Review
Environmental Sciences
Lei Zhao, Qisijing Liu, Yaning Jia, Huishu Lin, Yuanyuan Yu, Xuemei Chen, Ziquan Liu, Weixia Li, Tao Fang, Wenbing Jiang, Jianfeng Zhang, Huanhuan Cui, Penghui Li, Hongyu Li, Shike Hou, Liqiong Guo
Summary: This review and meta-analysis investigated the associations between exposure to organophosphate pesticides (Ops) and respiratory diseases, diabetes mellitus (DM), and cardiovascular diseases (CVDs). The results showed a significant positive association between OP exposure and respiratory diseases and DM, but no significant association with CVD.
Article
Biochemistry & Molecular Biology
Luigi Nibali, Abish S. Stephen, Robert P. Allaker, Antonino Di Pino, Valentina Terranova, Marcella Pisano, Salvatore Di Marca, Viviana Ferrara, Roberto Scicali, Francesco Purrello, Nikolaos Donos, Matteo Regolo, Lorenzo Malatino
Summary: Host genetic variants may influence the oral microbiome and play a role in the link between periodontitis and systemic diseases. This study investigated the associations between host genetic variants and subgingival microbiota in patients with metabolic syndrome. Specific SNPs within certain genes were found to be associated with microbial diversity, but no genome-wide associations were detected for periodontitis severity or metabolic syndrome components. Severe periodontitis was associated with pathogenic bacteria. Some SNPs were correlated with specific bacterial genera and taxa. This suggests that host genotypes may contribute to dysregulated immune responses in periodontitis and further interact with the oral microbiome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dentistry, Oral Surgery & Medicine
N. Fine, J. W. Chadwick, C. Sun, K. K. Parbhakar, N. Khoury, A. Barbour, M. Goldberg, H. C. Tenenbaum, M. Glogauer
Summary: The presence of periodontal diseases is closely related to other chronic inflammatory conditions such as cardiovascular disease, diabetes, and arthritis. Studies show that periodontal tissue inflammation affects the production and activation of polymorphonuclear neutrophils (PMNs), contributing to a hyperinflammatory response in the body. This systemic effect of PD on immune response can exacerbate inflammatory reactions when faced with secondary infections, highlighting the complex interactions between PD and other inflammatory diseases.
JOURNAL OF DENTAL RESEARCH
(2021)
Review
Dentistry, Oral Surgery & Medicine
David Herrera, Mariano Sanz, Lior Shapira, Carlos Brotons, Iain Chapple, Thomas Frese, Filippo Graziani, F. D. Richard Hobbs, Olivier Huck, Eva Hummers, Soren Jepsen, Oleg Kravtchenko, Phoebus Madianos, Ana Molina, Mehmet Ungan, Josep Vilaseca, Adam Windak, Shlomo Vinker
Summary: This study explores the implications for dentists and family doctors in the association between periodontal and systemic diseases and their roles in managing non-communicable diseases (NCDs) and promoting healthy lifestyles. The results show that periodontitis is independently associated with cardiovascular diseases, diabetes, chronic obstructive pulmonary disease (COPD), obstructive sleep apnea, and COVID-19 complications. Dentists and family doctors should collaborate in managing NCDs and implementing strategies for early detection of periodontitis and cardiovascular diseases or diabetes.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Article
Genetics & Heredity
Mengchen Zhou, Jiangtao Dong, Lingfeng Zha, Yuhua Liao
Summary: Observational studies have shown that dental diseases increase the risk of cardiovascular diseases, but the causal relationship between periodontal disease and cardiovascular diseases is still unclear. Using large-scale genome-wide association studies, two-sample Mendelian randomization was conducted to assess the association between genetic liability for dental diseases and major cardiovascular diseases. The results did not support dental diseases as the causes of cardiovascular diseases, and it is suggested that the observed associations may be explained by shared risk factors and comorbidities.
Article
Environmental Sciences
Weeberb J. Requia, Ana Maria Vicedo-Cabrera, Evan de Schrijver, Heresh Amini, Antonio Gasparrini
Summary: Further research on the impact of temperature on health in Brazil is needed. This study examines the relationship between high ambient temperature and hospital admissions for circulatory and respiratory diseases in Brazilian municipalities. The findings indicate that respiratory diseases are more strongly associated with high temperature.
ENVIRONMENTAL POLLUTION
(2023)
Review
Physiology
Mireya Martinez-Garcia, Enrique Hernandez-Lemus
Summary: Periodontitis is a common inflammatory disease that can progress into a systemic condition, causing systemic alterations and potentially exacerbating other health issues. The relationships between periodontitis and its related diseases are not fully understood, but a large body of evidence on different sources of information is available.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Physiology
Yan Yan, Min Mao, Yan-Qin Li, Yong-Ji Chen, He-Dong Yu, Wen-Zhong Xie, Qiao Huang, Wei-Dong Leng, Jie Xiong
Summary: Periodontitis is associated with an increased risk of heart failure, according to this study using data from the Third National Health and Nutrition Examination Survey.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Lisa Pennells, Stephen Kaptoge, Helena Bleken Ostergaard, Stephanie H. Read, Fabrizio Carinci, Josep Franch-Nadal, Carmen Petitjean, Owen Taylor, Steven H. J. Hageman, Zhe Xu, Fanchao Shi, Sarah Spackman, Stefano Gualdi, Naomi Holman, Rui Bebiano Da Providencia E Costa, Fabrice Bonnet, Hermann Brenner, Richard F. Gillum, Stefan Kiechl, Deborah A. Lawlor, Louis Potier, Ben Schoettker, Reecha Sofat, Henry Voelzke, Johann Willeit, Zane Baltane, Stephen Fava, Sandor Janos, Astrid Lavens, Santa Pildava, Tamara Poljicanin, Ivan Pristas, Peter Rossing, Reiff Sascha, Christa Scheidt-Nave, Iztok Stotl, Gail Tibor, Vilma Urbancic-Rovan, An-Sofie Vanherwegen, Dorte Vistisen, Yong Du, Matthew R. Walker, Peter Willeit, Brian Ference, Dirk De Bacquer, Martin Halle, Radu Huculeci, John William McEvoy, Adam Timmis, Panagiotis Vardas, Jannick A. N. Dorresteijn, Ian Graham, Angela Wood, Bjorn Eliasson, William Herrington, John Danesh, Didac Mauricio, Massimo Massi Benedetti, Naveed Sattar, Frank L. J. Visseren, Sarah Wild, Emanuele Di Angelantonio, Beverley Balkau, Frederic Fumeron, Hannah Stocker, Bernd Holleczek, Sabine Schipf, Carsten Oliver Schmidt, Marcus Doerr, Herbert Tilg, Christoph Leitner, Marlene Notdurfter, Julie Taylor, Caroline Dale, David Prieto-Merino, Richard F. Gillum, Tamara Buble, Pero Ivanko, Bendix Carstensen, Christin Heidemann, Tibor Gall, Janos Sandor, Jana Lepiksone, Caroline J. Magri, Joseph Azzopardi, Jordi Real, Bogdan Vlacho, Manel Mata-Cases
Summary: The study aimed to develop and validate a recalibrated prediction model (SCORE2-Diabetes) for estimating the 10-year risk of cardiovascular disease (CVD) in individuals with type 2 diabetes in Europe. The model showed good discrimination and improvement over previous models, with risk predictions varying based on individuals' diabetes-related factors. SCORE2-Diabetes enhances the identification of individuals at higher risk of CVD in Europe.
EUROPEAN HEART JOURNAL
(2023)
Article
Environmental Sciences
Xinlei Deng, Samantha Friedman, Ian Ryan, Wangjian Zhang, Guanghui Dong, Havidan Rodriguez, Fangqun Yu, Wenzhong Huang, Arshad Nair, Gan Luo, Shao Lin
Summary: This study examines the independent and synergistic effects of power outages (PO) and floods on various diseases in New York State. It finds that both PO and floods independently increase health risks, and their combined occurrence leads to the highest health risks. Immediate effects are observed for certain diseases, while delayed effects are found for others.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Cardiac & Cardiovascular Systems
Faraedon Zardawi, Sarhang Gul, Ali Abdulkareem, Aram Sha, Julian Yates
Summary: Periodontitis is potentially a risk factor for the development of atheroma in the arteries, highlighting the association between periodontal disease and atherosclerotic cardiovascular disease. Early diagnosis and treatment of periodontitis may be crucial in reducing complications associated with ACVDs. Further research with longer follow-up is needed to confirm the causal relationship between periodontal disease and ACVDs.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Peripheral Vascular Disease
Ruixing Zhang, Hongtao Yin, Mengdi Yang, Xianqiong Lei, Donghu Zhen, Zheng Zhang
Summary: Hypertension and osteoporosis are common comorbidities in the elderly. The effects of antihypertensive drugs on bone metabolism are controversial, with different drugs having different effects. Some drugs may improve bone density by stimulating osteoblast differentiation and reducing osteoclast generation, while others may not have a significant relationship with bone density or strength, and may even increase fracture risk.
Article
Environmental Sciences
Wenshan Yan, Xinwei Liu, Gexiang Zhang
Summary: Environmental lead exposure is a significant public health concern that requires comprehensive research. This study investigates the contribution of food to blood lead levels and examines the potential mediating effect of blood lead on disease occurrence. The findings indicate a correlation between the consumption of egg mixtures and legumes and blood lead levels. However, no significant mediating effect of blood lead on the relationship between food intake and diseases was found.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Health Care Sciences & Services
Christoph Schwarz, Adrian Ioan Hajdu, Ramona Dumitrescu, Ruxandra Sava-Rosianu, Vanessa Bolchis, Diana Anusca, Andreea Hanghicel, Aurora Doris Fratila, Roxana Oancea, Daniela Jumanca, Atena Galuscan, Marius Leretter
Summary: This study assessed the oral health condition of individuals by performing oral examinations and collecting data using questionnaires. The results showed a significant association between periodontitis and systemic diseases, and the severity of periodontitis diagnosis was less in non-smokers.
Article
Dentistry, Oral Surgery & Medicine
Sophie Jung, Marianna Gavriiloglou, Francois Severac, Lucille Haumesser, Amira Sayeh, Emmanuel Chatelus, Thierry Martin, Olivier Huck
Summary: This study evaluated the periodontal ligament surface, oral health-related quality of life, and levels of different biomarkers in the gingival crevicular fluid in SSc patients compared to controls. The results showed that SSc patients had widening of the periodontal ligament surface, increased number of missing teeth, and varying levels of gingival inflammation.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
