Targeting autocrine HB-EGF signaling with specific ADAM12 inhibition using recombinant ADAM12 prodomain

Targeting ADAM-17 with an inhibitory monoclonal antibody has antitumour effects in triple-negative breast cancer cells

(2015) F Caiazza et al.   BRITISH JOURNAL OF CANCER

A Monoclonal Antibody to ADAM17 Inhibits Tumor Growth by Inhibiting EGFR and Non-EGFR-Mediated Pathways

(2015) J. Rios-Doria et al.   MOLECULAR CANCER THERAPEUTICS

Molecular Network Analysis of Endometriosis Reveals a Role for c-Jun-Regulated Macrophage Activation

(2014) M. T. Beste et al.   Science Translational Medicine

A disintegrin and metalloproteinase-12 (ADAM12): Function, roles in disease progression, and clinical implications

(2013) Erin K. Nyren-Erickson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Autocrine-Derived Epidermal Growth Factor Receptor Ligands Contribute to Recruitment of Tumor-Associated Macrophage and Growth of Basal Breast Cancer Cells In Vivo

(2013) Nicole K. Nickerson et al.   ONCOLOGY RESEARCH

Molecular Determinants of Epidermal Growth Factor Binding: A Molecular Dynamics Study

(2013) Jeffrey M. Sanders et al.   PLoS One

ADAM-10 and -17 regulate endometriotic cell migration via concerted ligand and receptor shedding feedback on kinase signaling

(2013) M. A. Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiplexed Protease Activity Assay for Low-Volume Clinical Samples Using Droplet-Based Microfluidics and Its Application to Endometriosis

(2012) Chia-Hung Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors

(2012) Timothy R. Wilson et al.   NATURE

The cytoplasmic tail of heparin-binding EGF-like growth factor regulates bidirectional intracellular trafficking between the plasma membrane and ER

(2012) Miki Hieda et al.   FEBS Open Bio

ADAM12 induces estrogen-independence in breast cancer cells

(2011) Roopali Roy et al.   BREAST CANCER RESEARCH AND TREATMENT

Neuregulin-1-Mediated Autocrine Signaling Underlies Sensitivity to HER2 Kinase Inhibitors in a Subset of Human Cancers

(2011) Timothy R. Wilson et al.   CANCER CELL

EGF promotes the shedding of soluble E-cadherin in an ADAM10-dependent manner in prostate epithelial cells

(2011) Magdalena M. Grabowska et al.   CELLULAR SIGNALLING

Tumor cell-derived Timp-1 is necessary for maintaining metastasis-promoting Met-signaling via inhibition of Adam-10

(2011) Florian Schelter et al.   CLINICAL & EXPERIMENTAL METASTASIS

High-density fine-mapping of a chromosome 10q26 linkage peak suggests association between endometriosis and variants close to CYP2C19

(2011) Jodie N. Painter et al.   FERTILITY AND STERILITY

Inhibition of MT1-MMP activity using functional antibody fragments selected against its hemopexin domain

(2011) B. Basu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

ADAM9 Inhibition Increases Membrane Activity of ADAM10 and Controls α-Secretase Processing of Amyloid Precursor Protein

(2011) Marcia L. Moss et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ADAM12 Produced by Tumor Cells Rather than Stromal Cells Accelerates Breast Tumor Progression

(2011) C. Frohlich et al.   MOLECULAR CANCER RESEARCH

A recombinant decoy comprising EGFR and ErbB-4 inhibits tumor growth and metastasis

(2011) M Lindzen et al.   ONCOGENE

Cross-domain inhibition of TACE ectodomain

(2011) C. J. Tape et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective inhibition of ADAM12 catalytic activity through engineering of tissue inhibitor of metalloproteinase 2 (TIMP-2)

(2010) Marie Kveiborg et al.   BIOCHEMICAL JOURNAL

Unique Transcriptome, Pathways, and Networks in the Human Endometrial Fibroblast Response to Progesterone in Endometriosis

(2010) L. Aghajanova et al.   BIOLOGY OF REPRODUCTION

A hybrid blob-slice model for accurate and efficient detection of fluorescence labeled nuclei in 3D

(2010) Anthony Santella et al.   BMC BIOINFORMATICS

Clinical Benefit of INCB7839, a Potent and Selective Inhibitor of ADAM10 and ADAM17, in Combination with Trastuzumab in Metastatic HER2 Positive Breast Cancer Patients.

(2010) S. Friedman et al.   CANCER RESEARCH

Proteolytic Activity Matrix Analysis (PrAMA) for simultaneous determination of multiple protease activities

(2010) Miles A. Miller et al.   Integrative Biology

Tumor Necrosis Factor-  (TNF- ) Regulates Shedding of TNF-  Receptor 1 by the Metalloprotease-Disintegrin ADAM8: Evidence for a Protease-Regulated Feedback Loop in Neuroprotection

(2010) J. W. Bartsch et al.   JOURNAL OF NEUROSCIENCE

Structure of the EGF receptor transactivation circuit integrates multiple signals with cell context

(2010) Elizabeth J. Joslin et al.   Molecular BioSystems

Regulation of Heparin-Binding EGF-Like Growth Factor by miR-212 and Acquired Cetuximab-Resistance in Head and Neck Squamous Cell Carcinoma

(2010) Hiromitsu Hatakeyama et al.   PLoS One

Combination antibody treatment down-regulates epidermal growth factor receptor by inhibiting endosomal recycling

(2010) J. B. Spangler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Biomarkers in Human Head and Neck Tumor Cell Lines That Predict ForIn VitroSensitivity to Gefitinib

(2009) D. Mark Hickinson et al.   CTS-Clinical and Translational Science

A truncated soluble epidermal growth factor receptor-Fc fusion ligand trap displays anti-tumour activityin vivo

(2009) Timothy E. Adams et al.   GROWTH FACTORS

Synergistic Inhibition with a Dual Epidermal Growth Factor Receptor/HER-2/neu Tyrosine Kinase Inhibitor and a Disintegrin and Metalloprotease Inhibitor

(2008) L. Witters et al.   CANCER RESEARCH

The metalloproteinase ADAM-12 regulates bronchial epithelial cell proliferation and apoptosis

(2008) N. Rocks et al.   CELL PROLIFERATION

Autocrine Production of Amphiregulin Predicts Sensitivity to Both Gefitinib and Cetuximab in EGFR Wild-type Cancers

(2008) K. Yonesaka et al.   CLINICAL CANCER RESEARCH

Membrane-anchored growth factor, HB-EGF, on the cell surface targeted to the inner nuclear membrane

(2008) Miki Hieda et al.   JOURNAL OF CELL BIOLOGY

Gene expression profiles and functional characterization of human immortalized endometriotic epithelial and stromal cells

(2007) Sakhila K. Banu et al.   FERTILITY AND STERILITY