Novel regulatory principles of the spliceosomal Brr2 RNA helicase and links to retinal disease in humans

RNA structure analysis of human spliceosomes reveals a compact 3D arrangement of snRNAs at the catalytic core

(2013) Maria Anokhina et al.   EMBO JOURNAL

Structural basis for dual roles of Aar2p in U5 snRNP assembly

(2013) G. Weber et al.   GENES & DEVELOPMENT

Dissection of the factor requirements for spliceosome disassembly and the elucidation of its dissociation products using a purified splicing system

(2013) J.-B. Fourmann et al.   GENES & DEVELOPMENT

Sad1 Counteracts Brr2-Mediated Dissociation of U4/U6.U5 in Tri-snRNP Homeostasis

(2013) Y.-H. Huang et al.   MOLECULAR AND CELLULAR BIOLOGY

Structural Basis of Assembly Chaperone- Mediated snRNP Formation

(2013) Clemens Grimm et al.   MOLECULAR CELL

Crystal structure of Prp8 reveals active site cavity of the spliceosome

(2013) Wojciech P. Galej et al.   NATURE

An unanticipated early function of DEAD-box ATPase Prp28 during commitment to splicing is modulated by U5 snRNP protein Prp8

(2013) A. M. Price et al.   RNA

Inhibition of RNA Helicase Brr2 by the C-Terminal Tail of the Spliceosomal Protein Prp8

(2013) S. Mozaffari-Jovin et al.   SCIENCE

Structural Basis of Brr2-Prp8 Interactions and Implications for U5 snRNP Biogenesis and the Spliceosome Active Site

(2013) Thi Hoang Duong Nguyen et al.   STRUCTURE

Phosphorylation Drives a Dynamic Switch in Serine/Arginine-Rich Proteins

(2013) ShengQi Xiang et al.   STRUCTURE

Brr2p-mediated conformational rearrangements in the spliceosome during activation and substrate repositioning

(2012) D. Hahn et al.   GENES & DEVELOPMENT

The Prp8 RNase H-like domain inhibits Brr2-mediated U4/U6 snRNA unwinding by blocking Brr2 loading onto the U4 snRNA

(2012) S. Mozaffari-Jovin et al.   GENES & DEVELOPMENT

Dynamic Protein-Protein Interaction Wiring of the Human Spliceosome

(2012) Anna Hegele et al.   MOLECULAR CELL

Structural basis for functional cooperation between tandem helicase cassettes in Brr2-mediated remodeling of the spliceosome

(2012) K. F. Santos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pre-mRNA splicing in disease and therapeutics

(2012) Ravi K. Singh et al.   TRENDS IN MOLECULAR MEDICINE

Structure of a Key Intermediate of the SMN Complex Reveals Gemin2's Crucial Function in snRNP Assembly

(2011) Rundong Zhang et al.   CELL

Mechanism for Aar2p function as a U5 snRNP assembly factor

(2011) G. Weber et al.   GENES & DEVELOPMENT

DNA Unwinding by ASCC3 Helicase Is Coupled to ALKBH3-Dependent DNA Alkylation Repair and Cancer Cell Proliferation

(2011) Sebastian Dango et al.   MOLECULAR CELL

Structure of the spliceosomal U4 snRNP core domain and its implication for snRNP biogenesis

(2011) Adelaine K. W. Leung et al.   NATURE

SF1 and SF2 helicases: family matters

(2010) Margaret E Fairman-Williams et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Prognosis for splicing factor PRPF8 retinitis pigmentosa, novel mutations and correlation between human and yeast phenotypes

(2010) Katherine V. Towns et al.   HUMAN MUTATION

Spliceosome Structure and Function

(2010) C. L. Will et al.   Cold Spring Harbor Perspectives in Biology

The Spliceosome: Design Principles of a Dynamic RNP Machine

(2009) Markus C. Wahl et al.   CELL

Common Design Principles in the Spliceosomal RNA Helicase Brr2 and in the Hel308 DNA Helicase

(2009) Vladimir Pena et al.   MOLECULAR CELL

Structural evidence for consecutive Hel308-like modules in the spliceosomal ATPase Brr2

(2009) Lingdi Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure and function of an RNase H domain at the heart of the spliceosome

(2008) Vladimir Pena et al.   EMBO JOURNAL

Structural elucidation of a PRP8 core domain from the heart of the spliceosome

(2008) Dustin B Ritchie et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ATP-dependent unwinding of U4/U6 snRNAs by the Brr2 helicase requires the C terminus of Prp8

(2008) Corina Maeder et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A role for ubiquitin in the spliceosome assembly pathway

(2008) Priya Bellare et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal structure of the  -finger domain of Prp8 reveals analogy to ribosomal proteins

(2008) K. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA