The spliceosomal proteome: At the heart of the largest cellular ribonucleoprotein machine

The function of the NineTeen Complex (NTC) in regulating spliceosome conformations and fidelity during pre-mRNA splicing

(2010) Rebecca Hogg et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Structural studies of the spliceosome: blind men and an elephant

(2010) Andrew J Newman et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Molecular Architecture of the Human Prp19/CDC5L Complex

(2010) M. Grote et al.   MOLECULAR AND CELLULAR BIOLOGY

The DEAH Box ATPases Prp16 and Prp43 Cooperate to Proofread 5′ Splice Site Cleavage during Pre-mRNA Splicing

(2010) Prakash Koodathingal et al.   MOLECULAR CELL

Human PRP4 kinase is required for stable tri-snRNP association during spliceosomal B complex formation

(2010) Marc Schneider et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Spliceosome discards intermediates via the DEAH box ATPase Prp43p

(2010) R. M. Mayas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of the snRNAs in spliceosomal active site

(2010) Saba Valadkhan   RNA Biology

Spliceosome structure: Piece by piece

(2009) Dustin B. Ritchie et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The Spliceosome: Design Principles of a Dynamic RNP Machine

(2009) Markus C. Wahl et al.   CELL

Structural insights into RNA splicing

(2009) Navtej Toor et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structural mapping of spliceosomes by electron microscopy

(2009) Reinhard Lührmann et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Exon, intron and splice site locations in the spliceosomal B complex

(2009) Elmar Wolf et al.   EMBO JOURNAL

Spliceosomal Proteomics inTrypanosoma bruceiReveal New RNA Splicing Factors

(2009) Daniela Luz Ambrósio et al.   EUKARYOTIC CELL

The Role of Exon Sequences in C Complex Spliceosome Structure

(2009) Janine Ilagan et al.   JOURNAL OF MOLECULAR BIOLOGY

Cwc25 Is a Novel Splicing Factor Required after Prp2 and Yju2 To Facilitate the First Catalytic Reaction

(2009) Y.-F. Chiu et al.   MOLECULAR AND CELLULAR BIOLOGY

Common Design Principles in the Spliceosomal RNA Helicase Brr2 and in the Hel308 DNA Helicase

(2009) Vladimir Pena et al.   MOLECULAR CELL

The Evolutionarily Conserved Core Design of the Catalytic Activation Step of the Yeast Spliceosome

(2009) Patrizia Fabrizio et al.   MOLECULAR CELL

Crystal structure of human spliceosomal U1 snRNP at 5.5 Å resolution

(2009) Daniel A. Pomeranz Krummel et al.   NATURE

Structural evidence for consecutive Hel308-like modules in the spliceosomal ATPase Brr2

(2009) Lingdi Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Reconstitution of both steps of Saccharomyces cerevisiae splicing with purified spliceosomal components

(2009) Zbigniew Warkocki et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The RNA binding protein Cwc2 interacts directly with the U6 snRNA to link the nineteen complex to the spliceosome during pre-mRNA splicing

(2009) J. C. McGrail et al.   NUCLEIC ACIDS RESEARCH

Protein-free small nuclear RNAs catalyze a two-step splicing reaction

(2009) S. Valadkhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DExD/H-box Prp5 protein is in the spliceosome during most of the splicing cycle

(2009) T. R. Kosowski et al.   RNA

A structural analysis of the group II intron active site and implications for the spliceosome

(2009) K. S. Keating et al.   RNA

Physical and genetic interactions of yeast Cwc21p, an ortholog of human SRm300/SRRM2, suggest a role at the catalytic center of the spliceosome

(2009) R. J. Grainger et al.   RNA

A systematic characterization of Cwc21, the yeast ortholog of the human spliceosomal protein SRm300

(2009) M. Khanna et al.   RNA

Evidence that U2/U6 helix I promotes both catalytic steps of pre-mRNA splicing and rearranges in between these steps

(2009) M. A. Mefford et al.   RNA

The ribozyme core of group II introns: a structure in want of partners

(2009) François Michel et al.   TRENDS IN BIOCHEMICAL SCIENCES

Sm/Lsm Genes Provide a Glimpse into the Early Evolution of the Spliceosome

(2009) Stella Veretnik et al.   PLoS Computational Biology

UAP56 RNA helicase is required for axis specification and cytoplasmic mRNA localization in Drosophila

(2008) Carine Meignin et al.   DEVELOPMENTAL BIOLOGY

Structure and function of an RNase H domain at the heart of the spliceosome

(2008) Vladimir Pena et al.   EMBO JOURNAL

Distinct activities of the DExD/H-box splicing factor hUAP56 facilitate stepwise assembly of the spliceosome

(2008) H. Shen et al.   GENES & DEVELOPMENT

Conservation of the Protein Composition and Electron Microscopy Structure of Drosophila melanogaster and Human Spliceosomal Complexes

(2008) N. Herold et al.   MOLECULAR AND CELLULAR BIOLOGY

“Nought May Endure but Mutability”: Spliceosome Dynamics and the Regulation of Splicing

(2008) Duncan J. Smith et al.   MOLECULAR CELL

A Conformational Rearrangement in the Spliceosome Sets the Stage for Prp22-Dependent mRNA Release

(2008) Beate Schwer   MOLECULAR CELL

Isolation of an active step I spliceosome and composition of its RNP core

(2008) Sergey Bessonov et al.   NATURE

Structural elucidation of a PRP8 core domain from the heart of the spliceosome

(2008) Dustin B Ritchie et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Localization of Prp8, Brr2, Snu114 and U4/U6 proteins in the yeast tri-snRNP by electron microscopy

(2008) Irina Häcker et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ATP-dependent unwinding of U4/U6 snRNAs by the Brr2 helicase requires the C terminus of Prp8

(2008) Corina Maeder et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A role for ubiquitin in the spliceosome assembly pathway

(2008) Priya Bellare et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Phosphorylation of human PRP28 by SRPK2 is required for integration of the U4/U6-U5 tri-snRNP into the spliceosome

(2008) Rebecca Mathew et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal structure of the  -finger domain of Prp8 reveals analogy to ribosomal proteins

(2008) K. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of yeast U6 snRNPs: Arrangement of Prp24p and the LSm complex as revealed by electron microscopy

(2008) R. Karaduman et al.   RNA

A glimpse into the active site of a group II intron and maybe the spliceosome, too

(2008) K. T. Dayie et al.   RNA