Article
Environmental Sciences
Kamiran Aron Hamow, Zsuzsanna Ambrozy, Katalin Puskas, Imre Majlath, Monika Cseplo, Reka Matyus, Katalin Posta, Peter Lukacs, Laszlo Sagi
Summary: This study identified six specific biogenic volatile organic compounds (BVOCs) in wheat plants infected with powdery mildew, with three of them being the most abundant in symptomatic plants. These BVOCs serve as potential biomarkers for differentiating between healthy plants and those infected with mildew, even at early stages. They have promising applications in chemotyping and environmental monitoring in agricultural settings.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Agronomy
Mirjana Lalosevic, Radivoje Jevtic, Vesna Zupunski, Stevan Masirevic, Branka Orbovic
Summary: Powdery mildew is a common and economically important disease in the wheat growing area of Serbia. A large-scale survey of its causal agent revealed high virulence complexity and genetic diversity in the population, which are influential factors for the damaging epidemics it can cause.
Article
Biology
Antonin Dreiseitl
Summary: The study aimed to identify major resistances against powdery mildew in a set of wheat accessions from the Czech gene bank and group them according to their responses. Resistance to the pathogen was mainly found in varieties from Northwest Europe, and spring wheats exhibited more frequent resistance compared to winter wheats. These results will facilitate the breeding of new wheat cultivars with improved resistance to powdery mildew using the identified gene bank accessions.
Article
Microbiology
Yue Zhu, Shibo Zhu, Fang Zhang, Zhenrui Zhao, Michael J. J. Christensen, Zhibiao Nan, Xingxu Zhang
Summary: This study investigated the effects of the presence of Epichloe endophyte on photosynthesis in Achnatherum inebrians under pathogen infection. The results showed that the presence of Epichloe endophyte increased the photosynthetic rate and up-regulated genes involved in photosynthesis.
Article
Plant Sciences
Hongbo Yuan, Cong Jin, Hongcui Pei, Lifang Zhao, Xue Li, Jiali Li, Wanting Huang, Renchun Fan, Wende Liu, Qian-Hua Shen
Summary: The study reveals that the effector protein CSEP0027 of the barley mildew fungus interacts with barley catalase HvCAT1 to regulate host immunity and likely reactive oxygen species homeostasis, promoting fungal virulence during barley infection.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Plant Sciences
Shuangyu Bai, Jiaohui Long, Yuanyuan Cui, Zhaoyi Wang, Caixia Liu, Fenglou Liu, Zhangjun Wang, Qingfeng Li
Summary: The study identified that the biosynthetic pathways of salicylic acid, jasmonic acid, and ethylene were highly enriched during wheat infection by Blumeria graminis f. sp. tritici. Additionally, hormone-related genes showed significant expression from 1 to 4 days post-infection, with up-regulation of the salicylic acid pathway and suppression of the jasmonic acid and ethylene pathways.
Article
Agronomy
Habteab Goitom Gebremedhin, Yahui Li, Jinghuang Hu, Dan Qiu, Qiuhong Wu, Hongjun Zhang, Li Yang, Yang Zhou, Yijun Zhou, Zhiyong Liu, Peng Zhang, Hongjie Li
Summary: This study developed molecular markers for assisted breeding of wheat with powdery mildew resistance. These markers have important applications in wheat breeding and can enhance the efficiency of selecting disease-resistant wheat cultivars.
Article
Biochemistry & Molecular Biology
Kana Ueda, Yuichi Nakajima, Hiroshi Inoue, Kappei Kobayashi, Takumi Nishiuchi, Makoto Kimura, Takashi Yaeno
Summary: The precursor NMN was found to induce plant resistance to fungal infection, especially to the biotrophic stage. The experimental results showed that NMN treatment suppressed the formation of fungal appressoria-like structures and resulted in irregular hyphal growth direction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Niels Julian Maywald, Melissa Mang, Nathalie Pahls, Guenter Neumann, Uwe Ludewig, Davide Francioli
Summary: This study demonstrates the critical role of different forms of nitrogen fertilization in host-pathogen interactions and the assemblage of wheat rhizosphere microbiome.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Agronomy
Qasim A. Marzani, Muhsen M. Amin, Shirkoo A. Fateh
Summary: This study examined the effects of cultivar type and powdery mildew disease on lodging in barley. It was found that powdery mildew disease increased the occurrence of lodging, and different cultivars exhibited varying levels of lodging.
EUROPEAN JOURNAL OF PLANT PATHOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Francine Zaiosc Simmi, Rodrigo Oliveira Almeida, Keilor da Rosa Dorneles, Gustavo Maia Souza
Summary: Plant electrome refers to the collection of plant bioelectrical activity. The infection of plant tissues by different fungi can alter this activity and generate electrical signatures unique to each pathogen. This study evaluated the systemic variations of barley electrome caused by the inoculation of Blumeria graminis and Bipolaris sorokiniana on the leaves. The results showed that the inoculation of these pathogens resulted in greater electrome variations compared to the control, and each pathogen created a specific electrical signature that can identify the presence of pathogenic infection shortly after contact with the host surface.
COMPUTERS AND ELECTRONICS IN AGRICULTURE
(2023)
Article
Agronomy
Nitish Rattan Bhardwaj, Devinder Kumar Banyal, Ajoy Kumar Roy
Summary: A logistic regression model was developed to predict the high risk of powdery mildew in common oats using weather and disease data. The model incorporated increasing weekly average temperature, decreasing relative humidity, and decreasing sunshine as key predictors for high powdery mildew severity. This model can assist in advance fungicide spraying to reduce losses caused by powdery mildew in common oat, making it potentially the first model for predicting powdery mildew disease in India and possibly globally.
Article
Plant Sciences
Sutanni Sarkar, Gulab Chand Arya, Boaz Negin, Ekaterina Manasherova, Maggie Levy, Asaph Aharoni, Hagai Cohen
Summary: In this study, the researchers explored the contribution of cuticular lipid metabolism to barley domestication by comparing wild and domesticated barley variants. They found substantial differences in the morphology and tissue characteristics between the two variants. Further analysis revealed that wild barley leaves have a higher density of epicuticular waxes compared to domesticated leaves, but the ultrastructure of the cuticle is similar. Gene expression assays confirmed these findings, showing higher expression of epicuticular wax biosynthetic genes in wild barley leaves. The research provides new insights into the compositional variances in cuticular lipids of wild and domesticated barley leaves and their impact on plant-environment interactions.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2023)
Article
Plant Sciences
Yuli Jin, Tiantian Gu, Xiuquan Li, Hong Liu, Guohao Han, Zhipeng Shi, Yilin Zhou, Jieru Fan, Jing Wang, Wei Liu, He Zhao, Diaoguo An
Summary: This study identified an alternative splicing variant of Pm4, which provides information on the regulation of Pm4 gene function. Additionally, a new resistant resource for powdery mildew, PmYAV, was discovered.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Plant Sciences
Xiaohan Shi, Peipei Wu, Jinghuang Hu, Dan Qiu, Yunfeng Qu, Yahui Li, Yi Liu, Tesfay Gebrekirstos Gebremariam, Jingzhong Xie, Qiuhong Wu, Hongjun Zhang, Hongwei Liu, Li Yang, Guozhong Sun, Yang Zhou, Zhiyong Liu, Hongjie Li
Summary: The study identified the resistant genes Pm52 and Qaprpm.caas.2B, Qaprpm.caas.7A in winter wheat cultivar Liangxing 99 against powdery mildew through genetic analysis and gene mapping, providing important clues for further breeding efforts.
Article
Plant Sciences
Kenneth Madriz-Ordenana, Hans Jorgen Lyngs Jorgensen, Andreea Balan, Daniel Madriz Sorensen, Kai Lonne Nielsen, Hans Thordal-Christensen
Article
Cell Biology
Lara Smigielski, Geziel B. Aguilar, Mark Kwaaitaal, Wen-Ding Zhang, Hans Thordal-Christensen
CELLULAR MICROBIOLOGY
(2019)
Letter
Plant Sciences
Sravani Ram Veeragoni, Birgit Lange, Mario Serrano, Christiane Nawrath, Sibylle Bauer, Anton Rudolf Schaeffner, Hans Thordal-Christensen, Joerg Durner, Frank Gaupels
Review
Biochemistry & Molecular Biology
Hans Thordal-Christensen
CELLULAR AND MOLECULAR LIFE SCIENCES
(2020)
Article
Multidisciplinary Sciences
Leifu Chang, Jing Yang, Chang Hwa Jo, Andreas Boland, Ziguo Zhang, Stephen H. McLaughlin, Afnan Abu-Thuraia, Ryan C. Killoran, Matthew J. Smith, Jean-Francois Cote, David Barford
NATURE COMMUNICATIONS
(2020)
Article
Biochemistry & Molecular Biology
Ziguo Zhang, Dom Bellini, David Barford
NUCLEIC ACIDS RESEARCH
(2020)
Article
Multidisciplinary Sciences
Katerina Naydenova, Kyle W. Muir, Long-Fei Wu, Ziguo Zhang, Francesca Coscia, Mathew J. Peet, Pablo Castro-Hartmann, Pu Qian, Kasim Sader, Kyle Dent, Dari Kimanius, John D. Sutherland, Jan Lowe, David Barford, Christopher J. Russo
Summary: The structure of the RNA polymerase inhibitor favipiravir bound to the SARS-CoV-2 RNA-dependent RNA polymerase has been determined, revealing its binding mode at the catalytic site. The inhibitor is weakly incorporated into the RNA primer strand, leading to suppression of RNA replication in the presence of natural nucleotides.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Stanislau Yatskevich, Jessie S. Kroonen, Claudio Alfieri, Thomas Tischer, Anna C. Howes, Linda Clijsters, Jing Yang, Ziguo Zhang, Kaige Yan, Alfred C. O. Vertegaal, David Barford
Summary: SUMOylation of the APC/C rearranges the structure of the WHB domain of the cullin subunit, leading to reduced affinity of APC/C-Cdc20 for the mitotic checkpoint complex and allowing for more efficient ubiquitination of substrates in the presence of the MCC, contributing to timely anaphase onset.
Article
Multidisciplinary Sciences
Stanislau Yatskevich, Kyle W. Muir, Dom Bellini, Ziguo Zhang, Jing Yang, Thomas Tischer, Masa Predin, Tom Dendooven, Stephen H. McLaughlin, David Barford
Summary: This study reveals that CCAN can bind to CENP-A(Nuc) and form a robust structure around the linker DNA, enabling kinetochores to withstand forces exerted by the mitotic spindle.
Article
Plant Sciences
Kenneth Madriz-Ordenana, Sercan Pazarlar, Hans Jorgen Lyngs Jorgensen, Tue Kjaergaard Nielsen, Yingqi Zhang, Kai Lonne Nielsen, Lars Hestbjerg Hansen, Hans Thordal-Christensen
Summary: In addition to their ability to produce fungitoxic compounds, beneficial microorganisms associated with plants can also stimulate the plant immune system for long-term protection. Non-antifungal Bacillus strains were found to protect ornamental plants by triggering the plant's immune response.
Article
Oncology
Owen J. Chen, Ester Castellsague, Mohamed Moustafa-Kamal, Javad Nadaf, Barbara Rivera, Somayyeh Fahiminiya, Yilin Wang, Isabelle Gamache, Caterina Pacifico, Lai Jiang, Jian Carrot-Zhang, Leora Witkowski, Albert M. Berghuis, Stefan Schoenberger, Dominik Schneider, Morten Hillmer, Susanne Bens, Reiner Siebert, Colin J. R. Stewart, Ziguo Zhang, William C. H. Chao, Celia M. T. Greenwood, David Barford, Marc Tischkowitz, Jacek Majewski, William D. Foulkes, Jose G. Teodoro
Summary: Two germline CDC20 missense variants that segregate with cancer in two families compromise the spindle assembly checkpoint and lead to aberrant mitotic progression, which could predispose cells to transformation.
Article
Plant Sciences
Wenlin Liao, Mads E. Nielsen, Carsten Pedersen, Wenjun Xie, Hans Thordal-Christensen
Summary: This study reveals that the absence of encasement formation and hypersensitive reaction (HR) in susceptible barley attacked by the powdery mildew fungus is caused by the effector CSEP0162 targeting the plant MONENSIN SENSITIVITY1 (MON1). Interestingly, an Arabidopsis ecotype and barley also show resistance to powdery mildew that is dependent on MON1, involving both encasement response and HR. These findings highlight the importance of MON1 as a vital component of plant immunity.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Article
Multidisciplinary Sciences
Clinton A. Gabel, Zhuang Li, Andrew G. DeMarco, Ziguo Zhang, Jing Yang, Mark C. Hall, David Barford, Leifu Chang
Summary: This study investigates the structure and function of the human augmin complex. The authors utilized cryo-EM, computational methods, and CLMS to elucidate the molecular architecture of augmin. They found that augmin has a highly flexible structure and plays a role in regulating the assembly of the mitotic spindle.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Tom Dendooven, Ziguo Zhang, Jing Yang, Stephen H. McLaughlin, Johannes Schwab, Sjors H. W. Scheres, Stanislau Yatskevich, David Barford
Summary: The point centromere of budding yeast controls the assembly of large kinetochore complex for chromatid segregation. The kinetochore complex consists of the inner kinetochore (CCAN) and the outer kinetochore KNL1-MIS12-NDC80 (KMN) network. The cryo-electron microscopy structure reveals the assembly of the yeast inner kinetochore onto the centromere-specific CENP-A nucleosomes with unwrapped DNA ends. The CCAN protomers bind the free DNA duplexes and are connected through CBF3. A model is presented for the assembly of the inner kinetochore onto a point centromere and its organization of the outer kinetochore for chromosome attachment to the mitotic spindle.
Article
Biochemistry & Molecular Biology
Yuan Qin, Anna Maria Torp, Gaetan Glauser, Carsten Pedersen, Soren K. Rasmussen, Hans Thordal-Christensen
PLANT SIGNALING & BEHAVIOR
(2019)