Review
Biochemistry & Molecular Biology
Mariyam Kim, Laura Bakyt, Azamat Akhmetkaliyev, Dana Toktarkhanova, Denis Bulanin
Summary: Cancer stem cells (CSCs) are resistant to conventional chemotherapy and contribute to tumor relapse. Understanding the molecular mechanisms behind CSCs' chemoresistance is crucial for effective targeted therapy. Developmental signaling pathways, tumor microenvironment, epigenetic changes, and autophagy all play important roles in CSCs' chemoresistance development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Yongquan Tang, Yan Chen, Zhe Zhang, Bo Tang, Zongguang Zhou, Haining Chen
Summary: Cancer stem cells (CSCs) are cells with self-renewal and tumorigenic properties, playing crucial roles in tumor development and resistance to treatment. Targeting CSC signaling pathways is a promising therapeutic strategy, with advancements in cancer omics providing new targets. Nanotechnology for RNAi delivery can enhance efficacy by overcoming limitations of RNAi.
Review
Biochemistry & Molecular Biology
Roman Bubin, Romans Uljanovs, Ilze Strumfa
Summary: The discovery of cancer stem cells (CSCs) in leukemia has led to active research on stemness in neoplastic tissues. CSCs are a subpopulation of malignant cells with unique properties, including a dedifferentiated state, self-renewal, pluripotency, resistance to therapy, epigenetic alterations, and higher tumorigenicity. CSCs have been confirmed in various malignancies, including pancreatic ductal adenocarcinoma, which has a poor prognosis. This review aims to summarize the current knowledge on the markers and molecular features of CSCs in pancreatic ductal adenocarcinoma and the therapeutic options for their elimination.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Aaron Galindo-Vega, Vilma Maldonado-Lagunas, Irma B. Mitre-Aguilar, Jorge Melendez-Zajgla
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy due to a complex tumor microenvironment and the presence of cancer stem cells, which contribute to therapy resistance and tumor relapse. Understanding and targeting the tumor microenvironment and cancer stem cells may be crucial for effective PDAC therapies. This review summarizes recent advances in the role of tumor microenvironment in pancreatic neoplastic progression.
Review
Biochemistry & Molecular Biology
Lokender Kumar, Sanjay Kumar, Kumar Sandeep, Sanjay Kumar Singh Patel
Summary: Cancer poses a significant challenge for effective treatment due to its complex mechanism, different stages of progression, and lack of screening and identification procedures. Pancreatic cancer, with a low survival rate of around 5 years, is ranked seventh globally among mortality-associated cancers. Therefore, it is crucial to develop diagnostic procedures for early detection, understand pancreatic cancer mechanisms, and explore therapeutic strategies. This review highlights recent developments in pancreatic cancer progression, mechanisms, and therapeutic approaches, including molecular techniques and biomedicines for effective cancer treatment.
Article
Pharmacology & Pharmacy
Mengzhu Zheng, Canrong Wu, Kaiyin Yang, Yueying Yang, Yang Liu, Suyu Gao, Qiqi Wang, Chen Li, Lixia Chen, Hua Li
Summary: The novel selective HK2 inhibitor BNBZ was reported to directly bind to HK2, induce cancer cell apoptosis, and inhibit glycolysis of cancer cells. BNBZ significantly inhibited cancer cell proliferation in vitro and in vivo by targeting HK2 with high potency and low toxicity.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Oncology
Jae-Il Choi, Sung Ill Jang, Jaehyun Hong, Chul Hoon Kim, Soon Sung Kwon, Joon Seong Park, Jong-Baeck Lim
Summary: In this study, it was demonstrated that CD44(+), CD24(+) and EpCAM(+) cancer-initiating cells (CICs) were enriched in patient-derived organoids of PDAC. CD44-expressing CICs formed lumen structures within the organoids. Additionally, CD44(-) cancer cells from the organoids could re-form organoids and be re-programed as CD44-expressing CICs. The study also showed that the maintenance of CICs in PDAC organoids was mediated by interactions with endothelial cells through Wnt and Notch signaling pathways.
Review
Oncology
Wen Jess Li, Xiaozhuo Liu, Emily M. Dougherty, Dean G. Tang
Summary: The article reviews the tumor suppressive role of miRNA-34a in prostate cancer and discusses therapeutic development strategies for advanced prostate cancer patients.
Article
Biology
Pascaline Nanga Fru, Ekene Emmanuel Nweke, Nompumelelo Mthimkhulu, Sindisiwe Mvango, Marietha Nel, Lynne Alison Pilcher, Mohammed Balogun
Summary: Research has shown that polymer therapeutics can enhance the effectiveness of drugs on pancreatic cancer cells, inhibiting cell growth and affecting crucial chemoresistance-related genes. Furthermore, by inhibiting the production of the cytokine IL-6, it can improve the immune response, making it a promising direction for further exploration in pancreatic cancer treatment.
Review
Cell Biology
Shunhao Zhang, Yanji Gong, Chunjie Li, Wenbin Yang, Longjiang Li
Summary: Recent studies have shown the crucial role of cancer stem cells (CSCs) in various cancer processes, with their cellular plasticity not entirely explained by genetic mutations. The research on epigenetic modifications as a complementary explanation has been increasing in recent years, leading to the development of therapeutic strategies targeting CSCs. This review summarizes the understanding of CSCs and their role in cancer progression, focusing on epigenetic alterations and specific chemical inhibitors as primary cancer therapies.
CELL PROLIFERATION
(2021)
Review
Biochemistry & Molecular Biology
Dannel Yeo, Althea Bastian, Heidi Strauss, Payal Saxena, Peter Grimison, John E. J. Rasko
Summary: This review summarizes the data on the utility of CTCs in PDAC and discusses the molecular profiling and culture methods of CTCs. CTCs have the potential to be used in screening, early diagnosis, prognostic assessment, and personalized management of PDAC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Chika Miyagi-Shiohira, Issei Saitoh, Masami Watanabe, Hirofumi Noguchi
Summary: This study found significant differences in the expression levels of key genes between iF cells and iTS-P cells in pancreatic tissue, suggesting that these differences could be important markers for distinguishing between these two cell types.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Yasaman KalantarMotamedi, Ran Joo Choi, Siang-Boon Koh, Jo L. Bramhall, Tai-Ping Fan, Andreas Bender
Summary: Resistance to current therapies is common in pancreatic cancer, necessitating novel treatment options. A computational method was developed to select synergistic compound combinations based on transcriptomic profiles and pathway scoring system, successfully identifying effective compound combinations against pancreatic cancer cells.
Article
Biochemical Research Methods
Stephanie M. Venis, Hye-ran Moon, Yi Yang, Sagar M. Utturkar, Stephen F. Konieczny, Bumsoo Han
Summary: The pancreatic acinus is a functional unit of the exocrine pancreas and understanding its pathobiology is crucial for pancreatic diseases. A pancreatic acinus-on-chip (PAC) model has been developed using reprogrammed pancreatic cancer cells, providing a new and reliable platform for studying the initiation and progression of pancreatic cancers.
Review
Cell & Tissue Engineering
Yuxiang Zhang, Wei Ju, Hong Zhang, Liu Mengyun, Weiliang Shen, Xiao Chen
Summary: Tendinopathy is a disease caused by the degeneration of tendon tissue, and currently, there is no treatment available to prevent or delay its progression. Recent research suggests that MSCs-derived exosomes (MSCs-exos) may be useful for promoting tendon healing and could be considered as a potential treatment for tendinopathy.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Surgery
S. Schimmack, O. Strobel
Article
Oncology
Alia Abukiwan, Clifford C. Nwaeburu, Nathalie Bauer, Zhefu Zhao, Li Liu, Jury Gladkich, Wolfgang Gross, Axel Benner, Oliver Strobel, Joerg Fellenberg, Ingrid Herr
INTERNATIONAL JOURNAL OF ONCOLOGY
(2019)
Editorial Material
Surgery
O. Strobel, M. W. Buechler
Article
Gastroenterology & Hepatology
Ulla Klaiber, Pascal Probst, Felix J. Huettner, Thomas Bruckner, Oliver Strobel, Markus K. Diener, Andre L. Mihaljevic, Markus W. Buechler, Thilo Hackert
JOURNAL OF GASTROINTESTINAL SURGERY
(2020)
Article
Oncology
Vladimir J. Lozanovski, Georgios Polychronidis, Wolfgang Gross, Negin Gharabaghi, Arianeb Mehrabi, Thilo Hackert, Peter Schemmer, Ingrid Herr
INVESTIGATIONAL NEW DRUGS
(2020)
Article
Engineering, Biomedical
Zhe Wang, Nora Winkler, Baifeng Qian, Wolfgang Gross, Arianeb Mehrabi, Eduard Ryschich
ACTA BIOMATERIALIA
(2019)
Article
Oncology
Christina Georgikou, Libo Yin, Jury Gladkich, Xi Xiao, Carsten Sticht, Carolina de la Torre, Norbert Gretz, Wolfgang Gross, Michael Schaefer, Svetlana Karakhanova, Ingrid Herr
Article
Biochemistry & Molecular Biology
Sahar Ghassem-Zadeh, Katrin Hufnagel, Andrea Bauer, Jean-Louis Frossard, Masaru Yoshida, Hiromu Kutsumi, Hans Acha-Orbea, Matthias Neulinger-Munoz, Johannes Vey, Christoph Eckert, Oliver Strobel, Joerg D. Hoheisel, Klaus Felix
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Christina Georgikou, Laura Buglioni, Maximilian Bremerich, Nico Roubicek, Libo Yin, Wolfgang Gross, Carsten Sticht, Carsten Bolm, Ingrid Herr
Article
Oncology
Eva-Maria Kamionka, Baifeng Qian, Wolfgang Gross, Frank Bergmann, Thilo Hackert, Carlo A. Beretta, Nicolas Dross, Eduard Ryschich
Summary: Excessive desmoplasia is a hallmark of human pancreatic cancer and does not significantly impact T-cell migration or distribution in the tumor. The study found no correlation between collagen organization and T-cell distribution, suggesting that remodeling stroma collagen may not improve T-cell-tumor cell contact.
Article
Biochemistry & Molecular Biology
Tobias Pfeifer, Liping Bai, Jury Gladkich, Wolfgang Gross, Li Liu, Ingrid Herr, Michael Schaefer
Summary: TTFields treatment inhibits proliferation of PDAC cells, but its effects vary on different PDAC cell lines at different frequencies and field strengths, without inducing apoptosis or necrosis.
BIOELECTROCHEMISTRY
(2021)
Review
Oncology
Christopher Limb, Daniel S. K. Liu, Morten T. Veno, Eleanor Rees, Jonathan Krell, Izhar N. Bagwan, Elisa Giovannetti, Hardev Pandha, Oliver Strobel, Timothy A. Rockall, Adam E. Frampton
Article
Immunology
Yangyi Wang, Emilia Petrikova, Wolfgang Gross, Carsten Sticht, Norbert Gretz, Ingrid Herr, Svetlana Karakhanova
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Medicine, Research & Experimental
Qingliang Wang, Baifeng Qian, Michael Schafer, Wolfgang Gross, Arianeb Mehrabi, Eduard Ryschich
Article
Surgery
D. Kyuno, B. Qian, W. Gross, M. Schaefer, E. Ryschich