Article
Environmental Sciences
Sandra Isabel Moreno Abril, Ana Olmos Pin, Alexandre M. Schonemann, Marina Bellot, Cristian Gomez-Canela, Ricardo Beiras
Summary: Currently, endocrine disruptors (EDs) can be found in all the environmental compartments. The effects of acute exposure to 17 alpha-ethinylestradiol (EE2) in C. variegatus larvae were investigated. The results showed that EE2 exposure at different concentrations affected the gene expression of various markers, indicating that C. variegatus larvae are an efficient and sensitive model for biomonitoring estrogenic EDs (EEDs).
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Marine & Freshwater Biology
Alexandre M. Schonemann, Ricardo Beiras, Angel P. Diz
Summary: This study assessed quantitative proteomic changes in the liver of adult male Sheepshead minnow exposed to ethinyl estradiol (EE2). The findings provide valuable insights into the impact of estrogenic endocrine disruption in marine fish and identify potential molecular biomarkers for estrogen exposure in the environment.
AQUATIC TOXICOLOGY
(2022)
Article
Environmental Sciences
Tatiana Chenet, Annalaura Mancia, Gioacchino Bono, Fabio Falsone, Danilo Scannella, Carmela Vaccaro, Andrea Baldi, Martina Catani, Alberto Cavazzini, Luisa Pasti
Summary: This study found that microplastics were commonly present in the gastrointestinal tract of Atlantic horse mackerel, with larger plastic fragments mainly found in the larger specimens from one of the fishing areas. It also evaluated the impact of plastic pollution on the endocrine system function in adult fish T. Trachurus.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Michael Niederwanger, Josef Wieser, Melanie Thaler, Agnes Felber, Katja Schmoelz, Wolfgang Mark, Erich Tasser, Rudiger Kaufmann, Bernd Pelster
Summary: The efflux of organic contaminants from sewage treatment plants and extensive pesticide use in vineyards and orchards have detrimental effects on fish species, particularly their endocrine system. This study investigated the effects of sewage treatment plant efflux and pesticide use on selected fish species in Austrian freshwater streams. Biomarkers related to endocrine disruption were identified, and mRNA expression levels were measured. The results showed increased mRNA expression in the tested fish species, indicating the presence of endocrine disrupting chemicals. This study provides important insights for further research on the effects of these chemicals on fish populations.
FRONTIERS IN ENVIRONMENTAL SCIENCE
(2022)
Article
Andrology
Nobuyuki Sakurai, Yoshitaka Fujihara, Kiyonori Kobayashi, Masahito Ikawa
Summary: This study reveals the important role of epididymis-enriched genes in sperm maturation and acquisition of fertilizing ability. Knockout of these genes leads to reduced fertility in male mice.
Review
Biology
Paul M. Wassarman, Eveline S. Litscher
Summary: The presence of a zona pellucida (ZP) is essential for the fertility of female mammals, including mice and humans. It stabilizes the contacts between oocyte microvilli and follicle cell projections, supporting the development of growing oocytes and follicles. The absence of a ZP, due to gene inactivation or mutation, results in a loss of contacts and reduced production of ovulated eggs, leading to female infertility.
Article
Multidisciplinary Sciences
Yoshitaka Fujihara, Sarah Herberg, Andreas Blaha, Karin Panser, Kiyonori Kobayashi, Tamara Larasati, Maria Novatchkova, Hans-Christian Theussl, Olga Olszanska, Masahito Ikawa, Andrea Pauli
Summary: Fertilization is a crucial process initiating new individual development in sexually reproducing species. SPACA4, a sperm protein, is essential for efficient fertilization in mammals like mice, particularly for interactions with the zona pellucida. Its absence leads to subfertility in male knockout mice, with fertilization rescue observed when the zona pellucida is removed during in vitro experiments.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Biochemistry & Molecular Biology
Carla Moros-Nicolas, Pascale Chevret, Maria Jimenez-Movilla, Blanca Algarra, Paula Cots-Rodriguez, Leopoldo Gonzalez-Brusi, Manuel Aviles, Ma Jose Izquierdo-Rico
Summary: The zona pellucida (ZP) is a ancient extracellular matrix surrounding mammalian oocytes and embryos, preventing polyspermy and protecting the embryo. Studies have shown differences in ZP composition among different mammalian species, likely due to molecular evolution of the ZP gene family. Interactions with other proteins in the oviductal lumen may play different roles in different mammalian species.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Rasmus Sogaard, Henrik Holbech, Ulrik Norum, Poul Bjerregaard
Summary: The study investigated the estrogenic activity of chemical UV-filters 4-MBC and OMC in rainbow trout through intraperitoneal injections. Results showed that 4-MBC increased plasma vitellogenin concentrations dose-dependently, while OMC did not show statistically significant responses in exposed fish groups. This confirms the estrogenic effects of 4-MBC in fish in vivo.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Multidisciplinary Sciences
Seulgi Mun, Mi Young Noh, Erika R. Geisbrecht, Karl J. Kramer, Subbaratnam Muthukrishnan, Yasuyuki Arakane
Summary: Chitin deacetylases (CDAs) play a crucial role in arthropod locomotion and muscle attachment. Depletion of CDAs results in tendon cuticle breakage, muscle detachment, and defective locomotion. Furthermore, CDA deficiency leads to disrupted microtubule development, loss of adhesion junctions, and abnormal morphology of tendon cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Agriculture, Dairy & Animal Science
Andrew Benson, Josh Steed, Mia Malloy, Adam J. Davis
Summary: This study examined the impact of different genetic lines and egg locations on the abundance of ZP proteins in turkeys. The results revealed differences in protein abundance and inconsistencies with previous mRNA expression findings. This research provides valuable insights into the quantitative differences in this crucial protein layer and offers potential protein markers for improving fertility in the poultry industry.
Article
Genetics & Heredity
Corinne Loeuillet, Magali Dhellemmes, Caroline Cazin, Zine-Eddine Kherraf, Selima Fourati Ben Mustapha, Raoudha Zouari, Nicolas Thierry-Mieg, Christophe Arnoult, Pierre F. Ray
Summary: Oocyte maturation defect (OMD) is a common cause of female factor infertility, often caused by ovulatory disorders. Several genes including PATL2, TUBB8, WEE2, and ZP1 have been associated with OMD. This study identified a new frequent ZP1 variant and found degeneration and absence of oocytes in patients with ZP1 mutations.
Article
Chemistry, Multidisciplinary
Jiangsheng Xu, James G. Shamul, Nicholas A. Staten, Alisa M. White, Bin Jiang, Xiaoming He
Summary: This study presents a biomimetic microencapsulation approach for isolating and culturing high-quality human iPSCs, resulting in pluripotent iPSC spheroids with significantly improved quality. Hyaluronic acid (HA) is identified as crucial for isolating high-quality iPSCs in the biomimetic core-shell microencapsulation culture, and the isolated iPSCs demonstrate high pluripotency even after being cultured again in 2D. These findings and the bioinspired culture method have potential benefits for advancing human iPSC-based personalized medicine.
Article
Engineering, Environmental
Alper James G. Alcaraz, Kamil Mikulasek, David Potesil, Bradley Park, Kamran Shekh, Jessica Ewald, Connor Burbridge, Zbynek Zdrahal, David Schneider, Jianguo Xia, Doug Crump, Niladri Basu, Markus Hecker
Summary: This study established an embryo benchmark dose assay for rainbow trout using EE2 as a model compound to derive transcriptomic points-of-departure (tPODs) as an alternative to live-animal tests. The results showed that the 4-day alternative RBT embryonic assay was effective in deriving tPODs that are protective of chronic effects of EE2.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Environmental Sciences
Maria Florencia Ferreira, Fabiana L. Lo Nostro, Daniel A. Fernandez, Griselda Genovese
Summary: This study utilized gene expression analysis of Patagonotothen tessellata as a bioindicator species to demonstrate the impact of human activities in Ushuaia Bay and surrounding areas. Field surveys showed up-regulation of vtgAb and androgen receptors in fish from sites with higher anthropogenic influence.
MARINE ENVIRONMENTAL RESEARCH
(2021)
Article
Infectious Diseases
Fanny Berglund, Anna Johnning, D. G. Joakim Larsson, Erik Kristiansson
Summary: The objective was to expand the phylogeny of MBLs, revealing distinct monophyletic groups within subclasses B1 and B3 and identifying new variants of zinc binding sites. Based on the results, it is recommended to refine the nomenclature of MBLs into phylogenetic groups that accurately describe their characteristics.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Fisheries
Fabian G. Weichert, Charlotte Axen, Lars Forlin, Pedro A. Inostroza, Ulrike Kammann, Annikki Welling, Joachim Sturve, Noomi Asker
Summary: This study focused on the health issues faced by Atlantic salmon in the Baltic Sea, particularly the Red Skin Disease, and investigated the possible link between the disease and anthropogenic influences. By sampling different tissues and analyzing a range of biomarkers, biochemical, and hematological parameters using multivariate statistics, it was found that diseased fish exhibited severe osmotic hemodilution, immune response, and alterations in carbohydrate metabolism. The study contributes to understanding the disease patterns and may guide future research as a hypothesis generator.
JOURNAL OF FISH DISEASES
(2021)
Article
Environmental Sciences
Daniel Cerveny, Roman Grabic, Katerina Grabicova, Tomas Randak, D. G. Joakim Larsson, Andrew C. Johnson, Monika D. Jurgens, Mats Tysklind, Richard H. Lindberg, Jerker Fick
Summary: Through analyzing the plasma of wild fish from multiple countries, it was found that some pharmaceuticals exceeded 10% of the therapeutic plasma concentration in fish, including drugs that target the central nervous system like flupentixol, haloperidol, and risperidone. This not only highlights pharmaceuticals of environmental concern, but also emphasizes the importance of monitoring internal drug levels in aquatic wildlife.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Biology
Stefan Ebmeyer, Erik Kristiansson, D. G. Joakim Larsson
Summary: The emergence of antibiotic resistance genes is influenced by mobile resistance genes acquired through horizontal gene transfer. Majority of the resistance genes originated from taxa associated with infection in humans and domestic animals, likely due to antibiotic selection pressure.
COMMUNICATIONS BIOLOGY
(2021)
Article
Marine & Freshwater Biology
Johan Gustafsson, Karin Strom, Linus Arvstrand, Lars Forlin, Lillemor Asplund, Lennart Balk
Summary: The study on thiamine status in perch liver from the Baltic Sea showed seasonal variation, with the concentration increasing in spring and summer before decreasing in autumn, but remaining sufficient throughout. Therefore, thiamine deficiency is unlikely to be the direct cause of health effects observed in adult female perch from the Baltic Sea.
JOURNAL OF SEA RESEARCH
(2021)
Article
Marine & Freshwater Biology
Johan Gustafsson, Lars Forlin, Agnes M. L. Karlson, Anders Bignert, Henrik Dahlgren, Jari Parkkonen, Lillemor Asplund
Summary: The study on European perch from the Baltic Sea found that exposure to OH-PBDEs could lead to changes in biomarkers, with some biomarkers showing significant seasonal variation.
AQUATIC TOXICOLOGY
(2021)
Article
Biochemical Research Methods
Stefan Ebmeyer, Roelof Dirk Coertze, Fanny Berglund, Erik Kristiansson, D. G. Joakim Larsson
Summary: GEnView is a Python-based pipeline for comparative analysis of gene loci in a large number of bacterial genomes, providing users with automated, taxon-selective access to over 800,000 genomes and plasmids available in the NCBI Assembly and RefSeq databases.
Review
Microbiology
D. G. Joakim Larsson, Carl-Fredrik Flach
Summary: Antibiotic resistance is a global health challenge, with factors driving evolution and transmission being important to quantify and identify. The environment plays a crucial role, and understanding and managing the resistance crisis can be achieved through implementing monitoring and assessment methods to reduce risks.
NATURE REVIEWS MICROBIOLOGY
(2022)
Article
Genetics & Heredity
David Lund, Nicolas Kieffer, Marcos Parras-Molto, Stefan Ebmeyer, Fanny Berglund, Anna Johnning, D. G. Joakim Larsson, Erik Kristiansson
Summary: Macrolides are broad-spectrum antibiotics used to treat a range of infections. Resistance to macrolides is often conferred by mobile resistance genes encoding Erm methyltransferases or Mph phosphotransferases. In this study, new erm and mph genes were discovered in clinical settings, predicting new functional resistance genes that could become a significant clinical problem.
MICROBIAL GENOMICS
(2022)
Article
Ecology
Elin Dahlgren, Joacim Naslund, Lars Forlin, Lennart Balk, Lillemor Asplund, Dennis Lindqvist
Summary: In the disturbed Baltic Sea ecosystem, the health of several animal species is negatively affected by exposure to toxic compounds, reduced energy metabolism, and immune system disorders. A study investigated the association between fish health and exposure to chemicals affecting energy metabolism and immune defense in European flounder. The results showed significant associations between algal toxins, perfluorinated alkyl substances (PFAS), and thiamine concentration with biomarkers related to detoxification, liver function, immune system function, and blood status of the fish.
REGIONAL STUDIES IN MARINE SCIENCE
(2022)
Article
Infectious Diseases
Catarina Bourgard, Diego Rodriguez-Hernandez, Anastasia Rudenko, Carolin Rutgersson, Martin Palm, D. G. Joakim Larsson, Anne Farewell, Morten Grotli, Per Sunnerhagen
Summary: Antibiotic resistance among bacteria is a growing global challenge, particularly for Gram-negative bacteria. In this study, the antibacterial activity of a dicationic bisguanidine-arylfuran compound and its derivatives was investigated. The compounds demonstrated good activity against antibiotic-resistant Gram-negative bacteria, including those with different antibiotic susceptibility patterns. Moreover, the derivatives showed lower cytotoxicity and higher selectivity indices compared to the lead molecule.
Editorial Material
Microbiology
D. G. Joakim Larsson, Carl-Fredrik Flach, Ramanan Laxminarayan
Summary: A proposed EU directive calls for monitoring antibiotic resistance at sewage treatment plants serving more than 100,000 people to gather information on resistance in the population and environmental transmission risks. There are opportunities to enhance the informativeness and usability of the surveillance data, but challenges also exist.
NATURE REVIEWS MICROBIOLOGY
(2023)
Letter
Microbiology
D. G. J. Larsson, W. H. Gaze, R. Laxminarayan, E. Topp
NATURE MICROBIOLOGY
(2023)
Article
Biology
Fanny Berglund, Stefan Ebmeyer, Erik Kristiansson, D. G. Joakim Larsson
Summary: Wastewaters are likely environments for the initial mobilization of resistance genes, as they contain abundant bacterial species that serve as sources for many mobile resistance genes and corresponding genetic elements for mobility. Our analysis shows that wastewaters and wastewater-impacted environments have the highest abundance of origin species and mobilizing elements for resistance genes, compared to other environments such as human microbiota. These findings contribute to our understanding of where clinically relevant antibiotic resistance genes may have gained mobility and highlight the importance of wastewater management in combatting the spread of antibiotic resistance.
COMMUNICATIONS BIOLOGY
(2023)
Article
Ethics
Erik Malmqvist, Davide Fumagalli, Christian Munthe, D. G. Joakim Larsson
Summary: The human consumption of pharmaceuticals leads to the release of residues into the environment, posing risks to public health and the environment. To address these risks, it is important to consider how responsibilities and costs associated with managing them should be distributed among different actors. The Polluter Pays Principle (PPP) has been suggested as a possible approach, but it has limitations in identifying the responsible polluter and may impose excessive costs on certain actors. A hybrid framework that combines the PPP with the Ability to Pay Principle (APP) may offer a more balanced approach.
PUBLIC HEALTH ETHICS
(2023)
Article
Environmental Sciences
Toshimi Nakajima, Mao Kuragano, Makoto Yamada, Ryo Sugimoto
Summary: This study compared the contribution of submarine groundwater discharge (SGD) to river nutrient budgets at nearshore and embayment scales, and found that SGD-derived nutrients become more important at larger spatial scales.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Fan Liu, Lei Zhang, Chongyang Zhang, Ziguang Chen, Jingguang Li
Summary: NO2 emissions from wall-mounted gas stoves used for household heating have become a significant source of indoor pollution in Chinese urban areas. The high indoor concentration of NO2 poses potential health risks to residents. It is urgently necessary to establish relevant regulations and implement emission reduction technologies to reduce NO2 emissions from wall-mounted gas stoves.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Letter
Environmental Sciences
Hans Peter H. Arp, Raoul Wolf, Sarah E. Hale, Sivani Baskaran, Juliane Gluege, Martin Scheringer, Xenia Trier, Ian T. Cousins, Harrie Timmer, Roberta Hofman-Caris, Anna Lennquist, Andre D. Bannink, Gerard J. Stroomberg, Rosa M. A. Sjerps, Rosa Montes, Rosario Rodil, Jose Benito Quintana, Daniel Zahn, Herve Gallard, Tobias Mohr, Ivo Schliebner, Michael Neumann
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Philomina Onyedikachi Peter, Binessi Edouard Ifon, Francois Nkinahamira, Kayode Hassan Lasisi, Jiangwei Li, Anyi Hu, Chang-Ping Yu
Summary: This study investigates the relationship between dissolved organic matter (DOM) and Rare Earth Elements (REEs) in sediments from Yundang Lagoon, China. The results show four distinct fluorescent components, with protein-like substances being the most prevalent. Additionally, the total fluorescence intensity and LREE concentrations exhibit a synchronized increase from Outer to Inner to Songbai Lake core sediments. The findings demonstrate a strong correlation between DOM content and pollution levels.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Surya Gupta, Pasquale Borrelli, Panos Panagos, Christine Alewell
Summary: The objective of this study is to incorporate soil hydraulic properties into the erodibility factor (K) of USLE-type models. By modifying and improving the existing equations for soil texture and permeability, the study successfully included information on saturated hydraulic conductivity (Ksat) into the calculation of K factor. Using the Random Forest machine learning algorithm, two independent K factor maps with different spatial resolutions were generated. The results show that the decrease in K factor values has a positive impact on the modeling of soil erosion rates.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jesmin Akter, Wendy J. M. Smith, Yawen Liu, Ilho Kim, Stuart L. Simpson, Phong Thai, Asja Korajkic, Warish Ahmed
Summary: The choice of workflow in wastewater surveillance has a significant impact on SARS-CoV-2 concentrations, while having minimal effects on HF183 and no effect on HAdV 40/41 concentrations. Certain components in the workflow can be interchangeable, but factors such as buffer type, chloroform, and homogenization speed can affect the recovery of viruses and bacteria.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yu Luo, Xueting Yang, Diwei Wang, Hongmei Xu, Hongai Zhang, Shasha Huang, Qiyuan Wang, Ningning Zhang, Junji Cao, Zhenxing Shen
Summary: Atmospheric PM2.5, which can generate reactive oxygen species (ROS), is associated with cardiorespiratory morbidity and mortality. The study found that both the mass concentration of PM2.5 and the DTT activity were higher during the heating season than during the nonheating season. Combustion sources were the primary contributors to DTT activity during the heating season, while secondary formation dominated during the nonheating season. The study also revealed that biomass burning had the highest inherent oxidation potential among all sources investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Erin L. Murphy, Leah R. Gerber, Chelsea M. Rochman, Beth Polidoro
Summary: Plastic pollution has devastating consequences for marine organisms. This study uses a trait-based framework to develop a vulnerability index for marine mammals, seabirds, and sea turtles in Hawai'i. The index ranks 63 study species based on their vulnerability to macroplastic pollution, providing valuable information for species monitoring and management priorities.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Kenji Maurice, Amelia Bourceret, Sami Youssef, Stephane Boivin, Liam Laurent-Webb, Coraline Damasio, Hassan Boukcim, Marc-Andre Selosse, Marc Ducousso
Summary: Growing pressure from climate change and agricultural land use is destabilizing soil microbial community interactions. Little is known about microbial community resistance and adaptation to disturbances, hindering our understanding of recovery latency and implications for ecosystem functioning. This study found that anthropic disturbance and natural disturbance have different effects on the topology and stability of soil microbial networks.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yunhao Li, Yali Feng, Haoran Li, Yisong Yao, Chenglong Xu, Jinrong Ju, Ruiyu Ma, Haoyu Wang, Shiwei Jiang
Summary: Deep-sea mining poses a serious threat to marine ecosystems and human health by disturbing sediment and transmitting metal ions through the food chain. This study developed a new regenerative adsorption material, OMN@SA, which effectively removes metal ions. The adsorption mechanism and performance of the material for metal ion fixation were investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Antonio Medici, Margherita Lavorgna, Marina Isidori, Chiara Russo, Elena Orlo, Giovanni Luongo, Giovanni Di Fabio, Armando Zarrelli
Summary: Valsartan, a widely used antihypertensive drug, has been detected in high concentrations in surface waters due to its unchanged excretion and incomplete degradation in wastewater treatment plants. This study investigated the degradation of valsartan and identified 14 degradation byproducts. The acute and chronic toxicity of these byproducts were evaluated in key organisms in the freshwater trophic chain.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jiang Lin, Lianbao Chi, Qing Yuan, Busu Li, Mingbao Feng
Summary: This study investigated the photodegradation behavior and product formation of two representative pharmaceuticals in simulated estuary water. The study found that the formed transformation products of these pharmaceuticals have potential toxicity on marine organisms, including oxidative stress and damage to cellular components.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Hua Fang, Dongdong Jiang, Ye He, Siyi Wu, Yuehong Li, Ziqi Zhang, Haoting Chen, Zixin Zheng, Yan Sun, Wenxiang Wang
Summary: This study revealed that exposure to lower levels of air pollutants led to decreased pregnancy rates, with PM10, NO2, SO2, and CO emerging as the four most prominent pollutants. Individuals aged 35 and above exhibited heightened susceptibility to pollutants.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Ali Shaan Manzoor Ghumman, Rashid Shamsuddin, Amin Abbasi, Mohaira Ahmad, Yoshiaki Yoshida, Abdul Sami, Hamad Almohamadi
Summary: In this study, inverse vulcanized polysulfides (IVP) were synthesized by reacting molten sulfur with 4-vinyl benzyl chloride, and then functionalized using N-methyl D-glucamine (NMDG). The functionalized IVP showed a high mercury adsorption capacity and a machine learning model was developed to predict the amount of mercury removed. Furthermore, the functionalized IVP can be regenerated and reused, providing a sustainable and cost-effective adsorbent.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Rita Bonfiglio, Renata Sisto, Stefano Casciardi, Valeria Palumbo, Maria Paola Scioli, Erica Giacobbi, Francesca Servadei, Gerry Melino, Alessandro Mauriello, Manuel Scimeca
Summary: This study investigated the presence of aluminum in human colon cancer samples and its potential association with biological processes involved in cancer progression. Aluminum was found in tumor areas of 24% of patients and was associated with epithelial to mesenchymal transition (EMT) and cell death. Additional analyses revealed higher tumor mutational burden and mutations in genes related to EMT and apoptosis in aluminum-positive colon cancers. Understanding the molecular mechanisms of aluminum toxicity may improve strategies for the management of colon cancer patients.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)