Article
Biotechnology & Applied Microbiology
Yongliang Chu, Silong Sun, Yufen Huang, Qiang Gao, Xuefeng Xie, Peng Wang, Junxia Li, Lifeng Liang, Xiaohong He, Yiqi Jiang, Maojie Wang, Jianhua Yang, Xiumin Chen, Chu Zhou, Yue Zhao, Fen Ding, Yi Zhang, Xiaodong Wu, Xueyuan Bai, Jiaqi Wu, Xia Wei, Xianghong Chen, Zhen Yue, Xiaodong Fang, Qingchun Huang, Zhang Wang, Runyue Huang
Summary: The study found differences in gut microbiota of gout patients, with changes in the abundance of certain bacteria and related functional genes, which may be associated with urate degradation and inflammation in the body.
NPJ BIOFILMS AND MICROBIOMES
(2021)
Review
Cell Biology
Yew Mun Lee, Deryn En-Jie Teoh, Kay Yeung, Yih-Cherng Liou
Summary: Pin1 plays a crucial role in various diseases, particularly in neurodegenerative diseases and cancer. Its conservation across different species highlights its importance, and using different Pin1 models may provide insights for disease therapeutics.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Engineering, Environmental
Shuang Zhou, Min Gan, Xingxing Wang, Yisheng Zhang, Yingchun Fang, Guohua Gu, Yanhong Wang, Guanzhou Qiu
Summary: Pyrite-mediated arsenopyrite oxidation is a significant process affecting the mobility of arsenic (As). Reactive oxidation species (ROS) induced by iron sulfides have a notable impact on As transformation. This study investigated ROS formation and the redox conversion of As during the interaction between pyrite and arsenopyrite, considering the factors of O2, pH, and pyrite surface oxidation. The results revealed that pyrite promoted the oxidation of arsenopyrite and As(III) due to heterogeneous electron transfer, leading to increased ROS formation. This work enhances our understanding of arsenic transformation in the environment and has important implications for mitigating arsenic pollution.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Review
Cell Biology
Shu-Chao Wang, Xi-Min Hu, Kun Xiong
Summary: This paper reviews the role of Pin1 in regulated cell death and summarizes Pin1-related pathways. In addition to apoptosis in neurodegenerative diseases, Pin1 is also involved in regulated necrosis and autophagy, exhibiting distinct effects including both neurotoxic and neuroprotective effects. Understanding Pin1 in neuronal death may lead to the development of new therapeutic options for neurodegenerative disorders.
NEURAL REGENERATION RESEARCH
(2023)
Article
Green & Sustainable Science & Technology
Lianbiao Cui, Shimei Weng, Abdul Majeed Nadeem, Muhammad Zahid Rafique, Umer Shahzad
Summary: This study examines the relationship between economic complexity, human capital, renewable energy, urbanization, economic development, and ecological footprint in 20 countries. The results indicate that economic complexity, economic development, and urbanization increase the ecological footprint, while human capital and renewable energy contribute to the ecological footprint.
Article
Chemistry, Multidisciplinary
Baodan Zhang, Yiming Zhang, Xiaotong Wang, Hui Liu, Yawen Yan, Shiyuan Zhou, Yonglin Tang, Guifan Zeng, Xiaohong Wu, Hong-Gang Liao, Yongfu Qiu, Huan Huang, Lirong Zheng, Juping Xu, Wen Yin, Zhongyuan Huang, Yinguo Xiao, Qingshui Xie, Dong-Liang Peng, Chao Li, Yu Qiao, Shi-Gang Sun
Summary: Element doping/substitution can enhance the structural stability of layered cathodes. The study on Li1.2Ni0.2Mn0.6O2 reveals that the degree of disorder induced by Mg/Ti substitution affects the stability of TM-O, Li+ diffusion, and anion redox reversibility, leading to distinct electrochemical performance.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Biochemistry & Molecular Biology
Machi Kanna, Yusuke Nakatsu, Takeshi Yamamotoya, Akifumi Kushiyama, Midori Fujishiro, Hideyuki Sakoda, Hiraku Ono, Koji Arihiro, Tomoichiro Asano
Summary: Our previous studies have indicated that Pin1 plays an essential role in the development of non-alcoholic steatohepatitis (NASH) based on rodent models. Interestingly, elevation of serum Pin1 has been observed in NASH patients. However, the expression level of Pin1 in human NASH livers has not been investigated yet. In this study, we examined the expression level and subcellular distribution of Pin1 in NASH liver specimens and found that Pin1 expression was significantly higher, especially in nuclei, compared to healthy liver samples. Our findings also suggest that increased Pin1 expression, particularly in hepatic nuclei, is associated with lipid accumulation in NASH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Liang Zhao, Li-Zhou Lin, Ying Zeng, Wen-Kai Teng, Meng-Yun Chen, Jerry J. Brand, Ling-Ling Zheng, Nan-Qin Gan, Yong-Hui Gong, Xin-Yi Li, Jin Lv, Ting Chen, Bo-Ping Han, Li-Rong Song, Wen-Sheng Shu
Summary: In freshwater ecosystems, the interaction between algae and heterotrophic bacteria may lead to the formation of bacterial populations with the ability to degrade phosphonates, increasing the proliferation capabilities of cyanobacteria. Metatranscriptomic analysis of aggregate samples suggests that the cooperation between algae and heterotrophic bacteria plays a crucial role in the proliferation of cyanobacteria.
Review
Cell Biology
Francesca Fagiani, Marieva Vlachou, Daniele Di Marino, Ilaria Canobbio, Alice Romagnoli, Marco Racchi, Stefano Govoni, Cristina Lanni
Summary: Pin1 functions as a key regulator of vascular homeostasis by modulating nitric oxide bioavailability and influencing various pathways involved in vascular diseases. Understanding the role of Pin1 in vascular endothelium could provide new insights for potential therapeutic strategies in vascular pathologies and neurodegenerative diseases.
Article
Microbiology
Balakumaran Sathiyamani, Evangeline Ann Daniel, Samdani Ansar, Bennett Henzeler Esakialraj, Sameer Hassan, Prasanna D. Revanasiddappa, Amrutha Keshavamurthy, Sujata Roy, Umashankar Vetrivel, Luke Elizabeth Hanna
Summary: The functional significance of the HIV-1 Antisense Protein (ASP) is still not clear, despite sporadic reports suggesting its involvement in autophagy, transcriptional regulation, and viral latency. In this study, we used molecular modeling and dynamics simulation to predict the 3D structures of ASP from two reference strains of HIV-1, and identified common domains that support its potential role in transcriptional repression and autophagy. Cluster analysis further confirmed the accuracy of the prediction. This study provides a highly plausible structure for HIV-1 ASP, which can be further validated experimentally.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Cell Biology
Yasuka Matsunaga, Shun Hasei, Takeshi Yamamotoya, Hiroaki Honda, Akifumi Kushiyama, Hideyuki Sakoda, Midori Fujishiro, Hiraku Ono, Hisanaka Ito, Takayoshi Okabe, Tomoichiro Asano, Yusuke Nakatsu
Summary: Pin1 protein was significantly upregulated in colons of ulcerative colitis model mice, and its knockout led to attenuation of colitis, suggesting a potential role of Pin1 in inflammation. The inhibition of Pin1 partially prevented DSS-induced colitis in mice, indicating a possible therapeutic strategy for IBD.
Article
Biochemistry & Molecular Biology
Huan Zheng, Yueting Liang, Ben Hong, Yingyi Xu, Mengfan Ren, Yixu Wang, Liyuan Huang, Lina Yang, Jianmin Tao
Summary: This study identified 24 grapevine KCS (VvKCS) genes and provided new names based on their relative chromosome distribution. Based on sequence alignment and phylogenetic investigation, these genes were grouped into seven subgroups, members of the same subgroup having similar motif structures. The analysis revealed that some VvKCS genes showed significant differential expression at the critical stage of pollen wall formation, potentially affecting structural integrity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Environmental Sciences
Emna Zeghal, Annika Vaksmaa, Hortense Vielfaure, Teun Boekhout, Helge Niemann
Summary: Plastic debris has been accumulating in the ocean since the 1950s, raising concerns about its impact on marine life. While marine fungi are understudied, they have the potential to play an important role in degrading complex organic matter in marine habitats.
FRONTIERS IN MARINE SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Shan Wang, Yongbin Wang, Rui Yang, Wanhua Cai, Yaning Liu, Duanrong Zhou, Li Meng, Ping Wang, Binquan Huang
Summary: In this study, the identification and analysis of StJAZs and StMYCs in potatoes were conducted. The findings revealed the chromosomal position, phylogenetic development, gene structure, and promoter cis-acting parts of these genes. Protein-protein interaction analysis and yeast two-hybrid assay demonstrated the interaction between StJAZs and StMYCs, shedding light on the mechanism of JA signal response. Furthermore, expression profiling of these genes during abiotic stresses provided insights into their involvement in the response of potatoes to environmental stress, suggesting a potential avenue for genetic improvement.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Claire Cargemel, Sonia Baconnais, Magali Aumont-Nicaise, Magali Noiray, Lia Maurin, Jessica Andreani, Helene Walbott, Eric Le Cam, Francoise Ochsenbein, Stephanie Marsin, Sophie Quevillon-Cheruel
Summary: This study demonstrates that the bacterial replicative helicase loader DciA interacts with single-stranded and double-stranded DNA in an atypical mode, potentially acting as a DNA chaperone. Point mutations in DciA's long alpha-helix 1 affect its interaction with different DNA substrates and the loading of the helicase. These findings suggest that direct interaction between DciA and DNA may play a role in the helicase loading mechanism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Regina Freier, Eric Aragon, Radoslaw Pluta, Pau Martin-Malpartida, Lidia Ruiz, Miriam Condeminas, Cayetano Gonzalez, Maria J. Macias
Summary: Thioredoxins (Trxs) are ubiquitous enzymes that regulate the redox state in cells. In Drosophila, there are two germline-specific Trxs, Deadhead (Dhd) and thioredoxin T (TrxT), that have unique structural features which may guide future research on embryo development and redox homeostasis in fruit flies. These structures could also potentially be utilized for designing small-molecular binders to modulate native redox homeostasis and control plagues in Schizophora species.
Article
Multidisciplinary Sciences
Alvaro Rol, Toni Todorovski, Pau Martin-Malpartida, Anna Escola, Elena Gonzalez-Rey, Eric Aragon, Xavier Verdaguer, Mariona Valles-Miret, Josep Farrera-Sinfreu, Eduard Puig, Jimena Fernandez-Carneado, Berta Ponsati, Mario Delgado, Antoni Riera, Maria J. Macias
Summary: Inflammatory bowel diseases such as ulcerative colitis and Crohn's disease are characterized by chronic inflammation of the gastrointestinal tract and disrupted immune responses. Researchers have examined Cortistatin analogues that have enhanced half-life stability while maintaining immunomodulatory functionality.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Pau Martin-Malpartida, Emil Hausvik, Jarl Underhaug, Carles Torner, Aurora Martinez, Maria J. Macias
Summary: To simplify the analysis steps in target-based biophysical assays, we developed the HTSDSF explorer, a versatile, all-in-one, user-friendly application suite. It helps users quickly analyze and select primary hits, and determines preliminary binding constants through dose-response assays.
JOURNAL OF MOLECULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Julia Hernandez-Baixauli, Nerea Abasolo, Hector Palacios-Jordan, Elisabet Foguet-Romero, David Sunol, Mar Galofre, Antoni Caimari, Laura Baselga-Escudero, Josep M. Del Bas, Miquel Mulero
Summary: Chronic inflammation is a significant risk factor for various diseases, and understanding its progression is crucial. This study identified metabolic pathways and biomarkers associated with chronic inflammation, providing insights into the disruption of metabolic homeostasis caused by inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Soraya Learte-Aymami, Pau Martin-Malpartida, Lorena Roldan-Martin, Giuseppe Sciortino, Jose R. Couceiro, Jean-Didier Marechal, Maria J. Macias, Jose L. Mascarenas, M. Eugenio Vazquez
Summary: A short peptide was designed to reversibly bind to KRAS upon coordination to Pd(II), inhibiting its activated pathways in live cells. The peptide can efficiently internalize into cells and inhibit the MAPK kinase cascade.
COMMUNICATIONS CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Radoslaw Pluta, Eric Aragon, Nicholas A. Prescott, Lidia Ruiz, Rebeca A. Mees, Blazej Baginski, Julia R. Flood, Pau Martin-Malpartida, Joan Massague, Yael David, Maria J. Macias
Summary: FoxH1 is an essential maternal pioneer factor during embryonic development, and this study reveals the molecular basis for its binding specificity and pioneer factor activity through high-resolution structures of FoxH1 proteins and DNAs.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Pau Martin-Malpartida, Silvia Arrastia-Casado, Josep Farrera-Sinfreu, Rudolf Lucas, Hendrik Fischer, Bernhard Fischer, Douglas C. Eaton, Susan Tzotzos, Maria J. Macias
Summary: This article introduces the potential mechanism of solnatide as a novel therapeutic agent for treating pulmonary edema. By mimicking the action of human TNF, solnatide can activate ENaC, thereby enhancing alveolar fluid clearance. Through NMR analysis, researchers found that solnatide has a folding structure with a small hydrophobic core and two charged polarity regions. They propose a model for the interaction between solnatide and the C-terminal domain of the ENaCα subunit, which can guide future experiments and the design of new drugs.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Tiago Gomes, Pau Martin-Malpartida, Lidia Ruiz, Eric Aragon, Tiago N. Cordeiro, Maria J. Macias
Summary: The study unravels the structures of SMAD4 and SMAD2 proteins, revealing that they both have mixed architecture of globular domains and flexible linkers defining a new dimension of regulation. SMAD4FL is monomeric, while SMAD2FL exists in different monomer-dimer-trimer states driven by interactions of the MH2 domains. The study proposes that SMAD2FL dimers are key building blocks for the quaternary structures of SMAD complexes.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Lidia Ruiz, Zuzanna Kaczmarska, Tiago Gomes, Eric Aragon, Carles Torner, Regina Freier, Blazej Baginski, Pau Martin-Malpartida, Natalia de Martin Garrido, Jose. A. Marquez, Tiago N. Cordeiro, Radoslaw Pluta, Maria J. Macias
Summary: Smad transcription factors are key regulators in the TGF beta and BMP signaling pathways, forming monomers or dimers that influence gene expression. The dimer/monomer propensities of MH1 domains have specific effects on site clustering and spacing in Smad-responsive genes, affecting the regulation of cellular signaling.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)