Article
Genetics & Heredity
Yuanxue Yang, Yun Zhang, Aiyu Wang, Ailing Duan, Chao Xue, Kaiyun Wang, Ming Zhao, Jianhua Zhang
Summary: This study investigated the resistance of Spodoptera frugiperda to insecticides and the regulatory roles of miRNAs. RNA-Seq analysis revealed that differentially expressed miRNAs play an important role in the insecticide resistance of S. frugiperda. Overexpression of specific miRNAs significantly increased the mortality of S. frugiperda to insecticides.
FRONTIERS IN GENETICS
(2022)
Article
Clinical Neurology
Rukiye Tekdemir, Yavuz Selvi, Kursat Altinbas, Nadir Kocak
Summary: This study found that miRNAs play an important role in the pathogenesis of bipolar disorder and may serve as biomarkers for diagnosis and screening of the disorder.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Biology
Yun Ji, Lulu Wang, Guanglei Chang, Juan Yan, Liping Dai, Zhenyu Ji, Jingjing Liu, Meixia He, Hongliang Xu, Liguo Zhang
Summary: By analyzing genomic data, this study identified miR-421 and miR-550a-1 as potential prognostic indicators for esophageal adenocarcinoma (EAC). Experimental validation showed that these miRNAs were highly expressed in EAC tissues and cells, and their downregulation inhibited cell proliferation and migration. Additionally, 20 target mRNAs of these miRNAs were predicted, and 7 of them were found to have prognostic value. Some of these genes were enriched in the miRNA cancer pathway.
Article
Genetics & Heredity
Liping Zou, Qiwen Feng, Wei Xia, Changhong Zhu
Summary: This study aimed to identify common targets of miR-223-3p, miR-122-5p, and miR-93-5p in PCOS and assess their transcript levels in PCOS rat ovaries. Transcriptome profiles of granulosa cells from PCOS patients were analyzed to identify DEGs, followed by miRNA target prediction and functional analysis. The study identified several potential genes, including JMJD1C, PLCG2, SMAD3, FOSL2, TGFB1, TRIB1, GAS7, TRIM25, NFYA, and CALCRL, which may play a role in the development of PCOS. These findings contribute to the identification of potential biomarkers for the prevention and treatment of PCOS in the future.
FRONTIERS IN GENETICS
(2023)
Article
Cell Biology
Patricia de la Cruz-Ojeda, Tobias Schmid, Loreto Boix, Manuela Moreno, Victor Sapena, Juan M. Praena-Fernandez, Francisco J. Castell, Juan Manuel Falcon-Perez, Maria Reig, Bernhard Bruene, Miguel A. Gomez-Bravo, Alvaro Giraldez, Jordi Bruix, Maria T. Ferrer, Jordi Muntane
Summary: The study reveals that Sorafenib regulates a specific miRNA signature, where miR-200c-3p, miR-222-5p, and miR-512-3p have prognostic value and contribute to treatment response.
Article
Physiology
Jian Han, Xiaogang Cui, Tianqi Yuan, Zhiming Yang, Yue Liu, Yajuan Ren, Changxin Wu, Yunfei Bian
Summary: Circulating exosomal miRNAs have potential as biomarkers for diagnosis of cardiovascular diseases. In this study, the differentially expressed miRNAs in exosomes from plasma of SCAD patients were analyzed and their diagnostic potential for SCAD was investigated.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Pathology
Fengping Yan, Yuanyuan Chen, Xing Ye, Fu Zhang, Shiquan Wang, Le Zhang, Xiaoting Luo
Summary: Sudden cardiac death (SCD) is a major health threat and diagnostic challenges persist, especially in cases without positive autopsy findings. In this study, specific cardio-miRNAs were investigated as potential biomarkers for SCD diagnosis. The results showed that four cardio-miRNAs were significantly up-regulated in SCD samples, suggesting their potential as independent diagnostic biomarkers, with a combination of two miRNAs aiding in discriminating detailed causes of SCD.
DIAGNOSTIC PATHOLOGY
(2021)
Article
Microbiology
Ata Garajei, Milad Parvin, Hady Mohammadi, Abdolamir Allameh, Azin Hamidavi, Masoud Sadeghi, Azadeh Emami, Serge Brand
Summary: This study evaluated the expression of miR-486-3p, miR-561-5p, miR-548-3p, and miR-509-5p in tissue biopsy samples with and without OSCC. The results showed that the expression of miR-486-3p and miR-561-5p was significantly lower in cancer samples compared to normal tissue samples, while miR-548-3p expression increased in the OSCC group compared to the control group. There was no significant difference in miR-509-5p expression between OSCC and control groups.
Article
Biochemistry & Molecular Biology
Rosa Curcio, Giulia Poli, Consuelo Fabi, Chiara Sugoni, Maria Bruna Pasticci, Roberto Ferranti, Monica Rossi, Ilenia Folletti, Leandro Sanesi, Edoardo Santoni, Irene Dominioni, Massimiliano Cavallo, Giovanni Morgana, Lorenzo Mordeglia, Giovanni Luca, Giacomo Pucci, Stefano Brancorsini, Gaetano Vaudo
Summary: We investigated the association between circulating microRNAs and fibrosis development in COVID-19-related ARDS survivors. miR-17-5p, miR-223-3p, and miR-146a-5p were significantly down-regulated in patients with fibrosis-like lesions. Our results support the hypothesis that NLRP3-Inflammasome could be implicated in the process of fibrotic evolution of COVID-19-associated ARDS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Gabriela Loscalzo, Julia Scheel, Jose Santiago Ibanez-Cabellos, Eva Garcia-Lopez, Shailendra Gupta, Jose Luis Garcia-Gimenez, Salvador Mena-Molla, Alfredo Perales-Marin, Jose Morales-Rosello
Summary: In this study, 48 fetuses were evaluated using Doppler ultrasound and overexpressed miRNAs were identified in the cord blood of fetuses with late-onset fetal growth restriction (LO-FGR). The overexpressed miRNAs, including miR-25-3p, miR-185-5p, and miR-132-3p, were found to be associated with certain molecular pathways and gene ontologies related to cardiac development and neuron death. Furthermore, two miRNAs, miR-185-5p and miR-25-3p, were highlighted as important in cholesterol efflux and starvation responses associated with LO-FGR phenotypes. These findings suggest that evaluation of miR-25-3p, miR-132-3p, and miR-185-5p could serve as molecular biomarkers for the diagnosis and management of LO-FGR.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ah-Young Kwon, Ju-Yeon Jeong, Hyun Park, Sohyun Hwang, Gwangil Kim, Haeyoun Kang, Jin-Hyung Heo, Hye Jin Lee, Tae-Heon Kim, Hee Jung An
Summary: Alterations in miRNA expression are associated with cervical SqCC and metastasis, and miR-30e-5p may serve as an independent poor prognostic factor for survival.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Toxicology
Valentina Galbiati, Marine-Alexia Lefevre, Ambra Maddalon, Marc Vocanson, Martina Iulini, Marina Marinovich, Emanuela Corsini
Summary: The study investigates the role of miRNAs in dendritic cell maturation induced by contact sensitizers of different potency. Using iDCs derived from THP-1 cells, different contact allergens were tested. Results show the important role of miR-24-3p and miR-146a-5p in DCs activation. miR-24-3p is up-regulated by extreme and weak contact allergens, while miR-146a-5p is up-regulated by weak and moderate contact allergens and down-regulated by extreme ones. PKC beta is also involved in the expression of these miRNAs.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Clinical Neurology
Michaela Krivosova, Jana Adamcakova, Erik Kaadt, Birgitte Hviid Mumm, Dana Dvorska, Dusan Brany, Zuzana Dankova, Matus Dohal, Marek Samec, Nikola Ferencova, Ingrid Tonhajzerova, Igor Ondrejka, Igor Hrtanek, Peter Hutka, Miloslav Oppa, Juraj Mokry, Betina Elfving
Summary: This study investigated the plasma levels of vascular endothelial growth factor (VEGF) in children and adolescents with major depressive disorder (MDD) and examined the impact of antidepressant treatment on VEGF levels. The results showed that the levels of VEGF were significantly increased in depressed individuals and were decreased after a short course of antidepressant treatment. Additionally, certain microRNAs were found to be associated with the regulation of VEGF. This study supports the use of VEGF as a biomarker for MDD in children and adolescents and highlights the importance of understanding the underlying regulatory mechanisms.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Chairmandurai Aravindraja, Syam Jeepipalli, Krishna Mukesh Vekariya, Ruben Botello-Escalante, Edward K. L. Chan, Lakshmyya Kesavalu
Summary: This study aimed to investigate the global miRNA expression kinetics during the progression of periodontitis in mice infected with T. denticola. The results showed that T. denticola infection led to bacterial colonization and increased alveolar bone resorption. A total of 70 miRNAs with differential expression were identified, and miR-486, miR-126-3p, and miR-126-5p were found to be potential invasive biomarkers of T. denticola in periodontal disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Shuang Wu, Shihai Liu, Yongxian Cao, Geng Chao, Peng Wang, Huazheng Pan
Summary: This study identifies ZC3H13 as a potential tumor suppressor gene in hepatocellular carcinoma (HCC) and reveals the miR-362-3p/miR-425-5p-ZC3H13 axis as a regulatory pathway. The expression of ZC3H13 is closely associated with the prognosis and tumor immune infiltration in HCC.
Article
Orthopedics
Nami Han, Mohammad A. Yabroudi, Kristen Stearns-Reider, Wendy Helkowski, Brian M. Sicari, J. Peter Rubin, Stephen F. Badylak, Michael L. Boninger, Fabrisia Ambrosio
Article
Engineering, Biomedical
Christopher L. Dearth, Timothy J. Keane, Christopher A. Carruthers, Janet E. Reing, Luai Huleihel, Christian A. Ranallo, Elizabeth W. Kollar, Stephen F. Badylak
ACTA BIOMATERIALIA
(2016)
Review
Anatomy & Morphology
Ilea T. Swinehart, Stephen F. Badylak
DEVELOPMENTAL DYNAMICS
(2016)
Article
Engineering, Biomedical
Abigail E. Loneker, Denver M. Faulk, George S. Hussey, Antonio D'Amore, Stephen F. Badylak
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2016)
Article
Engineering, Biomedical
Jenna L. Dziki, Derek S. Wang, Catalina Pineda, Brian M. Sicari, Theresa Rausch, Stephen F. Badylak
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2017)
Editorial Material
Multidisciplinary Sciences
Stephen Badylak
Article
Cell & Tissue Engineering
Juan Diego Naranjo, Michelle E. Scarritt, Luai Huleihel, Anjani Ravindra, Crisanto M. Torres, Stephen F. Badylak
REGENERATIVE MEDICINE
(2016)
Article
Cell & Tissue Engineering
Shahab A. Shaffiey, Hongpeng Jia, Timothy Keane, Cait Costello, Deena Wasserman, Maria Quidgley, Jenna Dziki, Stephen Badylak, Chhinder P. Sodhi, John C. March, David J. Hackam
REGENERATIVE MEDICINE
(2016)
Editorial Material
Multidisciplinary Sciences
Stephen F. Badylak
Article
Cell & Tissue Engineering
Dmitry Tukmachev, Serhiy Forostyak, Zuzana Koci, Kristyna Zaviskova, Irena Vackova, Karel Vyborny, Ioanna Sandvig, Axel Sandvig, Christopher J. Medberry, Stephen F. Badylak, Eva Sykova, Sarka Kubinova
TISSUE ENGINEERING PART A
(2016)
Review
Cell & Tissue Engineering
Lina M. Quijano, Kristen M. Lynch, Christopher H. Allan, Stephen F. Badylak, Tabassum Ahsan
TISSUE ENGINEERING PART B-REVIEWS
(2016)
Article
Cell & Tissue Engineering
Keisuke Takanari, Yi Hong, Ryotaro Hashizume, Alexander Huber, Nicholas J. Amoroso, Antonio D'Amore, Stephen F. Badylak, William R. Wagner
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2016)
Article
Engineering, Biomedical
Tao Jin, Francesca J. Nicholls, William R. Crum, Harmanvir Ghuman, Stephen F. Badylak, Michel Modo
Article
Multidisciplinary Sciences
Jian Zhang, Wen Yue Cheng, Zhi Qian Hu, Neill J. Turner, Li Zhang, Qiang Wang, Stephen F. Badylak