Article
Multidisciplinary Sciences
Malen D. Moyano, Giulia Carbonari, Matias Bonilla, Maria E. Pedreira, Luis Brusco, Laura Kaczer, Cecilia Forcato
Summary: After encoding, memories go through a labile state followed by a stabilization process known as consolidation. During these periods of lability, the memory traces can be modified. The present study investigates the effect of an interference treatment on declarative memory consolidation, comparing different time intervals after acquisition.
Article
Neurosciences
Satoshi Kida
Summary: Memory retrieval is a dynamic process that involves reconsolidation, where retrieved memories return to a labile state and are re-stored. This discovery challenges the traditional view of memory consolidation and suggests that memory can be modified through reconsolidation. Extinction, on the other hand, weakens a conditioned fear memory through a new inhibitory learning process. In our research, we investigated the relationship between memory reconsolidation and extinction at behavioral, cellular, and molecular levels, finding that they have opposite effects on fear memory and interact with each other in a memory transition process.
BRAIN RESEARCH BULLETIN
(2023)
Article
Biochemistry & Molecular Biology
Cheng Qin, Xin-Lan Bian, Hai-Yin Wu, Jia-Yun Xian, Yu-Hui Lin, Cheng-Yun Cai, Ying Zhou, Xiao-Lin Kou, Ting-You Li, Lei Chang, Chun-Xia Luo, Dong-Ya Zhu
Summary: The study reveals that the association of nNOS with CAPON in the medial prefrontal cortex negatively regulates extinction memory, and dissociating this association can prevent the return of extinguished fear, enhancing long-term potentiation and excitatory synaptic transmission.
MOLECULAR PSYCHIATRY
(2021)
Article
Multidisciplinary Sciences
Jasmine Herszage, Marlene Bonstrup, Leonardo G. Cohen, Nitzan Censor
Summary: Abundant evidence suggests that consolidated memories can be modified after reactivation. This study explores whether motor skill memories can be modified after brief reactivations, even at the early stages of learning. The results indicate that memories formed during early learning are not susceptible to interference or enhancement within a rapid reactivation-induced time window, suggesting that reactivation-induced motor skill memory modulation may depend on longer timescales of consolidation.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Yu Arihara, Yudai Fukuyama, Satoshi Kida
Summary: This study demonstrates the essential role of the locus coeruleus (LC) in the consolidation, reconsolidation, and long-term extinction of contextual fear memory. The LC, through its projections to brain regions, plays a modulatory role in memory storage and maintenance.
BRAIN RESEARCH BULLETIN
(2023)
Review
Neurosciences
Arturo Romano, Ramiro Freudenthal, Mariana Feld
Summary: Memory acquisition, formation, and maintenance depend on synaptic post-translational machinery and regulation of gene expression triggered by transduction pathways. Studies on the crab Neohelice granulata have revealed key plasticity mechanisms involved in memory, including activation of ERK and NF-κB transcription factor, involvement of synaptic proteins, and neuroepigenetic regulation of gene expression. This article reviews the most significant findings in this memory model.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Neurosciences
Joseph E. LeDoux
Summary: Karim Nader revolutionized memory research by revitalizing interest in the often neglected topic of post-retrieval manipulations of memory, and this study had a significant impact on the field.
BRAIN RESEARCH BULLETIN
(2022)
Article
Neurosciences
Sofia Leal Santos, Michelle Stackmann, Andrea Munoz Zamora, Alessia Mastrodonato, Allegra De Landri, Nick Vaughan, Briana K. Chen, Marcos Lanio, Christine A. Denny
Summary: The study found that propranolol reduces fear expression by altering network-correlated activity and weakening the reactivation of initial traumatic memory trace. Experimental results showed that propranolol has a certain effect on reducing fear expression when administered before delayed context reexposure.
BIOLOGICAL PSYCHIATRY
(2021)
Article
Neurosciences
Denisse Paredes, Anna R. Knippenberg, David A. Morilak
Summary: Current pharmacotherapies for PTSD and MDD are ineffective for many patients, while behavioral therapies such as exposure therapy can be effective for treatment-resistant patients. Fear extinction after chronic stress in rats models the effects of exposure therapy, requiring neuronal activity and protein synthesis in the IL cortex for beneficial effects. Extinction triggers BDNF-Erk signaling in the IL cortex to reverse stress-induced cognitive impairments.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Elena F. Shevtsova, Plamena R. Angelova, Olga A. Stelmashchuk, Noemi Esteras, Nataliia A. Vasil'eva, Andrey Maltsev, Pavel N. Shevtsov, Alexander Shaposhnikov, Vladimir P. Fisenko, Sergey O. Bachurin, Andrey Y. Abramov
Summary: This study found that compounds Tg-2112x and Tg-2113x have protective effects on cells by reducing mitochondrial calcium uptake and preventing cell death and mitochondrial depolarization induced by beta-amyloid. Additionally, Tg-2113x restored fear extinction in aged mice. This research provides a basis for the development of a novel generation of disease-modifying neuroprotective agents.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Zhonghua Dai, Ying Liu, Lina Nie, Weiqi Chen, Xing Xu, Yonghui Li, Jianjun Zhang, Fang Shen, Nan Sui, Jing Liang
Summary: Extinction training during the reconsolidation window following memory recall is effective for promoting the extinction of pathological memory. However, this effect has not been consistently replicated in different studies. This study identifies a neural circuit that, when activated, enhances the extinction process through the recall-extinction procedure.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Biology
Maha E. Wally, Masanori Nomoto, Kareem Abdou, Emi Murayama, Kaoru Inokuchi
Summary: Short-term memory (STM) can be optogenetically retrieved at a time point when natural recall is not possible, revealing the long-term existence of an STM engram. Re-training leads to natural long-term recall, indicating facilitated consolidation. Protein synthesis, NMDAR activity, and NREM sleep play important roles in the long-term storage of an STM trace.
COMMUNICATIONS BIOLOGY
(2022)
Article
Behavioral Sciences
B. K. B. Murthy, S. Somatakis, A. F. Ulivi, H. Klimmt, T. P. Castello-Waldow, N. Haynes, R. E. Huettl, A. Chen, Alessio Attardo
Summary: Subpopulations of neurons with increased activity during memory encoding are considered as cellular engrams. Correlated synaptic activity between these engram neurons is thought to strengthen their connections, increasing the likelihood of recalling neural activity patterns. Labeling synaptic engrams using a transsynaptic GFP reconstitution system can highlight the synaptic connections between engram neurons.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Andressa Radiske, Maria Carolina Gonzalez, Diana A. Noga, Janine Rossato, Lia R. M. Bevilaqua, Martin Cammarota
Summary: Research on adult male Wistar rats showed that different subunits of NMDARs in the hippocampus play distinct roles in the stability and destabilization of extinction memory. GluN2B-containing NMDARs are necessary for extinction memory destabilization, while GluN2A-containing NMDARs are involved in its restabilization. Pharmacological modulation of these receptor subtypes around the time of extinction memory recall may regulate the dominance of extinction memory over the original memory trace.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Myrto Panopoulou, Oliver M. Schlueter
Summary: Frequent relapse hinders successful treatment of substance use disorders by triggering the retrieval of drug-associated memories. This study investigates the cellular and molecular mechanisms underlying drug-induced memory retrieval using a conditioned place preference (CPP) procedure in mice. The results suggest that Ca2+-permeable AMPA receptors (CP-AMPARs) in the nucleus accumbens (NAc) play a key role in regulating the threshold for drug-induced retrieval and behavioral expression of drug memories.
MOLECULAR PSYCHIATRY
(2022)
Review
Cell Biology
Alyssa Kearly, Andrew D. L. Nelson, Aleksandra Skirycz, Monika Chodasiewicz
Summary: Stress Granules (SGs) and Processing-bodies (P-bodies) are important biomolecular condensates that play crucial roles in maintaining mRNA balance and regulating stress responses. They are composed of proteins and RNAs involved in translation, protein folding, and energy metabolism.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
P. Lemonnier, T. Lawson
Summary: Stomatal conductance plays a crucial role in determining CO2 uptake and water loss in plants, affecting overall water status and productivity. However, the signals coordinating mesophyll demands for CO2, the role of chloroplasts in stomatal function, and other GC metabolic processes in stomatal function remain poorly understood.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Matteo Gionfriddo, Timothy Rhodes, Spencer M. Whitney
Summary: Rubisco is a key enzyme that facilitates the entry of CO2 into the biosphere, but its catalytic properties are slow and error-prone. More effective Rubisco variants have been discovered in certain algae, offering the potential to significantly improve crop productivity. However, incompatibilities in protein folding have hindered the transplantation of these variants into plants. Directed evolution is now being explored to enhance Rubisco catalysis.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Vittoria Clapero, Stephanie Arrivault, Mark Stitt
Summary: The Calvin-Benson cycle has undergone massive selection and co-evolution with carbon-concentrating mechanisms due to changing environmental factors. Metabolite profiling reveals species-specific variations in the operation of the cycle, indicating the influence of different modes of photosynthesis. Connectivity analysis identifies constraints and driving factors for cross-species diversity in the cycle.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Sukhbir Kaur, David D. Roberts
Summary: Thrombospondin-1 modulates cell behavior by interacting with components of the extracellular matrix and cell surface receptors. Its release and expression are influenced by injuries and various diseases, while its sustained presence in the extracellular space is regulated by receptor-mediated clearance. Thrombospondin-1 plays important roles in immune responses.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Richard P. Tucker, Josephine C. Adams
Summary: Thrombospondins (TSPs) play diverse roles in animals and have been found to belong to a superfamily that includes different subgroups such as mega-TSPs, sushi-TSPs, and poriferan-TSPs. Invertebrates encode a greater diversity of TSP superfamily members than vertebrates.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
James Petrik, Sylvia Lauks, Bianca Garlisi, Jack Lawler
Summary: Many cancers start with a small nest of transformed cells that can remain dormant. Thrombospondin-1 (TSP-1) initially promotes dormancy by suppressing angiogenesis, but over time, factors promoting angiogenesis become dominant and recruit various cells to form a complex tumor microenvironment. TSPs play a role in the proliferation, migration, and invasion of cells in the tumor microenvironment, as well as influencing the immune characteristics and phenotype of tumor-associated macrophages.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Hana Fakim, Christine Vande Velde
Summary: There has been increasing attention to the role of phase-separated biomolecular condensates, specifically stress granules, in neurodegenerative diseases like ALS. ALS-associated mutations in genes involved in stress granule assembly have been found, and stress granule proteins have been detected in pathological inclusions in ALS patient neurons. However, protein components of stress granules are also present in other physiological biomolecular condensates, which have not been adequately discussed in relation to ALS. This review explores the functions of TDP-43 and FUS in physiological condensates occurring in the nucleus and neurites beyond stress granules, and discusses the impact of ALS-linked mutations on their ability to phase separate and perform their functions in stress-independent biomolecular condensates.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Alexander Lin, Yogambha Ramaswamy, Ashish Misra
Summary: Smooth muscle cells, endothelial cells, and macrophages in blood vessels display remarkable heterogeneity, and their developmental origins may influence their plasticity. Unbiased single cell whole transcriptome analysis techniques are revolutionizing the understanding of cellular diversity and plasticity, providing insights for therapeutic research.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Elton P. Hudson
Summary: The Calvin Benson cycle plays a crucial role in the ecological and biotechnological aspects of bacteria. Recent studies have shed light on the regulation of this cycle in bacteria, with post-transcriptional and post-translational regulation being important in phototrophic bacteria, and transcriptional regulation being prominent in chemolithoautotrophic bacteria. Understanding the regulation of the Calvin Benson cycle has implications for enhancing CO2 fixation and improving the synthesis of desired products. Non-canonical cycles may offer potential benefits for industrial applications.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Xin-Guang Zhu, Haim Treves, Honglong Zhao
Summary: This paper discusses the major regulatory mechanisms over the Calvin Benson Cycle (CBC) that maintain homeostasis of metabolite levels. These mechanisms include redox regulation of enzymes, metabolite regulations (especially allosteric regulations), and balanced activities of enzymes. These regulatory mechanisms are crucial for maintaining high flux and photosynthetic efficiency in CBC.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Hunter C. Herriage, Yi-Ting Huang, Brian R. Calvi
Summary: Apoptosis prevents the inappropriate acquisition of extra copies of the genome, known as polyploidy, but the polyploid state can suppress apoptosis. The mechanisms linking apoptosis and polyploid cell cycles are still largely unknown, and studying the regulation of apoptosis in development and cancer could lead to more effective therapies.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Daniel Campbell, Steven Zuryn
Summary: Mitochondrial dynamics play a crucial role in regulating cellular and organismal homeostasis, impacting various aspects of an organism's healthspan. By studying the nematode Caenorhabditis elegans, a comprehensive understanding of the impact of mitochondrial dynamics on homeostasis over a lifetime can be obtained.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Diba Borgmann, Henning Fenselau
Summary: Maintaining blood glucose at an appropriate physiological level requires coordination of multiple organs and tissues, with the vagus nerve playing a key role in central control. Recent studies have revealed the cellular identity, neuroanatomical organization, and functional contributions of vagal neurons in the regulation of systemic glucose metabolism. These findings provide new insights into the precise roles of vagal neurons in coordinating glucose levels and offer potential avenues for treating glucose metabolism disorders.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Tatiana C. Coverdell, Stephen B. G. Abbott, John N. Campbell
Summary: In this article, we review how genetic technology and single-cell genomics are revealing the organizational principles of the efferent vagus in unprecedented detail.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)