Article
Fisheries
Zhengshi Zhang, Xiucong Hu, Qianying Diao, Panpan Zhang, Ying Wu, Zhenjie Cao, Yongcan Zhou, Chunsheng Liu, Yun Sun
Summary: In this study, a macrophage migration inhibitory factor (TroMIF) was identified from golden pompano and its function was analyzed. TroMIF showed high similarity with other known MIF sequences and was most closely related to large yellow croaker. TroMIF was highly expressed in the liver and head kidney and its expression was up-regulated after E. tarda infection. In vitro experiments showed that rTroMIF could inhibit the migration of lymphocytes and macrophages and enhance macrophage phagocytic activity. Furthermore, rTroMIF increased the expression levels of pro-inflammatory cytokines and had enzymatic redox activity. Overexpression of TroMIF enhanced the ability to resist E. tarda infection, while knockdown of TroMIF expression increased the bacterial load. These results suggest that TroMIF plays an important role in antibacterial immunity.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Annette Ives, Didier Le Roy, Charlotte Theroude, Juergen Bernhagen, Thierry Roger, Thierry Calandra
Summary: The cytokine MIF plays a chemokine-like role in promoting the migration of dendritic cells (DCs) by activating the Src/PI3K signaling pathway and myosin II complexes. MIF contributes to the recruitment of DCs to draining lymph nodes through autocrine and paracrine activities acting via CD74. These findings indicate that MIF is crucial for DC motility and trafficking.
Article
Immunology
Arturo Gonzalez de la Aleja, Cristina Herrero, Monica Torres-Torresano, Juan Vladimir de la Rosa, Barbara Alonso, Enrique Capa-Sardon, Ittai B. Muller, Gerrit Jansen, Amaya Puig-Kroeger, Miguel A. Vega, Antonio Castrillo, Angel L. Corbi
Summary: LXR activation limits the anti-inflammatory polarization of human macrophages and promotes the acquisition of an inflammatory profile, which is associated with the expression of specific genes and the release of activin A.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Virology
Alperen Aksakal, Bugra Kerget, Ferhan Kerget, Seda Askin
Summary: The study revealed the correlation between serum migration inhibitory factor (MIF) level and disease severity in COVID-19, with higher MIF levels potentially indicating a more severe condition. MIF levels can serve as an important predictive indicator for early disease prognosis in COVID-19.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Juan Cai, Lin Huang, Hongri Tang, Hongling Xu, Lingjun Wang, Minghui Zheng, Hongsong Yu, Hui Liu
Summary: The MIF produced by Thelazia callipaeda can induce M2-like macrophage polarization through TLR4-mediated activation of the PI3K-Akt pathway, potentially aiding in disrupting the host immune system.
Article
Biochemistry & Molecular Biology
Mauro Vasella, Stefan Wolf, Eamon C. Francis, Gerrit Grieb, Pablo Pfister, Gregory Reid, Juergen Bernhagen, Nicole Lindenblatt, Epameinondas Gousopoulos, Bong-Sung Kim
Summary: Lipedema is a chronic disorder mainly affecting women, with an unknown etiology. Recent research suggests that the accumulation and polarization of macrophages may be involved in lipedema. This study provides evidence for the potential involvement of the MIF family, specifically the MIF-1-CD74 axis, in lipedema.
Article
Biochemistry & Molecular Biology
Ji Ae Kim, Ye Young Kim, Seung Hak Lee, Chul Jung, Mi Hee Kim, Dae Yul Kim
Summary: The macrophage migration inhibitory factor (MIF) exerts a neuroprotective effect, facilitating neurological recovery and protecting brain tissue from ischemic injury in an in vivo model of ischemic stroke.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yuxin Zhang, Zhonglong Liu, Kexin Wang, Shenji Lu, Shuai Fan, Lili Xu, Bin Cai
Summary: This study revealed the role of MIF and TGF-β1 in post-traumatic joint contracture, showing that MIF can enhance TGF-β1 production in fibroblasts through MAPK signaling, leading to fibroblast function changes and joint capsule fibrosis. Further investigation into this mechanism may lead to potential therapeutic targets for PTJC.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Fisheries
Qiang Fu, Jie Hu, Pei Zhang, Yuqing Li, Shoucong Zhao, Min Cao, Ning Yang, Chao Li
Summary: Seventeen CC and CXC chemokine genes were identified in the turbot genome, making it a valuable resource for comparative immunological studies and functional characterization of chemokines in teleost.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Caroline Swoboda, Lena Deloch, Claudia von Zimmermann, Tanja Richter-Schmidinger, Bernd Lenz, Johannes Kornhuber, Christiane Muehle
Summary: This study investigated the potential of MIF at genetic, expression, and protein levels as a risk factor and biomarker for diagnosing, monitoring, or predicting MDD. The results suggest a genetic effect of MIF in women but do not provide strong evidence for its utility as a biomarker for MDD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Dongwei Xu, Xiaoye Qu, Yizhu Tian, Zhao Jie, Zhifeng Xi, Feng Xue, Xueyun Ma, Jianjun Zhu, Qiang Xia
Summary: This study demonstrated that macrophage Notch1 controls TAK1-mediated innate immune responses and RIPK3-mediated hepatocyte necroptosis through activation of beta-catenin. Beta-catenin is essential for macrophage Notch1-mediated immune regulation in liver ischemia and reperfusion injury (IRI), indicating its potential as a therapeutic target. The macrophage Notch1-beta-catenin axis is a crucial regulatory mechanism in IR-triggered liver inflammation, offering novel therapeutic possibilities in organ IRI and transplant recipients.
CELL COMMUNICATION AND SIGNALING
(2022)
Review
Immunology
Yao Song, Xinying Li, Dingming Huang, Hongjie Song
Summary: Periapical lesions are infectious diseases that occur in the apical region of teeth, leading to alveolar bone destruction and possible systemic impacts. Macrophages play a crucial role in the development of these lesions, but their differential polarization complicates the understanding of the regulatory mechanism. This review provides new insights into the potential role of macrophages in determining the turnover of periapical lesions and discusses alternative treatment strategies for apical periodontitis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
D. Zhang, T. Xu, Q. Xu, Q. Dong, Y. Luo, L. Gao, Y. Pan
Summary: This study revealed significant increases in levels of MCP-1 and MIF in periodontitis patients, along with enhanced secretion of MIF in gingival epithelial tissue. Limited evidence suggested a correlation between MIF and periodontal conditions, with Porphyromonas gingivalis potentially contributing to periodontitis development and progression through MIF.
ARCHIVES OF ORAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yuqing Li, Pei Zhang, Chengbin Gao, Min Cao, Ning Yang, Xingchun Li, Chao Li, Qiang Fu
Summary: The study identified chemokine ligands and receptors from Sebastes schlegelii genome, which showed widespread expression in healthy tissues and differential expression after infection, interacting with immune-related genes. These findings provide insights for further functional characterization and comparative immunological studies in teleost fish.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Critical Care Medicine
Tianlong Li, Jiahao Zhang, Minghui Long, Xiaofang Jiang, Cheng Yang, Fengqin Wang, Lianjiu Su, Zhiyong Peng
Summary: This study found that serum MIF level might serve as a biomarker for predicting the occurrence, development, and outcomes of septic AKI.