Article
Biochemistry & Molecular Biology
Courtney S. Wilkinson, Harrison L. Blount, Marek Schwendt, Lori A. Knackstedt
Summary: This study used a rat model of PTSD to investigate the effects of stress on monoamine concentrations in brain regions associated with PTSD in female rats. The findings indicate that stress exposure can lead to long-term alterations in monoamine function in female rats, suggesting potential interventions using MAOIs as a treatment for PTSD in women.
Article
Clinical Neurology
Yun Wang, Xiaohua Liu, Daihui Peng, Yan Wu, Yun'ai Su, Jia Xu, Xiancang Ma, Yi Li, Jianfei Shi, Xiaojing Cheng, Han Rong, Yiru Fang
Summary: This preliminary trial compared the efficacy and safety of different treatment methods in patients with anxiety/somatic subtype MDD. The results showed that mirtazapine/SNRIs, mirtazapine/SNRIs+CBT, mirtazapine+SNRIs, or mirtazapine+SNRIs+physical therapies achieved similar improvement in depression severity, depressive symptoms, and quality of life in patients. Additionally, the safety profile of all four interventions was manageable.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2022)
Article
Neurosciences
Marilia B. Malta, Joelcimar Martins, Leonardo S. Novaes, Nilton B. dos Santos, Luciane Sita, Rosana Camarini, Cristoforo Scavone, Jackson Bittencourt, Carolina D. Munhoz
Summary: The stress response is a complex process involving multiple factors that mainly act through activating the HPA axis to produce a series of behavioral, endocrine, and autonomic changes. Ineffective self-regulation of stress can be harmful to the organism and predisposes it to pathologies. In the chronic unpredictable stress experimental model, CRF and GCs play crucial roles.
MOLECULAR NEUROBIOLOGY
(2021)
Review
Medicine, General & Internal
Agoston Patthy, Janos Murai, Janos Hanics, Anna Pinter, Peter Zahola, Tomas G. M. Hokfelt, Tibor Harkany, Alan Alpar
Summary: Alzheimer's disease (AD) is a devastating neurodegenerative disorder for which an effective therapy has yet to be found. Research suggests that early damage to the ascending monoaminergic system in the brainstem may be an early sign and potential trigger of AD. In addition, cortical malfunction and local neurohistopathology are also related to the progression of AD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Neurosciences
Lindsay J. Agostinelli, Scott C. Seaman, Clifford B. Saper, Dustin P. Fykstra, Marco M. Hefti, Timothy R. Koscik, Brian J. Dlouhy, Alexander G. Bassuk
Summary: Researchers report a study that combines high-resolution MRI and detailed histology to study the impact of neurologic disease on specific cell groups in the human brainstem and cerebellum. These findings are crucial for understanding and diagnosing brainstem lesions.
JOURNAL OF NEUROSCIENCE
(2023)
Review
Neurosciences
Xin Yang, Fei Geng
Summary: A large body of literature has highlighted the significance of the corticotropin-releasing factor (CRF) system in regulating neuropsychiatric diseases. Anxiety disorders are among the most common neuropsychiatric disorders and studies have shown that the CRF family plays a role in their development and maintenance. Thus, targeting the CRF family is considered a potential treatment for anxiety disorders.
JOURNAL OF NEUROSCIENCE RESEARCH
(2023)
Review
Neurosciences
Cooper D. Grossman, Jeremiah Y. Cohen
Summary: This article discusses the evolution of nervous systems to adapt to the dynamics of the environment and explains this process through the study of learning and decision-making. The article focuses on the slow dynamics of neuronal networks and the role of neuromodulators in temporal scaling.
ANNUAL REVIEW OF NEUROSCIENCE
(2022)
Article
Neurosciences
Rachel P. Tillage, Stephanie L. Foster, Daniel Lustberg, L. Cameron Liles, Katharine E. McCann, David Weinshenker
Summary: The noradrenergic and galaninergic systems play important roles in stress-induced behavior, with NE promoting acute stress-induced anxiety and noradrenergic-derived galanin mediating more persistent responses. NE and galanin have complementary but distinguishable roles in behavioral responses to stress.
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Emanuela Micioni Di Bonaventura, Luca Botticelli, Fabio Del Bello, Gianfabio Giorgioni, Alessandro Piergentili, Wilma Quaglia, Adele Romano, Silvana Gaetani, Maria Vittoria Micioni Di Bonaventura, Carlo Cifani
Summary: The melanocortinergic neural circuit, particularly the melanocortin-4 receptor (MC4R) subtype, plays a role in influencing energy expenditure, feeding behavior, stress responses, and stress-related behaviors such as anxiety and depression. MC4R agonists exacerbate stress-induced anxiety and depressive behavior, while MC4R antagonists have been shown to mitigate such disorders, suggesting a potential novel treatment approach for anxiety and depression induced by stress.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Behavioral Sciences
Amine Bahi, Jean-Luc Dreyer
Summary: This study aimed to determine whether reductions in SERT expression in the hippocampus were sufficient to ameliorate anxiety- and ethanol-related behaviors in socially defeated mice. The results showed that hippocampal SERT loss-of-function prevented stress-elicited anxiogenic-like effects and decreased consumption and preference for ethanol. Pearson correlation analysis confirmed that SERT hippocampal mRNA expression correlated with measures of anxiety- and ethanol-related behaviors.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Mohamed Z. Elhussiny, Haruka Nishimura, Phuong Tran, Shogo Haraguchi, Elizabeth R. Gilbert, Mark A. Cline, Takashi Bungo, Mitsuhiro Furuse, Vishwajit S. Chowdhury
Summary: The objective of this study was to investigate the mechanism of brain monoamine metabolism in taurine-induced hypothermia and appetite suppression. Central taurine activates dopamine-beta-hydroxylase and tryptophan hydroxylase to produce norepinephrine and 5-HT, which then induces hypothermia and anorexia, respectively.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Behavioral Sciences
Natalie N. Maffeo, Cary M. Springer, Julia D. Albright
Summary: The serotonin-norepinephrine reuptake inhibitor venlafaxine is increasingly used in dogs for the treatment of aggression, anxiety, and fear-related behavior problems. In a retrospective clinical trial, it was found that 71.8% of dog owners reported venlafaxine as helpful, with a median dose of 1.65 mg/kg every 12 hours.
JOURNAL OF VETERINARY BEHAVIOR-CLINICAL APPLICATIONS AND RESEARCH
(2023)
Article
Behavioral Sciences
Hiroko Mochizuki-Kawai, Yukio Ichitani, Saho Ayabe-Kanamura, Kazuo Yamada
Summary: Odor stimuli can promote relaxation and reduce anxiety. This study compared the effects of a novel odor and a familiar odor associated with a positive experience on anxiety-like behaviors in rats. The results showed that exposure to the familiar odor reduced anxiety, especially in females.
Article
Pharmacology & Pharmacy
Stephen Daniels, Mostafa El Mansari, Rami Hamoudeh, Pierre Blier
Summary: Ketamine exerts its antidepressant effects by modulating neuronal activity, enhancing dopamine neuronal activity and normalizing norepinephrine neuronal activity in the locus coeruleus and ventral tegmental area.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Clinical Neurology
Sayed Ausim Azizi
Summary: Monoamines play important roles in regulating brain function and have both physiological and pathological significance in influencing perception and behavior.
Article
Neurosciences
Falk W. Lohoff, Gregory V. Carr, Bethany Brookshire, Thomas N. Ferraro, Irwin Lucki
Article
Biochemistry & Molecular Biology
Gongliang Zhang, Ingrid P. Buchler, Michael DePasquale, Michael Wormald, Gangling Liao, Huijun Wei, James C. Barrow, Gregory V. Carr
ACS CHEMICAL NEUROSCIENCE
(2019)
Article
Chemistry, Medicinal
Glen Ernst, Daniel Akuma, Vinh Au, Ingrid P. Buchler, Spencer Byers, Gregory V. Carr, Sabine Defays, Pablo de Leon, Thierry Demaude, Michael DePasquale, Veronique Durieu, Yifang Huang, Emilie Jigorel, Martha Kimos, Anna Kolobova, Florian Montel, Florence Moureau, Michael Poslusney, Dominique Swinnen, Marie-Christine Vandergeten, Nathalie Van Houtvin, Huijun Wei, Noelle White, Martyn Wood, James C. Barrow
ACS MEDICINAL CHEMISTRY LETTERS
(2019)
Editorial Material
Neurosciences
Rita J. Valentino, Walter Koroshetz, Nora D. Volkow
BIOLOGICAL PSYCHIATRY
(2020)
Article
Neurosciences
Spencer Byers, Ingrid P. Buchler, Michael DePasquale, Helen L. Rowley, Rajiv S. Kulkarni, Lucy Pinder, Anna Kolobova, Cailian Li, Vinh Au, Daniel Akuma, Gongliang Zhang, Huijun Wei, Sharon C. Cheetham, James C. Barrow, Gregory V. Carr
PSYCHOPHARMACOLOGY
(2020)
Article
Behavioral Sciences
Adrienne C. DeBrosse, Abigail M. Wheeler, James C. Barrow, Gregory V. Carr
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2020)
Article
Neurosciences
Rita J. Valentino, Raymond J. Dingledine
Summary: The cholinergic regulation of hippocampal circuit activity, characterized by diverse cellular actions of acetylcholine in different sites within hippocampal circuitry, plays a crucial role in optimizing the encoding of new information, promoting consolidation, and coordinating with recall of prior memories. Through decades of research, the foundational findings on the inhibitory effects of acetylcholine on Schaffer collaterals have become integral in understanding the cholinergic modulation of hippocampal function in learning and memory.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Alexander Shaver, J. D. Mahlum, Karen Scida, Melanie L. Johnston, Miguel Aller Pellitero, Yao Wu, Gregory V. Carr, Netzahualcoyotl Arroyo-Curras
Summary: The measurement of serum vancomycin levels is critical for optimizing dosing, and current methods are complex. This study developed a simplified sensor to measure vancomycin levels without sample dilution. By optimizing the aptamer sequence, the sensitivity of the sensor was improved, allowing for a wider dynamic range.
Article
Psychology, Biological
Adrienne C. DeBrosse, Ye Li, Robyn Wiseman, Racine Ross, Sy'Keria Garrison, Henry L. Hallock, James C. Barrow, Keri Martinowich, Gregory V. Carr
Summary: This study investigated the effects of stimulus degradation on the performance of mice in a touchscreen version of a rodent continuous performance test (rCPT). The results showed that stimulus degradation significantly decreased performance, affecting both stimulus discrimination and reaction time.
BEHAVIOURAL PROCESSES
(2022)
Article
Neurosciences
Henry L. Hallock, Suhaas S. Adiraju, Jorge Miranda-Barrientos, Jessica M. McInerney, Seyun Oh, Adrienne C. DeBrosse, Ye Li, Gregory V. Carr, Keri Martinowich
Summary: Sustained attention is impaired in psychiatric disorders, and there is a need for new treatments. Continuous performance tests (CPTs) are used to measure sustained attention and can be used for drug discovery. This study identified electrophysiological correlates of attentional performance in a rodent CPT, showing neural activity in the locus coeruleus and prelimbic cortex. These findings may serve as translational biomarkers for screening novel therapeutics for attention impairments.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Clinical Neurology
Rita J. Valentino, Sunila G. Nair, Nora D. Volkow
Summary: The prevention and treatment of addiction is challenging due to the complex interactions between biological and social determinants. The use of multiple drugs and different stages of addiction require a deep understanding of pharmacological interactions and neurobiological processes. Individual susceptibility to addiction varies based on multiple factors such as genetics, sex, drug exposure, and social and environmental factors. Understanding these interactions is crucial for identifying the biobehavioral basis of addiction and developing effective prevention and treatment strategies.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Meeting Abstract
Neurosciences
Henry Hallock, Jessica Valerino, Adrienne DeBrosse, Michael Noback, Henry Quillian, James Barrow, Andrew Jaffe, Gregory Carr, Keri Martinowich
NEUROPSYCHOPHARMACOLOGY
(2020)
Meeting Abstract
Neurosciences
Michael Noback, Gongliang Zhang, Noelle White, Gregory Carr, James Barrow
NEUROPSYCHOPHARMACOLOGY
(2020)
Meeting Abstract
Neurosciences
Henry Hallock, Jessica Valerino, Adrienne DeBrosse, Michael Noback, Henry Quillian, James Barrow, Gregory Carr, Keri Martinowich
BIOLOGICAL PSYCHIATRY
(2020)
Meeting Abstract
Neurosciences
Gregory Carr, Michael Noback, Noelle White, James Barrow
NEUROPSYCHOPHARMACOLOGY
(2019)