Review
Gastroenterology & Hepatology
Brennan Spiegel
Summary: This article proposes a hypothesis, known as the gravity hypothesis, that seeks to explain the pathogenesis of irritable bowel syndrome (IBS) by relating it to the influence of gravity on human evolution. It suggests that ineffective gravity management systems may lead to the development of IBS. The article reviews the impact of gravity on human evolution, discusses the imperfect adaptation of Homo sapiens to gravity, and explores the consequences of gravity intolerance in relation to IBS. It also considers the diagnostic and therapeutic implications of this hypothesis and suggests further experiments to support or reject it.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zijuan Bi, Shisheng Zhang, Yangyang Meng, Ya Feng, Yinshu Wang, Enkang Wang, Xiangxue Pan, Ruixin Zhu, Haiting Fan, Shuhua Pang, Lixin Zhu, Jianye Yuan
Summary: The knockout of the SERT gene may lead to changes in the serotonin system, causing VH and accelerated gastrointestinal motility in female rats, which can be used as an animal model of IBS.
Review
Gastroenterology & Hepatology
Stuart M. Brierley, Beverley Greenwood-Van Meerveld, Giovanni Sarnelli, Keith A. Sharkey, Martin Storr, Jan Tack
Summary: This review provides an overview of the potential of the gastrointestinal endocannabinoid system as a therapeutic target for the management of pain in irritable bowel syndrome. It discusses the role of endocannabinoid system in regulating gastrointestinal function and pain processing, compares cannabinoids to other treatment modalities, and explores emerging therapeutic candidates targeting the endocannabinoid system for pain relief in irritable bowel syndrome.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Multidisciplinary Sciences
Isabelle A. M. van Thiel, Aimilia A. Stavrou, Auke de Jong, Bart Theelen, Mark Davids, Theodorus B. M. Hakvoort, Iris Admiraal-van den Berg, Isabelle C. M. Weert, Martine A. M. Hesselink-van de Kruijs, Duong Vu, Christine Moissl-Eichinger, Sigrid E. M. Heinsbroek, Daisy M. A. E. Jonkers, Ferry Hagen, Teun Boekhout, Wouter J. de Jonge, Rene M. van den Wijngaard
Summary: Irritable bowel syndrome (IBS) is a common disorder characterized by chronic abdominal pain and changes in bowel movements. Visceral hypersensitivity may be caused by intestinal fungi, but the diversity of fungal communities does not differ between IBS subgroups. The study highlights the importance of conducting strain-specific cause-and-effect studies in IBS research.
SCIENTIFIC REPORTS
(2022)
Review
Gastroenterology & Hepatology
Mariana Brizuela, Joel Castro, Andrea M. Harrington, Stuart M. Brierley
Summary: This review discusses the underlying causes of chronic visceral pain in patients with IBS, highlighting the role of mediators and receptors that induce itch in the skin acting as gut irritants. Activation of these receptors triggers changes in neuronal excitability, leading to visceral hypersensitivity and pain, suggesting potential therapeutic targets for more effective treatment options.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Siyu Tian, Hang Zhang, Siqi Chen, Pengning Wu, Min Chen
Summary: This bibliometric study provides a comprehensive summary of the research trend and developments in visceral hypersensitivity in Irritable Bowel Syndrome (IBS). The study reveals that China, the United States, and Belgium are the main contributors in this field, focusing on exploring the disease mechanisms and sensitizing factors. Additionally, the study highlights the potential relationship between gut microbiota and visceral hypersensitivity, suggesting probiotics as a promising direction for future research in this area.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Sahar M. El-Haggar, Sahar K. Hegazy, Sherief M. Abd-Elsalam, Mostafa M. Bahaa
Summary: The study suggests that pentoxifylline could be a promising adjuvant anti-inflammatory drug in the treatment of abdominal pain in IBS patients, reducing inflammation and alleviating pain.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Chemistry, Medicinal
Ewa Dudzinska, Andreas M. Grabrucker, Pawel Kwiatkowski, Robert Sitarz, Monika Sienkiewicz
Summary: Visceral stimuli from the digestive tract are transmitted to the brain via nerves, causing overreaction in the brain of irritable bowel syndrome (IBS) patients. Stress and dysbiosis can lead to inflammation and gastrointestinal hypersensitivity. Treating IBS involves reducing visceral hypersensitivity and regulating the intestinal microbiota.
Article
Clinical Neurology
Zhong Chen, Yuan Liu, Xianhe Wu, Wei Lin, Zihan Liu, Yang Huang, Yu Chen, Ying Tang, Aiqin Chen, Chun Lin
Summary: The dysregulation of circRNAs is functionally associated with chronic pain, and this study found that circKcnk9 expression is increased in IBS-like rats. The study also revealed that circKcnk9 regulates c-Fos expression and visceral hypersensitivity through binding with miR-124-3p. This study provides a potential therapeutic target for IBS through targeting circKcnk9.
Review
Gastroenterology & Hepatology
Iam van Thiel, W. J. de Jonge, R. M. van den Wijngaard
Summary: Although the gut microbiota consists of bacteria, viruses, and fungi, most studies on the microbiota-gut-brain axis in IBS have primarily focused on bacteria due to their higher presence. However, recent research on the intestinal mycobiome in inflammatory bowel disease suggests that the low numbers of fungi and viruses may still have relevance. This review discusses the current IBS mycobiome data and how these findings could relate to previous observations in IBS, as well as identifies questions for future research.
Article
Pharmacology & Pharmacy
Hind Hussein, Guy E. Boeckxstaens
Summary: This article reviews the multiple risk factors of irritable bowel syndrome (IBS) and discusses the role of food in the disease, especially its association with abdominal pain. Recent findings suggest an immune-mediated mechanism underlying food-induced abdominal pain in IBS.
CURRENT OPINION IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Shuai Peng, Yuan Xia, Ying Wang, Xiaoyun Yu, Zunan Wu, Li Zhang, Ke Xu, Lei Shen, Hesheng Luo
Summary: This study provides a bibliometric and visual analysis of research on abdominal pain in inflammatory bowel disease, discussing the current status, research hotspots, and future developments. The United States is the leading country in terms of article output, and gut microbiota, depression, and stress are identified as hotspots and trends in this research area. However, further exploration is needed to address outstanding issues in this field.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Microbiology
Enfu Tao, Yuhao Wu, Chenmin Hu, Zhenya Zhu, Diya Ye, Gao Long, Bo Chen, Rui Guo, Xiaoli Shu, Wei Zheng, Ting Zhang, Xinyi Jia, Xiao Du, Marong Fang, Mizu Jiang
Summary: The study demonstrates that maternal separation induces irritable bowel syndrome (IBS) from early life to adulthood in mice. The disrupted intestinal mitochondrial structure and significant dysbiosis of intestinal microbiota in early life may contribute to the initiation and progression of IBS.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Yuanxia Lv, Jing Wen, Yingying Fang, Haoyuan Zhang, Jianwu Zhang
Summary: CRF is a 41-amino acid polypeptide that coordinates various systems in the body, mediating visceral hypersensitivity like in irritable bowel syndrome. However, the lack of sufficient understanding of the multiple variants of CRF-R1 and CRF-R1 antagonists hinders the successful translation of preclinical studies into clinical trials. Investigating the sites of action of central and peripheral CRF is crucial for accelerating this translation process.
Review
Neurosciences
Yuanzhen Yang, Jiaqi Wang, Chaoyang Zhang, Yi Guo, Meidan Zhao, Man Zhang, Zhongzheng Li, Feifei Gao, Yu Luo, Yiru Wang, Junyi Cao, Mingfang Du, Yuzhe Wang, Xiaowei Lin, Zhifang Xu
Summary: This review explores the central and peripheral analgesic mechanisms of acupuncture in the treatment of Irritable Bowel Syndrome (IBS). Acupuncture can alleviate inflammation and pain, regulate emotional components, and improve pain caused by IBS.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Gastroenterology & Hepatology
Joan Antoni Fernandez-Blanco, Javier Estevez, Terez Shea-Donohue, Vicente Martinez, Patri Vergara
JOURNAL OF CROHNS & COLITIS
(2015)
Article
Gastroenterology & Hepatology
Ferran Jardi, Monica Aguilera, Patri Vergara, Vicente Martinez
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2015)
Article
Gastroenterology & Hepatology
F. Jardi, J. A. Fernandez-Blanco, V. Martinez, P. Vergara
NEUROGASTROENTEROLOGY AND MOTILITY
(2016)
Editorial Material
Cell Biology
Maria-Angeles Aller, Natalia Arias, Vicente Martinez, Patri Vergara, Jaime Arias
INFLAMMATION RESEARCH
(2018)
Article
Gastroenterology & Hepatology
Evangelina Teran-Ventura, Monica Aguilera, Patri Vergara, Vicente Martinez
JOURNAL OF CROHNS & COLITIS
(2014)
Article
Gastroenterology & Hepatology
Ferran Jardi, Joan A. Fernandez-Blanco, Vicente Martinez, Patri Vergara
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2014)
Article
Gastroenterology & Hepatology
Maria-Angeles Aller, Vicente Martinez, Ana Arias, Maria-Paz Nava, Valentin Cuervas-Mons, Patri Vergara, Jaime Arias
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2019)
Review
Biochemistry & Molecular Biology
Vicente Martinez, Amaia Iriondo De-Hond, Francesca Borrelli, Raffaele Capasso, Maria Dolores del Castillo, Raquel Abalo
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Biochemistry & Molecular Biology
Jose Antonio Uranga, Vicente Martinez, Raquel Abalo
Article
Biochemistry & Molecular Biology
Marina Ferrer, Monica Aguilera, Vicente Martinez
Summary: In a mouse study, rifaximin did not significantly alter gut commensal microbiota and Toll-like receptors in healthy mice, showing only minor changes and no modulation of the immune system. These findings suggest a potential modulatory role of rifaximin in inflammatory and dysbiotic gut conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Sergio Lopez-Estevez, Georgia Gris, Beatriz de la Puente, Alicia Carceller, Vicente Martinez
Summary: Sigma-1 receptors play an important role in intestinal inflammation-associated referred hyperalgesia, with knockout mice showing significant attenuation in inflammation associated hypersensitivity. The absence of sigma(1)Rs had little impact on colitis generation and progression, but did show reduction in edema and down-regulation of iNOS gene expression during the chronic phase.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Gastroenterology & Hepatology
Sergio Lopez-Estevez, Josep Manuel Lopez-Torrellardona, Marc Parera, Vicente Martinez
Summary: This study explores the validity of DSS-induced colitis in rats as a model to mimic chronic intestinal hypersensitivity. The results indicate that DSS-induced colitis can generate a long-lasting state of visceral hypersensitivity and reproduce the changes in intestinal sensitivity characteristics of inflammatory and functional gastrointestinal disorders in humans. This research is of great importance for the development of new pharmacological treatments against visceral pain.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Biochemistry & Molecular Biology
Javier Estevez, Vicente Martinez
Summary: Toll-like receptors (TLRs) play a role in microbial regulation of gastrointestinal functions, including the epithelial barrier function (EBF). This study investigated the effects of TLR7 stimulation on colonic EBF in rats. Results showed that TLR7 stimulation with imiquimod had a pro-barrier effect, while the combination with dimethyl sulfoxide (DMSO) had a detrimental effect on EBF. These effects were not associated with changes in gene expression or distribution of tight junction-related proteins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Lorena Ortega Moreno, Ana Bagues, Vicente Martinez, Raquel Abalo
Summary: Parkinson's disease (PD) is a severe neurodegenerative disease with disabling motor alterations diagnosed at a late stage, along with early non-motor symptoms like constipation. Current treatments only reduce motor symptoms with drawbacks, so new approaches targeting PD etiopathogeny and biomarkers are needed. Gastrointestinal origins of PD, modulation of gut microbiome, and lipidomics as a tool for personalized analysis show promise in understanding and treating PD.
Article
Gastroenterology & Hepatology
M. Aguilera, M. Cerda-Cuellar, V. Martinez