Review
Cell Biology
Ning Zeng, Hongbo Chen, Yiping Wu, Zeming Liu
Summary: Wound healing in the human body is a complex physiological regulation mechanism, with adipose stem cells playing an important role in regenerative medicine. Adipose stem cells are easy to obtain, high-yielding, rich in components and cytokines, and highly practical.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Marek Konop, Mateusz Rybka, Adrian Drapala
Summary: Researchers are exploring the use of keratin biomaterials as wound dressings to aid in skin regeneration, due to their tissue biocompatibility, biodegradability, mechanical durability, and natural abundance properties.
Article
Chemistry, Medicinal
Alireza Afshar, Arezoo Khoradmehr, Fariborz Nowzari, Neda Baghban, Masoud Zare, Maryam Najafi, Seyedeh Zahra Keshavarzi, Fatemeh Zendehboudi, Gholamhossein Mohebbi, Alireza Barmak, Fatemeh Mohajer, Nahid Basouli, Mohammadreza Keshtkar, Aida Iraji, Fatemeh Sari Aslani, Cambyz Irajie, Iraj Nabipour, Mehdi Mahmudpour, Nader Tanideh, Amin Tamadon
Summary: The study aimed to evaluate the wound healing properties of brittle star extracts in vitro and in vivo. Hydroalcoholic extracts of brittle star undergoing arm regeneration were evaluated for their wound healing effect. GC-MS analysis, MTT cell viability and migration assays, Western blot, and computational analysis tests were performed. The study showed positive proliferative effects of the extracts, with certain compounds exhibiting strong affinity with proteins. In vivo analysis demonstrated that the extracts from 7 and 14 days of arm regeneration promoted wound healing and had better wound healing outcomes compared to other groups.
Review
Chemistry, Physical
Deborah dos Santos Gomes, Rayssa de Sousa Victor, Bianca Viana de Sousa, Gelmires de Araujo Neves, Lisiane Navarro de Lima Santana, Romualdo Rodrigues Menezes
Summary: This review article aims to explore the potential applications of ceramic nanofibers in regenerative medicine and analyze their characteristics and potential advantages by gathering the latest research findings.
Article
Materials Science, Biomaterials
Wanxin Guo, Binan Zhao, Muhammad Shafiq, Xiao Yu, Yihong Shen, Jie Cui, Yujie Chen, Pengfei Cai, Zhengchao Yuan, Mohamed EL-Newehy, Hany EL-Hamshary, Yosry Morsi, Binbin Sun, Jianfeng Pan, Xiumei Mo
Summary: The objective of this research was to screen for the effect of different types of bio-elastomers as hemostatic dressings. A PU-TA/Gel sponge was prepared, which showed promising potential in terms of porosity, water absorption ratio, cytocompatibility, hemolysis, clotting time, and wound healing. The sponge rapidly induced stable blood clots and good skin regeneration.
REGENERATIVE BIOMATERIALS
(2023)
Article
Endocrinology & Metabolism
S. E. Aragona, G. Mereghetti, G. Ciprandi
Summary: Wound healing requires time and cost, imposing burdens on patients, families, and society. The innovative approach of Wound Regeneration 4.0, integrating anti-inflammatory and regenerative medicine, has significantly shortened healing time, improved quality of life, and reduced costs. The use of LumiHeal(R) gel with multi-LED light promotes wound healing.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Article
Endocrinology & Metabolism
S. E. Aragona, G. Mereghetti, G. Ciprandi
Summary: Wound healing is a complex process that has been constantly evolving in our understanding. The field of Regenerative Medicine, focusing on the use of stem cells and biomaterials, has recently gained great attention. The healing process encompasses inflammatory reaction, cell proliferation, and extracellular matrix remodelling. However, wound repair often results in incomplete regeneration and hyperproduction of collagen, leading to new tissue with 80% similarity to the original tissue. Regenerative Medicine research has focused on in vitro and in vivo cellular models to study tissue repair and regeneration. This new perspective aims to shift the focus from inflammation to regeneration.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Review
Chemistry, Multidisciplinary
Ruotao Li, Kai Liu, Xu Huang, Di Li, Jianxun Ding, Bin Liu, Xuesi Chen
Summary: Skin wound repair is a complex process involving multiple cellular and molecular interactions. Bioactive materials can promote wound healing by modulating the wound microenvironment and cell behaviors.
Review
Anatomy & Morphology
Muhammad Fahad Amin, Muhammad Sarmad Zubair, Muhammad Ammar
Summary: Wound healing is a complex process involving various components like extracellular matrix, blood vessels, proteases, cytokines, and chemokines. Despite numerous studies and the development of various wound healing products, poor wound healing still leads to significant morbidity and mortality incidents. Understanding the effects of topical applications of therapeutic options, such as thyroxine, is crucial for promoting fast wound healing.
Review
Cell Biology
Diana Pereira, Ines Sequeira
Summary: Epithelial tissues have a natural ability for renewal and regeneration, crucial for providing the ultimate barrier against the external environment. The oral mucosa is known for its outstanding healing potential with minimal scarring, contributing to reducing fibrotic tissue formation. The combination of cell therapy and bioengineering to leverage the scarless properties of the oral mucosa for skin and esophageal wound healing is a promising avenue for achieving scarless wound healing.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Physical
Donald R. Griffin, Maani M. Archang, Chen-Hsiang Kuan, Westbrook M. Weaver, Jason S. Weinstein, An Chieh Feng, Amber Ruccia, Elias Sideris, Vasileios Ragkousis, Jaekyung Koh, Maksim Plikus, Dino Di Carlo, Tatiana Segura, Philip O. Scumpia
Summary: The study aimed to slow MAP scaffold degradation by changing the chirality of peptides, but unexpectedly, D-peptide crosslinked MAP scaffolds led to accelerated degradation in vivo, promoting tissue regeneration and enhancing wound healing. D-MAP triggered an immune response against D-chiral peptides and intact adaptive immune system was crucial for skin regeneration induced by the hydrogel.
Review
Chemistry, Multidisciplinary
Jiayi Mao, Lu Chen, Zhengwei Cai, Shutong Qian, Zhimo Liu, Binfan Zhao, Yuguang Zhang, Xiaoming Sun, Wenguo Cui
Summary: The review discusses the use of macrophage immunotherapy in promoting wound healing, as well as the importance of biomaterials in regulating macrophage signaling for tissue regeneration.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Review
Biotechnology & Applied Microbiology
Jianghui Qin, Fang Chen, Pingli Wu, Guoming Sun
Summary: Wound healing is a complex biological process with bioengineered scaffolds playing a key role in regenerative therapy. Although advancements have been made, challenges remain in achieving ideal treatment for deep cutaneous injuries. Designing innovative scaffolds, precursor development, and therapeutic interventions hold promise for future wound healing strategies.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Luisa A. DiPietro, Traci A. Wilgus, Timothy J. Koh
Summary: Macrophages play a prominent role in skin wound healing, with functions including host defense and support of new tissue growth. However, the exact role of macrophages in wound healing remains elusive, as some wounds can heal well even with limited or no functional macrophages. Recent advances in understanding macrophage phenotypes and cellular plasticity in wounds may provide new insights and paradigms on macrophage function in wounds.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Biomedical
Soung-Hoon Lee, Soohwan An, Yeong Chan Ryu, Seol Hwa Seo, Sohyun Park, Mi Jeong Lee, Seung-Woo Cho, Kang-Yell Choi
Summary: This study identifies a novel pro-regenerative material that promotes wound healing and scar reduction in mice by inhibiting the interaction between CXXC5 and Dvl. The material promotes wound healing by suppressing alpha-SMA expression and inducing stem cell marker expression, as well as inducing Collagen III expression for regenerative healing. These findings suggest that the material could be a potential therapeutic agent for promoting wound healing and scar attenuation.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Orthopedics
Nami Han, Mohammad A. Yabroudi, Kristen Stearns-Reider, Wendy Helkowski, Brian M. Sicari, J. Peter Rubin, Stephen F. Badylak, Michael L. Boninger, Fabrisia Ambrosio
Article
Engineering, Biomedical
Christopher L. Dearth, Timothy J. Keane, Christopher A. Carruthers, Janet E. Reing, Luai Huleihel, Christian A. Ranallo, Elizabeth W. Kollar, Stephen F. Badylak
ACTA BIOMATERIALIA
(2016)
Article
Engineering, Biomedical
Jian Zhang, Zhi Qian Hu, Neill J. Turner, Shi Feng Teng, Wen Yue Cheng, Hai Yang Zhou, Li Zhang, Hong Wei Hu, Qiang Wang, Stephen F. Badylak
Article
Engineering, Biomedical
Antonio D'Amore, Tomo Yoshizumi, Samuel K. Luketich, Matthew T. Wolf, Xinzhu Gu, Marcello Cammarata, Richard Hoff, Stephen F. Badylak, William R. Wagner
Article
Engineering, Biomedical
Harmanvir Ghuman, Andre R. Massensini, Julia Donnelly, Sung-Min Kim, Christopher J. Medberry, Stephen F. Badylak, Michel Modo
Article
Engineering, Biomedical
Jenna L. Dziki, Derek S. Wang, Catalina Pineda, Brian M. Sicari, Theresa Rausch, Stephen F. Badylak
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2017)
Article
Cell & Tissue Engineering
Juan Diego Naranjo, Michelle E. Scarritt, Luai Huleihel, Anjani Ravindra, Crisanto M. Torres, Stephen F. Badylak
REGENERATIVE MEDICINE
(2016)
Article
Cell & Tissue Engineering
Shahab A. Shaffiey, Hongpeng Jia, Timothy Keane, Cait Costello, Deena Wasserman, Maria Quidgley, Jenna Dziki, Stephen Badylak, Chhinder P. Sodhi, John C. March, David J. Hackam
REGENERATIVE MEDICINE
(2016)
Editorial Material
Multidisciplinary Sciences
Stephen F. Badylak
Article
Cell & Tissue Engineering
Dmitry Tukmachev, Serhiy Forostyak, Zuzana Koci, Kristyna Zaviskova, Irena Vackova, Karel Vyborny, Ioanna Sandvig, Axel Sandvig, Christopher J. Medberry, Stephen F. Badylak, Eva Sykova, Sarka Kubinova
TISSUE ENGINEERING PART A
(2016)
Review
Cell & Tissue Engineering
Lina M. Quijano, Kristen M. Lynch, Christopher H. Allan, Stephen F. Badylak, Tabassum Ahsan
TISSUE ENGINEERING PART B-REVIEWS
(2016)
Article
Oncology
Daisuke Matsui, Ali H. Zaidi, Samantha A. Martin, Ashten N. Omstead, Juliann E. Kosovec, Luai Huleihel, Lindsey T. Saldin, Christina DiCarlo, Jan F. Silverman, Toshitaka Hoppo, Gene G. Finley, Stephen F. Badylak, Ronan J. Kelly, Blair A. Jobe
Review
Cell & Tissue Engineering
Ricardo Londono, Vijay S. Gorantla, Stephen F. Badylak
STEM CELLS INTERNATIONAL
(2016)
Article
Engineering, Biomedical
Tao Jin, Francesca J. Nicholls, William R. Crum, Harmanvir Ghuman, Stephen F. Badylak, Michel Modo
Article
Multidisciplinary Sciences
Jian Zhang, Wen Yue Cheng, Zhi Qian Hu, Neill J. Turner, Li Zhang, Qiang Wang, Stephen F. Badylak