Computational classification models for predicting the interaction of drugs with P-glycoprotein and breast cancer resistance protein

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(2016)   CHEMISTRY & BIODIVERSITY

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(2016)   Molecular Informatics

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(2016)   Quantitative structure-activity relationships & combinatorial science

Predicting substrates of the human breast cancer resistance protein using a support vector machine method

(2013) Eszter Hazai et al.   BMC BIOINFORMATICS

Accurate Models for P-gp Drug Recognition Induced from a Cancer Cell Line Cytotoxicity Screen

(2013) Jurica Levatić et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of Novel Breast Cancer Resistance Protein (BCRP) Inhibitors by Virtual Screening

(2013) Yongmei Pan et al.   MOLECULAR PHARMACEUTICS

Development of Conformation Independent Computational Models for the Early Recognition of Breast Cancer Resistance Protein Substrates

(2013) Melisa Edith Gantner et al.   Biomed Research International

Role of breast cancer resistance protein (BCRP/ABCG2) in cancer drug resistance

(2012) Karthika Natarajan et al.   BIOCHEMICAL PHARMACOLOGY

Breast Cancer Resistance Protein and P-Glycoprotein in Brain Cancer: Two Gatekeepers Team Up

(2012) Sagar Agarwal et al.   CURRENT PHARMACEUTICAL DESIGN

Prediction of aqueous solubility of drug-like molecules using a novel algorithm for automatic adjustment of relative importance of descriptors implemented in counter-propagation artificial neural networks

(2012) Slavica Erić et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Inhibition of Human MDR1 and BCRP Transporter ATPase Activity by Organochlorine and Pyrethroid Insecticides

(2012) Kristin M. Bircsak et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

QSAR Models for P-Glycoprotein Transport Based on a Highly Consistent Data Set

(2012) Fabio Broccatelli   Journal of Chemical Information and Modeling

New Use for an Old Drug: Inhibiting ABCG2 with Sorafenib

(2012) Y. Wei et al.   MOLECULAR CANCER THERAPEUTICS

Comparison of Different Approaches to Define the Applicability Domain of QSAR Models

(2012) Faizan Sahigara et al.   MOLECULES

LIBSVM

(2012) Chih-Chung Chang et al.   ACM Transactions on Intelligent Systems and Technology

A prediction model of substrates and non-substrates of breast cancer resistance protein (BCRP) developed by GA–CG–SVM method

(2011) Lei Zhong et al.   COMPUTERS IN BIOLOGY AND MEDICINE

Computational models for predicting substrates or inhibitors of P-glycoprotein

(2011) Lei Chen et al.   DRUG DISCOVERY TODAY

The controversial role of ABC transporters in clinical oncology

(2011) Akina Tamaki et al.   Essays in Biochemistry

The P-glycoprotein multidrug transporter

(2011) Frances J. Sharom   Essays in Biochemistry

P-glycoprotein Substrate Models Using Support Vector Machines Based on a Comprehensive Data set

(2011) Zhi Wang et al.   Journal of Chemical Information and Modeling

A Novel Approach for Predicting P-Glycoprotein (ABCB1) Inhibition Using Molecular Interaction Fields

(2011) Fabio Broccatelli et al.   JOURNAL OF MEDICINAL CHEMISTRY

ADME Evaluation in Drug Discovery. 10. Predictions of P-Glycoprotein Inhibitors Using Recursive Partitioning and Naive Bayesian Classification Techniques

(2011) Lei Chen et al.   MOLECULAR PHARMACEUTICS

Predicting P-Glycoprotein-Mediated Drug Transport Based On Support Vector Machine and Three-Dimensional Crystal Structure of P-glycoprotein

(2011) Zsolt Bikadi et al.   PLoS One

Interaction Between ABCB1 and Professional Exposure to Organochlorine Insecticides in Parkinson Disease

(2010) Fabien Dutheil et al.   ARCHIVES OF NEUROLOGY

Structure and Function of the Human Breast Cancer Resistance Protein (BCRP/ABCG2)

(2010) Zhanglin Ni et al.   CURRENT DRUG METABOLISM

Kinetic Analysis of the Cooperation of P-Glycoprotein (P-gp/Abcb1) and Breast Cancer Resistance Protein (Bcrp/Abcg2) in Limiting the Brain and Testis Penetration of Erlotinib, Flavopiridol, and Mitoxantrone

(2010) H. Kodaira et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Breast Cancer Resistance Protein and P-glycoprotein Limit Sorafenib Brain Accumulation

(2010) J. S. Lagas et al.   MOLECULAR CANCER THERAPEUTICS

Impact of the Recent Mouse P-Glycoprotein Structure for Structure-Based Ligand Design

(2010) Freya Klepsch et al.   Molecular Informatics

Membrane transporters in drug development

(2010)   NATURE REVIEWS DRUG DISCOVERY

DrugBank 3.0: a comprehensive resource for 'Omics' research on drugs

(2010) C. Knox et al.   NUCLEIC ACIDS RESEARCH

Structure–Activity Relationships and Quantitative Structure–Activity Relationships for Breast Cancer Resistance Protein (ABCG2)

(2009) Yash A. Gandhi et al.   AAPS Journal

ABC transporters: the power to change

(2009) Douglas C. Rees et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Identification of Novel Specific and General Inhibitors of the Three Major Human ATP-Binding Cassette Transporters P-gp, BCRP and MRP2 Among Registered Drugs

(2009) Pär Matsson et al.   PHARMACEUTICAL RESEARCH

Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding

(2009) S. G. Aller et al.   SCIENCE

Understanding polyspecificity of multidrug ABC transporters: closing in on the gaps in ABCB1

(2009) Daniel A.P. Gutmann et al.   TRENDS IN BIOCHEMICAL SCIENCES

Ins and outs of the ABCG2 multidrug transporter: An update on in vitro functional assays

(2008) Csilla Hegedűs et al.   ADVANCED DRUG DELIVERY REVIEWS

Drug transporters: recent advances concerning BCRP and tyrosine kinase inhibitors

(2008) C Lemos et al.   BRITISH JOURNAL OF CANCER

Computational models for prediction of interactions with ABC-transporters

(2008) Gerhard F. Ecker et al.   DRUG DISCOVERY TODAY

The role of ABC transporters in drug absorption, distribution, metabolism, excretion and toxicity (ADME–Tox)

(2008) Gergely Szakács et al.   DRUG DISCOVERY TODAY

An Unexpected Synergist Role of P-Glycoprotein and Breast Cancer Resistance Protein on the Central Nervous System Penetration of the Tyrosine Kinase Inhibitor Lapatinib (N- -6-[5-( methyl)-2-furyl]-4-quinazolinamine; GW572016)

(2008) J. W. Polli et al.   DRUG METABOLISM AND DISPOSITION

Efflux Transporters: Newly Appreciated Roles in Protection against Pollutants

(2008) David Epel et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Structure and mechanism of ATP-binding cassette transporters

(2008) K. P Locher   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Human ABC transporters ABCG2 (BCRP) and ABCG4

(2008) S. Koshiba et al.   XENOBIOTICA

Structure, function and regulation of P-glycoprotein and its clinical relevance in drug disposition

(2008) S.-F. Zhou   XENOBIOTICA

A regulatory viewpoint on transporter-based drug interactions

(2008) L. Zhang et al.   XENOBIOTICA

ABC multidrug transporters: structure, function and role in chemoresistance

(2007) Frances J Sharom   PHARMACOGENOMICS