Review
Physiology
Maddison Reed, Michael G. Jonz
Summary: This review aims to summarize the receptor types implicated in O-2 sensing in fish gills, including serotonergic, cholinergic, purinergic, and dopaminergic receptor subtypes. Recent transcriptomic analysis has shed light on specific receptor targets in the gills, but the lack of receptor characterization at the cellular level remains a major limitation in understanding the neurochemical control of hypoxia signalling.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Fisheries
J. G. Herranz-Jusdado, E. Morel, M. C. Ordas, D. Martin, F. Docando, L. Gonzalez, E. Sanjuan, P. Diaz-Rosales, M. Saura, B. Fouz, C. Tafalla
Summary: This study investigates the differentiation of B cells to plasmablasts/plasma cells in the skin and gills of rainbow trout in response to Yersinia ruckeri. The transcription levels of genes related to B cell function in both mucosal surfaces and in spleen and kidney were analyzed, and the presence and size of B cells, as well as the presence of plasmablasts secreting total or specific IgMs, were evaluated after infection. The results show that B cells in the skin and gills of rainbow trout can differentiate to plasmablasts/plasma cells in response to Y. ruckeri, and these cells can secrete specific IgMs as soon as 5 days after exposure.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Fisheries
Anna Kuparinen, Darby Gielewski, Jeffrey A. Hutchings
Summary: This study examines the relationship between gill area and metabolic rate in fish, providing evidence that gill area can explain a significant proportion of species-level deviations from mass-specific metabolic rates.
JOURNAL OF FISH BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Junho Eom, Chris M. Wood
Summary: Research has found that trout possess both external ammonia sensors and dual internal ammonia sensors, with external sensors causing short term hypoventilation and internal sensors leading to hyperventilation, playing important roles in limiting the uptake of toxic waterborne ammonia and increasing ammonia excretion in the gills.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2021)
Article
Environmental Sciences
Ping Liu, Longwen Fu, Bowei Li, Mingsan Man, Yunxia Ji, Qi Kang, Xiyan Sun, Dazhong Shen, Lingxin Chen
Summary: A simple and low-cost microfluidic chip platform was developed for cultivating cells, embryos, and larvae of fish. It allows real-time observation of development and investigation of the effects of different dissolved oxygen on fish.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Editorial Material
Biochemistry & Molecular Biology
Artem Smirnov, Eleonora Candi
Summary: Skin acts as a barrier to protect the body and is directly exposed to oxygen. The role of oxygen in in vitro generation of skin graft is not clear. Teshima et al. discovered the impact of the HIF pathway on epidermal differentiation in skin models and how air-lifting of cultures affects HIF activity and keratinocyte differentiation.
Article
Biology
Andreas Ekstrom, Erika Sundell, Daniel Morgenroth, Tristan McArley, Anna Gardmark, Magnus Huss, Erik Sandblom
Summary: The study found that European perch can thermally adjust physiological traits to increase tolerance to hypoxia, especially in the face of long-term climate warming. This suggests that some fish species may have a certain level of resilience to the decreased hypoxia tolerance caused by climate warming.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2021)
Review
Cell Biology
T. van Vliet, F. Casciaro, M. Demaria
Summary: Oxygen is crucial for tissue function, disruptions in oxygen pathways lead to health issues and aging. Oxygen-modulating therapies and natural oxygen oscillations may impact lifespan and healthy aging.
AGEING RESEARCH REVIEWS
(2021)
Article
Fisheries
Michal Stosik, Beata Tokarz-Deptula, Wieslaw Deptula
Summary: The paper discusses the issue of intestinal mucosa immunity in teleost fish. The organization and functional properties of the elements that determine this immunity are reviewed according to current data. The knowledge of intestinal mucosal immunity in teleost fish has great potential for practical applications in the field of epidemiological safety.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Cell Biology
Wen Pan, Angela L. Scott, Colin A. Nurse, Michael G. Jonz
Summary: This study utilized transgenic zebrafish ETvmat2:GFP as a tool to label specialized oxygen chemoreceptors (NECs) and successfully identified NECs in live tissue and cell preparations, showcasing its potential for high-throughput experimentation. Additionally, the study observed changes in filamental NEC frequency, size, and gene expression in response to acclimation to severe hypoxia, highlighting the dynamic nature of NECs in teleost fish.
CELL AND TISSUE RESEARCH
(2021)
Article
Cell Biology
Hilde Sindre, Mona C. Gjessing, Johanna Hol Fosse, Lene C. Hermansen, Inger Bockerman, Marit M. Amundsen, Maria K. Dahle, Anita Solhaug
Summary: The establishment of the first Lumpfish Gill cell line (LG-1) provides valuable insights into the biology of lumpfish, with the cells originating from an epithelial or endothelial cell type. LG-1 can serve as an important in vitro research tool for studying gill cell function and host-pathogen interactions in lumpfish.
Article
Physiology
Derek A. Somo, Ken Chu, Jeffrey G. Richards
Summary: The gill oxygen limitation hypothesis suggests that the scaling of metabolic rate in fishes is limited by oxygen supply due to mismatched growth rates of gill surface area and body mass. This study tested the hypothesis in Oligocottus maculosus and found no support for it, suggesting a distributed control of oxyregulatory capacity instead. Gill surface area scaling was sufficient to meet oxygen demand and respiratory capacity did not change with body mass. These results indicate that the hypothesis does not explain the distribution of O. maculosus.
JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMS AND ENVIRONMENTAL PHYSIOLOGY
(2023)
Article
Physiology
Paige V. Cochrane, Michael G. Jonz, Patricia A. Wright
Summary: The study shows that the development of NEC in K. marmoratus is largely unaffected by environmental oxygen levels during the embryonic stage, suggesting interspecies variation in oxygen-induced plasticity in the oxygen-sensing system of fishes.
JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMS AND ENVIRONMENTAL PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yi Lei, Liandong Yang, Yu Zhou, Cheng Wang, Wenqi Lv, Lin Li, Shunping He
Summary: Research on the genetic basis of hypoxic adaptation in high-altitude environments is active in evolutionary biology. The study investigated Hb concentration in fish at different altitudes, finding species-specific Hb concentration with a non-positive correlation with altitude. The discovery of positively selected Hb genes in schizothoracinae fishes indicates potential functional divergence in Hb isoforms.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Environmental Sciences
Patricia Pinto, L. Anjos, M. D. Estevao, S. Santos, C. Santa, B. Manadas, T. Monsinjon, Adelino V. M. Canario, D. M. Power
Summary: This study evaluated the impacts of exposure to fluoxetine (FLX) and 17 beta-estradiol (E2) on European sea bass scales and identified the complex disruptive effects of these pollutants on protein synthesis and energy metabolism. The study provides insights into the routes of action and potential biomarkers of pollutant exposure.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Physiology
Alyssa R. Mickle, Jesus D. Penaloza-Aponte, Richard Coffey, Natale A. Hall, David Baekey, Erica A. Dale
Summary: Closed-loop epidural stimulation (CL-ES) can improve respiratory deficits caused by cervical spinal cord injury, restoring diaphragm activity and enhancing contralateral activity. This treatment has the potential to lead to lasting recovery and device independence.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Article
Physiology
Shawn Miller Jr, Edgar Juarez Lopez, Jessica M. L. Grittner, Brendan J. Dougherty
Summary: This study tested the impact of CO2 supplementation at different concentrations on ventilatory long-term facilitation (vLTF) in rats and found that 2% CO2 supplementation during and after acute, intermittent hypoxia (AIH) was sufficient to maintain isocapnia and induce significant vLTF.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Article
Physiology
Behnam Vafadari, Yoshitaka Oku, Charlotte Tacke, Ali Harb, Swen Huelsmann
Summary: The preBo·tzinger Complex (preBo·tC) in the brainstem plays a critical role in generating respiratory rhythm. This study aimed to investigate the activity of inhibitory glycinergic neurons in the preBo·tC of anesthetized mice. Using juxtacellular recordings and optogenetic activation, the researchers were able to identify and characterize the activity pattern of these inhibitory neurons in relation to the breathing rhythm.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Article
Physiology
Stephen M. Johnson, Maia G. Gumnit, Sarah M. Johnson, Tracy L. Baker, Jyoti J. Watters
Summary: Low-level activation of mu-opioid receptors can increase the amplitude of inspiratory bursts in neonatal rat brainstem-spinal cord preparations. Endomorphin-2, an endogenous ligand for these receptors, was found to have similar effects. Disinhibition of inhibitory synaptic transmission may not be involved in the changes induced by endomorphin-2, and different mechanisms may underlie the increase in burst amplitude and decrease in burst frequency.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Article
Physiology
Raphael Martins de Abreu, Beatrice Cairo, Patricia Rehder-Santos, Claudio Donisete da Silva, Etore De Favari Signini, Juliana Cristina Milan-Mattos, Camila Akemi Sakaguchi, Aparecida Maria Catai, Alberto Porta
Summary: The purpose of this study was to determine the association between exercise capacity based on peak oxygen uptake (VO2peak) and resting cardiorespiratory coupling (CRC) levels. The results showed that resting CRC values were associated with exercise capacity in athletes but not in non-athletes.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Article
Physiology
Sarah M. Russel, Raluca E. Gosman, Katherine Gonzalez, Joshua Wright, Dennis O. Frank-Ito
Summary: This study aimed to characterize the response of different nasal morphologies to airflow-related variables during rapid/deep inspiration. The results showed that notched nasal vestibules had higher resistance values and airflow velocities, while standard nasal vestibules had higher mucosal heat flux. Different nasal phenotypes may predispose individuals to exercise-induced rhinitis.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Article
Physiology
Ivan Poliacek, Lukas Martvon, Michal Simera, Marcel Veternik, Jakub Misek, Lucia Cibulkova, Kimberly E. Iceman, Donald C. Bolser, Teresa Pitts
Summary: An animal model study evaluated the effects of an abdominal incision on cough and swallow, revealing that abdominal wall manipulations can increase pharyngeal muscle activity during swallow without affecting the cough reflex. Swallowing tended to occur more during the inspiratory phase. The results highlight the important role of abdominal wall sensory feedback in regulating swallow motor patterns.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Article
Physiology
Rui Yu, Tatsuma Okazaki, Yuzhuo Ren, Junko Okuyama, Satoru Ebihara, Shin-Ichi Izumi
Summary: Body postures significantly influence respiratory muscle force, cough pressure, subjective ease of coughing, and pulmonary function. The 60-degree semi-recumbent posture and sitting posture show better results compared to the supine posture.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Article
Physiology
Suzuna Sato, Koji Ishida, Noriko I. Tanaka, Keisho Katayama
Summary: Respiratory muscle endurance training has beneficial effects on whole-body endurance performance. A novel high-intensity interval (HII) protocol is found to enhance the efficacy of respiratory muscle training programs.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Letter
Physiology
R. Arieli
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Correction
Physiology
Ivan Poliacek, Michal Simera, Marcel Veternik, Zuzana Kotmanova, Teresa Pitts, Jan Hanacek, Jana Plevkova, Peter Machac, Nadezda Visnovcova, Jakub Misek, Jan Jakus
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Article
Physiology
Dimitrios I. Bourdas, Nickos D. Geladas
Summary: This study examined the effects of breath-hold training on the performance of novice and elite breath-hold divers. The results showed that breath-hold training significantly improved red blood cell concentration, hemoglobin oxygen saturation steady state duration, and breath-hold time in novice divers. Elite divers had better breath-hold performance and higher peak mean arterial pressure compared to novices. The study suggests that breath-hold training can enhance the performance of divers.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)