Article
Pharmacology & Pharmacy
Xueping Yang, Qingyun Yv, Fanlong Ye, Sheng Chen, Zhang He, Wenwei Li, Fang Dong
Summary: This study found that Echinacoside (ECH) exerts neurotrophic and anti-inflammatory effects by regulating the IL-6/JAK2/STAT3 pathway and the phosphorylation of STAT3, promoting the mutually beneficial influence of the two effects to maximize its neuroprotective function.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jia-jia Xu, Run-jing Li, Zheng-hao Zhang, Cui Yang, Shi-xiao Liu, Yan-ling Li, Min-wei Chen, Wei-wei Wang, Gong-ye Zhang, Gang Song, Zheng-rong Huang
Summary: Loganin alleviates Ang II-induced cardiac hypertrophy through inhibiting the JAK2/STAT3 and NF-kappa B signaling pathways, reducing cardiac fibrosis and pro-inflammatory cytokine secretion. Additionally, Loganin demonstrates no toxicity or side effects on normal cells and organs.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Sijia Li, Chenguang Zhou, Yinghui Zhu, Zhiwen Chao, Zhiyuan Sheng, Yongxin Zhang, Yuanzheng Zhao
Summary: The study shows that Ferrostatin-1 can effectively protect astrocytes from ferroptosis induced by Angiotensin II, reduce the production of inflammatory factors, and exert protective effects by activating the Nrf2/HO-1 signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Cell Biology
Ruowen Gong, Ruyi Han, Xiaonan Zhuang, Wenyi Tang, Gezhi Xu, Lei Zhang, Jihong Wu, Jun Ma
Summary: miR-375 alleviates cell proliferation and angiogenesis in retinal microvascular endothelial cells, potentially providing new therapeutic targets for retinal diseases.
Article
Cell Biology
Xuhui Fan, Haotian Fu, Ni Xie, Hangcheng Guo, Tiantian Fu, Yunfeng Shan
Summary: The study revealed that panaxadiol significantly inhibited proliferation and induced apoptosis in human pancreatic cancer cells, as well as suppressed the migration of pancreatic cancer cells, suggesting its potential as an anti-tumor agent for pancreatic cancer treatment.
Article
Immunology
Yuanyuan Wu, Zhipeng Sun, Tingting Wang, Yan Wang, Liang Zhong, Fanli Kong
Summary: The anti-inflammatory agent MaR1 has been found to ameliorate cognitive dysfunction, Tau hyperphosphorylation, and synaptic protein reduction induced by repeated exposure to sevoflurane during the postnatal period. The protective effect of MaR1 is mediated through the JAK2/STAT3/IL-6 signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Xuankang Wang, Xin Li, Xiaoshuang Zuo, Zhuowen Liang, Tan Ding, Kun Li, Yangguang Ma, Penghui Li, Zhijie Zhu, Cheng Ju, Zhihao Zhang, Zhiwen Song, Huilin Quan, Jiawei Zhang, Xueyu Hu, Zhe Wang
Summary: This study found that PBM can promote motor function recovery, inhibit the activation of neurotoxic microglia and astrocytes, alleviate neuroinflammation and tissue apoptosis, and increase the number of neurons retained after SCI. It was also observed that PBM can suppress the Lcn2/JAK2-STAT3 crosstalk involved in the activation of neurotoxic microglia and astrocytes after SCI.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Plant Sciences
Rong Wang, Xiaolong Hu, Jingjin Wang, Lina Zhou, Yu Hong, Yuanhao Zhang, Fei Xiong, Xiaoqi Zhang, Wen-Cai Ye, Hao Wang
Summary: The study identified proanthocyanidins (PS-1-4) from peanut skin as platelet-enhancing ingredients to improve chemotherapy-induced thrombocytopenia (CIT). PS-1 was shown to promote the proliferation and differentiation of MKs via the JAK2/STAT3 pathway, both in vitro and in vivo.
Article
Pharmacology & Pharmacy
Chien-Yi Hsu, Thi Thuy Tien Vo, Chiang-Wen Lee, Yuh-Lien Chen, Wei-Ning Lin, Hsin-Chung Cheng, Quang Chanh Vo, I-Ta Lee
Summary: The study found that CORM-2 can inhibit Ang II-induced inflammatory responses and alleviate the proliferation, migration, and inflammation of vascular smooth muscle cells. In addition, CORM-2 also reduces monocyte adhesion and cell migration by inhibiting specific molecules and signaling pathways. The results of the study also suggest that CORM-2 can reverse Ang II-induced IL-6 overexpression by activating Nrf2 and HO-1.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Hematology
Tong Wei, Jing Gao, Chenglin Huang, Bei Song, Mengwei Sun, Weili Shen
Summary: The study found that infiltration macrophages play a key role in promoting perivascular adipose tissue remodeling in hypertensive mice. SIRT3-mediated metabolic shift regulates NLRP3 inflammasome activation, with potential therapeutic implications. Ang II accelerates adipose tissue inflammation and fibrosis, highlighting the role of SIRT3 in metabolic inflammation.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Minmin Xu, Li Ren, Jinhua Fan, Lu Huang, Liming Zhou, Xuegang Li, Xiaoli Ye
Summary: Berberine was found to inhibit proliferation, induce apoptosis and cell cycle arrest of gastric cancer cells, as well as suppress migration and invasion. In addition, it was shown to modulate signaling pathways related to IL-6/JAK2/STAT3, providing a theoretical basis for its use in gastric cancer prevention.
Article
Fisheries
Jixiu Wang, Qianhui Sun, Jiaqi Wu, Wanping Tian, Huanling Wang, Hong Liu
Summary: This study identifies the functional distinctions and overlaps among the four maSTAT3 isoforms in blunt snout bream and reveals the differential regulation of IL-6 classical signaling and trans-signaling on downstream immune genes via the JAK2/ STAT3 pathway.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Mengting Zhang, Wanhong Wu, Caoxin Huang, Teng Cai, Nengjiang Zhao, Suhuan Liu, Shuyu Yang
Summary: This study investigated the effects and mechanisms of the traditional Chinese medicine formula SX-1 in treating chronic stress-induced depression and liver injury. The results showed that SX-1 effectively ameliorated depression-like behaviors and hepatic injuries caused by chronic stress, possibly through the blockade of hepatic IL-6/JAK2/STAT3 signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Tongzhou Liang, Taiqiu Chen, Jincheng Qiu, Wenjie Gao, Xianjian Qiu, Yuanxin Zhu, Xudong Wang, Yanbo Chen, Hang Zhou, Zhihuai Deng, Pengfei Li, Caixia Xu, Yan Peng, Anjing Liang, Peiqiang Su, Bo Gao, Dongsheng Huang
Summary: Evidence suggests that ROR alpha plays a crucial role in cartilage development and OA pathogenesis by regulating the expression of cartilage matrix components. Blocking ROR alpha can reverse cartilage damage and elevate the expression of cartilage matrix components. Additionally, ROR alpha affects the IL-6/STAT3 signaling pathway, highlighting its potential as a treatment target in OA therapy.
CELL DEATH & DISEASE
(2021)
Article
Geriatrics & Gerontology
Ping Li, Qian Wu, Xiaoqiong Li, Bangyan Hu, Wen Wen, Shijun Xu
Summary: Shenqi Yizhi Granule (SYG) may exert protective effects on cognitive impairment induced by amyloid-beta oligomers through inhibition of astrocyte reactivity regulated by the JAK2/STAT3 signaling pathway, suggesting its potential therapeutic value for neurological and psychiatric disorders such as Alzheimer's disease.
EXPERIMENTAL GERONTOLOGY
(2021)