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Multidisciplinary Sciences
Qing Guo, Shuai Shen, Gefei Guan, Chen Zhu, Cunyi Zou, Jingyuan Cao, Wen Cheng, Xiaoyan Xu, Juanhan Yu, Zhiguo Lin, Guoli Wang, Ling Chen, Peng Cheng, Anhua Wu
Summary: Glioblastoma (GBM) shares common signaling pathways involving TIM-3, an immune checkpoint, between tumor and non-tumor cells. The study reveals that TIM-3 in glioma cells not only regulates the malignant behaviors of glioma cells but also induces macrophage migration and transition to an anti-inflammatory/protumorigenic phenotype through the TIM-3/IL6 signal. Blocking this feedback loop may provide a novel therapeutic strategy for GBM.
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Cell Biology
Fabian L. Cardenas-Diaz, Derek C. Liberti, John P. Leach, Apoorva Babu, Jonathan Barasch, Tian Shen, Maria A. Diaz-Miranda, Su Zhou, Yun Ying, Danielle A. Callaway, Michael P. Morley, Edward E. Morrisey
Summary: By using single-cell transcriptomics, tissue damage segmentation, and mouse lineage tracing, we found that Tfcp2l1 is a regulator of lung alveolus regeneration. Loss of Tfcp2l1 inhibits self-renewal and enhances AT2-AT1 differentiation in adult AT2 cells. Tfcp2l1 temporally regulates AT2 self-renewal and differentiation in alveolar regions undergoing active regeneration.
Article
Cell & Tissue Engineering
Chandler W. Jensen-Cody, Adrianne K. Crooke, Pavana G. Rotti, Vitaly Ievlev, Weam Shahin, Soo-Yeun Park, Thomas J. Lynch, John F. Engelhardt
Summary: The transcription factor Lef-1 plays a crucial role in regulating proliferation and differentiation of mouse tracheal basal cells. The deletion of Lef-1 leads to cell cycle arrest, downregulation of key genes related to DNA damage response and cell cycle progression, affecting basal cell self-renewal and tracheal epithelium regeneration. The study suggests that modulating Lef-1 function in airway basal cells may have potential applications in regenerative medicine.
Review
Oncology
Xin Wang, Jihye Lee, Changqing Xie
Summary: Some cancers have a higher relapse rate due to the presence of cancer stem cells (CSCs) that display stem-like characteristics and contribute to tumor growth, metastasis, and poor prognosis. Autophagy is a mechanism that helps CSCs maintain their stemness and resistance to therapy. However, recent studies have also suggested that autophagy can have anti-tumor effects. This review summarizes the current literature on the role of autophagy in CSC maintenance and suggests that regulation of autophagy could be targeted in future cancer therapies.
Review
Cell & Tissue Engineering
Shuo Zhang, Neng Zhu, Hong Fang Li, Jia Gu, Chan Juan Zhang, Duan Fang Liao, Li Qin
Summary: Cancer stem cells (CSCs) are a subpopulation of cancer cells with stem cell properties, and lipid rafts play a crucial role in CSCs, making them promising therapeutic targets for cancer treatment.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Cell Biology
Morgan Brisset, Patrick Mehlen, Olivier Meurette, Frederic Hollande
Summary: The heterogeneity of cancer cells plays a significant role in therapeutic failure and post-treatment recurrence. Targeting specific subpopulations responsible for chemoresistance and recurrence may improve treatment outcomes in cancer patients. However, the complexity and incomplete understanding of tumor cell subpopulations make it challenging to achieve this.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Editorial Material
Biochemistry & Molecular Biology
Christopher G. Hubert, Shaun R. Stauffer, Justin D. Lathia
Summary: A new signaling network that connects epigenetic regulation to self-renewal and therapeutic resistance in cancer stem cells is revealed in this study.
Article
Oncology
Yanjing Jia, Jie Zhao, Jinjie Yang, Jie Shao, Zihao Cai
Summary: This study identified miR-301 as a key regulator in breast cancer progression, accelerating malignant phenotype through the CPEB1/SIRT1/SOX2 axis.
MOLECULAR THERAPY-ONCOLYTICS
(2021)
Article
Cell Biology
Fu-Sheng Chou, Chu-Yen Chen, An-Chun Lee, Pei-Shan Wang
Summary: Individuals with intrauterine growth restriction (IUGR) are at an increased risk for neurodevelopmental impairment. This study used a murine maternal hypoxia-induced IUGR model to investigate its impact on fetal neural stem cell (NSC) development. It was found that IUGR is associated with a defect in the cell cycle progression of fetal NSCs, leading to a decrease in the number of layer-specific neurons. However, the newly generated neurons in IUGR still maintain their temporal identity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Haidong Huang, Xingjiang Yu, Xiangzi Han, Jing Hao, Jianjun Zhao, Gurkan Bebek, Shideng Bao, Richard A. Prayson, Ahmad M. Khalil, Eckhard Jankowsky, Jennifer S. Yu
Summary: The Piwi-like family members are overexpressed in glioblastoma, with Piwil1 being the most frequently overexpressed. Piwil1 is enriched in glioma stem-like cells to maintain self-renewal, and its knockdown leads to changes in gene expression and cell cycle arrest, senescence, or apoptosis. Piwil1 regulates the mRNA stability of key genes involved in cancer stem cell maintenance, and its knockdown suppresses tumor growth and promotes survival in animal models of glioblastoma.
Review
Oncology
Yutong Zhao, Cheng Qin, Bangbo Zhao, Yuanyang Wang, Zeru Li, Tianyu Li, Xiaoying Yang, Weibin Wang
Summary: Pancreatic cancer is a highly aggressive malignancy with self-renewal and proliferation capacity of pancreatic cancer stem cells playing a crucial role in metastasis and therapy resistance. This review focuses on the regulation of pancreatic cancer stem cells, including stemness-related signaling pathways, stimuli in tumor cells and the tumor microenvironment, and the development of innovative stemness-targeted therapies. Understanding the plasticity and molecular mechanisms of PCSCs will help identify new treatment strategies for this devastating disease.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Multidisciplinary Sciences
Joachim Hanna, Flavio Beke, Louise M. O'Brien, Chrysa Kapeni, Hung-Chang Chen, Valentina Carbonaro, Alexander B. Kim, Kamal Kishore, Timon E. Adolph, Mikkel-Ole Skjoedt, Karsten Skjoedt, Marc de la Roche, Maike de la Roche
Summary: The study implicates Hedgehog signaling in Th17 polarization and intestinal immunopathology, suggesting the potential therapeutic use of Hedgehog inhibitors in the treatment of inflammatory bowel disease.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Giang Le Minh, Emily M. Esquea, Tejsi T. Dhameliya, Jessica Merzy, Mi-Hye Lee, Lauren E. Ball, Mauricio J. Reginato
Summary: Breast tumor development is regulated by cancer stem-like cells (CSC) which are capable of self-renewal and differentiation. O-GlcNAc transferase (OGT) and O-GlcNAcylation are enriched in CSC populations and promote stemness and tumorigenesis of breast cancer cells. Upregulation of KLF8 is associated with OGT enrichment and plays a potential role in regulating CSC properties.
FRONTIERS IN ONCOLOGY
(2023)
Article
Cell Biology
Idil Orhon, Cecilia Rocchi, Beatriz Villarejo-Zori, Paola Serrano Martinez, Mirjam Baanstra, Uilke Brouwer, Patricia Boya, Rob Coppes, Fulvio Reggiori
Summary: In dormant salivary gland stem cells, autophagy has a slower flux compared to self-renewing cells; however, enhancement of autophagy upon activation promotes self-renewal and tissue regeneration. Autophagy is a key pathway in activating self-renewal in low proliferative adult tissues, with potential for promoting tissue regeneration through pharmacological manipulation.
Article
Cell Biology
Yunyun Chen, Kun Zhang, Rui Zhang, Zhuo Wang, Liang Yang, Tingting Zhao, Shihui Zhang, Yong Lin, Hongzhou Zhao, Yongpan Liu, Yuxuan Wei, Yijian Zhou, Jiaying Zhang, Xianzong Ye, Jing Zhao, Xinxin Li, Jianwen Que, Songlin Shi, Kuancan Liu
Summary: Research suggests that SOX2 functions as an oncogene in esophageal squamous cell carcinoma (ESCC). However, directly targeting SOX2 is not feasible due to its roles in tissue maintenance. This study identified CDP as a SOX2 binding partner enriched in ESCC and found that blocking the interaction between CDP and SOX2 with peptide aptamers, such as P58, inhibits ESCC progression. Synthetic peptide P58, containing a cell-penetrating peptide and a fluorophore, also demonstrated efficacy in blocking ESCC growth and metastasis in mice and zebrafish. Targeting the SOX2 binding partner CDP with peptide P58 provides an alternative approach to treating ESCC with increased SOX2 levels.
CELL DEATH DISCOVERY
(2023)
