Sensing the messenger: The diverse ways that bacteria signal through c-di-GMP

Nitric Oxide Regulation of Cyclic di-GMP Synthesis and Hydrolysis in Shewanella woodyi

(2012) Niu Liu et al.   BIOCHEMISTRY

You’ve come a long way: c-di-GMP signaling

(2012) Holger Sondermann et al.   CURRENT OPINION IN MICROBIOLOGY

A full-length bifunctional protein involved in c-di-GMP turnover is required for long-term survival under nutrient starvation in Mycobacterium smegmatis

(2012) B. K. Bharati et al.   MICROBIOLOGY-SGM

The orphan histidine protein kinase SgmT is a c-di-GMP receptor and regulates composition of the extracellular matrix together with the orphan DNA binding response regulator DigR in Myxococcus xanthus

(2012) Tobias Petters et al.   MOLECULAR MICROBIOLOGY

Indirect Modulation of the Intracellular c-Di-GMP Level inShewanella oneidensisMR-1 by MxdA

(2011) Shauna Rakshe et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Interactions of the c-di-GMP riboswitch with its second messenger ligand

(2011) Kathryn D. Smith et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Integration of Cyclic di-GMP and Quorum Sensing in the Control of vpsT and aphA in Vibrio cholerae

(2011) Disha Srivastava et al.   JOURNAL OF BACTERIOLOGY

Systematic Analysis of Diguanylate Cyclases That Promote Biofilm Formation by Pseudomonas fluorescens Pf0-1

(2011) P. D. Newell et al.   JOURNAL OF BACTERIOLOGY

The Atypical Two-component Sensor Kinase Lpl0330 fromLegionella pneumophilaControls the Bifunctional Diguanylate Cyclase-Phosphodiesterase Lpl0329 to Modulate Bis-(3′-5′)-cyclic Dimeric GMP Synthesis

(2011) Mélanie Levet-Paulo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Solution Structure of the PilZ Domain Protein PA4608 Complex with Cyclic di-GMP Identifies Charge Clustering as Molecular Readout

(2011) Judith Habazettl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclic di-GMP Activation of Polynucleotide Phosphorylase Signal-Dependent RNA Processing

(2011) Jason R. Tuckerman et al.   JOURNAL OF MOLECULAR BIOLOGY

The overlapping host responses to bacterial cyclic dinucleotides

(2011) Ali A. Abdul-Sater et al.   MICROBES AND INFECTION

The CRP/FNR family protein Bcam1349 is a c-di-GMP effector that regulates biofilm formation in the respiratory pathogen Burkholderia cenocepacia

(2011) Mustafa Fazli et al.   MOLECULAR MICROBIOLOGY

STING is a direct innate immune sensor of cyclic di-GMP

(2011) Dara L. Burdette et al.   NATURE

Intranasal c-di-GMP-adjuvanted plant-derived H5 influenza vaccine induces multifunctional Th1 CD4+ cells and strong mucosal and systemic antibody responses in mice

(2011) Abdullah S. Madhun et al.   VACCINE

The Structure of an Unconventional HD-GYP Protein from Bdellovibrio Reveals the Roles of Conserved Residues in this Class of Cyclic-di-GMP Phosphodiesterases

(2011) A. L. Lovering et al.   mBio

Structural Basis for c-di-GMP-Mediated Inside-Out Signaling Controlling Periplasmic Proteolysis

(2011) Marcos V. A. S. Navarro et al.   PLOS BIOLOGY

A c-di-GMP Effector System Controls Cell Adhesion by Inside-Out Signaling and Surface Protein Cleavage

(2011) Peter D. Newell et al.   PLOS BIOLOGY

MrkH, a Novel c-di-GMP-Dependent Transcriptional Activator, Controls Klebsiella pneumoniae Biofilm Formation by Regulating Type 3 Fimbriae Expression

(2011) Jonathan J. Wilksch et al.   PLoS Pathogens

Molecular strategies for phosphorylation-mediated regulation of response regulator activity

(2010) Rong Gao et al.   CURRENT OPINION IN MICROBIOLOGY

TheN-Ethyl-N-Nitrosourea-InducedGoldenticketMouse Mutant Reveals an Essential Function ofStingin theIn VivoInterferon Response toListeria monocytogenesand Cyclic Dinucleotides

(2010) John-Demian Sauer et al.   INFECTION AND IMMUNITY

Binding of Cyclic Diguanylate in the Non-catalytic EAL Domain of FimX Induces a Long-range Conformational Change

(2010) Yaning Qi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of PP4397 Reveals the Molecular Basis for Different c-di-GMP Binding Modes by Pilz Domain Proteins

(2010) Junsang Ko et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural Insight into the Mechanism of c-di-GMP Hydrolysis by EAL Domain Phosphodiesterases

(2010) Anatoli Tchigvintsev et al.   JOURNAL OF MOLECULAR BIOLOGY

Coupling between the BLUF and EAL domains in the blue light-regulated phosphodiesterase BlrP1

(2010) Maria Khrenova et al.   JOURNAL OF MOLECULAR MODELING

Unphosphorylated CsgD controls biofilm formation in Salmonella enterica serovar Typhimurium

(2010) Katherina Zakikhany et al.   MOLECULAR MICROBIOLOGY

Structural characterization reveals that a PilZ domain protein undergoes substantial conformational change upon binding to cyclic dimeric guanosine monophosphate

(2010) Jae-Sun Shin et al.   PROTEIN SCIENCE

An Allosteric Self-Splicing Ribozyme Triggered by a Bacterial Second Messenger

(2010) E. R. Lee et al.   SCIENCE

Asymmetrical Distribution of the Second Messenger c-di-GMP upon Bacterial Cell Division

(2010) M. Christen et al.   SCIENCE

c-di-AMP Secreted by Intracellular Listeria monocytogenes Activates a Host Type I Interferon Response

(2010) J. J. Woodward et al.   SCIENCE

Vibrio cholerae VpsT Regulates Matrix Production and Motility by Directly Sensing Cyclic di-GMP

(2010) P. V. Krasteva et al.   SCIENCE

A novel C-di-GMP effector linking intracellular virulence regulon to quorum sensing and hypoxia sensing

(2010) Lian-Hui Zhang   Virulence

Intermolecular interactions between HD-GYP and GGDEF domain proteins mediate virulence-related signal transduction inXanthomonas campestris

(2010) Robert P. Ryan et al.   Virulence

Second messenger-mediated spatiotemporal control of protein degradation regulates bacterial cell cycle progression

(2009) A. Duerig et al.   GENES & DEVELOPMENT

The Cyclic Nucleotide Monophosphate Domain of Xanthomonas campestris Global Regulator Clp Defines a New Class of Cyclic Di-GMP Effectors

(2009) F. Tao et al.   JOURNAL OF BACTERIOLOGY

Cyclic di-GMP Allosterically Inhibits the CRP-Like Protein (Clp) of Xanthomonas axonopodis pv. citri

(2009) J. L. Leduc et al.   JOURNAL OF BACTERIOLOGY

The Functional Role of a Conserved Loop in EAL Domain-Based Cyclic di-GMP-Specific Phosphodiesterase

(2009) F. Rao et al.   JOURNAL OF BACTERIOLOGY

Crystal Structures of YkuI and Its Complex with Second Messenger Cyclic Di-GMP Suggest Catalytic Mechanism of Phosphodiester Bond Cleavage by EAL Domains

(2009) George Minasov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP

(2009) Sarah M. McWhirter et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PILZ Protein Structure and Interactions with PILB and the FIMX EAL Domain: Implications for Control of Type IV Pilus Biogenesis

(2009) Cristiane R. Guzzo et al.   JOURNAL OF MOLECULAR BIOLOGY

Determinants for the Activation and Autoinhibition of the Diguanylate Cyclase Response Regulator WspR

(2009) Nabanita De et al.   JOURNAL OF MOLECULAR BIOLOGY

The cAMP Receptor-Like Protein CLP Is a Novel c-di-GMP Receptor Linking Cell–Cell Signaling to Virulence Gene Expression in Xanthomonas campestris

(2009) Ko-Hsin Chin et al.   JOURNAL OF MOLECULAR BIOLOGY

Co-regulation ofXanthomonas campestrisvirulence by quorum sensing and a novel two-component regulatory system RavS/RavR

(2009) Ya-Wen He et al.   MOLECULAR MICROBIOLOGY

Structure and mechanism of a bacterial light-regulated cyclic nucleotide phosphodiesterase

(2009) Thomas R. M. Barends et al.   NATURE

Structural and mechanistic determinants of c-di-GMP signalling

(2009) Tilman Schirmer et al.   NATURE REVIEWS MICROBIOLOGY

LapD is a bis-(3',5')-cyclic dimeric GMP-binding protein that regulates surface attachment by Pseudomonas fluorescens Pf0-1

(2009) P. D. Newell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Catalytically Incompetent by Design

(2009) Rong Gao et al.   STRUCTURE

Structural Analysis of the GGDEF-EAL Domain-Containing c-di-GMP Receptor FimX

(2009) Marcos V.A.S. Navarro et al.   STRUCTURE

Identification and Characterization of Cyclic Diguanylate Signaling Systems Controlling Rugosity in Vibrio cholerae

(2008) S. Beyhan et al.   JOURNAL OF BACTERIOLOGY

Catalytic Mechanism of Cyclic Di-GMP-Specific Phosphodiesterase: a Study of the EAL Domain-Containing RocR from Pseudomonas aeruginosa

(2008) F. Rao et al.   JOURNAL OF BACTERIOLOGY

The HupR Receiver Domain Crystal Structure in its Nonphospho and Inhibitory Phospho States

(2008) Karen M. Davies et al.   JOURNAL OF MOLECULAR BIOLOGY

Identification of FleQ fromPseudomonas aeruginosaas a c-di-GMP-responsive transcription factor

(2008) Jason W. Hickman et al.   MOLECULAR MICROBIOLOGY

Listeria monocytogenes multidrug resistance transporters activate a cytosolic surveillance pathway of innate immunity

(2008) G. T. Crimmins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

XC1028 fromXanthomonas campestrisadopts a PilZ domain-like structure without a c-di-GMP switch

(2008) Tso-Ning Li et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Crystal structure of Escherichia coli PNPase: Central channel residues are involved in processive RNA degradation

(2008) Z. Shi et al.   RNA

Riboswitches in Eubacteria Sense the Second Messenger Cyclic Di-GMP

(2008) N. Sudarsan et al.   SCIENCE

Phosphorylation-Independent Regulation of the Diguanylate Cyclase WspR

(2008) Nabanita De et al.   PLOS BIOLOGY