Article
Biology
Maria Nikolova, Mladen Naydenov, Ilias Glogovitis, Apostol Apostolov, Merli Saare, Nageswara Boggavarapu, Andres Salumets, Vesselin Baev, Galina Yahubyan
Summary: Research has shown that miR/isomiR play a crucial role in regulating embryo implantation, with dynamic changes in their expression patterns and interactions with target genes influencing the establishment of endometrial receptivity. This study highlights the complex regulatory network involved in endometrial miR/isomiR dynamics and their impact on implantation failure-related pathologies, providing insights into potential therapeutic targets for improving fertility outcomes.
Article
Multidisciplinary Sciences
Pu Cheng, Jiong Ma, Xia Zheng, Chunxia Zhou, Xuejun Chen
Summary: This study investigated immune-related prognostic markers for endometrial carcinoma (EC) and identified gene modules and pathways associated with the immune microenvironment in EC. A total of 14 novel immune-related prognostic biomarkers were identified, providing insights into the tumor microenvironment and potential novel therapeutic targets for EC.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Junyu Zhai, Shang Li, Jingwen Hu, Minzhi Gao, Yun Sun, Zi-Jiang Chen, Linda C. Giudice, Yanzhi Du
Summary: This study assessed the profiling of core circadian clock genes in the human endometrium across the menstrual cycle, with a focus on the role of PER2 in window of implantation (WOI) and recurrent implantation failure (RIF). The research found varied expression of circadian clock genes and confirmed the positive regulation of PER2 to SHTN1, KLF5, and STEAP4 in compromised endometrial receptivity and RIF. Aberrant expression of endometrial PER2 may contribute to impaired endometrial receptivity and development of RIF through the regulation of SHTN1, KLF5, and STEAP4.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Environmental Sciences
Yuxiang Liang, Qizhi Shuai, Ying Wang, Shanshan Jin, Zihan Feng, Binghong Chen, Ting Liang, Zhizhen Liu, Hong Zhao, Zhaoyang Chen, Chunfang Wang, Jun Xie
Summary: The study reveals that 1-NP has adverse effects on embryo implantation in mice and endometrial receptivity in humans, possibly achieved through inhibition of signaling pathways, receptor expression, and cell proliferation.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Obstetrics & Gynecology
Merli Saare, Ankita Lawarde, Vijayachitra Modhukur, Iveta Mikeltadze, Helle Karro, Ave Minajeva, Andres Salumets, Maire Peters
Summary: The study found that there is no synchronicity between paired samples of endometrium and ovarian endometriomas throughout the menstrual cycle, suggesting a need to revise the concept of cycling endometrial tissue inside the endometriomas.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Genetics & Heredity
Zhaochong Tan, Limeng Wu, Yan Fang, Pingshan Chen, Rong Wan, Yang Shen, Jianping Hu, Zhenhong Jiang, Kui Hong
Summary: This study analyzed the expression pattern of nuclear-encoded mitochondrial genes in HCM and identified 316 differentially expressed NMGenes. Pathway enrichment analysis and protein-protein interaction network construction revealed the dysregulation of energy metabolism-related pathways and identified potential transcription factors regulating the expression of DE-NMGenes. Furthermore, a mouse model was used to validate the upregulation of certain genes in HCM.
FRONTIERS IN GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Hanqing Liu, Ziwen Lu, Xiaofeng Shi, Lanlan Liu, Peishan Zhang, Erica A. Golemis, Zhigang Tu
Summary: The study found that HSP90 inhibition effectively suppresses the growth of MCL cells, with 12-hour exposure almost as efficient as continuous exposure. By transcriptome analysis and functional studies, several genes were consistently downregulated in MCL cells after transient ganetespib treatment, which are involved in DNA replication and repair.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Oncology
Shunsuke Hanaki, Makoto Habara, Takahiro Masaki, Keisuke Maeda, Yuki Sato, Makoto Nakanishi, Midori Shimada
Summary: The study uncovered that NIPP1 functions as a modulator of E2F1 target genes by linking PKA and PP1γ during DNA damage, playing a crucial role in cell proliferation.
Article
Plant Sciences
Mouboni Dutta, Anusree Saha, Mazahar Moin, Pulugurtha Bharadwaja Kirti
Summary: This study analyzed the expression patterns of rice GRAS TF genes under abiotic and biotic stress conditions, identifying genes that were induced immediately after stress onset, especially in the roots of ABA-treated plants. OsGRAS39 was found to be highly expressed under sheath blight infection and abiotic stress treatments, with OsGRAS8, OsSHR1 and OsSLR1 also showing responsiveness. The research suggests that GRAS genes are potential candidate genes for enhancing stress tolerance in rice and other crop plants.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Tianyi Wang, Bingxin Zhang, Danhui Li, Xiaoli Qi, Chijin Zhang
Summary: The study identified specific gene signatures in pediatric AD compared to adult AD, with up-regulated genes involving granulocyte and neutrophil migration and chemotaxis, and down-regulated genes relating to biological adhesion. Pathway analysis revealed up-regulated genes participating in chemokine signaling, while down-regulated genes were involved in junctions and cytoskeleton regulation. Hub genes identified in the study could serve as potential therapeutic targets and diagnostic biomarkers for pediatric AD.
BIOSCIENCE REPORTS
(2021)
Article
Obstetrics & Gynecology
Amruta D. S. Pathare, Indira Hinduja
Summary: Recurrent implantation failure (RIF) is a major obstacle in IVF treatment. A study was conducted to analyze gene expression in non-pregnant RIF patients vs fertile women under controlled ovarian stimulation (COS), revealing significant downregulation of cell adhesion function and confirming downregulation of six out of eight related genes in RIF patients. These findings suggest the importance of these genes in the endometrial receptivity (ER) mechanism under COS. Additional analysis in larger cohorts is needed to validate the study findings in RIF patients undergoing IVF.
REPRODUCTIVE SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Madhu Sudhana Saddala, Xu Yang, Shibo Tang, Hu Huang
Summary: This study identified the core set of sensome and pro-inflammatory genes and their regulators in retinal microglial cells using transcriptome and data mining approaches. The transcriptional regulators identified may play crucial roles in regulating the sensome and inflammatory genes of RMCs and contribute to the pathogenesis of retinal neurodegenerative diseases.
Article
Biochemical Research Methods
Feng Pang, Dong Shi, Lin Yuan
Summary: Cervical cancer, ovarian cancer, and endometrial cancer are the top three cancers in women. This study utilized gene chip and high-throughput sequencing technology to analyze genomic functional omics data and identify potential markers for diagnosis and treatment. The study also explored common differentially expressed genes (DEGs) among these cancers using public databases. The results revealed that DEGs were involved in biological processes such as cell division, mitotic nuclear division, sister chromatid cohesion, and DNA replication. The DEGs also exhibited specific functions in cell components and molecular functions. Additionally, pathway analysis indicated enrichment of upregulated DEGs in cell cycle-related pathways, while downregulated DEGs were enriched in pathways related to thiamine metabolism and protein processing in the endoplasmic reticulum. The most significant module was associated with cell division and microtubule motor activity.
CURRENT BIOINFORMATICS
(2023)
Article
Biotechnology & Applied Microbiology
Martyna Gongerowska-Jac, Marcin Jan Szafran, Dagmara Jakimowicz
Summary: This study introduces a novel approach to identify regulatory proteins that control transcription in Streptomyces. The experimental results demonstrate that the SCO4804 gene positively influences the transcription of topA, revealing a new player in the control of chromosome topology in these bacteria.
MICROBIAL CELL FACTORIES
(2021)
Article
Oncology
Yan Fu, Cheng'en Hu, Peizhun Du, Guangjian Huang
Summary: E2F1 plays a significant role in maintaining gastric cancer stemness properties and is closely associated with clinical characteristics and prognosis in gastric cancer patients. High expression of E2F1 is correlated with worse overall survival, suggesting its potential as a prognostic biomarker and therapeutic target in gastric cancer.
JOURNAL OF ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Johanna Abrigo, Fabian Campos, Felipe Simon, Claudia Riedel, Daniel Cabrera, Cristian Vilos, Claudio Cabello-Verrugio
BIOLOGICAL CHEMISTRY
(2018)
Article
Chemistry, Multidisciplinary
Abhishek Sahu, Youngmin Hwang, Cristian Vilos, Jong-Min Lim, Sunghyun Kim, Won Il Choi, Giyoong Tae
Review
Cell Biology
Johanna Abrigo, Alvaro A. Elorza, Claudia A. Riedel, Cristian Vilos, Felipe Simon, Daniel Cabrera, Lisbell Estrada, Claudio Cabello-Verrugio
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2018)
Review
Pharmacology & Pharmacy
Maria Francisca Matus, Cristian Vilos, Bruno A. Cisterna, Eduardo Fuentes, Ivan Palomo
VASCULAR PHARMACOLOGY
(2018)
Article
Nanoscience & Nanotechnology
Maria Francisca Matus, Martin Luduena, Cristian Vilos, Ivan Palomo, Marcelo M. Mariscal
BEILSTEIN JOURNAL OF NANOTECHNOLOGY
(2018)
Editorial Material
Cell Biology
Claudio Cabello-Verrugio, Cristian Vilos, Raquel Rodrigues-Diez, Lisbell Estrada
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2018)
Article
Medicine, General & Internal
Ariel Fuentes, Karina Sequeira, Alejandro Tapia
REVISTA MEDICA DE CHILE
(2019)
Article
Chemistry, Multidisciplinary
Juan P. Garcia-Lopez, Cristian Vilos, Carmen G. Feijoo
JOURNAL OF CONTROLLED RELEASE
(2019)
Article
Multidisciplinary Sciences
Bruno A. Cisterna, Anibal A. Vargas, Carlos Puebla, Paola Fernandez, Rosalba Escamilla, Carlos F. Lagos, Maria F. Matus, Cristian Vilos, Luis A. Cea, Esteban Barnafi, Hugo Gaete, Daniel F. Escobar, Christopher P. Cardozo, Juan C. Saez
NATURE COMMUNICATIONS
(2020)
Article
Medicine, Research & Experimental
Johanna Abrigo, Felipe Simon, Daniel Cabrera, Cristian Vilos, Claudio Cabello-Verrugio
Summary: This study evaluated the effects of combined administration of andrographolide and Ang-(1-7) on a murine model of sarcopenia by aging. The results showed that the combination treatment improved physical performance, muscle strength, and fiber diameter in the aged mice.
CURRENT MOLECULAR MEDICINE
(2022)
Review
Biotechnology & Applied Microbiology
Franco Tacchi, Josue Orozco-Aguilar, Danae Gutierrez, Felipe Simon, Javier Salazar, Cristian Vilos, Claudio Cabello-Verrugio
Summary: Skeletal muscle is crucial for human body function, but pathological conditions like trauma or genetic diseases can impair it. Tissue engineering with biomaterials can promote skeletal muscle regeneration, and new technologies with nanocarriers offer unique therapeutic options.
Review
Cell Biology
Andrea Gonzalez, Felipe Simon, Oscar Achiardi, Cristian Vilos, Daniel Cabrera, Claudio Cabello-Verrugio
Summary: Sarcopenic obesity is a condition that combines obesity and sarcopenia, primarily occurring in older individuals. It is associated with metabolic syndrome and increased risk factors. Oxidative stress plays a critical role in the pathophysiology of sarcopenic obesity.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Review
Biotechnology & Applied Microbiology
Leandro Zuniga, Angel Cayo, Wendy Gonzalez, Cristian Vilos, Rafael Zuniga
Summary: This article summarizes the important role of potassium channels in cancer, including promoting cell proliferation, resistance to apoptosis, metabolic changes, angiogenesis, and migratory capabilities, and discusses strategies for designing new drugs.
ONCOTARGETS AND THERAPY
(2022)
Article
Medicine, Research & Experimental
Nitin Bharat Charbe, Carlos F. Lagos, Cristian Andres Vilos Ortiz, Murtaza Tambuwala, Sushesh Srivatsa Palakurthi, Flavia C. Zacconi
Summary: Ligand-based targeting using PCSK9 conjugated liposomes shows promising potential as a targeted delivery system for cancer treatment, with significantly higher growth inhibition in cancer cells compared to unconjugated liposomes.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Pharmacology & Pharmacy
Javier Salazar, Thais Carmona, Flavia C. Zacconi, Diego Venegas-Yazigi, Claudio Cabello-Verrugio, Won Il Choi, Cristian Vilos
Summary: Skin plays a preventive role in protecting the body's internal organs from damage caused by microorganisms and external environmental assaults. The dermis, representing the main section of the skin, contributes critically to skin physiology due to its diverse cellularity, vasculature, and release of molecular mediators. The complex structure of the skin limits substance transport, leading to the study of different nanoparticles for skin illness treatment and dermo-cosmetic applications. This study provides a detailed morphological description of the dermis, analyzes its role in regulating skin homeostasis and its alterations in pathophysiological conditions, and highlights its potential as a therapeutic target. Additionally, the use of nanoparticles for skin illness treatments, focusing on dermis release, and the promotion of metal-organic frameworks as an integrative strategy for skin treatments are described.