Cell Therapy Strategies to Combat Immunosenescence

Cellular senescence: from growth arrest to immunogenic conversion

(2015) D. G. A. Burton et al.   AGE

Increases of M2a macrophages and fibrosis in aging muscle are influenced by bone marrow aging and negatively regulated by muscle-derived nitric oxide

(2015) Ying Wang et al.   AGING CELL

Autophagy Controls Acquisition of Aging Features in Macrophages

(2015) Amanda J. Stranks et al.   Journal of Innate Immunity

Premature Immunosenescence Is Associated with Memory Dysfunction in Rheumatoid Arthritis

(2015) Laura Esteves Petersen et al.   NEUROIMMUNOMODULATION

Efficient in vitro generation of functional thymic epithelial progenitors from human embryonic stem cells

(2015) Min Su et al.   Scientific Reports

Regeneration of the aged thymus by a single transcription factor

(2014) N. Bredenkamp et al.   DEVELOPMENT

Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

(2014) C. Franceschi et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Targeting macrophages rescues age-related immune deficiencies in C57BL/6J geriatric mice

(2013) Connie Jackaman et al.   AGING CELL

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

(2013) Tamara Tchkonia et al.   JOURNAL OF CLINICAL INVESTIGATION

Generation of Engraftable Hematopoietic Stem Cells From Induced Pluripotent Stem Cells by Way of Teratoma Formation

(2013) Nao Suzuki et al.   MOLECULAR THERAPY

Understanding immunosenescence to improve responses to vaccines

(2013) Jörg J Goronzy et al.   NATURE IMMUNOLOGY

Telomere Dynamics in Mice and Humans

(2013) Rodrigo T. Calado et al.   SEMINARS IN HEMATOLOGY

Maintenance of Peripheral Naive T Cells Is Sustained by Thymus Output in Mice but Not Humans

(2012) Ineke den Braber et al.   IMMUNITY

The mouse lymph node as an ectopic transplantation site for multiple tissues

(2012) Junji Komori et al.   NATURE BIOTECHNOLOGY

Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity

(2012) Guangjin Li et al.   NATURE MEDICINE

Peripheral selection rather than thymic involution explains sudden contraction in naive CD4 T-cell diversity with age

(2012) P. L. F. Johnson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Age-related changes in CD8 T cell homeostasis and immunity to infection

(2012) Janko Nikolich-Žugich et al.   SEMINARS IN IMMUNOLOGY

The narrowing of the CD8 T cell repertoire in old age

(2011) Marcia A Blackman et al.   CURRENT OPINION IN IMMUNOLOGY

Rejuvenating senescent and centenarian human cells by reprogramming through the pluripotent state

(2011) L. Lapasset et al.   GENES & DEVELOPMENT

Functional CD8 T Cell Memory Responding to Persistent Latent Infection Is Maintained for Life

(2011) A. Lang et al.   JOURNAL OF IMMUNOLOGY

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Impact of caloric and dietary restriction regimens on markers of health and longevity in humans and animals: a summary of available findings

(2011) John F Trepanowski et al.   Nutrition Journal

Accumulation of DNA Damage in Hematopoietic Stem and Progenitor Cells during Human Aging

(2011) Claudia E. Rübe et al.   PLoS One

Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age

(2011) W. W. Pang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV Infection, Inflammation, Immunosenescence, and Aging

(2010) Steven G. Deeks   Annual Review of Medicine

CD28− T cells: their role in the age-associated decline of immune function

(2009) Nan-ping Weng et al.   TRENDS IN IMMUNOLOGY