Article
Genetics & Heredity
Peace Mabeta, Rodney Hull, Zodwa Dlamini
Summary: Angiogenesis is a critical process in cancer growth, and long noncoding ribonucleic acids (lncRNAs) have been found to play a role in regulating the angiogenic switch. They can act both as pro-angiogenic and anti-angiogenic factors, and the expression levels of pro-angiogenic lncRNAs are correlated with patient survival. These lncRNAs have the potential to be used as prognostic biomarkers and therapeutic targets for inhibiting or modifying tumor angiogenesis.
Article
Biochemistry & Molecular Biology
Ersilia Varone, Alessandra Decio, Alexander Chernorudskiy, Lucia Minoli, Laura Brunelli, Federica Ioli, Arianna Piotti, Roberta Pastorelli, Maddalena Fratelli, Marco Gobbi, Raffaella Giavazzi, Ester Zito
Summary: Deficiency of ERO1 inhibits tumor cell migration and lung metastases by negatively regulating tumor angiogenesis and impeding oxidative folding of angiogenic factors; ERO1 levels are higher in aggressive basal breast tumors and correlate inversely with disease- and metastasis-free interval, suggesting its potential as a marker for tumor aggressiveness.
Review
Biochemistry & Molecular Biology
Olga Balberova, Evgeny Bykov, Natalia A. Shnayder, Marina M. Petrova, Oksana A. Gavrilyuk, Dania S. Kaskaeva, Irina A. Soloveva, Kirill Petrov, Elena Y. Mozheyko, German Medvedev, Regina F. Nasyrova
Summary: Regular physical activity in cyclic sports can influence the angiogenic switch, impacting the balance between proangiogenic and anti-angiogenic molecules. Disruption of this balance can lead to a decrease in functional resources of the nervous, musculoskeletal, cardiovascular, and respiratory systems, affecting sports performance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Jin-Woo Lee, Jin Hur, Yoo-Wook Kwon, Cheong-Whan Chae, Jae-Il Choi, Injoo Hwang, Ji-Yeon Yun, Jin-A Kang, Young-Eun Choi, Young Hyun Kim, Sang Eun Lee, Cheol Lee, Dong Hyun Jo, Heeyoung Seok, Byong Seung Cho, Sung Hee Baek, Hyo-Soo Kim
Summary: KAI1, mainly expressed in pericytes, is a novel endogenous anti-angiogenic factor that inhibits angiogenesis through inducing LIF and directly binding to VEGF and PDGF. Supplementation of KAI1 significantly inhibits tumor angiogenesis and growth, and a peptide derived from it has shown anti-angiogenic effects in vivo.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Zhen-Ling Liu, Huan-Huan Chen, Li-Li Zheng, Li-Ping Sun, Lei Shi
Summary: Angiogenesis is a complex process regulated by various molecules and plays a crucial role in tumor growth and metastasis. Targeted therapeutic research based on these molecules has led to the emergence of promising anti-angiogenic strategies in cancer therapy.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Biotechnology & Applied Microbiology
Claudia Kuehlbach, Sabine Hensler, Margareta M. Mueller
Summary: Tumor cells modify tissue homeostasis by secreting cytokines, activating the tumor microenvironment and promoting vascularization. A 3D organotypic model with microtumor spheroids and various cell types has been established to study tumor-stroma interactions. This model is suitable for testing novel anticancer therapeutics targeting both the tumor and the vascular compartment.
BIOENGINEERING-BASEL
(2021)
Article
Engineering, Civil
Xiaoxi Hu, Yuan Cao, Yongkui Sun, Tao Tang
Summary: This paper proposes a computer vision method for detecting wear on railway automatic switch stationary contacts in few-shot scenarios. The method includes two key modules, which can accurately detect and measure the size of different stationary contacts.
IEEE TRANSACTIONS ON INTELLIGENT TRANSPORTATION SYSTEMS
(2022)
Article
Biochemistry & Molecular Biology
Luciana M. Gutierrez, Matias Valenzuela Alvarez, Yuanzheng Yang, Fiorella Spinelli, Maria Jose Cantero, Laura Alaniz, Mariana G. Garcia, Eugenie S. Kleinerman, Alejandro Correa, Marcela F. Bolontrade
Summary: Osteosarcoma metastatic cells gain in angiogenic-related pathways may relate more to a prosurvival switch than to an advantage feature for lung colonization. Despite higher adhesion and gain in angiogenesis pathways, metastatic cells do not display major angiogenic potential. Antiangiogenic treatments may affect cell survival rather than angiogenesis in OS cells with different metastatic potential.
Review
Chemistry, Multidisciplinary
Pingping Liang, Byron Ballou, Xinyi Lv, Weili Si, Marcel P. Bruchez, Wei Huang, Xiaochen Dong
Summary: Anti-angiogenic therapy targeting vascular endothelial cells to prevent tumor growth has shown modest clinical efficiency in solid tumors. Combining advanced drug delivery techniques or other therapeutic strategies with anti-angiogenic therapy can result in significantly synergistic effects in fighting cancer. Clinical difficulties of traditional anti-angiogenic therapy are discussed, while promising applications of anti-angiogenic nanoagents in monotherapies and combination therapies are highlighted.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Luca Ricciardi, Willem Verboom, Jean-Paul Lange, Jurriaan Huskens
Summary: This study demonstrates an effective conversion of xylose into furfural with a selectivity of over 90% using a three-solvent system. The use of an apolar aromatic solvent, a polar organic solvent, and acidic water catalyzes the formation of furfural. The transition of the three-solvent system from biphasic to monophasic conditions under reaction conditions is crucial for achieving high selectivity.
Article
Oncology
Hosein Rostamian, Keyvan Fallah-Mehrjardi, Mohammad Khakpoor-Koosheh, John M. Pawelek, Jamshid Hadjati, Christine E. Brown, Hamid R. Mirzaei
Summary: The therapeutic efficacy of CAR T cells in hematological malignancies is remarkable, but limited in solid tumors due to challenges of persistence and dysfunction in an immunosuppressive tumor microenvironment. Reprogramming CAR T cell metabolism and targeting metabolic pathways can enhance antitumor activity, with strategies focusing on promoting longevity and altering cellular fate within tumors.
Review
Immunology
Neema Ahishakiye Jumapili, Maida Zivalj, Romina Mora Barthelmess, Geert Raes, Timo W. M. De Groof, Nick Devoogdt, Benoit Stijlemans, Cecile Vincke, Jo A. Van Ginderachter
Summary: mAbs have limitations in their distribution and penetration in tumor microenvironment, as well as their ability to reach the brain. Nanobodies, being smaller in size, possess superior abilities in tumor penetration and infiltration into brain tumors. However, the rapid clearance of nanobodies from circulation may affect their suitability for therapy, although their noncovalent binding to albumin can help increase their serum half-life.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Laura A. Wengert, Sarah J. Backe, Dimitra Bourboulia, Mehdi Mollapour, Mark R. Woodford
Summary: Mitochondrial function relies on molecular chaperones, including heat shock proteins (Hsps) such as Hsp90 and its chaperone TNF-receptor-associated protein-1 (TRAP1). TRAP1, primarily localized in mitochondria, plays a crucial role in cellular metabolic reprogramming and mitochondrial apoptosis. Upregulation of TRAP1 promotes the growth of cancer cells by enhancing glycolytic metabolism and inhibiting mitochondrial permeability transition, while attenuation of TRAP1 induces apoptosis in cancer cells. Furthermore, TRAP1 is subject to post-translational modifications that regulate its function and downstream effectors.
Article
Chemistry, Multidisciplinary
Alexandre Bordat, Tanguy Boissenot, Nada Ibrahim, Marianne Ferrere, Manon Leveque, Lea Potiron, Stephanie Denis, Sebastien Garcia-Argote, Olivia Carvalho, Jerome Abadie, Catherine Cailleau, Gregory Pieters, Nicolas Tsapis, Julien Nicolas
Summary: Chemotherapy is commonly administered via the intravenous route, but has limitations. Researchers have developed a new method for subcutaneous administration of anticancer drugs through the design of hydrophilic polymer prodrugs, which successfully avoids local toxicity and outperforms commercial formulations.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Biochemistry & Molecular Biology
Sean M. O'Cathail, Chieh-Hsi Wu, Rachael Thomas, Maria A. Hawkins, Tim S. Maughan, Annabelle Lewis
Summary: This study demonstrates that NRF2 plays a role in mediating radiation resistance in colorectal cancer, with potential therapeutic implications. By affecting metabolic pathways, NRF2 may improve radioresistance in rectal cancer patients and could be a target for therapeutic interventions.
