标题
Challenges and opportunities in developing novel drugs for TB
作者
关键词
-
出版物
Future Medicinal Chemistry
Volume 3, Issue 11, Pages 1373-1400
出版商
Future Science, LTD
发表日期
2011-09-01
DOI
10.4155/fmc.11.115
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Activity of Carbapenems Combined with Clavulanate against Murine Tuberculosis
- (2011) Nicolas Veziris et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Activity of the Fluoroquinolone DC-159a in the Initial and Continuation Phases of Treatment of Murine Tuberculosis
- (2011) Zahoor Ahmad et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Diarylquinolines, synthesis pathways and quantitative structure–activity relationship studies leading to the discovery of TMC207
- (2011) Jerome Guillemont et al. Future Medicinal Chemistry
- Benzoxaboroles: a new class of potential drugs for human African trypanosomiasis
- (2011) Robert T Jacobs et al. Future Medicinal Chemistry
- Early bactericidal activity of delamanid (OPC-67683) in smear-positive pulmonary tuberculosis patients
- (2011) A. H. Diacon et al. INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
- Inactivation Kinetics of a New Target of β-Lactam Antibiotics
- (2011) Sébastien Triboulet et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structure and mechanism of the hexameric MecA–ClpC molecular machine
- (2011) Feng Wang et al. NATURE
- The challenge of new drug discovery for tuberculosis
- (2011) Anil Koul et al. NATURE
- A multistage tuberculosis vaccine that confers efficient protection before and after exposure
- (2011) Claus Aagaard et al. NATURE MEDICINE
- Phosphodiesterase 4 Inhibition Reduces Innate Immunity and Improves Isoniazid Clearance of Mycobacterium tuberculosis in the Lungs of Infected Mice
- (2011) Mi-Sun Koo et al. PLoS One
- Structure-based design of anti-infectives
- (2010) Anil K Agarwal et al. Annals of the New York Academy of Sciences
- Challenges of antibacterial discovery revisited
- (2010) Michael N. Gwynn et al. Annals of the New York Academy of Sciences
- Activities of NXL104 Combinations with Ceftazidime and Aztreonam against Carbapenemase-ProducingEnterobacteriaceae
- (2010) David M. Livermore et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Evaluation of Standard Chemotherapy in the Guinea Pig Model of Tuberculosis
- (2010) D. J. Ordway et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Activities of TMC207, Rifampin, and Pyrazinamide againstMycobacterium tuberculosisInfection in Guinea Pigs
- (2010) Shaobin Shang et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- In Vitro Activities of DC-159a, a Novel Fluoroquinolone, against Mycobacterium Species
- (2010) A. Disratthakit et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Comparative Studies Evaluating Mouse Models Used for Efficacy Testing of Experimental Drugs againstMycobacterium tuberculosis
- (2010) Mary A. De Groote et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Evaluation of Ceftazidime and NXL104 in Two Murine Models of Infection Due to KPC-ProducingKlebsiella pneumoniae
- (2010) Andrea Endimiani et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Early Bactericidal Activity and Pharmacokinetics of PA-824 in Smear-Positive Tuberculosis Patients
- (2010) A. H. Diacon et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- In Vitro Interactions between New Antitubercular Drug Candidates SQ109 and TMC207
- (2010) V. M. Reddy et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- The chemical biology of new drugs in the development for tuberculosis
- (2010) Clifton E Barry et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Drugs in Development for Tuberculosis
- (2010) Ann M. Ginsberg DRUGS
- Respiratory ATP synthesis: the new generation of mycobacterial drug targets?
- (2010) Dirk Bald et al. FEMS MICROBIOLOGY LETTERS
- ATP synthase in slow- and fast-growing mycobacteria is active in ATP synthesis and blocked in ATP hydrolysis direction
- (2010) Anna C. Haagsma et al. FEMS MICROBIOLOGY LETTERS
- Killing of non-replicating Mycobacterium tuberculosis by 8-hydroxyquinoline
- (2010) C. M. Darby et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Unexpected Abundance of Coenzyme F420-Dependent Enzymes in Mycobacterium tuberculosis and Other Actinobacteria
- (2010) J. D. Selengut et al. JOURNAL OF BACTERIOLOGY
- Synthesis and Structure−Activity Relationships of Aza- and Diazabiphenyl Analogues of the Antitubercular Drug (6S)-2-Nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824)
- (2010) Iveta Kmentova et al. JOURNAL OF MEDICINAL CHEMISTRY
- Benzothiazinones: Prodrugs That Covalently Modify the Decaprenylphosphoryl-β-d-ribose 2′-epimerase DprE1 ofMycobacterium tuberculosis
- (2010) Claudia Trefzer et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Global tuberculosis drug development pipeline: the need and the reality
- (2010) Zhenkun Ma et al. LANCET
- Structure-based discovery of antibacterial drugs
- (2010) Katie J. Simmons et al. NATURE REVIEWS MICROBIOLOGY
- Development of a repressible mycobacterial promoter system based on two transcriptional repressors
- (2010) Francesca Boldrin et al. NUCLEIC ACIDS RESEARCH
- Improved mycobacterial tetracycline inducible vectors
- (2010) Kerstin J. Williams et al. PLASMID
- Gluconeogenic carbon flow of tricarboxylic acid cycle intermediates is critical for Mycobacterium tuberculosis to establish and maintain infection
- (2010) J. Marrero et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural and Theoretical Studies Indicate that the Cylindrical Protease ClpP Samples Extended and Compact Conformations
- (2010) Matthew S. Kimber et al. STRUCTURE
- Evaluation of the Mycobacterium smegmatis and BCG models for the discovery of Mycobacterium tuberculosis inhibitors
- (2010) Mudassar Altaf et al. TUBERCULOSIS
- Leads for antitubercular compounds from kinase inhibitor library screens
- (2010) Sophie Magnet et al. TUBERCULOSIS
- Rifamycins – Obstacles and opportunities
- (2010) Paul A. Aristoff et al. TUBERCULOSIS
- EspA Acts as a Critical Mediator of ESX1-Dependent Virulence in Mycobacterium tuberculosis by Affecting Bacterial Cell Wall Integrity
- (2010) Alejandra Garces et al. PLoS Pathogens
- New Antituberculous Drugs in Development
- (2010) Umesh G. Lalloo et al. Current HIV/AIDS Reports
- Crystallization and preliminary crystallographic studies ofMycobacterium tuberculosisDNA gyrase B C-terminal domain, part of the enzyme reaction core
- (2009) Guangsen Fu et al. Acta Crystallographica Section F-Structural Biology and Crystallization Communications
- Dominant Role of the sst1 Locus in Pathogenesis of Necrotizing Lung Granulomas during Chronic Tuberculosis Infection and Reactivation in Genetically Resistant Hosts
- (2009) Alexander V. Pichugin et al. AMERICAN JOURNAL OF PATHOLOGY
- Costs and Cost-effectiveness of Four Treatment Regimens for Latent Tuberculosis Infection
- (2009) David P. Holland et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Cell-Mediated Immune Responses in Tuberculosis
- (2009) Andrea M. Cooper Annual Review of Immunology
- Pharmacokinetics-Pharmacodynamics of Pyrazinamide in a Novel In Vitro Model of Tuberculosis for Sterilizing Effect: a Paradigm for Faster Assessment of New Antituberculosis Drugs
- (2009) T. Gumbo et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Linezolid in the Treatment of Multidrug‐Resistant Tuberculosis
- (2009) G. F. Schecter et al. CLINICAL INFECTIOUS DISEASES
- New Anti-Tuberculosis Drugs: Strategies, Sources and New Molecules
- (2009) Juan Palomino et al. CURRENT MEDICINAL CHEMISTRY
- Therapeutic potential of boron-containing compounds
- (2009) Stephen J Baker et al. Future Medicinal Chemistry
- Metabolic characteristics and importance of the universal methionine salvage pathway recycling methionine from 5â²-methylthioadenosine
- (2009) Eva Albers IUBMB LIFE
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- (2009) Javier Suarez et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Pristinamycin-inducible gene regulation in mycobacteria
- (2009) Francesca Forti et al. JOURNAL OF BIOTECHNOLOGY
- Structure−Activity Relationships of Antitubercular Nitroimidazoles. 2. Determinants of Aerobic Activity and Quantitative Structure−Activity Relationships
- (2009) Pilho Kim et al. JOURNAL OF MEDICINAL CHEMISTRY
- Structure−Activity Relationships of Antitubercular Nitroimidazoles. 1. Structural Features Associated with Aerobic and Anaerobic Activities of 4- and 5-Nitroimidazoles
- (2009) Pilho Kim et al. JOURNAL OF MEDICINAL CHEMISTRY
- Nitazoxanide Kills Replicating and NonreplicatingMycobacterium tuberculosisand Evades Resistance
- (2009) Luiz Pedro S. de Carvalho et al. JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis and Structure−activity Relationships of Antitubercular 2-Nitroimidazooxazines Bearing Heterocyclic Side Chains
- (2009) Hamish S. Sutherland et al. JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis and Structure−Activity Studies of Biphenyl Analogues of the Tuberculosis Drug (6S)-2-Nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824)
- (2009) Brian D. Palmer et al. JOURNAL OF MEDICINAL CHEMISTRY
- Evaluation of BACTEC 460 TB system for rapid in vitro screening of drugs against latent state Mycobacterium tuberculosis H37Rv under hypoxia conditions
- (2009) Shivsharan Kharatmal et al. JOURNAL OF MICROBIOLOGICAL METHODS
- R207910 (TMC207) : un nouvel antibiotique pour le traitement de la tuberculose
- (2009) N. Lounis et al. MEDECINE ET MALADIES INFECTIEUSES
- MenA Is a Promising Drug Target for Developing Novel Lead Molecules to Combat Mycobacterium tuberculosis
- (2009) Michio Kurosu et al. Medicinal Chemistry
- ACCase 6 is the essential acetyl-CoA carboxylase involved in fatty acid and mycolic acid biosynthesis in mycobacteria
- (2009) D. G. Kurth et al. MICROBIOLOGY-SGM
- The Diarylquinoline TMC207 for Multidrug-Resistant Tuberculosis
- (2009) Andreas H. Diacon et al. NEW ENGLAND JOURNAL OF MEDICINE
- Improved tetracycline repressors for gene silencing in mycobacteria
- (2009) Marcus Klotzsche et al. NUCLEIC ACIDS RESEARCH
- A Novel In Vitro Multiple-Stress Dormancy Model for Mycobacterium tuberculosis Generates a Lipid-Loaded, Drug-Tolerant, Dormant Pathogen
- (2009) Chirajyoti Deb et al. PLoS One
- A class of selective antibacterials derived from a protein kinase inhibitor pharmacophore
- (2009) J. Richard Miller et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Recent advances in the diagnosis and treatment of multidrug-resistant tuberculosis
- (2009) Suhail Ahmad et al. RESPIRATORY MEDICINE
- Benzothiazinones Kill Mycobacterium tuberculosis by Blocking Arabinan Synthesis
- (2009) V. Makarov et al. SCIENCE
- Meropenem-Clavulanate Is Effective Against Extensively Drug-Resistant Mycobacterium tuberculosis
- (2009) J.-E. Hugonnet et al. SCIENCE
- Drug Discovery and Natural Products: End of an Era or an Endless Frontier?
- (2009) J. W.-H. Li et al. SCIENCE
- Antibiotics for Emerging Pathogens
- (2009) M. A. Fischbach et al. SCIENCE
- Eliminating latent tuberculosis
- (2009) Douglas B. Young et al. TRENDS IN MICROBIOLOGY
- Antituberculosis activity of the molecular libraries screening center network library
- (2009) Joseph A. Maddry et al. TUBERCULOSIS
- High-throughput screening for inhibitors of Mycobacterium tuberculosis H37Rv
- (2009) Subramaniam Ananthan et al. TUBERCULOSIS
- Efficacy and safety of live attenuated persistent and rapidly cleared Mycobacterium tuberculosis vaccine candidates in non-human primates
- (2009) Michelle H. Larsen et al. VACCINE
- New Drugs against Tuberculosis: Problems, Progress, and Evaluation of Agents in Clinical Development
- (2008) J. van den Boogaard et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Structure–activity relationship of truncated analogs of caprazamycins as potential anti-tuberculosis agents
- (2008) Shinpei Hirano et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Selective Killing of Nonreplicating Mycobacteria
- (2008) Ruslana Bryk et al. Cell Host & Microbe
- Targeting the Transcriptional and Translational Machinery of the Endosymbiotic Organelle in Apicomplexans
- (2008) Tobias Fleige et al. CURRENT DRUG TARGETS
- New anti-tuberculosis drugs in clinical trials with novel mechanisms of action
- (2008) Emma C. Rivers et al. DRUG DISCOVERY TODAY
- Novel β-lactam antibiotics and inhibitor combinations
- (2008) Matteo Bassetti et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Mycobacterium tuberculosis ClpC1
- (2008) Narayani P. Kar et al. FEBS Journal
- Tuberculous Granulomas Are Hypoxic in Guinea Pigs, Rabbits, and Nonhuman Primates
- (2008) L. E. Via et al. INFECTION AND IMMUNITY
- The Peptidoglycan of Stationary-Phase Mycobacterium tuberculosis Predominantly Contains Cross-Links Generated by L,D-Transpeptidation
- (2008) M. Lavollay et al. JOURNAL OF BACTERIOLOGY
- The Actinobacterialmce4Locus Encodes a Steroid Transporter
- (2008) William W. Mohn et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Diarylquinolines Are Bactericidal for Dormant Mycobacteria as a Result of Disturbed ATP Homeostasis
- (2008) Anil Koul et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Physicochemical Properties of Antibacterial Compounds: Implications for Drug Discovery
- (2008) Rosemarie O’Shea et al. JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis, Reduction Potentials, and Antitubercular Activity of Ring A/B Analogues of the Bioreductive Drug (6S)-2-Nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824)
- (2008) Andrew M. Thompson et al. JOURNAL OF MEDICINAL CHEMISTRY
- A simple whole cell based high throughput screening protocol using Mycobacterium bovis BCG for inhibitors against dormant and active tubercle bacilli
- (2008) Arshad Khan et al. JOURNAL OF MICROBIOLOGICAL METHODS
- Structural studies of type I topoisomerases
- (2008) N. M. Baker et al. NUCLEIC ACIDS RESEARCH
- Intermediates in the reduction of the antituberculosis drug PA-824, (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine, in aqueous solution
- (2008) Robert F. Anderson et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- Mycobacterial persistence requires the utilization of host cholesterol
- (2008) A. K. Pandey et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- PA-824 Kills Nonreplicating Mycobacterium tuberculosis by Intracellular NO Release
- (2008) R. Singh et al. SCIENCE
- Using Animal Models to Develop New Treatments for Tuberculosis
- (2008) Eric Nuermberger SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE
- Disseminated disease severity as a measure of virulence of Mycobacterium tuberculosis in the guinea pig model
- (2008) Gopinath S. Palanisamy et al. TUBERCULOSIS
- Nitrile-inducible gene expression in mycobacteria
- (2008) Amit K. Pandey et al. TUBERCULOSIS
- Synthesis of Caprazamycin Analogues and Their Structure−Activity Relationship for Antibacterial Activity
- (2007) Shinpei Hirano et al. JOURNAL OF ORGANIC CHEMISTRY
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