Article
Psychology, Multidisciplinary
Arit Glicksohn, Ladan Shams, Aaron R. Seitz
Summary: Memory involves encoding, consolidating, and retrieving information. Targeted memory reactivation is an experimental method that reactivates sensory components to enhance memory retrieval. In this study, participants were presented with everyday objects, some of which were tagged with sounds. Unusual objects and sounds were created as "oddballs". During a reactivation phase, participants listened to a replay of normal and oddball sounds. The results showed that participants had better memory for oddball objects, especially when their sounds were reactivated.
FRONTIERS IN PSYCHOLOGY
(2023)
Review
Neurosciences
Kosuke Okuda, Kristoffer Hojgaard, Lucia Privitera, Guelberk Bayraktar, Tomonori Takeuchi
Summary: This article explores the cellular and molecular mechanisms underlying initial memory consolidation in the hippocampus, focusing on the synaptic tagging and capture hypothesis and its relevance to dopaminergic signaling. The research summarizes electrophysiological STC processes and the behavioral tagging hypothesis, as well as discussing the function of synaptic tags and plasticity-related proteins in the STC process and initial memory consolidation. The study also describes candidate molecules for these roles and proposes future directions for advancing understanding of the molecular mechanisms involved in the STC process.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Review
Cell Biology
Dae Hee Han, Pojeong Park, Dong Il Choi, Tim V. P. Bliss, Bong-Kiun Kaang
Summary: Memory consists of different phases, including cellular consolidation, systems consolidation, reconsolidation, and extinction. Recent studies have shown that simple association memories can be encoded by a subset of neurons called engram cells. The activity of these cells is necessary and sufficient for memory recall. However, it is still unclear how engram cells encode different phases of memory, and further research is needed. The possibility that the synapses between engram cells, known as the synaptic engram, constitute the memory needs to be examined. This review summarizes recent findings on cellular engrams and discusses the distinct molecular mechanisms required for cellular and synaptic engrams.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
James Delorme, Lijing Wang, Varna Kodoth, Yifan Wang, Jingqun Ma, Sha Jiang, Sara J. Aton
Summary: The study found that sleep loss alters cytosolic ribosomal transcripts while learning almost does not, and the effects of learning are masked by subsequent sleep deprivation. Additionally, sleep deprivation affects fewer membrane-bound ribosomal transcripts, while learning changes more, especially long non-coding RNAs.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Cheng Qin, Xin-Lan Bian, Hai-Yin Wu, Jia-Yun Xian, Yu-Hui Lin, Cheng-Yun Cai, Ying Zhou, Xiao-Lin Kou, Ting-You Li, Lei Chang, Chun-Xia Luo, Dong-Ya Zhu
Summary: The study reveals that the association of nNOS with CAPON in the medial prefrontal cortex negatively regulates extinction memory, and dissociating this association can prevent the return of extinguished fear, enhancing long-term potentiation and excitatory synaptic transmission.
MOLECULAR PSYCHIATRY
(2021)
Article
Neurosciences
Timothy Tadros, Maxim Bazhenov
Summary: Relational memory is critical for mammalian reasoning. Sleep plays a crucial role in offline processing and improving the ability to make indirect associations.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Satoshi Kida
Summary: Memory retrieval is a dynamic process that involves reconsolidation, where retrieved memories return to a labile state and are re-stored. This discovery challenges the traditional view of memory consolidation and suggests that memory can be modified through reconsolidation. Extinction, on the other hand, weakens a conditioned fear memory through a new inhibitory learning process. In our research, we investigated the relationship between memory reconsolidation and extinction at behavioral, cellular, and molecular levels, finding that they have opposite effects on fear memory and interact with each other in a memory transition process.
BRAIN RESEARCH BULLETIN
(2023)
Article
Behavioral Sciences
Michelle G. Craske, Christina F. Sandman, Murray B. Stein
Summary: The neurobiology of extinction learning has informed exposure therapy, which is the standard treatment for fear and anxiety disorders. Extinction learning leads to the formation of a new inhibitory memory that competes with the intact fear memory, potentially leading to fear recurrence. Strategies to enhance exposure therapy include maximizing prediction error and strengthening the consolidation and retrieval of extinction learning. However, not all individuals respond to treatment. Future research on reward processing, stimulus valuation, and decision-making is needed to improve the effectiveness of exposure-based treatments.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Multidisciplinary Sciences
Jasmine Herszage, Marlene Bonstrup, Leonardo G. Cohen, Nitzan Censor
Summary: Abundant evidence suggests that consolidated memories can be modified after reactivation. This study explores whether motor skill memories can be modified after brief reactivations, even at the early stages of learning. The results indicate that memories formed during early learning are not susceptible to interference or enhancement within a rapid reactivation-induced time window, suggesting that reactivation-induced motor skill memory modulation may depend on longer timescales of consolidation.
SCIENTIFIC REPORTS
(2023)
Review
Neurosciences
Irene Reyes-Resina, Sebastian Samer, Michael R. Kreutz, Anja M. Oelschlegel
Summary: Sleep plays a central role in memory consolidation and brain function; however, the specific molecular mechanisms underlying these processes are still not fully understood, with many unknown factors hindering a deeper appreciation of their impact on synaptic function and memory formation.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Cell Biology
Akash K. Singh, Sin H. Neo, Christine Liwang, Karen K. L. Pang, Jason C. K. Leng, Sarmistha H. Sinha, Mahesh S. Shetty, Madavan Vasudevan, Vinay J. Rao, Ila Joshi, Muthusamy Eswaramoorthy, Maria V. Pavon, Ang R. Sheila, Sheeja Navakkode, Tapas K. Kundu, Sreedharan Sajikumar
Summary: Research shows that small molecule activators like TTK21 can activate p300/CBP, restore expression of genes related to neural plasticity, and potentially serve as therapeutic molecules for neurodegenerative diseases like AD.
Review
Neurosciences
M. B. Parent
Summary: Episodic meal-related memories play a significant role in tracking and controlling eating behavior, and their effects on subsequent intake can last longer than physiological signals. Research suggests that dorsal hippocampal neurons mediate the inhibitory effects of meal-related memory on future intake.
Article
Behavioral Sciences
Morvarid Meamar, Ali Rashidy-Pour, Abbas Ali Vafaei, Payman Raise-Abdullahi
Summary: This study aimed to investigate the interaction between glucocorticoids and beta-adrenoceptors of the infra-limbic cortex (IL) in regulating the acquisition and consolidation of fear memory extinction in rats. The results showed that activating beta-adrenergic receptors in the IL mediates glucocorticoid effects on the acquisition and consolidation of auditory-conditioned fear memory extinction.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Neurosciences
Kristoffer Hojgaard, Bianka Szollosi, Kim Henningsen, Natsumi Minami, Nobuhiro Nakanishi, Erik Kaadt, Makoto Tamura, Richard G. M. Morris, Tomonori Takeuchi, Betina Elfving
Summary: The study found that contextual novelty leads to different gene expression changes in mice and rats, but one gene (Agap3) was upregulated in both species. Agap3 may be involved in maintaining functional plasticity by regulating glutamate receptor trafficking. However, these changes cannot be fully reversed with a specific drug.
Review
Behavioral Sciences
Mohammad Dastgheib, Asvini Kulanayagam, Hans C. Dringenberg
Summary: This article challenges the concept of sleep-dependent memory consolidation by summarizing evidence for effective memory consolidation during wakefulness. The engagement of plasticity mechanisms, active both during sleep and wakefulness, is proposed as the critical factor determining memory formation. Sleep falls along a continuum of behavioral states that vary in their effectiveness to support memory consolidation.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Behavioral Sciences
Jefferson Menezes, Ben-Hur Souto das Neves, Rithiele Goncalves, Fernando Benetti, Pamela Billig Mello-Carpes
BEHAVIOURAL BRAIN RESEARCH
(2020)
Article
Behavioral Sciences
Lucas Aschidamini Marcondes, Eduarda Godfried Nachtigall, Andre Zanluchi, Jociane de Carvalho Myskiw, Ivan Izquierdo, Cristiane Regina Guerino Furini
NEUROBIOLOGY OF LEARNING AND MEMORY
(2020)
Article
Neurosciences
Cristiane R. G. Furini, Eduarda G. Nachtigall, Jonny A. K. Behling, Eduardo S. Assis Brasil, Bruna F. Saenger, Rodrigo F. Narvaes, Jociane de Carvalho Myskiw, Ivan Izquierdo
Article
Multidisciplinary Sciences
Scheila Daiane Schmidt, Alessia Costa, Barbara Rani, Eduarda Godfried Nachtigall, Maria Beatrice Passani, Fabrizio Carta, Alessio Nocentini, Jociane de Carvalho Myskiw, Cristiane Regina Guerino Furini, Claudiu T. Supuran, Ivan Izquierdo, Patrizio Blandina, Gustavo Provensi
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Behavioral Sciences
Scheila Daiane Schmidt, Carolina Garrido Zinn, Jonny Anderson Kielbovicz Behling, Ana Flavia Furian, Cristiane Regina Guerino Furini, Jociane de Carvalho Myskiw, Ivan Izquierdo
Summary: Social recognition memory is crucial for social relationships and deficits in psychiatric disorders may result from alterations in SRM processing by the hippocampus and amygdala. PACAP, a neuropeptide that modulates synaptic function and social behavior, could play a key role in these mechanisms.
NEUROBIOLOGY OF LEARNING AND MEMORY
(2021)
Article
Behavioral Sciences
Rodrigo F. Narvaes, Cristiane R. G. Furini
Summary: Wnt pathways have been consistently associated with key features of cellular development and memory formation. The canonical and non-canonical pathways play crucial roles in processes related to memory, as well as potential treatments for Alzheimer's disease. Understanding these pathways may lead to better insights into neurobiological and pathological processes.
NEUROBIOLOGY OF LEARNING AND MEMORY
(2022)
Article
Neurosciences
Lucas A. Marcondes, Jociane De C. Myskiw, Eduarda G. Nachtigall, Rodrigo F. Narvaes, Ivan Izquierdo, Cristiane R. G. Furini
Summary: The prelimbic cortex (PrL) is crucial for encoding and expressing contextual fear memory. Protein kinase M zeta (PKM zeta) has been shown to maintain memories by inhibiting the endocytosis of GluA2-containing AMPA receptors. This study found that acute inhibition of GluA2-dependent AMPAR endocytosis in the PrL does not affect recent or remote contextual fear memory maintenance. However, inhibition of PKM zeta in the PrL at a remote time point disrupts contextual fear memory maintenance, which can be prevented by blocking GluA2-dependent removal of AMPARs.
Article
Biochemistry & Molecular Biology
Augusto F. Uberti, Natalia Callai-Silva, Matheus V. C. Grahl, Angela R. Piovesan, Eduarda G. Nachtigall, Cristiane R. G. Furini, Celia Regina Carlini
Summary: Alzheimer's disease (AD) causes dementia and memory loss in the elderly. Research suggests a possible association between Helicobacter pylori infection and tauopathies such as AD, potentially mediated by the bacterium's urease enzyme.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Scheila Daiane Schmidt, Eduarda Godfried Nachtigall, Lucas Aschidamini Marcondes, Andre Prime Zanluchi, Cristiane R. G. Furini, Maria Beatrice Passani, Claudiu T. Supuran, Patrizio Blandina, Ivan Izquierdo, Gustavo Provensi, Jociane De Carvalho Myskiw
Summary: Growing evidence suggests that brain carbonic anhydrases (CAs) play a crucial role in cognition, particularly in social recognition and memory. This study investigated the effects of CAs activation and inhibition in the hippocampus and prefrontal cortex on short-term and long-term social recognition memory in rats. The results demonstrate the importance of CAs in modulating social recognition memory, with differential effects observed in the prefrontal cortex and hippocampus.
Article
Behavioral Sciences
Rodrigo F. Narvaes, Eduarda G. Nachtigall, Lucas A. Marcondes, Ivan Izquierdo, Jociane de C. Myskiw, Cristiane R. G. Furini
Summary: This study found that both the canonical Wnt/β-catenin and non-canonical Wnt/Ca2+ signaling pathways are involved in fear memory retrieval, highlighting the importance of the medial prefrontal cortex in this process.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Behavioral Sciences
Jessica Rosa, Jociane de Carvalho Myskiw, Natalia Gindri Fiorenza, Cristiane Regina Guerino Furini, Gerson Guilherme Sapiras, Ivan Izquierdo
Summary: This study explores the role of the hippocampal cholinergic system and mTOR in memory formation and extinction processes. The results demonstrate a dose-dependent effect of cholinergic receptor agonists on extinction memory, and the involvement of muscarinic receptors in the hippocampus independent of mTOR in this memory process.
BEHAVIOURAL BRAIN RESEARCH
(2023)
