Article
Chemistry, Multidisciplinary
Nedah Alkattan, Noura Alasmael, Viko Ladelta, Niveen M. Khashab, Nikos Hadjichristidis
Summary: Poly(2-oxazoline)s (POxs) are synthesized using microwave-assisted cationic ring-opening polymerization (CROP). The resulting CCS POxs exhibit excellent biocompatibility and stealth properties, making them promising candidates for drug delivery applications. Loading the anti-cancer drug doxorubicin (DOX) into the CCS POxs enhances their cytotoxicity against HeLa cells.
NANOSCALE ADVANCES
(2023)
Article
Polymer Science
Rui Yang, Pei Dai, Shu Zhang, Ri-Wei Xu, Song Hong, Wen-Feng Lin, Yi-Xian Wu
Summary: The study focuses on preparing a cross-linked imidazolium functionalized anion-exchange membrane with high ionic conductivity and chemical stability, making it a potential material for fuel cell applications.
Article
Chemistry, Multidisciplinary
Xuan Zhang, Zhan-Wei Li, Ying Wu, Xiaoguang Ge, Lichao Su, Hongjuan Feng, Zongsheng Wu, Huanghao Yang, Jibin Song
Summary: The development of organic-inorganic Janus nanocomposites enables precise control and ratiometric imaging of photoacoustic agents, showing great potential for real-time and accurate detection of diverse biological targets in living systems.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Polymer Science
Jaeman J. Shin
Summary: The effect of inorganic nanoparticles on the structure of hybrid block copolymer particles and the local distribution of nanoparticles is studied. The study focuses on comparing the nanoparticles made of Au and Fe3O4. The distribution of nanoparticles inside the particles was found to affect the overall particle morphology. Au nanoparticles were selectively localized inside certain domains regardless of the particle morphology, while Fe3O4 nanoparticles clustered and segregated to the interfaces of the particles.
Article
Chemistry, Multidisciplinary
Christopher M. Brown, David J. Lundberg, Jessica R. Lamb, Ilia Kevlishvili, Denise Kleinschmidt, Yasmeen S. Alfaraj, Heather J. Kulik, Maria Francesca Ottaviani, Nathan J. Oldenhuis, Jeremiah A. Johnson
Summary: This study introduces a modular heterogeneous catalysis platform that immobilizes catalysts onto supports to improve recyclability and efficiency. The approach utilizes self-assembled metal-organic cages/polyhedra to create well-defined catalyst-functionalized junctions, resulting in nanoconfined catalyst domains.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Materials Science, Multidisciplinary
Jisu Hong, Yonghwan Kwon, Min Sang Kwon, Chaenyung Cha
Summary: This paper presents a brush copolymer, P(AzPEG), as a multifunctional polymeric cross-linker for carboxylate-containing acrylic adhesives. The density and length of the AzPEG brush can be conveniently controlled to effectively regulate the mechanical and adhesive properties of the adhesive without significant changes in concentration.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Polymer Science
Beste Cagdas Tunali, Omer Akturk, Durukan Sahingoz, Mustafa Turk, Ayten Celebi Keskin
Summary: In this study, polyethyleneimine-capped gold nanoparticles (PEI-AuNPs) were synthesized using the pulsed laser ablation in liquid (PLAL) technique, and then combined with Bombyx mori silk fibroin (SF) to form nanocomposites (PEI-SF-AuNPs). The biocompatibility of PEI-AuNPs and PEI-SF-AuNPs in breast cancer cells MCF-7 and MDA-MB231 were tested, and it was found that PEI-AuNP1 showed the least cytotoxicity. Therefore, PEI-AuNP1 nanocomposites can be suggested as siRNA carriers in gene-based breast cancer therapies.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Chemistry, Applied
Hiroki Miura, Kaede Ameyama, Tetsuya Shishido
Summary: We discovered that gold nanoparticles act as catalysts for the single-electron transfer in the decarboxylative cross-coupling reaction between N-hydroxy phthalimide esters and disilanes or diborons. This allows for the generation of various alkylsilanes and alkyl boronates without the need for external bases. Mechanistic investigation revealed that the supported gold nanoparticles enable the generation of alkyl radical and silyl radical, enabling radical cross-coupling. The reusability and environmentally-friendly nature of supported gold catalyst as well as the scalability of the reaction system enable the practical transformation of carboxylic acid derivatives into value-added organosilicon and organoboron compounds.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Article
Polymer Science
Yakun Guo, Yuewen Yu, Keyu Shi, Wangqing Zhang
Summary: The ABA triblock copolymer nanoparticles of PHPMA-b-PS-b-PHPMA with a hydrophobic core of PS and a hydrophilic corona of PHPMA were synthesized by dispersion RAFT polymerization. It was found that these nanoparticles have a larger diameter and higher chain density compared to similar PHPMA-b-PS diblock copolymer nanoparticles, making them efficient emulsifiers that can decrease interfacial tension.
Article
Chemistry, Analytical
Jose Luis Carreon Gonzalez, Perla Elvia Garcia Casillas, Christian Chapa Gonzalez
Summary: The use of gold nanoparticles coated with silica and PEG has shown potential as drug delivery systems due to their improved stability and drug loading capacity. The coatings significantly enhanced the nanoparticles' ability to deliver drugs and extended their circulation time in the body. These findings suggest that gold nanoparticles coated with silica and PEG could be further developed as targeted and controlled release drug delivery systems.
Article
Pharmacology & Pharmacy
Carmen Ferrero, Marta Casas, Isidoro Caraballo
Summary: In this study, we successfully synthesized stimuli-responsive polymersomes that can respond to the tumor cell environment, and demonstrated their efficient encapsulation and release of the highly cytotoxic anticancer drug doxorubicin hydrochloride (Dox center dot HCl). The polymersomes were formed under physiological conditions using a solvent-exchange method, and showed stable morphology and size. In vitro release studies revealed a delayed release of the drug from the polymersomes, and enhanced drug release through cleavage of the disulfide bonds in the reductive environment.
Article
Engineering, Environmental
Xiang Lan, Hao Zhang, Haishan Qi, Simin Liu, Xiangyu Zhang, Lei Zhang
Summary: This study designs a triblock protein (MZAgP) consisting of zwitterionic peptide, mussel adhesive peptide, and silver-binding peptide. MZAgP can be easily attached to various substrates to form an antibacterial coating, which exhibits multiple functions including inhibiting bacterial growth, reducing bacterial and protein adhesion, and preventing biofilm formation. In vivo tests demonstrate that the coating can effectively restrain bacterial infections and alleviate foreign body response with excellent biocompatibility. This study reveals the potential of MZAgP as a multifunctional protein material for fabricating novel antibacterial coatings to relieve implant-associated infections.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Physical
Mariia Chernykh, Dmytro Zavalny, Viktoriya Sokolova, Stanislav Ponomarenko, Svitlana Prylutska, Yuliia Kuziv, Vasyl Chumachenko, Andrii Marynin, Nataliya Kutsevol, Matthias Epple, Uwe Ritter, Jacek Piosik, Yuriy Prylutskyy
Summary: A new water-soluble thermosensitive star-like copolymer, dextran-graft-poly-N-iso-propilacrylamide (D-g-PNIPAM), was successfully synthesized and shown to effectively deliver the drug doxorubicin to cancer cells, demonstrating higher toxicity towards cancer cells compared to doxorubicin alone.
Review
Chemistry, Multidisciplinary
Yucen Tao, Vivianne Jakobsson, Xiaoyuan Chen, Jingjing Zhang
Summary: This article introduces the integration of therapeutics and diagnostics, known as theranostics. It discusses the application of therapeutic radioligands in cancer treatment, as well as the use of binding substances to prolong their circulation time. The article also summarizes the structure of human serum albumin, efforts in finding new binders, and the recent progress of PSMA-targeting radioligands.
ACCOUNTS OF CHEMICAL RESEARCH
(2023)
Article
Chemistry, Applied
Anbazhagan Sathiyaseelan, Kandasamy Saravanakumar, Arokia Vijaya Anand Mariadoss, Myeong-Hyeon Wang
Summary: A pH-responsive nano-drug delivery system was developed for enhanced glioblastoma treatment, showing improved cell death through dual drug release and confirmed drug internalization in cell organelles.
CARBOHYDRATE POLYMERS
(2021)
Review
Chemistry, Multidisciplinary
Yuce Li, Jun Xie, Wooram Um, Dong Gil You, Seunglee Kwon, Lianbin Zhang, Jintao Zhu, Jae Hyung Park
Summary: Immunotherapy is a potent cancer therapy but its clinical applications are limited by low response rates and immune-related adverse effects. Sono/photodynamic nanomedicines (SPNs) have gained attention for enhancing immunotherapy by generating reactive oxygen species and promoting immunogenic cancer cell death.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Jae Dong Kim, Hwa Seung Han, Hye-In Kim, Ji Suk Choi, Jae Hyung Park, Jong-Ho Kim, Ki Young Choi, Yong Woo Cho
Summary: This study demonstrates a facile, biocompatible, and shape-controllable synthesis of Gold Nanocrystals (AuNCs) using human alpha-elastin (H alpha E) self-assemblies as a shape-directing template, reducing agent, and surfactant. The unique optical and electromagnetic properties of the AuNCs make them potentially suitable for a wide range of biomedical applications.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Seunglee Kwon, Sol Shin, Minjae Do, Byeong Hoon Oh, Yeari Song, Van Dat Bui, Eun Sook Lee, Dong-Gyu Jo, Yong Woo Cho, Deok-Ho Kim, Jae Hyung Park
Summary: The biological significance of extracellular vesicles (EVs) as intercellular communication mediators has been increasingly revealed in various physiological processes and disease pathogenesis. EVs can be used as innate biotherapeutics for regenerative and immunomodulatory purposes, as well as therapeutic targets for pathological EVs. Moreover, the ability of EVs to transport functional cargos makes them potential means for delivering drug molecules.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Engineering, Biomedical
Jueun Jeon, Been Yoon, Wooram Um, Yeari Song, Jeongjin Lee, Dong Gil You, Jae Yoon An, Jae Hyung Park
Summary: Sonodynamic therapy (SDT) has emerged as a promising alternative to photodynamic therapy for treating deeply located tumors accessible by ultrasound. However, the therapeutic potential of conventional sonosensitizers is limited. This study reports immunostimulatory nanoparticles (iCRET NPs) for sonoimmunotherapy, which amplify the reactive oxygen species (ROS) production and induce immunogenic cell death in the tumor microenvironment (TME). The iCRET NPs effectively inhibit tumor growth and metastasis when combined with anti-PD-1 antibodies.
Article
Engineering, Biomedical
Jae Ah Lee, Jung Min Shin, Seok Ho Song, Chan Ho Kim, Soyoung Son, Sol Shin, Jae Hyung Park
Summary: Therapeutic cancer vaccines have the potential to activate highly specific cytotoxic T cells, making them an attractive option for personalized cancer immunotherapy. However, their low immunogenicity has limited their use in clinical settings. To overcome this limitation, researchers have developed 'find-me' signaling polymeric microparticles (F-PMs) that efficiently recruit dendritic cells (DCs) and facilitate antigen presentation. When injected into tumor-bearing mice, F-PMs significantly increase mature DCs in the lymph nodes, resulting in effective tumor inhibition. Moreover, co-administration of F-PMs and an immune checkpoint inhibitor leads to a higher enrichment of CD8+ cytotoxic T cells in the tumor microenvironment. This study demonstrates the potential of F-PMs as a promising therapeutic option for cancer treatment.
Article
Chemistry, Analytical
Yurim Kim, Hong Yeol Yoon, Il Keun Kwon, Inchan Youn, Sungmin Han
Summary: Heart rate variability is closely related to cancer pain and can be used as a tool for assessing pain.
Article
Pharmacology & Pharmacy
Jeongrae Kim, Yongwhan Choi, Suah Yang, Jaewan Lee, Jiwoong Choi, Yujeong Moon, Jinseong Kim, Nayeon Shim, Hanhee Cho, Man Kyu Shim, Sangmin Jeon, Dong-Kwon Lim, Hong Yeol Yoon, Kwangmeyung Kim
Summary: By using DOX as an ICD inducer and PLGA-based nanoparticles for controlled release, continuous ICD induction and reduced cell viability can be achieved. Direct injection of DP-NPs allows DOX to remain in the tumor site for 14 days and enhances antitumor immunity, with minimal toxicities.
Article
Chemistry, Physical
Jueun Jeon, Dong Gil You, Anup Dey, Been Yoon, Yuce Li, Jae Hyung Park
Summary: Chemiluminescence is a favorable technique for reactive oxygen species (ROS) imaging, but its short duration limits its clinical applications. In this work, nanoparticles consisting of a self-immolative polymer (SIP) and hydrophobic dyes are discovered to induce sustained chemiluminescence, which is available for long-term in vivo ROS imaging. These SIP-based nanoparticles generate highly efficient ROS-selective chemiluminescence signals and have potential as contrast agents for in vivo disease diagnosis.
CHEMISTRY OF MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Wan Su Yun, Man Kyu Shim, Seungho Lim, Sukyung Song, Jinseong Kim, Suah Yang, Hee Sook Hwang, Mi Ra Kim, Hong Yeol Yoon, Dong-Kwon Lim, In-Cheol Sun, Kwangmeyung Kim
Summary: In this study, a promising approach of using mesenchymal stem cells (MSCs) for the deep tumor delivery of gold nanorods (AuNRs) has been demonstrated. The AuNRs are modified and chemically conjugated to the MSCs, allowing deep tissue penetration and enhanced photothermal effect against colon tumor growth. This provides a potential method for effective photothermal therapy.
Article
Pharmacology & Pharmacy
Hanhee Cho, Man Kyu Shim, Yujeong Moon, Sukyung Song, Jinseong Kim, Jiwoong Choi, Jeongrae Kim, Youngjoo Lee, Jung Yeon Park, Yongju Kim, Cheol-Hee Ahn, Mi Ra Kim, Hong Yeol Yoon, Kwangmeyung Kim
Summary: This study proposes tumor-specific monomethyl auristatin E (MMAE) prodrug nanoparticles for safe and effective chemotherapy. The nanoparticles efficiently accumulate within tumor tissues and inhibit tumor cell growth by releasing MMAE. Meanwhile, these nanoparticles maintain a non-toxic inactive state in normal tissues, reducing the toxicity of MMAE.
Review
Pharmacology & Pharmacy
Jeongrae Kim, Yongwhan Choi, Dong-Hwee Kim, Hong Yeol Yoon, Kwangmeyung Kim
Summary: This review summarizes recent advances in the use of injectable hydrogels for combination immunotherapy in treating tumors. Injectable hydrogels, with their biocompatibility, degradability, and controllable properties, can effectively encapsulate various immunotherapeutic agents and elicit antitumor immune responses. The review also discusses the application of injectable hydrogels in chemoimmunotherapy, photoimmunotherapy, and radioimmunotherapy.
Article
Chemistry, Multidisciplinary
Seok Ho Song, Torsha Ghosh, Dong Gil You, Hyeyeon Joo, Jeongjin Lee, Jaeah Lee, Chan Ho Kim, Jueun Jeon, Sol Shin, Jae Hyung Park
Summary: This study investigates the use of tumor microenvironment-responsive polymer chains to mask immune checkpoint antibodies, which can mitigate immune-related adverse events (irAEs) and selectively target tumors. The results support a strategy to separate toxicity from efficacy in antibody-based therapies and demonstrate the translational potential for cancer immunotherapy.
Article
Engineering, Biomedical
Jueun Jeon, Been Yoon, Anup Dey, Seok Ho Song, Yuce Li, Hyeyeon Joo, Jae Hyung Park
Summary: To enhance the immunogenicity of Doxorubicin (DOX), researchers developed a ROS-responsive self-immolative polymer (R-SIP) that efficiently destroys redox homeostasis in cancer cells. The DOX-encapsulated R-SIP (DR-SIP) induces immunogenic cell death and promotes dendritic cell maturation. In vivo studies showed that DR-SIP significantly inhibits tumor growth.
Article
Pharmacology & Pharmacy
Andre-Rene Blaudszun, Woo Jun Kim, Wooram Um, Hong Yeol Yoon, Man Kyu Shim, Kwangmeyung Kim
Summary: This study proposes a combinational photodynamic and cancer immunotherapy using adoptive transfer of photosensitizer-loaded cytotoxic T cells. The loaded T cells efficiently produce reactive oxygen species under visible light irradiation and significantly inhibit tumor growth in a murine lymphoma model.
Article
Engineering, Biomedical
Ngoc Phung Ly, Hwa Seung Han, Myungsuk Kim, Jae Hyung Park, Ki Young Choi
Summary: This article provides a comprehensive introduction to plant-derived vesicles (PDVs), including their biological characteristics, purification methods, and a summary of their current development potential for cancer therapy.
BIOACTIVE MATERIALS
(2023)
