Enhancement of stereoselectivities in asymmetric synthesis using fluorinated solvents, auxiliaries, and catalysts

Fluorine as a Control Element in Asymmetric Synthesis

(2014) Vincent Bizet et al.   CHIMIA

Molecular Design Exploiting a FluorinegaucheEffect as a Stereoelectronic Trigger

(2014) Yannick P. Rey et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Conformation-induced remote meta-C–H activation of amines

(2014) Ri-Yuan Tang et al.   NATURE

High-turnover hypoiodite catalysis for asymmetric synthesis of tocopherols

(2014) M. Uyanik et al.   SCIENCE

Recent advances in asymmetric fluorination and fluoroalkylation reactions via organocatalysis

(2014) Jin-Hong Lin et al.   TETRAHEDRON LETTERS

A comparative study of the asymmetric epoxidation of aromatic olefins using the first generation manganese salen epoxidation catalysts and their light fluorous variants: an interesting discovery on the use of benzotrifluoride as a cosolvent

(2014) Yuki Kobayashi et al.   TETRAHEDRON-ASYMMETRY

Enantioselective Fluoroamination: 1,4-Addition to Conjugated Dienes Using Anionic Phase-Transfer Catalysis

(2013) Hunter P. Shunatona et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Organocatalytic Fluorination-Induced Wagner-Meerwein Rearrangement

(2013) Fedor Romanov-Michailidis et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Modulating NHC catalysis with fluorine

(2013) Yannick P Rey et al.   Beilstein Journal of Organic Chemistry

The influence of fluorine in asymmetric catalysis

(2013) Dominique Cahard et al.   CHEMICAL SOCIETY REVIEWS

Enantioselective Aziridination of Cyclic Enals Facilitated by the Fluorine-Iminium IonGaucheEffect

(2013) István Gábor Molnár et al.   CHEMISTRY-A EUROPEAN JOURNAL

Fluorinated Organocatalysts for the Enantioselective Epoxidation of Enals: Molecular Preorganisation by the Fluorine-Iminium Ion Gauche Effect

(2012) Eva-Maria Tanzer et al.   CHEMISTRY-A EUROPEAN JOURNAL

Designing Fluorinated Cinchona Alkaloids for Enantioselective Catalysis: Controlling Internal Rotation by a Fluorine-Ammonium Ion gauche Effect (φNCCF)

(2012) Eva-Maria Tanzer et al.   CHEMISTRY-A EUROPEAN JOURNAL

Asymmetric Fluorination of Enamides: Access to α-Fluoroimines Using an Anionic Chiral Phase-Transfer Catalyst

(2012) Robert J. Phipps et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hexafluoroisopropanol: a powerful solvent for the hydrogenation of indole derivatives. Selective access to tetrahydroindoles or cis-fused octahydroindoles

(2012) Damien Clarisse et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Highly efficient asymmetric aldol reaction in brine using a fluorous sulfonamide organocatalyst

(2012) Tsuyoshi Miura et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Asymmetric Allylic Monofluoromethylation and Methylation of Morita-Baylis-Hillman Carbonates with FBSM and BSM by Cooperative Cinchona Alkaloid/FeCl2 Catalysis

(2011) Tatsuya Furukawa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fluorine Conformational Effects in Organocatalysis: An Emerging Strategy for Molecular Design

(2011) Lucie E. Zimmer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Hexafluorobenzene: a powerful solvent for a noncovalent stereoselective organocatalytic Michael addition reaction

(2011) Alessandra Lattanzi et al.   CHEMICAL COMMUNICATIONS

Catalytic Enantioselective Formation of C−C Bonds by Addition to Imines and Hydrazones: A Ten-Year Update

(2011) Shu̅ Kobayashi et al.   CHEMICAL REVIEWS

The fluorous effect in biomolecular applications

(2011) Massimo Cametti et al.   CHEMICAL SOCIETY REVIEWS

Bifunctional N-Acyl-Aminophosphine-Catalyzed Asymmetric [4+2] Cycloadditions of Allenoates and Imines

(2011) Hua Xiao et al.   CHEMISTRY-A EUROPEAN JOURNAL

Enantioselective Cyclopropenation of Alkynes with Acceptor/Acceptor-Substituted Diazo Reagents via Co(II)-Based Metalloradical Catalysis

(2011) Xin Cui et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A New Type of Bis(sulfonamide)-Diamine Ligand for a Cu(OTf)2-Catalyzed Asymmetric Friedel–Crafts Alkylation Reaction of Indoles with Nitroalkenes

(2011) Jing Wu et al.   ORGANIC LETTERS

Organocatalytic Asymmetric Strecker Reaction of Di- and Trifluoromethyl Ketoimines. Remarkable Fluorine Effect

(2011) Yun-Lin Liu et al.   ORGANIC LETTERS

Asymmetric Electrophilic Fluorination Using an Anionic Chiral Phase-Transfer Catalyst

(2011) V. Rauniyar et al.   SCIENCE

β-Aminosulfonamide-Catalyzed Direct Asymmetric Aldol Reaction in Brine

(2011) Tsuyoshi Miura et al.   SYNLETT

Fluoro-Organocatalysts: Conformer Equivalents as a Tool for Mechanistic Studies

(2010) Christof Sparr et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The C–F bond as a conformational tool in organic and biological chemistry

(2010) Luke Hunter   Beilstein Journal of Organic Chemistry

Asymmetric Construction of Stereogenic Carbon Centers Featuring a Trifluoromethyl Group from Prochiral Trifluoromethylated Substrates

(2010) Jing Nie et al.   CHEMICAL REVIEWS

Transition Metal-Catalyzed Enantioselective Hydrogenation of Enamines and Imines

(2010) Jian-Hua Xie et al.   CHEMICAL REVIEWS

Experimental and Theoretical Conformational Analysis of 5-Benzylimidazolidin-4-one Derivatives - a ‘Playground’ for Studying Dispersion Interactions and a ‘Windshield-Wiper’ Effect in Organocatalysis

(2010) Dieter Seebach et al.   HELVETICA CHIMICA ACTA

A novel class of fluorinated cinchona alkaloids as surface modifiers for the enantioselective heterogeneous hydrogenation of α-ketoesters

(2010) Cecilia Mondelli et al.   JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL

Pd-Catalyzed Asymmetric Hydrogenation of Unprotected Indoles Activated by Brønsted Acids

(2010) Duo-Sheng Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Concise Enantioselective Synthesis of (−)-Ranirestat

(2010) Barry M. Trost et al.   ORGANIC LETTERS

Novel Axially Chiral Phosphine Ligand with a Fluoro Alcohol Moiety for Rh-Catalyzed Asymmetric Arylation of Aromatic Aldehydes

(2010) Satoshi Morikawa et al.   ORGANIC LETTERS

Fluoroalcohols: versatile solvents in hypervalent iodine chemistry and syntheses of diaryliodonium(III) salts

(2010) Toshifumi Dohi et al.   TETRAHEDRON

Sequential perfluoroalkylation and asymmetric reduction of nitriles triggered with perfluoroalkyl titanates: catalytic asymmetric synthesis of perfluoroalkyl amines

(2010) Koichi Mikami et al.   TETRAHEDRON LETTERS

The Fluorine-Iminium IonGaucheEffect: Proof of Principle and Application to Asymmetric Organocatalysis

(2009) Christof Sparr et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fluorous Linker-Facilitated Chemical Synthesis

(2009) Wei Zhang   CHEMICAL REVIEWS

Selectivity Enhancement for theJacobsen-KatsukiEpoxidation in Fluorinated Solvents

(2009) Nizam Havare et al.   HELVETICA CHIMICA ACTA

Synthesis of secondary α-perfluoroalkyl- and tertiary α,α-bis(perfluoroalkyl)-N-methylprolinols and their catalytic activities in the acyl transfer reaction

(2009) Kazumasa Funabiki et al.   JOURNAL OF FLUORINE CHEMISTRY

Catalytic Asymmetric Intermolecular Stetter Reaction of Heterocyclic Aldehydes with Nitroalkenes: Backbone Fluorination Improves Selectivity

(2009) Daniel A. DiRocco et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Highly enantioselective organocatalytic synthesis of piperidines. Formal synthesis of (−)-Paroxetine

(2009) Guillem Valero et al.   TETRAHEDRON LETTERS

Direct asymmetric aldol reactions in brine using novel sulfonamide catalyst

(2009) Tsuyoshi Miura et al.   TETRAHEDRON LETTERS

Catalytic Enantioselective Michael Addition of 1-Fluorobis(phenylsulfonyl)methane to α,β-Unsaturated Ketones Catalyzed by Cinchona Alkaloids

(2008) Tatsuya Furukawa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Phase-vanishing methods based on fluorous phase screen: A simple way for efficient execution of organic synthesis

(2008) Ilhyong Ryu et al.   CHEMICAL RECORD

Update 1 of: Asymmetric Fluorination, Trifluoromethylation, and Perfluoroalkylation Reactions

(2008) Jun-An Ma et al.   CHEMICAL REVIEWS

Enantioselective Synthesis of [7]Helicene: Dramatic Effects of Olefin Additives and Aromatic Solvents in Asymmetric Olefin Metathesis

(2008) Alain Grandbois et al.   CHEMISTRY-A EUROPEAN JOURNAL

The Many Roles for Fluorine in Medicinal Chemistry

(2008) William K. Hagmann   JOURNAL OF MEDICINAL CHEMISTRY

Asymmetric Synthesis of (αR)-Polyfluoroalkylated Prolinols Based on the Perfluoroalkyl-Induced Highly Stereoselective Reduction of PerfluoroalkylN-Boc-pyrrolidyl Ketones

(2008) Kazumasa Funabiki et al.   JOURNAL OF ORGANIC CHEMISTRY

Catalytic, Asymmetric Transannular Aldolizations: Total Synthesis of (+)-Hirsutene

(2008) Carley L. Chandler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Development of Novel Methods for Synthesis of Heterocyclic Compounds Catalyzed by Transition Metals in Fluorinated Alcohols

(2008) Akio SAITO   YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN

Understanding organofluorine chemistry. An introduction to the C–F bond

(2007) David O'Hagan   CHEMICAL SOCIETY REVIEWS