Article
Medicine, General & Internal
Haley Nakata, Tara Shelby, Jennifer C. Wang, Gabriel J. Bouz, Cory K. Mayfield, Daniel A. Oakes, Jay R. Lieberman, Alexander B. Christ, Nathanael D. Heckmann
Summary: This study aimed to assess the complications associated with the combinations of non-steroidal anti-inflammatory drugs (NSAIDs) in patients who underwent total joint arthroplasty (TJA). The study found that certain combinations of NSAIDs were associated with increased odds of acute kidney injury, stroke, and periprosthetic joint infection. Therefore, caution should be exercised when prescribing NSAIDs.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Chen Yuan Kam, Ishani D. Singh, David G. Gonzalez, Catherine Matte-Martone, Paloma Sola, Guiomar Solanas, Julia Bonjoch, Edward Marsh, Karen K. Hirschi, Valentina Greco
Summary: A functional network of blood vessels is crucial for organ growth and homeostasis in live mice, but the mechanisms of vascular maturation and homeostasis are not fully understood. By tracking neonatal endothelial cells over time, researchers discovered that capillary plexus expansion is driven by vessel regression to optimize network perfusion. Neonatal endothelial cells rearrange and become stable in adulthood, while adult endothelial cells reactivate migration to assist vessel repair. Global ablation shows coordinated maintenance of the adult vascular architecture that allows for eventual network recovery. Additionally, neonatal remodeling and adult maintenance of the skin vascular plexus are regulated by temporally restricted VEGFR2 signaling. This study provides insights into the fundamental mechanisms underlying vascular maturation and adult homeostasis in vivo.
Review
Physiology
Jingwei Lu, Li Jiang, Yixuan Chen, Kexin Lyu, Bin Zhu, Yujie Li, Xueli Liu, Xinyue Liu, Longhai Long, Xiaoqiang Wang, Houping Xu, Dingxuan Wang, Sen Li
Summary: This review summarizes the effects of bFGF in tendon healing, including the promotion of neovascularization and acceleration of the inflammatory response in the inflammatory phase, stimulation of collagen secretion and acceleration of tendon healing in the cell proliferation phase, and promotion of collagen transition in the remodeling phase. However, excessive injection of bFGF may lead to negative effects.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Nuha Wazzan
Summary: This study presented the first available simulation of the interactions between four NSAIDs and a nanographene surface, revealing that the DIC@NG system had the largest binding energy, in agreement with experimental findings. The calculated results showed that the DIC@NG system had the most stable adsorption and highest removal rate, with the most negative free energy change.
ARABIAN JOURNAL OF CHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Hugo Ribeiro, Ines Rodrigues, Leonardo Napoleao, Luis Lira, Denise Marques, Manuel Verissimo, Jose Paulo Andrade, Marilia Dourado
Summary: This narrative review examines the safest NSAIDs to use in the elderly based on the best available evidence. Understanding patient characteristics and basic pharmacology can improve treatment safety and adherence.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Immunology
Jing Zhang, Hongguang Sheng, Xiaoyi Tang, Panpan Xia, Zhangwang Li, Minxuan Xu, Jianyong Ma, Yunfeng Shen, Peng Yu, Xiao Liu
Summary: According to a post-hoc analysis from the ORCHID trial, the use of non-steroidal anti-inflammatory drugs (NSAIDs) in hospitalized American adult COVID-19 patients is not associated with worse clinical outcomes, including 28-day mortality or hospital discharge. Furthermore, a meta-analysis of 14 studies involving 48,788 COVID-19 patients showed that NSAID use had a survival benefit and decreased the risk of severe COVID-19.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Gastroenterology & Hepatology
Sema Oncel, Marc D. Basson
Summary: The integrity of the gastrointestinal mucosa is crucial for gut homeostasis, and the balance between mucosal injury and healing is vital. Harmful agents such as acid, pepsin, nonsteroidal anti-inflammatory drugs, or Helicobacter pylori can break down the mucosal barrier and cause injury. The healing process involves complex and overlapping mechanisms that are regulated by extracellular factors. Current therapeutics aim to reduce damage to the gastrointestinal tract, but complete healing is not always achieved. Recent research focuses on improving mucosal defense and promoting mucosal repair directly.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Chemistry, Medicinal
Zhuming Zhang, Avijit Ghosh, Peter J. Connolly, Peter King, Thomas Wilde, Jianyao Wang, Yawei Dong, Xueliang Li, Daohong Liao, Hao Chen, Gaochao Tian, Javier Suarez, William G. Bonnette, Vineet Pande, Karen A. Diloreto, Yifan Shi, Shefali Patel, Beth Pietrak, Lawrence Szewczuk, Carlo Sensenhauser, Shannon Dallas, James P. Edwards, Kurtis E. Bachman, David C. Evans
Summary: This study reported a series of gut-restricted, selective COX-2 inhibitors characterized by high colonic exposure and minimized systemic exposure, showing significant inhibition of adenoma progression and survival extension in an APC(min/+) mouse model. However, their chemoprotective effects were mainly driven by systemic COX-2 inhibition, resulting in less than expected efficacies.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Zhao-Xuan Lu, Bing-Qing Dong, Heng-Le Wei, Liang Chen
Summary: This study aims to investigate potential predictors of non-steroidal anti-inflammatory drugs (NSAIDs) efficacy in migraine therapy and their influence on efficacy. The results showed that migraine-related and psychiatric parameters play a critical role in predicting the outcomes of acute migraine treatment. Additionally, the models based on predictors can optimize drug selection and improve treatment benefits.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Yiyuan Xia, Yifan Xiao, Zhi-Hao Wang, Xia Liu, Ashfaqul M. Alam, John P. Haran, Beth A. Mccormick, Xiji Shu, Xiaochuan Wang, Keqiang Ye
Summary: This study reveals that gut dysbiosis is associated with Alzheimer's disease (AD) pathogenesis and certain Bacteroides strains are found to be elevated in the gut microbiota of AD patients. Specifically, Bacteroides fragilis and its metabolites 12-HHTrE and PGE2 are shown to activate microglia and induce AD pathologies. Moreover, recolonization of mice with AD patient fecal samples containing these Bacteroides strains leads to the development of AD pathologies, accompanied by upregulation of the C/EBP beta/Asparaginyl endopeptidase (AEP) pathway, microglia activation, and cognitive disorders. The findings suggest a causal role for Bacteroides fragilis and its metabolites in activating microglia and inducing AD pathologies in transgenic mice.
NATURE COMMUNICATIONS
(2023)
Review
Environmental Sciences
Nguyen Chi Huynh, Thuy Thi Thanh Nguyen, Duyen Thi Cam Nguyen, Thuan Van Tran
Summary: Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used pharmaceuticals that enter water sources and cause adverse effects on aquatic organisms and humans. High concentrations of NSAIDs have been detected in wastewater, leading to genotoxicity, endocrine disruption, and other harmful effects. Metal-organic frameworks and advanced porous carbons have shown promise in effectively removing NSAIDs from water.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Multidisciplinary Sciences
Toru Imai, Katsuyuki Hazama, Yasuhiro Kosuge, Shinichiro Suzuki, Susumu Ootsuka
Summary: In this study, the efficacy of using rebamipide in combination with loxoprofen and diclofenac to prevent NSAID-induced lower gastrointestinal tract injury was evaluated using the FAERS and JADER databases. The results suggest that rebamipide may have a prophylactic effect.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Chunjiang Wang, Weijin Fang, Liying Song, Zhenzhen Deng, Zuojun Li, Linli Sun
Summary: This study investigated the clinical features of Kounis syndrome induced by non-steroidal anti-inflammatory drugs (NSAIDs). The most frequently involved NSAIDs were diclofenac, metamizole, and aspirin. Kounis syndrome mainly occurred within 30 minutes after administration, with a maximum latency of 1 month. Chest pain, dyspnea, and allergic reactions were the most common clinical manifestations.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Nutrition & Dietetics
Raymond John Playford, Michael James Weiser
Summary: Colostrum is the milk produced in the first few days after birth, containing high levels of immunoglobulins, antimicrobial peptides, and growth factors that are important for supporting growth, development, and immunologic defense. Numerous studies have shown therapeutic benefits of bovine colostrum for maintaining wellbeing, treating medical conditions, and in animal husbandry.
Article
Biochemistry & Molecular Biology
Christina N. Banti, Angelos G. Kalampounias, Sotiris K. Hadjikakou
Summary: The low water solubility of aspirin has led to the development of new water-soluble formulations, such as SLS@ASPH micelle. The inhibitory activity of SLS@ASPH against LOX is 3.5-fold stronger than that of free SLS. The toxicity of SLS@ASPH was tested on HaCaT cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Glen Davison, Tania Marchbank, Daniel S. March, Rhys Thatcher, Raymond J. Playford
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2016)
Article
Physiology
Daniel S. March, Tania Marchbank, Raymond J. Playford, Arwel W. Jones, Rhys Thatcher, Glen Davison
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Tania Marchbank, Raymond J. Playford
Article
Biochemistry & Molecular Biology
Tania Marchbank, Nikki Mandir, Denis Calnan, Robert A. Goodlad, Theo Podasd, Raymond J. Playford
Article
Nutrition & Dietetics
Glen Davison, Arwel W. Jones, Tania Marchbank, Raymond J. Playford
EUROPEAN JOURNAL OF NUTRITION
(2020)
Article
Multidisciplinary Sciences
Raymond J. Playford, Tania Marchbank
Article
Nutrition & Dietetics
Raymond J. Playford, Mark Garbowsky, Tania Marchbank
JOURNAL OF NUTRITION
(2020)
Review
Biochemistry & Molecular Biology
Jorge Berlanga-Acosta, Ileidys Iglesias-Marichal, Nadia Rodriguez-Rodriguez, Yssel Mendoza-Mari, Ariana Garcia-Ojalvo, Maday Fernandez-Mayola, Raymond J. Playford
Article
Multidisciplinary Sciences
Raymond J. Playford, Meg Cattell, Tania Marchbank
Correction
Multidisciplinary Sciences
Raymond J. Playford, Meg Cattell, Tania Marchbank
Article
Multidisciplinary Sciences
Raymond John Playford, Michael James Weiser, Tania Marchbank
Summary: Soy and to a lesser extent casein enhanced the biostability of BC against digestive enzymes. Co-packaging BC with soy flour could result in a decreased dose being required, improving cost-effectiveness and patient compliance.
Article
Biochemistry & Molecular Biology
Jorge Berlanga-Acosta, Maday Fernandez-Mayola, Yssel Mendoza-Mari, Ariana Garcia-Ojalvo, Indira Martinez-Jimenez, Nadia Rodriguez-Rodriguez, Raymond J. Playford, Osvaldo Reyes-Acosta, Laura Lopez-Marin, Gerardo Guillen-Nieto
Summary: Lower-extremity arterial disease is a serious health issue that can lead to amputation, disability, and death. This study suggests the existence of a vascular tissue memory that can be transferred from humans to animals, causing arterial wall thickening and other vascular pathologies. The researchers found that the infiltration of arteriosclerotic tissue homogenates into rats resulted in significant thickening of arteriolar walls and other vascular changes. These findings may contribute to a better understanding of atherosclerosis pathobiology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Stephen J. Allen, Salma Belnour, Elizabeth Renji, Bernie Carter, Lucy Bray, Angela Allen, Emma Jones, Britta Urban, Sarah Moule, Duolao Wang, Raymond J. Playford
Summary: This study assessed the effectiveness of bovine colostrum in children and young people with Crohn's disease, showing that BC may be an acceptable nutritional supplement for this population.
Article
Medicine, General & Internal
Paul Kelly, Lauren Bell, Beatrice Amadi, Mutsa Bwakura-Dangarembizi, Kelley VanBuskirk, Kanta Chandwe, Miyoba Chipunza, Deophine Ngosa, Nivea Chulu, Susan Hill, Simon Murch, Raymond Playford, Andrew Prendergast
Article
Physiology
Tania Marchbank, Asif Mahmood, Raymond J. Playford
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2013)