlop, Richard S. Houlston, Anneke Lucassen, Margaret McCartney, Alan McNeill, Amit Sud
BRITISH JOURNAL OF CANCER
(2023)
Article
Multidisciplinary Sciences
William Hill, Emilia L. Lim, Clare E. Weeden, Claudia Lee, Marcellus Augustine, Kezhong Chen, Feng-Che Kuan, Fabio Marongiu, Edward J. Evans, David A. Moore, Felipe S. Rodrigues, Oriol Pich, Bjorn Bakker, Hongui Cha, Renelle Myers, Febe van Maldegem, Jesse Boumelha, Selvaraju Veeriah, Andrew Rowan, Cristina Naceur-Lombardelli, Takahiro Karasaki, Monica Sivakumar, Swapnanil De, Deborah R. Caswell, Ai Nagano, James R. M. Black, Carlos Martinez-Ruiz, Min Hyung Ryu, Ryan D. Huff, Shijia Li, Marie-Julie Fave, Alastair Magness, Alejandro Suarez-Bonnet, Simon L. Priestnall, Margreet Luechtenborg, Katrina Lavelle, Joanna Pethick, Steven Hardy, Fiona E. McRonald, Meng-Hung Lin, Clara I. Troccoli, Moumita Ghosh, York E. Miller, Daniel T. Merrick, Robert L. Keith, Maise Al Bakir, Chris Bailey, Mark S. Hill, Lao H. Saal, Yilun Chen, Anthony M. George, Christopher Abbosh, Nnennaya Kanu, Se-Hoon Lee, Nicholas McGranahan, Christine D. Berg, Peter Sasieni, Richard Houlston, Clare Turnbull, Stephen Lam, Philip Awadalla, Eva Groenroos, Julian Downward, Tyler Jacks, Christopher Carlsten, Ilaria Malanchi, Allan Hackshaw, Kevin Litchfield, Jason F. Lester, James DeGregori, Mariam Jamal-Hanjani, Charles Swanton
Summary: This study reveals a strong association between PM2.5 air pollutants and lung cancer risk, suggesting that these pollutants promote lung cancer development by acting on cells with pre-existing oncogenic mutations in healthy lung tissue. The mechanism involves the influx of macrophages and release of interleukin-1 beta, which induce a progenitor-like state in EGFR mutant lung alveolar type II epithelial cells, fueling tumorigenesis. The findings underscore the tumor-promoting role of PM2.5 air pollutants and emphasize the need for public health policy initiatives to address air pollution.
Correction
Genetics & Heredity
Ceres Fernandez-Rozadilla, Maria Timofeeva, Zhishan Chen, Philip Law, Minta Thomas, Stephanie Schmit, Virginia Diez-Obrero, Li Hsu, Juan Fernandez-Tajes, Claire Palles, Kitty Sherwood, Sarah Briggs, Victoria Svinti, Kevin Donnelly, Susan Farrington, James Blackmur, Peter Vaughan-Shaw, Xiao-ou Shu, Jirong Long, Qiuyin Cai, Xingyi Guo, Yingchang Lu, Peter Broderick, James Studd, Jeroen Huyghe, Tabitha Harrison, David Conti, Christopher Dampier, Mathew Devall, Fredrick Schumacher, Marilena Melas, Gad Rennert, Mireia Obon-Santacana, Vicente Martin-Sanchez, Ferran Moratalla-Navarro, Jae Hwan Oh, Jeongseon Kim, Sun Ha Jee, Keum Ji Jung, Sun-Seog Kweon, Min-Ho Shin, Aesun Shin, Yoon-Ok Ahn, Dong-Hyun Kim, Isao Oze, Wanqing Wen, Keitaro Matsuo, Koichi Matsuda, Chizu Tanikawa, Zefang Ren, Yu-Tang Gao, Wei-Hua Jia, John Hopper, Mark Jenkins, Aung Ko Win, Rish Pai, Jane Figueiredo, Robert Haile, Steven Gallinger, Michael Woods, Polly Newcomb, David Duggan, Jeremy Cheadle, Richard Kaplan, Timothy Maughan, Rachel Kerr, David Kerr, Iva Kirac, Jan Bohm, Lukka-Pekka Mecklin, Pekka Jousilahti, Paul Knekt, Lauri Aaltonen, Harri Rissanen, Eero Pukkala, Johan Eriksson, Tatiana Cajuso, Ulrika Hanninen, Johanna Kondelin, Kimmo Palin, Tomas Tanskanen, Laura Renkonen-Sinisalo, Brent Zanke, Satu Mannisto, Demetrius Albanes, Stephanie Weinstein, Edward Ruiz-Narvaez, Julie Palmer, Daniel Buchanan, Elizabeth Platz, Kala Visvanathan, Cornelia Ulrich, Erin Siegel, Stefanie Brezina, Andrea Gsur, Peter Campbell, Jenny Chang-Claude, Michael Hoffmeister, Hermann Brenner, Martha Slattery, John Potter, Konstantinos Tsilidis, Matthias Schulze, Marc Gunter, Neil Murphy, Antoni Castells, Sergi Castellvi-Bel, Leticia Moreira, Volker Arndt, Anna Shcherbina, Mariana Stern, Bens Pardamean, Timothy Bishop, Graham Giles, Melissa Southey, Gregory Idos, Kevin McDonnell, Zomoroda Abu-Ful, Joel Greenson, Katerina Shulman, Flavio Lejbkowicz, Kenneth Offit, Yu-Ru Su, Robert Steinfelder, Temitope Keku, Bethany van Guelpen, Thomas Hudson, Heather Hampel, Rachel Pearlman, Sonja Berndt, Richard Hayes, Marie Elena Martinez, Sushma Thomas, Douglas Corley, Paul Pharoah, Susanna Larsson, Yun Yen, Heinz-Josef Lenz, Emily White, Li Li, Kimberly Doheny, Elizabeth Pugh, Tameka Shelford, Andrew Chan, Marcia Cruz-Correa, Annika Lindblom, David Hunter, Amit Joshi, Clemens Schafmayer, Peter Scacheri, Anshul Kundaje, Deborah Nickerson, Robert Schoen, Jochen Hampe, Zsofia Stadler, Pavel Vodicka, Ludmila Vodickova, Veronika Vymetalkova, Nickolas Papadopoulos, Chistopher Edlund, William Gauderman, Duncan Thomas, David Shibata, Amanda Toland, Sanford Markowitz, Andre Kim, Stephen Chanock, Franzel van Duijnhoven, Edith Feskens, Lori Sakoda, Manuela Gago-Dominguez, Alicja Wolk, Alessio Naccarati, Barbara Pardini, Liesel FitzGerald, Soo Chin Lee, Shuji Ogino, Stephanie Bien, Charles Kooperberg, Christopher Li, Yi Lin, Ross Prentice, Conghui Qu, Stephane Bezieau, Catherine Tangen, Elaine Mardis, Taiki Yamaji, Norie Sawada, Motoki Iwasaki, Christopher Haiman, Loic Le Marchand, Anna Wu, Chenxu Qu, Caroline McNeil, Gerhard Coetzee, Caroline Hayward, Ian Deary, Sarah Harris, Evropi Theodoratou, Stuart Reid, Marion Walker, Li Yin Ooi, Victor Moreno, Graham Casey, Stephen Gruber, Ian Tomlinson, Wei Zheng, Malcolm Dunlop, Richard Houlston, Ulrike Peters
Article
Multidisciplinary Sciences
Jianxin Shi, Kouya Shiraishi, Jiyeon Choi, Keitaro Matsuo, Tzu-Yu Chen, Juncheng Dai, Rayjean J. Hung, Kexin Chen, Xiao-Ou Shu, Young Tae Kim, Maria Teresa Landi, Dongxin Lin, Wei Zheng, Zhihua Yin, Baosen Zhou, Bao Song, Jiucun Wang, Wei Jie Seow, Lei Song, I-Shou Chang, Wei Hu, Li-Hsin Chien, Qiuyin Cai, Yun-Chul Hong, Hee Nam Kim, Yi-Long Wu, Maria Pik Wong, Brian Douglas Richardson, Karen M. Funderburk, Shilan Li, Tongwu Zhang, Charles Breeze, Zhaoming Wang, Batel Blechter, Bryan A. Bassig, Jin Hee Kim, Demetrius Albanes, Jason Y. Y. Wong, Min-Ho Shin, Lap Ping Chung, Yang Yang, She-Juan An, Hong Zheng, Yasushi Yatabe, Xu-Chao Zhang, Young-Chul Kim, Neil E. Caporaso, Jiang Chang, James Chung Man Ho, Michiaki Kubo, Yataro Daigo, Minsun Song, Yukihide Momozawa, Yoichiro Kamatani, Masashi Kobayashi, Kenichi Okubo, Takayuki Honda, Dean H. Hosgood, Hideo Kunitoh, Harsh Patel, Shun-ichi Watanabe, Yohei Miyagi, Haruhiko Nakayama, Shingo Matsumoto, Hidehito Horinouchi, Masahiro Tsuboi, Ryuji Hamamoto, Koichi Goto, Yuichiro Ohe, Atsushi Takahashi, Akiteru Goto, Yoshihiro Minamiya, Megumi Hara, Yuichiro Nishida, Kenji Takeuchi, Kenji Wakai, Koichi Matsuda, Yoshinori Murakami, Kimihiro Shimizu, Hiroyuki Suzuki, Motonobu Saito, Yoichi Ohtaki, Kazumi Tanaka, Tangchun Wu, Fusheng Wei, Hongji Dai, Mitchell J. Machiela, Jian Su, Yeul Hong Kim, In-Jae Oh, Victor Ho Fun Lee, Gee-Chen Chang, Ying-Huang Tsai, Kuan-Yu Chen, Ming-Shyan Huang, Wu-Chou Su, Yuh-Min Chen, Adeline Seow, Jae Yong Park, Sun-Seog Kweon, Kun-Chieh Chen, Yu-Tang Gao, Biyun Qian, Chen Wu, Daru Lu, Jianjun Liu, Ann G. Schwartz, Richard Houlston, Margaret R. Spitz, Ivan P. Gorlov, Xifeng Wu, Ping Yang, Stephen Lam, Adonina Tardon, Chu Chen, Stig E. Bojesen, Mattias Johansson, Angela Risch, Heike Bickeboeller, Bu-Tian Ji, H-Erich Wichmann, David C. Christiani, Gadi Rennert, Susanne Arnold, Paul Brennan, James McKay, John K. Field, Sanjay S. Shete, Loic Le Marchand, Geoffrey Liu, Angeline Andrew, Lambertus A. Kiemeney, Shan Zienolddiny-Narui, Kjell Grankvist, Mikael Johansson, Angela Cox, Fiona Taylor, Jian-Min Yuan, Philip Lazarus, Matthew B. Schabath, Melinda C. Aldrich, Hyo-Sung Jeon, Shih Sheng Jiang, Jae Sook Sung, Chung-Hsing Chen, Chin-Fu Hsiao, Yoo Jin Jung, Huan Guo, Zhibin Hu, Laurie Burdett, Meredith Yeager, Amy Hutchinson, Belynda Hicks, Jia Liu, Bin Zhu, Sonja I. Berndt, Wei Wu, Junwen Wang, Yuqing Li, Jin Eun Choi, Kyong Hwa Park, Sook Whan Sung, Li Liu, Chang Hyun Kang, Wen-Chang Wang, Jun Xu, Peng Guan, Wen Tan, Chong-Jen Yu, Gong Yang, Alan Dart Loon Sihoe, Ying Chen, Yi Young Choi, Jun Suk Kim, Ho-Il Yoon, In Kyu Park, Ping Xu, Qincheng He, Chih-Liang Wang, Hsiao-Han Hung, Roel C. H. Vermeulen, Iona Cheng, Junjie Wu, Wei-Yen Lim, Fang-Yu Tsai, John K. C. Chan, Jihua Li, Hongyan Chen, Hsien-Chih Lin, Li Jin, Jie Liu, Norie Sawada, Taiki Yamaji, Kathleen Wyatt, Shengchao A. Li, Hongxia Ma, Meng Zhu, Zhehai Wang, Sensen Cheng, Xuelian Li, Yangwu Ren, Ann Chao, Motoki Iwasaki, Junjie Zhu, Gening Jiang, Ke Fei, Guoping Wu, Chih-Yi Chen, Chien-Jen Chen, Pan-Chyr Yang, Jinming Yu, Victoria L. Stevens, Joseph F. Fraumeni, Nilanjan Chatterjee, Olga Y. Gorlova, Chao Agnes Hsiung, Christopher I. Amos, Hongbing Shen, Stephen J. Chanock, Nathaniel Rothman, Takashi Kohno, Qing Lan
Summary: This study identified 12 novel susceptibility variants for lung adenocarcinoma and a total of 28 loci associated with the disease in East Asian populations. Additionally, new candidate genes were discovered, contributing to the understanding of the disease etiology. These findings have important implications for the research and translational applications of lung adenocarcinoma in individuals from East Asian populations.
NATURE COMMUNICATIONS
(2023)
Review
Oncology
Marta Maccari, Chooyoung Baek, Mario Caccese, Susanna Mandruzzato, Alba Fiorentino, Valeria Interno, Alberto Bosio, Giulia Cerretti, Marta Padovan, Ahmed Idbaih, Giuseppe Lombardi
Summary: Glioblastoma (GBM) is a common and aggressive brain tumor with poor treatment outcomes. Standard therapies have not been effective, leading to a growing interest in immunotherapic approaches. However, GBM is highly immunosuppressive, which may explain the failures of immunotherapy clinical trials. This review examines the current landscape of immunotherapy strategies in GBM, focusing on the challenge of immunoresistance and potential mechanisms to overcome it.
Meeting Abstract
Biochemistry & Molecular Biology
Dominik Jung, Sonali Pechlivanis, Susanne Moebus, Nils Lehmann, Amir A. Mahabdi, Per Hoffmann, Raimund Erbel, Markus M. Noethen, Hagen Sjard Bachmann
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Carlo Maj, Emadeldin Hassanin, Hannah Klinkhammer, Friederike David, Dheeraj Bobbili, Rana Aldisi, Nuria Duenas, Claudia Perne, Markus M. Noethen, Robert Huneburg, Peter Krawitz, Joan Brunet, Gabriel Capella, Patrick May, Andreas Forstner, Andreas Mayr, Isabel Spier, Stefan Aretz
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Eva Beins, Ronja Hollstein, Kerstin Ludwig, Per Hoffmann, Markus M. Noethen, Andreas Forstner
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)
Review
Psychiatry
Gunter Schumann, Ole A. Andreassen, Tobias Banaschewski, Vince D. Calhoun, Nicholas Clinton, Sylvane Desrivieres, Ragnhild Eek Brandlistuen, Jianfeng Feng, Soeren Hese, Esther Hitchen, Per Hoffmann, Tianye Jia, Viktor Jirsa, Andre F. Marquand, Frauke Nees, Markus M. Noethen, Gaia Novarino, Elli Polemiti, Markus Ralser, Michael Rapp, Kerstin Schepanski, Tamara Schikowski, Mel Slater, Peter Sommer, Bernd Carsten Stahl, Paul M. Thompson, Sven Twardziok, Dennis van der Meer, Henrik Walter, Lars Westlye
Summary: Climate change, pollution, urbanization, socioeconomic inequality, and the COVID-19 pandemic have affected brain health. Research using innovative data integration tools can identify brain mechanisms underlying environment-related mental illness and inform innovative treatments. This research will lead to the development of objective biomarkers and evidence-based interventions to improve outcomes of environment-related mental illness.