RNA mediated toll-like receptor stimulation in health and disease

TLR7 Is Involved in Sequence-Specific Sensing of Single-Stranded RNAs in Human Macrophages

(2014) M. P. Gantier et al.   JOURNAL OF IMMUNOLOGY

Modifications in Small Interfering RNA That Separate Immunostimulation from RNA Interference

(2014) F. Eberle et al.   JOURNAL OF IMMUNOLOGY

Identification of RNA Sequence Motifs Stimulating Sequence-Specific TLR8-Dependent Immune Responses

(2014) A. Forsbach et al.   JOURNAL OF IMMUNOLOGY

RNA-Based Therapeutics: Current Progress and Future Prospects

(2012) John C. Burnett et al.   CHEMISTRY & BIOLOGY

The 2′-O-methylation status of a single guanosine controls transfer RNA–mediated Toll-like receptor 7 activation or inhibition

(2012) Stefanie Jöckel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Identification of modifications in microbial, native tRNA that suppress immunostimulatory activity

(2012) Stefanie Gehrig et al.   JOURNAL OF EXPERIMENTAL MEDICINE

BC1-FMRP interaction is modulated by 2′-O-methylation: RNA-binding activity of the tudor domain and translational regulation at synapses

(2012) Caroline Lacoux et al.   NUCLEIC ACIDS RESEARCH

Structural Basis for the Activation of Innate Immune Pattern-Recognition Receptor RIG-I by Viral RNA

(2011) Eva Kowalinski et al.   CELL

Structural Insights into RNA Recognition by RIG-I

(2011) Dahai Luo et al.   CELL

Tumor vaccination using messenger RNA: prospects of a future therapy

(2011) Sebastian Kreiter et al.   CURRENT OPINION IN IMMUNOLOGY

DNA binding to proteolytically activated TLR9 is sequence-independent and enhanced by DNA curvature

(2011) Yue Li et al.   EMBO JOURNAL

Recognition of yeast nucleic acids triggers a host-protective type I interferon response

(2011) Carmelo Biondo et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Suppression of collagen-induced arthritis by intra-articular lentiviral vector-mediated delivery of Toll-like receptor 7 short hairpin RNA gene

(2011) S-Y Chen et al.   GENE THERAPY

Selective uptake of naked vaccine RNA by dendritic cells is driven by macropinocytosis and abrogated upon DC maturation

(2011) M Diken et al.   GENE THERAPY

Host Defense Pathways: Role of Redundancy and Compensation in Infectious Disease Phenotypes

(2011) Simone Nish et al.   IMMUNITY

Innate Immune Recognition of an AT-Rich Stem-Loop DNA Motif in the Plasmodium falciparum Genome

(2011) Shruti Sharma et al.   IMMUNITY

Unc93B1 Restricts Systemic Lethal Inflammation by Orchestrating Toll-like Receptor 7 and 9 Trafficking

(2011) Ryutaro Fukui et al.   IMMUNITY

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

(2011) Taro Kawai et al.   IMMUNITY

siRNA-induced immunostimulation through TLR7 promotes antitumoral activity against HPV-driven tumors in vivo

(2011) Norliana Khairuddin et al.   IMMUNOLOGY AND CELL BIOLOGY

Phase I clinical development of Atu027, a siRNA formulation targeting PKN3 in patients with advanced solid tumors

(2011) Dirk Strumberg et al.   INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS

Molecular Mechanism of Signal Perception and Integration by the Innate Immune Sensor Retinoic Acid-inducible Gene-I (RIG-I)

(2011) Marco Binder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase

(2011) Sarah E. Ewald et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Conventional Dendritic Cells Mount a Type I IFN Response against Candida spp. Requiring Novel Phagosomal TLR7-Mediated IFN-  Signaling

(2011) C. Bourgeois et al.   JOURNAL OF IMMUNOLOGY

Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides

(2011) Katey J. Rayner et al.   NATURE

Programming the magnitude and persistence of antibody responses with innate immunity

(2011) Sudhir Pai Kasturi et al.   NATURE

Nucleoside modifications in RNA limit activation of 2'-5'-oligoadenylate synthetase and increase resistance to cleavage by RNase L

(2011) B. R. Anderson et al.   NUCLEIC ACIDS RESEARCH

Therapeutical targeting of nucleic acid-sensing Toll-like receptors prevents experimental cerebral malaria

(2011) Bernardo S. Franklin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dual or Triple Activation of TLR7, TLR8, and/or TLR9 by Single-Stranded Oligoribonucleotides

(2011) Alexandra Forsbach et al.   Nucleic Acid Therapeutics

Type I Interferon Production Induced by Streptococcus pyogenes-Derived Nucleic Acids Is Required for Host Protection

(2011) Nina Gratz et al.   PLoS Pathogens

RNA nucleotide methylation

(2011) Yuri Motorin et al.   Wiley Interdisciplinary Reviews-RNA

Macrophages recognize streptococci through bacterial single-stranded RNA

(2010) Sachin D Deshmukh et al.   EMBO REPORTS

CD14 is a coreceptor of Toll-like receptors 7 and 9

(2010) Christoph L. Baumann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Rational Design of Immunostimulatory siRNAs

(2010) Michael P Gantier et al.   MOLECULAR THERAPY

TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus

(2010) Cristiana Guiducci et al.   NATURE

IFI16 is an innate immune sensor for intracellular DNA

(2010) Leonie Unterholzner et al.   NATURE IMMUNOLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Synergistic effects between analogs of DNA and RNA improve the potency of siRNA-mediated gene silencing

(2010) Glen F. Deleavey et al.   NUCLEIC ACIDS RESEARCH

The RNA modification database, RNAMDB: 2011 update

(2010) W. A. Cantara et al.   NUCLEIC ACIDS RESEARCH

Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation

(2010) Bart R. Anderson et al.   NUCLEIC ACIDS RESEARCH

UNC93B1 Mediates Host Resistance to Infection with Toxoplasma gondii

(2010) Mariane B. Melo et al.   PLoS Pathogens

Synthetic oligoribonucleotides-containing secondary structures act as agonists of Toll-like receptors 7 and 8

(2009) Tao Lan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Phosphorothioate-Stimulated Uptake of siRNA by Mammalian Cells: A Novel Route for Delivery

(2009) Anke Detzer et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Bacterial RNA is recognized by different sets of immunoreceptors

(2009) Florian Eberle et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Approaching the Asymptote: 20 Years Later

(2009) Ruslan Medzhitov   IMMUNITY

Critical Role for Asparagine Endopeptidase in Endocytic Toll-like Receptor Signaling in Dendritic Cells

(2009) Fernando E. Sepulveda et al.   IMMUNITY

Alternating 2′-O-ribose methylation is a universal approach for generating non-stimulatory siRNA by acting as TLR7 antagonist

(2009) Svetlana Hamm et al.   IMMUNOBIOLOGY

Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing

(2009) Ryutaro Fukui et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Selection of Molecular Structure and Delivery of RNA Oligonucleotides to Activate TLR7 versus TLR8 and to Induce High Amounts of IL-12p70 in Primary Human Monocytes

(2009) A. Ablasser et al.   JOURNAL OF IMMUNOLOGY

Identification of an N-Terminal Recognition Site in TLR9 That Contributes to CpG-DNA-Mediated Receptor Activation

(2009) M. E. Peter et al.   JOURNAL OF IMMUNOLOGY

Not All Polyriboinosinic-polyribocytidylic Acids (Poly I:C) are Equivalent for Inducing Maturation of Dendritic Cells

(2009) Tony Avril et al.   JOURNAL OF IMMUNOTHERAPY

Toll-like Receptor 7 Selective Synthetic Oligoribonucleotide Agonists: Synthesis and Structure−Activity Relationship Studies

(2009) Tao Lan et al.   JOURNAL OF MEDICINAL CHEMISTRY

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

(2009) Teresa Fernandes-Alnemri et al.   NATURE

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

(2009) Veit Hornung et al.   NATURE

HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses

(2009) Hideyuki Yanai et al.   NATURE

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

(2009) Beom Seok Park et al.   NATURE

Bacterial recognition by TLR7 in the lysosomes of conventional dendritic cells

(2009) Giuseppe Mancuso et al.   NATURE IMMUNOLOGY

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

(2009) Tilmann Bürckstümmer et al.   NATURE IMMUNOLOGY

Homology modeling of human Toll-like receptors TLR7, 8, and 9 ligand-binding domains

(2009) Tiandi Wei et al.   PROTEIN SCIENCE

HIN-200 Proteins Regulate Caspase Activation in Response to Foreign Cytoplasmic DNA

(2009) T. L. Roberts et al.   SCIENCE

Accessing the therapeutic potential of immunostimulatory nucleic acids

(2008) Winfried Barchet et al.   CURRENT OPINION IN IMMUNOLOGY

Chemically modified siRNA: tools and applications

(2008) J WATTS et al.   DRUG DISCOVERY TODAY

Does the understanding of immune activation by RNA predict the design of safe siRNAs?

(2008) Mouldy Sioud   Frontiers in Bioscience-Landmark

The DNA Sugar Backbone 2′ Deoxyribose Determines Toll-like Receptor 9 Activation

(2008) Tobias Haas et al.   IMMUNITY

IRAK-4- and MyD88-Dependent Pathways Are Essential for the Removal of Developing Autoreactive B Cells in Humans

(2008) Isabelle Isnardi et al.   IMMUNITY

Modulation of Double-stranded RNA Recognition by the N-terminal Histidine-rich Region of the Human Toll-like Receptor 3

(2008) Kotaro Fukuda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TLR7-dependent and FcγR-independent production of type I interferon in experimental mouse lupus

(2008) Pui Y. Lee et al.   JOURNAL OF EXPERIMENTAL MEDICINE

UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes

(2008) You-Me Kim et al.   NATURE

The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor

(2008) Sarah E. Ewald et al.   NATURE

LNA-mediated microRNA silencing in non-human primates

(2008) Joacim Elmén et al.   NATURE

Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9

(2008) Boyoun Park et al.   NATURE IMMUNOLOGY

5′-triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma

(2008) Hendrik Poeck et al.   NATURE MEDICINE

A second binding site for double-stranded RNA in TLR3 and consequences for interferon activation

(2008) Nina Pirher et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

tRNAdb 2009: compilation of tRNA sequences and tRNA genes

(2008) F. Juhling et al.   NUCLEIC ACIDS RESEARCH

MODOMICS: a database of RNA modification pathways. 2008 update

(2008) A. Czerwoniec et al.   NUCLEIC ACIDS RESEARCH

The TLR3 signaling complex forms by cooperative receptor dimerization

(2008) J. N. Leonard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis of Toll-Like Receptor 3 Signaling with Double-Stranded RNA

(2008) L. Liu et al.   SCIENCE