Article
Nutrition & Dietetics
Chung Y. Hsu, Jung-Nien Lai, Woon-Man Kung, Chao-Hsien Hung, Hei-Tung Yip, Yu-Chen Chang, Cheng-Yu Wei
Summary: Tube feeding, specifically nasogastric tube (NGT) placement, is commonly used for patients with severe swallowing issues. This study in Taiwan aimed to determine the prevalence and outcomes of long-term NGT placement. The results showed that long-term NGT use was associated with a higher risk of comorbidities and mortality.
Article
Medicine, General & Internal
Poyin Huang, Yi-Chiung Hsu, Chien-Hsun Li, Sun-Wung Hsieh, Kuo-Wei Lee, Kun-Han Wu, Wen-Ching Chen, Chung-Wei Lin, Chun-Hung Chen
Summary: In this study, 100 dysphagia patients were evaluated using various methods and followed up to assess the association between dysphagia severity and subsequent pneumonia. Only VF-DSS was significantly associated with pneumonia, while other evaluations showed no correlation. Therefore, VF-DSS can be used to predict the occurrence of pneumonia in dysphagia patients.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Automation & Control Systems
Bernardo A. Hernandez Vicente, Paul A. Trodden, Sean R. Anderson
Summary: Model Predictive Control (MPC) is widely used in autonomous driving, typically with nonlinear physically derived models. However, feedback control systems can correct model errors, making it sufficient to use a linear time-invariant (LTI) model for control design, especially with robust control methods. This approach is often neglected in driverless car research. In this study, we propose a two-step control scheme based on Tube MPC (TMPC), using a low-order data-driven LTI model to handle uncertainty and ensuring constraint compliance despite modeling errors. The results show that an LTI model is effective for lane-keeping tasks, TMPC can prevent lane departure and collisions due to model uncertainty, and linear models allow for algorithmic improvements that significantly reduce computation time compared to naive MPC implementations.
IEEE TRANSACTIONS ON CONTROL SYSTEMS TECHNOLOGY
(2023)
Review
Biology
Ji-Youn Kim
Summary: This study summarized the experimentally induced oropharyngeal dysphagia rodent models reported so far, providing a basis for research on swallowing disorders.
Article
Multidisciplinary Sciences
Dougho Park, Seok Il Son, Min Sol Kim, Tae Yeon Kim, Jun Hwa Choi, Sang-Eok Lee, Daeyoung Hong, Mun-Chul Kim
Summary: Machine learning models were established to screen aspiration in patients with acute stroke. The Gugging Swallowing Screen (GUSS) was evaluated and compared with machine learning models. Among the models, the ridge regression model performed the best, with a higher sensitivity than the GUSS. The modified Rankin scale was identified as the most important feature for machine learning performance. The proposed machine learning prediction models are valid and practical for screening aspiration in patients with acute stroke.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Christopher Kobylecki, Irena Shiderova, Mihaela Boca, Emilia Michou
Summary: The severity of dysphagia in PD is closely related to the severity of falls, but not to gait freezing. This finding may help to pinpoint the anatomical substrate of levodopa-resistant axial symptoms in PD and provide insights for further management.
NEUROLOGICAL SCIENCES
(2022)
Article
Nutrition & Dietetics
Rachel Strahm, Manuel Weber, Reiner Wiest, Kai-Uwe Schmitt
Summary: This study examined the effects of early tube feeding compared to tube feeding after 24 hours on clinical parameters. Patients with percutaneous endoscopic gastrostomy (PEG) received tube feeding 4 hours after tube insertion following the updated ESPEN guidelines. An observational study analyzed whether the new scheme affected patient complaints, complications, or hospitalization duration. The study found that the new scheme did not impact patient complaints or complications, but it significantly reduced hospitalization duration.
Article
Medicine, Research & Experimental
Itzel Condado-Morales, Viktoria Sokolova, Per -Olof Wahlund, Kristine E. Heding, Sarah Auclair, Jonathan S. Kingsbury, Paolo Arosio, Nikolai Lorenzen
Summary: Monoclonal antibodies formulated as high-protein-concentration solutions may experience physical stability issues. This study proposes a two-step strategy using asymmetric field-flow fractionation (AF4) and polyethylene glycol (PEG) precipitation assays to identify antibodies with problematic behaviors at high concentrations. AF4 allows for the measurement of self-association and retention time, while PEG assay confirms problematic molecules and distinguishes between opalescence and high-viscosity issues. This strategy enables early selection of antibodies that are compatible with high-concentration formulations.
MOLECULAR PHARMACEUTICS
(2023)
Article
Construction & Building Technology
Lihua Chen, Pouyan Fakharian, Danial Rezazadeh Eidgahee, Mohammad Haji, Alireza Mohammad Alizadeh Arab, Younes Nouri
Summary: Recycled aggregate concrete is an effective solution for construction waste disposal and sustainable environmental development. However, its limitations in terms of elastic modulus and compressive strength restrict its use to non-structural cases. The use of composite columns can help overcome this limitation and predicting their compressive strength aids in their design.
JOURNAL OF BUILDING ENGINEERING
(2023)
Article
Medicine, General & Internal
Blessy Antony, Hannah Blau, Elena Casiraghi, Johanna J. Loomba, Tiffany J. Callahan, Bryan J. Laraway, Kenneth J. Wilkins, Corneliu C. Antonescu, Giorgio Valentini, Andrew E. Williams, Peter N. Robinson, Justin T. Reese, T. M. Murali
Summary: Predicting the incidence of long COVID using electronic health record data and machine learning methods is effective. Specific features like drugs and certain symptoms showed the highest influence on the prediction task.
Article
Clinical Neurology
Bingjie Li, Tong Zhang, Jun Zhao, Pengkun Li, Zhangwei Wu, Shengjie Zhao
Summary: This study aimed to predict nasogastric tube (NGT) removal in patients with poststroke dysphagia (PSD) by non-swallowing function assessment. The results showed that age, difference in swallowing function assessment scores, and item 9 of NIHSS were predictors of NGT removal. The predictive model established through non-swallowing assessment can predict swallowing recovery.
FRONTIERS IN NEUROLOGY
(2023)
Article
Immunology
Tai-Han Lin, Chih-Wei Yang, Wei-Kuo Chang
Summary: Oropharyngeal dysphagia is associated with an increased risk of pneumonia requiring hospitalization in older patients. PEG is a better choice than NGT for long-term enteral feeding in this patient population.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Clinical Neurology
Takaaki Hattori, Naoko Mitani, Yoshiyuki Numasawa, Reo Azuma, Satoshi Orimo
Summary: This study aimed to identify the neuroanatomical predictors of oropharyngeal dysphagia and tube dependency in patients with supratentorial or infratentorial ischemic strokes. The right precentral gyrus and parts of the internal capsule are associated with oropharyngeal dysphagia, while the four supratentorial areas are associated with tube dependency. The dorsal upper medulla is associated with both oropharyngeal dysphagia and tube dependency.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Ecology
Suchinta Arif, Aaron MacNeil
Summary: Ecologists often rely on observational data to understand causal relationships, but predictive techniques are not suitable for drawing causal conclusions. Instead, valid causal inference methods such as the backdoor criterion can be used to determine causal relationships in observational studies.
Article
Oncology
Nedeljko Jovanovic, Colleen Dreyer, Sarah Hawkins, Kendra Thouless, David Palma, Philip C. Doyle, Julie A. Theurer
Summary: Patients treated for oropharyngeal cancer are at increased risk for functional decline, with weight and swallowing-related quality of life decreasing significantly in the first year post-treatment regardless of feeding tube placement. These findings can improve patient monitoring and communication in the clinical setting, potentially leading to better outcomes for those with OPC.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Oncology
Richard C. Cardoso, Mona Kamal, Jhankruti Zaveri, Mark S. Chambers, G. Brandon Gunn, Clifton D. Fuller, Stephen Y. Lai, Frank E. Mott, Holly McMillan, Katherine A. Hutcheson
Summary: The study found a 31% prevalence of self-reported trismus, with severity correlating with quality of life and dysphagia. Trismus severity was negatively associated with T-stage, nodal stage, tumor sub-site, and concurrent chemoradiation.
SUPPORTIVE CARE IN CANCER
(2021)
Review
Oncology
Nicolette Taku, Li Wang, Adam S. Garden, David I. Rosenthal, G. Brandon Gunn, William H. Morrison, C. David Fuller, Jack Phan, Jay P. Reddy, Amy C. Moreno, Michael T. Spiotto, Gregory Chronowski, Shalin J. Shah, Lauren L. Mayo, Neil D. Gross, Renata Ferrarotto, X. Ronald Zhu, Xiaodong Zhang, Steven J. Frank
Summary: The rise in HPV-associated OPC, diagnosed at a young age with a good prognosis, has led to the need for treatment techniques like IMPT, which reduce side effects. Preclinical studies show that HPV-positive squamous cell carcinoma is more sensitive to proton radiation. Retrospective studies suggest that IMPT has lower rates of side effects compared to intensity-modulated photon radiotherapy. Two phase III trials are expected to provide evidence on the effectiveness of IMPT for these patients.
CURRENT TREATMENT OPTIONS IN ONCOLOGY
(2021)
Article
Otorhinolaryngology
Kevin Diao, Theresa P. Nguyen, Amy C. Moreno, Jay P. Reddy, Adam S. Garden, Catherine H. Wang, Samuel Tung, Congjun Wang, Xin A. Wang, David Rosenthal, Clifton D. Fuller, Gary B. Gunn, Steven J. Frank, William H. Morrison, Shalin J. Shah, Anna Lee, Michael T. Spiotto, Shirley Y. Su, Renata Ferrarotto, Jack Phan
Summary: The study observed a median overall survival of 44.3 months for patients receiving SBRT retreatment for recurrent head and neck cancers. Systemic therapy had a positive impact on improving regional and distant control, while toxicities were influenced by anatomic site and systemic therapy.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Fabiana Gregucci, Alba Fiorentino, Rosario Mazzola, Francesco Ricchetti, Ilaria Bonaparte, Alessia Surgo, Vanessa Figlia, Roberta Carbonara, Morena Caliandro, Maria Paola Ciliberti, Ruggero Ruggieri, Filippo Alongi
Summary: The study aimed to evaluate the ability of contrast-enhanced CT image-based radiomic analysis in predicting local response in pancreatic cancer patients treated with SBRT. The analysis identified GLCM25_Correlation and NID25_Busyness as independent predictive variables for LR, with promising predictive value. The findings suggest the potential for a more personalized approach to SBRT in different patient subgroups.
Article
Oncology
Luca Nicosia, Vanessa Figlia, Nicola Ricottone, Francesco Cuccia, Rosario Mazzola, Niccolo Giaj-Levra, Francesco Ricchetti, Michele Rigo, Fatemeh Jafari, Stefano Maria Magrini, Andrea Girlando, Filippo Alongi
Summary: This study aims to demonstrate the effectiveness of stereotactic body radiotherapy (SBRT) in delaying the switch to a subsequent systemic treatment in patients with oligoprogressive breast cancer. The results show that SBRT can delay the progression of treatment, but patient selection is necessary, and several predictive factors for individualized treatment have been identified.
CLINICAL & EXPERIMENTAL METASTASIS
(2022)
Article
Oncology
Francesco Cuccia, Rosario Mazzola, Vanessa Figlia, Niccolo Giaj-Levra, Luca Nicosia, Francesco Ricchetti, Michele Rigo, Giorgio Attina, Claudio Vitale, Edoardo Pastorello, Ruggero Ruggieri, Filippo Alongi
Summary: This study reports the retrospective data of patients who received stereotactic body radiotherapy for pulmonary oligometastases. The results suggest that SBRT is a feasible and effective treatment option with favorable outcomes and low toxicity. Sequential oligometastases patients have a higher survival advantage, and local control is associated with improved progression-free survival rates.
STRAHLENTHERAPIE UND ONKOLOGIE
(2022)
Article
Oncology
Francesco Cuccia, Michele Rigo, Vanessa Figlia, Niccolo Giaj-Levra, Rosario Mazzola, Luca Nicosia, Francesco Ricchetti, Giovanna Trapani, Antonio De Simone, Davide Gurrera, Stefania Naccarato, Gianluisa Sicignano, Ruggero Ruggieri, Filippo Alongi
Summary: This study reports the preliminary data of using 1.5T MR-Linacs for prostate or prostate bed re-irradiation. The study found that this treatment option has minimal toxicity and encouraging clinical outcomes.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Stefania Naccarato, Michele Rigo, Roberto Pellegrini, Peter Voet, Hafid Akhiat, Davide Gurrera, Antonio De Simone, Gianluisa Sicignano, Rosario Mazzola, Vanessa Figlia, Francesco Ricchetti, Luca Nicosia, Niccolo Giaj-Levra, Francesco Cuccia, Nadejda Stavreva, Dobromir S. Pressyanov, Pavel Stavrev, Filippo Alongi, Ruggero Ruggieri
Summary: This study compared the adaptive planning and manual planning for SBRT treatment of prostate cancer. The study found that the automated planning (mCycle) performed better than manual planning in terms of target dose coverage and rectal dose sparing on the 1.5T MR-Linac. However, mCycle plans consumed slightly more delivery time and monitor units. This study provides a feasible solution for adaptive planning on the 1.5T MR-Linac.
ADVANCES IN RADIATION ONCOLOGY
(2022)
Article
Medicine, General & Internal
Luca Nicosia, Giovanna Trapani, Michele Rigo, Matilde Fiorini, Niccolo Giaj-Levra, Rosario Mazzola, Edoardo Pastorello, Francesco Ricchetti, Filippo Alongi, Francesco Cuccia, Vanessa Figlia
Summary: This study evaluated the efficacy and toxicity of daily adaptive MR-guided SBRT on a 1.5 T MR-linac for treating lymph node oligometastases from PCa. The results showed that lymph node SBRT on a 1.5 T MR-linac provides high local control rates with an excellent toxicity profile.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Health Care Sciences & Services
Filippo Alongi, Michele Rigo, Vanessa Figlia, Luca Nicosia, Rosario Mazzola, Niccolo Giaj Levra, Francesco Ricchetti, Giovanna Trapani, Giorgio Attina, Claudio Vitale, Edoardo Pastorello, Antonio De Simone, Davide Gurrera, Stefania Naccarato, Gianluisa Sicignano, Ruggero Ruggieri, Francesco Cuccia
Summary: This study reports the preliminary outcomes of adverse events and quality of life in the first 100 patients treated with 1.5T MR-guided stereotactic body radiotherapy for prostate cancer. The results show that the treatment had minimal acute toxicity and improved the quality of life for patients.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Oncology
Edoardo Pastorello, Luca Nicosia, Francesco Cuccia, Laura Olivari, Matilde Fiorini, Niccolo Giaj Levra, Rosario Mazzola, Francesco Ricchetti, Michele Rigo, Paolo Ravelli, Salvatore D'Alessandro, Matteo Salgarello, Ruggero Ruggieri, Filippo Alongi
Summary: This study evaluated the efficacy, toxicity, and pattern of relapse in SBRT delivered to non-spinal-bone metastases from prostate cancer. The results showed that SBRT is a safe and effective tool for the local progression-free survival in primary bone lesions, and intraosseous relapse was a relatively rare event.
Article
Radiology, Nuclear Medicine & Medical Imaging
Luca Nicosia, Rosario Mazzola, Claudio Vitale, Francesco Cuccia, Vanessa Figlia, Niccolo Giaj-Levra, Francesco Ricchetti, Michele Rigo, Ruggiero Ruggeri, Stefano Cavalleri, Filippo Alongi
Summary: This study evaluated the impact of moderately hypofractionated postoperative radiotherapy on prostate cancer. The findings showed that this treatment approach achieved acceptable disease control rate without increasing or causing unexpected toxicity. Gleason score and hormone therapy were found to be associated with disease progression and biochemical relapse.
Article
Oncology
Stephen Palasi, Ning Zhang, Mikaela Bankston, Joy Godby, Hannah Burrows, Jennifer Lagunas, William Perkison, Brandon Gunn, Mark S. Chambers, David Rosenthal, William Morrison, Adam Garden, Clifton David Fuller, Sharon Giordano, Eugene J. Koay
Summary: The purpose of this study was to identify clinical and epidemiological factors associated with the utilization of a complex oral treatment device for head and neck cancer patients undergoing radiation therapy. Retrospective analysis of data from the SEER-Medicare databases revealed that age, gender, and geographical disparities were linked to the utilization of the device. Further research and development are needed to improve availability and increase utilization among specific patient populations.
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
(2021)
Article
Oncology
Alexander D. Sherry, Dario Pasalic, G. Brandon Gunn, C. David Fuller, Jack Phan, David Rosenthal, William H. Morrison, Erich M. Sturgis, Neil D. Gross, Maura L. Gillison, Renata Ferrarotto, Adel K. El-Naggar, Adam S. Garden, Steven J. Frank
Summary: PRT for HNCUP was associated with highly favorable dosimetric and clinical outcomes, including minimal oral mucositis, xerostomia, and dysphagia. Toxicity and QOL may be superior with PRT compared with conventional radiation therapy and PRT maintains equivalent oncologic control.
INTERNATIONAL JOURNAL OF PARTICLE THERAPY
(2021)
Article
Oncology
Grace L. Smith, Shuangshuang Fu, Matthew S. Ning, Diem-Khanh Nguyen, Paul M. Busse, Robert L. Foote, Adam S. Garden, Gary B. Gunn, Clifton D. Fuller, William H. Morrison, Gregory M. Chronowski, Shalin J. Shah, Lauren L. Mayo, Jack Phan, Jay P. Reddy, James W. Snider, Samir H. Patel, Sanford R. Katz, Alexander Lin, Nasiruddin Mohammed, Roi Dagan, Nancy Y. Lee, David Rosenthal, Steven J. Frank
Summary: This study compared work outcomes in patients with oropharyngeal cancer receiving intensity-modulated proton therapy (IMPT) versus intensity-modulated photon therapy (IMRT) for chemoradiation therapy. The results showed that patients treated with IMPT demonstrated better trends in recovery.
INTERNATIONAL JOURNAL OF PARTICLE THERAPY
(2021)
Article
Oncology
Derek A. Mumaw, Allison J. Hazy, Aleksander Vayntraub, Thomas J. Quinn, Kamran Salari, John H. Chang, Noah Kalman, Sanford Katz, James Urbanic, Robert H. Press, Arpi Thukral, Henry Tsai, George E. Laramore, Jason Molitoris, Carlos Vargas, Samir H. Patel, Craig Stevens, Rohan L. Deraniyagala
Summary: This study evaluated contralateral recurrences in patients with oropharyngeal squamous cell carcinoma who received unilateral proton beam therapy. The results showed a favorable contralateral neck failure rate that was comparable to photon irradiation.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Kangpyo Kim, Dongryul Oh, Jae Myoung Noh, Yang Won Min, Hong Kwan Kim, Yong Chan Ahn
Summary: This study suggests that hypofractionated radiation therapy alone is a feasible option for early stage esophageal squamous cell carcinoma patients. Particularly, in patients with tumor length < 3 cm, this treatment scheme shows favorable local control rates with low incidence of esophageal toxicities.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Lin Chen, Jing Li, Kunpeng Li, Jiang Hu, Qingjie Li, Chenglong Huang, Gaoyuan Wang, Na Liu, Linglong Tang
Summary: This study analyzed the probability of hearing impairment after radiotherapy for nasopharyngeal carcinoma and developed a predictive model, providing dose limitation suggestions to improve patients' quality of life.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Yiwei Yang, Jianxin Wang, Feng Gao, Zhen Liu, Tangzhi Dai, Haowen Zhang, Hongyu Zhu, Tingting Wang, Dexin Xiao, Kui Zhou, Zheng Zhou, Dai Wu, Xiaobo Du, Sen Bai
Summary: This paper provides a comprehensive description of the current status of PARTER, which is the first experimental FLASH platform utilizing megavoltage X-rays. It showcases the reliable performance and stability of the dosimeters and monitors used in PARTER, as well as the satisfactory dose distribution and characteristics of the FLASH X-rays. The platform effectively meets the requirements of preclinical research on megavoltage X-ray FLASH and undergoes continuous upgrades.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Maria Thor, Kelly Fitzgerald, Aditya Apte, Jung Hun Oh, Aditi Iyer, Otasowie Odiase, Saad Nadeem, Ellen D. Yorke, Jamie Chaft, Abraham J. Wu, Michael Offin, Charles B. Simone Ii, Isabel Preeshagul, Daphna Y. Gelblum, Daniel Gomez, Joseph O. Deasy, Andreas Rimner
Summary: The purpose of this study was to identify predictors of disease progression in early-stage non-small cell lung cancer (NSCLC) patients after receiving definitive stereotactic body radiation therapy (SBRT). The results showed that tumor diameter and SUVmax were the most frequently reported features associated with progression/survival, and a re-fitted model including these two features had the best performance.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Yong-Qiao He, Tong-Min Wang, Da-Wei Yang, Wen-Qiong Xue, Chang-Mi Deng, Dan-Hua Li, Wen-Li Zhang, Ying Liao, Ruo-Wen Xiao, Lu-Ting Luo, Hua Diao, Xia-Ting Tong, Yan-Xia Wu, Xue-Yin Chen, Jiang-Bo Zhang, Ting Zhou, Xi-Zhao Li, Pei-Fen Zhang, Xiao-Hui Zheng, Shao-Dan Zhang, Ye-Zhu Hu, Guan-Qun Zhou, Jun Ma, Ying Sun, Wei-Hua Jia
Summary: In this study, researchers aimed to establish a predictive model for radiation-induced brain injury (RBI) in nasopharyngeal carcinoma (NPC) patients by incorporating clinical factors and newly developed genetic variants. They conducted a large-scale retrospective study and a genome-wide association study to develop a polygenic risk score (PRS) for RBI risk prediction. The results showed that the PRS, combined with clinical factors, improved the accuracy of RBI risk stratification and suggested personalized radiotherapy.
RADIOTHERAPY AND ONCOLOGY
(2024)
Review
Oncology
Xiaoyong Xiang, Zhe Ji, Jing Jin
Summary: A review of studies suggests that brachytherapy as a salvage therapy for recurrent glioblastoma shows acceptable safety and good post-treatment clinical efficacy for selected patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
M. Berbee, C. T. Muijs, F. E. M. Voncken, L. Wee, M. Sosef, B. van Etten, J. W. van Sandick, F. A. R. M. Warmerdam, J. J. de Haan, E. Oldehinkel, J. M. van Dieren, L. Boersma, J. A. Langendijk, A. van der Schaaf, J. B. Reitsma, E. Schuit
Summary: This study externally validated a model for predicting 2-year total mortality in lung cancer patients in esophageal cancer patients. The intercept and/or slope of the original model needed adjustment to achieve good performance in esophageal cancer patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Dominique Reijtenbagh, Jeremy Godart, Joan Penninkhof, Sandra Quint, Andras Zolnay, Jan-Willem Mens, Mischa Hoogeman
Summary: This study compared the performance of the current PotD strategy with non-adaptive and fully online-adaptive techniques in the treatment of cervical cancer patients. The findings show that the PotD protocol is effective in improving normal tissue sparing compared to no adaptation, while fully online-adaptive approaches can further reduce target volume but come with a more complex workflow.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Albrecht Weiss, Steffen Loeck, Ting Xu, Zhongxing Liao, Aswin L. Hoffmann, Esther G. C. Troost
Summary: Traditional models for predicting radiation pneumonitis may not be applicable to non-small cell lung cancer patients treated with passively-scattered proton therapy. The use of effective alpha/beta parameter can predict the occurrence of radiation pneumonitis in these patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Z. A. R. Gouw, J. Jeong, A. Rimner, N. Y. Lee, A. Jackson, A. Fu, J-j. Sonke, J. O. Deasy
Summary: This study investigates the effectiveness of non-uniform fractionation schedules in radiotherapy for early-stage non-small cell lung cancer. Through modeling, optimized schedules are proposed to minimize local failures and toxicity risk. The results suggest that non-standard primer shot fractionation can reduce hypoxia-induced radioresistance and improve treatment outcomes.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Sara Ronchi, Alessandro Cicchetti, Maria Bonora, Rossana Ingargiola, Anna Maria Camarda, Stefania Russo, Sara Imparato, Paolo Castelnuovo, Ernesto Pasquini, Piero Nicolai, Mohssen Ansarin, Michele Del Vecchio, Marco Benazzo, Ester Orlandi, Barbara Vischioni
Summary: This study evaluates the efficacy and toxicity of carbon ion radiotherapy (CIRT) in locally advanced head and neck mucosal melanoma patients. The results show that CIRT is safe and effective in treating the local region, and immunotherapy after relapse can improve overall survival. However, further prospective trials are needed to assess the role of targeted/immune- systemic therapy in this disease.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Dominik Wawrzuta, Justyna Klejdysz, Marzanna Chojnacka
Summary: This study analyzed articles about radiation oncology published in The New York Times since its inception in 1851, and identified changes in media sentiment and prevalent themes related to radiotherapy. The findings suggest an increasing negative sentiment in media coverage towards radiotherapy, with a shift towards reporting treatment errors, toxicity, and ineffectiveness.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Elaine Limkin, Pierre Blanchard, Benjamin Lacas, Jean Bourhis, Mahesh Parmar, Lisa Licitra, Quynh-Thu Le, Sue S. Yom, Catherine Fortpied, Johannes Langendijk, Jan B. Vermorken, Jacques Bernier, Jens Overgaard, Jonathan Harris, Jean-Pierre Pignon, Anne Auperin
Summary: This study investigated the impact of season of radiotherapy on the outcomes of head and neck squamous cell cancer patients. The results showed that the season of radiotherapy did not have any significant effect on patient outcomes.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Fabio L. Cury, Gustavo A. Viani, Andre G. Gouveia, Camila V. S. Freire, Gabriel de A. Grisi, Fabio Y. Moraes
Summary: In limb-sparing treatment of soft tissue sarcoma patients, a 5-day course of preoperative radiotherapy results in high local control and favorable R0 margins, with acceptable complication rates, particularly for patients receiving higher biological equivalent doses.
RADIOTHERAPY AND ONCOLOGY
(2024)
