Review
Immunology
Diana Coman, Isabelle Coales, Luke B. Roberts, Joana F. Neves
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the intestine with a complex etiology involving genetics, gut microbiome, environment, and immune system. Recent research has suggested that innate lymphoid cells (ILCs) may play a significant role in the dysregulation of intestinal immunity observed in IBD. Despite being rare in the intestine, helper-like ILCs may contribute to the exacerbation of IBD pathology.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Integrative & Complementary Medicine
Wenbin Dai, Longhai Long, Xiaoqiang Wang, Sen Li, Houping Xu
Summary: This review surveyed the in vivo effects of phytochemicals targeting TLR4 in different models of IBD and highlighted the significance of TLR4 as a therapeutic target for IBD.
Review
Gastroenterology & Hepatology
Stefano Fiorucci, Adriana Carino, Monia Baldoni, Luca Santucci, Emanuele Costanzi, Luigina Graziosi, Eleonora Distrutti, Michele Biagioli
Summary: Bile acids generated at the host liver and through microbial metabolism play a crucial role in mediating communication between the intestinal microbiota and host immune system. The expression and function of bile acid-activated receptors are dependent on the structure of the intestinal microbiota, with implications for maintaining a tolerogenic phenotype in the intestine.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Review
Gastroenterology & Hepatology
Weiwei Luo, Li Tian, Bei Tan, Zhaohua Shen, Mengwei Xiao, Shuai Wu, Xiangrui Meng, Xing Wu, Xiaoyan Wang
Summary: Inflammatory bowel disease (IBD) is a chronic and non-specific condition that may be caused by dysbiosis, genetic factors, and environmental factors. Recent studies have identified a new type of lymphocytes, called innate lymphoid cells, which could offer novel approaches for the treatment of IBD by influencing intestinal mucosal homeostasis.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Immunology
Huanyu Jiang, Yubiao Zhang, Geliang Hu, Xiaobin Shang, Jianghua Ming, Ming Deng, Yaming Li, Yonggang Ma, Shiqing Liu, Yan Zhou
Summary: The study reveals the important role of surfactant protein D (SP-D) in regulating inflammation and immune response in osteoarthritis (OA). SP-D exhibits chondroprotective properties by downregulating inflammation-related genes, suppressing cytokine production, and reducing infiltration of inflammatory cells. The binding of SP-D to the TLR4/MD-2 complex further inhibits TLR4-mediated signaling activation. These findings suggest that SP-D has a beneficial effect in attenuating inflammation and preserving cartilage integrity in OA.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pathology
Ioanna Aggeletopoulou, Markos Marangos, Stelios F. Assimakopoulos, Athanasia Mouzaki, Konstantinos Thomopoulos, Christos Triantos
Summary: Studies show that there are characteristic microbial patterns in various systemic autoimmune diseases, including inflammatory bowel disease (IBD). Vitamin D deficiency, which predisposes to autoimmune diseases and IBD, can lead to changes in the gut microbiome and disruption of intestinal epithelial barrier integrity. This review explores the role of the gut microbiome in IBD and discusses how vitamin D and vitamin D receptor (VDR)-associated signaling pathways contribute to the development and progression of IBD by affecting gut barrier function, microbial community, and immune system function. Understanding the cellular functions of vitamin D-VDR signaling in intestinal epithelial cells may lead to the development of new treatment strategies for IBD in the future.
AMERICAN JOURNAL OF PATHOLOGY
(2023)
Article
Oncology
Jun Ying, Haiyang Zhou, Zhiguo Wang, Qing You, Junnan Chen, Hao Lu, Jian Zhang
Summary: Background: Chemotherapy resistance is a major obstacle to the efficacy of chemotherapy in colon cancer. Therefore, improving the chemotherapy sensitivity of colorectal cancer cells is crucial for enhancing the prognosis of colon cancer patients. Methods: Cell viability of colorectal cancer cell lines was assessed using the CCK-8 assay. Toll-like receptor 4 (TLR4) expression in colorectal cancer cell lines was investigated through real-time PCR and western blot. The role of TLR4 in the stemness of colorectal cancer cell lines was analyzed by infecting cells with lentivirus containing TLR4 siRNA. Results: Aspirin was found to effectively enhance chemosensitivity and inhibit the stemness of CT26 and HCT116 colorectal cancer cell lines. Aspirin inhibited clone formation, reduced the volume and number of cell spheres, and down-regulated stemness-related genes. Moreover, aspirin also down-regulated TLR4 expression in colorectal cancer cells. TLR4 positive colorectal cancer cells demonstrated higher chemotherapy resistance potential and stronger stemness compared to TLR4 negative colorectal cancer cells. Conclusion: Our study indicates that aspirin increases chemosensitivity of colorectal cancer cells and inhibits the expression of toll-like receptor 4.
CANCER CELL INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Ying Dou, Kelly Maurer, Maire Conrad, Trusha Patel, Rawan Shraim, Kathleen E. Sullivan, Judith Kelsen
Summary: The study found that intermediate monocytes were consistently decreased in patients with VEO-IBD compared to controls, while mucosal-associated invariant T cells were significantly lower in patients with long-standing disease. Levels were less than half of those seen in the age-matched control cohort. The innate lymphoid cells type 2 population was expanded in the youngest patients.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2021)
Review
Gastroenterology & Hepatology
Ana Elisa Valencise Quaglio, Thais Gagno Grillo, Ellen Cristina Souza De Oliveira, Luiz Claudio Di Stasi, Ligia Yukie Sassaki
Summary: Dysbiosis in the gut microbiota is closely associated with various gastrointestinal disorders such as IBS, IBD, and CRC, potentially leading to mucosal barrier disruption, chronic inflammation, and cancer progression. Specific harmful bacteria, like E. coli and ETBF, are linked to an increased risk of developing CRC.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Cell Biology
Valentino Le Noci, Giancarla Bernardo, Francesca Bianchi, Elda Tagliabue, Michele Sommariva, Lucia Sfondrini
Summary: The microbiota is a complex ecosystem of active microorganisms in mammals, playing critical roles in maintaining health, symbiosis with the immune system, pathogen defense, and tolerance to commensal microbes. Toll-like receptors (TLRs) are key in sensing the microbiota, associated with cancer development, and potentially disrupting TLR tolerance.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Angela Saez, Raquel Gomez-Bris, Beatriz Herrero-Fernandez, Claudia Mingorance, Cristina Rius, Jose M. Gonzalez-Granado
Summary: Inflammatory bowel disease (IBD) is a complex condition involving chronic intestinal inflammation and is associated with genetics, environment, immune system, and intestinal barrier function. Recent studies have shown that innate lymphoid cells (ILCs) play crucial roles in intestinal homeostasis and IBD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Jinta Asami, Toshiyuki Shimizu
Summary: TLRs are crucial in recognizing pathogenic molecular patterns and initiating immune responses. Recent advances in structural and mechanistic studies have provided insights into the activation and inhibition mechanisms of TLRs, enhancing our understanding of their functional properties.
Review
Biochemistry & Molecular Biology
Adrian Boicean, Victoria Birlutiu, Cristian Ichim, Paula Anderco, Sabrina Birsan
Summary: Inflammatory bowel diseases (IBD) are complex diseases characterized by chronic inflammation in the gastrointestinal tract. Fecal microbiota transplantation (FMT) has shown increasing effectiveness and safety in treating recurrent Clostridium difficile infection (CDI) and co-infection of SARS-CoV-2 and CDI. By modifying the gut microbiota, FMT offers an alternative approach to indirectly influence the host's immune system in a safe way, improving clinical symptoms and endoscopic findings in IBD patients. Further validation is needed to establish a clinical protocol for FMT in IBD.
Article
Fisheries
Hansam Cho, Ki Hoon Park, Yuyeon Jang, Yeondong Cho, Yoon-Ki Heo, Minjee Kim, Young Bong Kim
Summary: Outbreaks of infectious disease in shrimp pose a serious threat to shrimp agriculture worldwide. Shrimp lack adaptive immunity and rely solely on innate immunity for defense against infectious disease. Toll-like receptors play a critical role in the shrimp innate immune system, with the identification of a new Toll-like receptor gene (MnToll) in Macrobrachium nipponense potentially involved in defense against WSSV.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Yuri Haneishi, Yuma Furuya, Mayu Hasegawa, Antonio Picarelli, Mauro Rossi, Junki Miyamoto
Summary: Inflammatory bowel disease (IBD) is a rapidly increasing inflammatory disease of the gastrointestinal tract worldwide. Recent research suggests that factors such as genetics, environment, microbiota, and immune responses are involved in its development, but the underlying causes are unclear. Dysbiosis of gut microbiota, particularly a decrease in specific genera, has been identified as a possible trigger for IBD. Improving gut microbiota and identifying specific bacterial species are crucial for understanding and treating IBD and autoimmune diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Yanbo Yu, Wenjing Yang, Yanqing Li, Yingzi Cong
INFLAMMATORY BOWEL DISEASES
(2020)
Article
Immunology
Kevin T. Kline, Haifeng Lian, Xiaoying S. Zhong, Xiuju Luo, John H. Winston, Yingzi Cong, Tor C. Savidge, Roderick H. Dashwood, Don W. Powell, Qingjie Li
JOURNAL OF IMMUNOLOGY
(2020)
Article
Immunology
Xiangsheng Huang, Wenjing Yang, Suxia Yao, Anthony J. Bilotta, Yao Lu, Zheng Zhou, Pawan Kumar, Sara M. Dann, Yingzi Cong
JOURNAL OF IMMUNOLOGY
(2020)
Review
Immunology
Wenjing Yang, Yingzi Cong
Summary: The gut microbiota and microbiota-derived metabolites play a critical role in maintaining immune homeostasis and are involved in the pathogenesis of various immune-related inflammatory disorders.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yu Yu, Wenjing Yang, Anthony J. Bilotta, Xiaojing Zhao, Yingzi Cong, Yanqing Li
Summary: The study found that host-derived L-lactate can promote intestinal epithelial cell (IEC) migration by increasing mitochondrial ATP production in IEC, aiding in promoting intestinal wound healing. Additionally, administering mice with L-lactate can suppress colitis induced by dextran sulfate sodium.
Article
Immunology
Yuejin Liang, Xiaofang Wang, Hui Wang, Wenjing Yang, Panpan Yi, Lynn Soong, Yingzi Cong, Jiyang Cai, Xuegong Fan, Jiaren Sun
Summary: IL-33 promotes activation and proliferation of CD8(+) T cells via mTORC1 in LCMV infection.
Article
Immunology
Wenjing Yang, Liang Chen, Leiqi Xu, Anthony J. Bilotta, Suxia Yao, Zhanju Liu, Yingzi Cong
Summary: This study demonstrates the role of miR-10a in regulating IL-10 production in CD4(+) T cells to maintain intestinal homeostasis. The deficiency of miR-10a in CD4(+) T cells led to increased resistance to intestinal inflammation, with increased IL-10 production. Blocking the IL-10/IL-10R pathway exacerbated colitis induced by miR-10a-deficient CD4(+)CD45Rb(hi) T cells.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Yi Li, Jianping Chen, Andrew A. Bolinger, Haiying Chen, Zhiqing Liu, Yingzi Cong, Allan R. Brasier, Irina Pinchuk, Bing Tian, Jia Zhou
Summary: Inflammatory bowel disease (IBD) is a serious chronic gastrointestinal disease, with long-term inflammation contributing to neoplastic transformation and colorectal cancer development. The discovery of new small molecule drugs targeting specific pathways in mucosal inflammation offers hope for the treatment of IBD.
INFLAMMATORY BOWEL DISEASES
(2021)
Article
Medicine, Research & Experimental
Wenjing Yang, Tianming Yu, Yingzi Cong
Summary: CD4(+) T cell metabolic pathways and gut microbiota play important roles in the pathogenesis of autoimmune disorders.
PRECISION CLINICAL MEDICINE
(2022)
Editorial Material
Gastroenterology & Hepatology
Wenjing Yang, Yingzi Cong
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Tianming Yu, Wenjing Yang, Suxia Yao, Yanbo Yu, Maki Wakamiya, George Golovko, Yingzi Cong
Summary: The STING pathway regulates intestinal IgA production by maintaining a group of acetate-producing bacteria, which is mediated by GPR43. The role of STING in intestinal IgA response is still not well understood.
INFLAMMATORY BOWEL DISEASES
(2023)
Editorial Material
Gastroenterology & Hepatology
Wenjing Yang, Yingzi Cong
Summary: Animal models of colitis have provided important insights into the underlying mechanisms of inflammatory bowel disease (IBD). T cell adoptive transfer models have become a valuable tool in investigating the immunopathogenesis of intestinal inflammation, with CD4(+) T cell responses playing a critical role in the development of IBD.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Ramasatyaveni Geesala, Ke Zhang, You-Min Lin, John C. Johnson, Yingzi Cong, Steven Cohn, Xuan-Zheng Shi
Summary: This study found that mechanical stress could induce the expression of Th17-polarizing cytokines in the colon, and exclusive enteral nutrition (EEN) attenuates Th17 immune response by reducing mechanical stress-induced IL-6 in Crohn's-like colitis.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Anthony J. Bilotta, Chunyan Ma, Wenjing Yang, Yanbo Yu, Yu Yu, Xiaojing Zhao, Zheng Zhou, Suxia Yao, Sara M. Dann, Yingzi Cong
Summary: The study revealed that propionate enhances intestinal epithelial cell migration by promoting cell spreading and polarization, leading to increased cell speed and persistence. This effect is mediated by inhibition of class I HDAC, GPR43, and STAT3 signaling. Propionate was also shown to promote cell migration under homeostatic conditions and protect against ulcer formation in experimental colitis.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Immunology
Roberta Caruso, Bernard C. Lo, Gabriel Nunez
NATURE REVIEWS IMMUNOLOGY
(2020)
