期刊
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
卷 82, 期 8, 页码 1553-1562出版社
WILEY
DOI: 10.1002/prot.24567
关键词
x-ray structure; immunoglobulin; homology modeling; canonical structures; antigen-binding site
To assess the state of the art in antibody 3D modeling, 11 unpublished high-resolution x-ray Fab crystal structures from diverse species and covering a wide range of antigen-binding site conformations were used as a benchmark to compare Fv models generated by seven structure prediction methodologies. The participants included: Accerlys Inc, Chemical Computer Group (CCG), Schrodinger, Jeff Gray's lab at John Hopkins University, Macromoltek, Astellas Pharma/Osaka University and Prediction of ImmunoGlobulin Structure (PIGS). The sequences of benchmark structures were submitted to the modelers and PIGS, and a set of models were generated for each structure. We provide here an overview of the organization, participants and main results of this second antibody modeling assessment (AMA-II). Also, we compare the results with the first antibody assessment published in this journal (C) 2014 Wiley Periodicals, Inc.
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