Structural basis for proton conduction and inhibition by the influenza M2 protein

Membrane Protein Structure and Dynamics from NMR Spectroscopy

(2012) Mei Hong et al.   Annual Review of Physical Chemistry

NMR Determination of Protein Partitioning into Membrane Domains with Different Curvatures and Application to the Influenza M2 Peptide

(2012) Tuo Wang et al.   BIOPHYSICAL JOURNAL

Hydrogen-Bonding Partner of the Proton-Conducting Histidine in the Influenza M2 Proton Channel Revealed From 1H Chemical Shifts

(2012) Mei Hong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Paramagnetic Cu(II) for Probing Membrane Protein Structure and Function: Inhibition Mechanism of the Influenza M2 Proton Channel

(2012) Yongchao Su et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Solid-State NMR Studies of Amyloid Fibril Structure

(2011) Robert Tycko   Annual Review of Physical Chemistry

Evaluation of the antiviral drug susceptibility of influenza viruses in Italy from 2004/05 to 2009/10 epidemics and from the recent 2009 pandemic

(2011) Simona Puzelli et al.   ANTIVIRAL RESEARCH

Structural and dynamic mechanisms for the function and inhibition of the M2 proton channel from influenza A virus

(2011) Jun Wang et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Computational Studies of Influenza A Virus at Three Important Targets: Hemagglutinin, Neuraminidase and M2 Protein

(2011) Thanyada Rungrotmongkol et al.   CURRENT PHARMACEUTICAL DESIGN

Emergence and Phylogenetic Analysis of Amantadine-Resistant Influenza A Subtype H3N2 Viruses in Dublin, Ireland, over Six Seasons from 2003/2004 to 2008/2009

(2011) A. Salter et al.   INTERVIROLOGY

Adamantane- and Oseltamivir-Resistant Seasonal A (H1N1) and Pandemic A (H1N1) 2009 Influenza Viruses in Guangdong, China, during 2008 and 2009

(2011) Jie Zhou et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Free Energy Calculations on the Two Drug Binding Sites in the M2 Proton Channel

(2011) Ruo-Xu Gu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Membrane-Dependent Effects of a Cytoplasmic Helix on the Structure and Drug Binding of the Influenza Virus M2 Protein

(2011) Sarah Cady et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

NMR Detection of pH-Dependent Histidine–Water Proton Exchange Reveals the Conduction Mechanism of a Transmembrane Proton Channel

(2011) Fanghao Hu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Specific Binding of Adamantane Drugs and Direction of Their Polar Amines in the Pore of the Influenza M2 Transmembrane Domain in Lipid Bilayers and Dodecylphosphocholine Micelles Determined by NMR Spectroscopy

(2011) Sarah D. Cady et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular Dynamics Simulation Directed Rational Design of Inhibitors Targeting Drug-Resistant Mutants of Influenza A Virus M2

(2011) Jun Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tidal surge in the M2 proton channel, sensed by 2D IR spectroscopy

(2011) A. Ghosh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Investigation of Rimantadine Inhibition of the AM2-BM2 Chimera Channel of Influenza Viruses

(2011) Rafal M. Pielak et al.   STRUCTURE

Evolutionary genomics of the pandemic 2009 H1N1 influenza viruses (pH1N 1v)

(2011) Yanhua Qu et al.   Virology Journal

Comprehensive assessment of 2009 pandemic influenza A (H1N1) virus drug susceptibility in vitro

(2010) Larisa V Gubareva et al.   ANTIVIRAL THERAPY

Conformational plasticity of the influenza A M2 transmembrane helix in lipid bilayers under varying pH, drug binding, and membrane thickness

(2010) Fanghao Hu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Computational study of drug binding to the membrane-bound tetrameric M2 peptide bundle from influenza A virus

(2010) Ekta Khurana et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Influenza Virus M2 Protein Mediates ESCRT-Independent Membrane Scission

(2010) Jeremy S. Rossman et al.   CELL

Genetic Makeup of Amantadine-Resistant and Oseltamivir-Resistant Human Influenza A/H1N1 Viruses

(2010) H. Zaraket et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Multiple Proton Confinement in the M2 Channel from the Influenza A Virus

(2010) Vincenzo Carnevale et al.   Journal of Physical Chemistry C

Conformational Changes of an Ion Channel Detected Through Water−Protein Interactions Using Solid-State NMR Spectroscopy

(2010) Wenbin Luo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Proton Transport through the Influenza A M2 Channel: Three-Dimensional Reference Interaction Site Model Study

(2010) Saree Phongphanphanee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Kinetic Analysis of the M2 Proton Conduction of the Influenza Virus

(2010) Rafal M. Pielak et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure of the amantadine binding site of influenza M2 proton channels in lipid bilayers

(2010) Sarah D. Cady et al.   NATURE

Structure and mechanism of proton transport through the transmembrane tetrameric M2 protein bundle of the influenza A virus

(2010) R. Acharya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proton and cation transport activity of the M2 proton channel from influenza A virus

(2010) T. Leiding et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coexistence of two adamantane binding sites in the influenza A M2 ion channel

(2010) M. R. Rosenberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insight into the Mechanism of the Influenza A Proton Channel from a Structure in a Lipid Bilayer

(2010) M. Sharma et al.   SCIENCE

Mechanisms of Proton Conduction and Gating in Influenza M2 Proton Channels from Solid-State NMR

(2010) F. Hu et al.   SCIENCE

Where does amantadine bind to the influenza virus M2 proton channel?

(2010) Dima Kozakov et al.   TRENDS IN BIOCHEMICAL SCIENCES

Emergence of amantadine-resistant avian influenza H5N1 virus in India

(2010) C. Tosh et al.   VIRUS GENES

Structure and Dynamics of Membrane Proteins by Magic Angle Spinning Solid-State NMR

(2009) Ann McDermott   Annual Review of Biophysics

Structure and Function of the Influenza A M2 Proton Channel

(2009) Sarah D. Cady et al.   BIOCHEMISTRY

Functional Studies and Modeling of Pore-Lining Residue Mutants of the Influenza A Virus M2 Ion Channel

(2009) Victoria Balannik et al.   BIOCHEMISTRY

Binding Hot Spots and Amantadine Orientation in the Influenza A Virus M2 Proton Channel

(2009) Gwo-Yu Chuang et al.   BIOPHYSICAL JOURNAL

Genomic events underlying the changes in adamantane resistance among influenza A(H3N2) viruses during 2006-2008

(2009) Varough Deyde et al.   Influenza and Other Respiratory Viruses

Why Amantadine Loses Its Function in Influenza M2 Mutants: MD Simulations

(2009) Chittima Laohpongspaisan et al.   Journal of Chemical Information and Modeling

High prevalence of amantadine resistance among circulating European porcine influenza A viruses

(2009) A. Krumbholz et al.   JOURNAL OF GENERAL VIROLOGY

Accurate Measurement of Methyl13C Chemical Shifts by Solid-State NMR for the Determination of Protein Side Chain Conformation: The Influenza A M2 Transmembrane Peptide as an Example

(2009) Mei Hong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Discovery of Spiro-Piperidine Inhibitors and Their Modulation of the Dynamics of the M2 Proton Channel from Influenza A Virus

(2009) Jun Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular dynamics calculations suggest a conduction mechanism for the M2 proton channel from influenza A virus

(2009) E. Khurana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An amantadine-sensitive chimeric BM2 ion channel of influenza B virus has implications for the mechanism of drug inhibition

(2009) Y. Ohigashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of the functional core of the influenza A virus A/M2 proton-selective ion channel

(2009) C. Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Free-energy profiles for ions in the influenza M2-TMD channel

(2009) Morad Mustafa et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Reversion of Influenza A (H3N2) Virus from Amantadine Resistant to Amantadine Sensitive by Further Reassortment in Japan during the 2006-to-2007 Influenza Season

(2008) Y. Furuse et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Structure of Amantadine-Bound M2 Transmembrane Peptide of Influenza A in Lipid Bilayers from Magic-Angle-Spinning Solid-State NMR: The Role of Ser31 in Amantadine Binding

(2008) Sarah D. Cady et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure and mechanism of the M2 proton channel of influenza A virus

(2008) Jason R. Schnell et al.   NATURE

Structural basis for the function and inhibition of an influenza virus proton channel

(2008) Amanda L. Stouffer et al.   NATURE

Amantadine-induced conformational and dynamical changes of the influenza M2 transmembrane proton channel

(2008) S. D. Cady et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional studies indicate amantadine binds to the pore of the influenza A virus M2 proton-selective ion channel

(2008) X. Jing et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Interplay of Functional Tuning, Drug Resistance, and Thermodynamic Stability in the Evolution of the M2 Proton Channel from the Influenza A Virus

(2008) Amanda L. Stouffer et al.   STRUCTURE

Initial structural and dynamic characterization of the M2 protein transmembrane and amphipathic helices in lipid bilayers

(2003) Changlin Tian et al.   PROTEIN SCIENCE

Structure of the transmembrane region of the M2 protein H+ channel

(2002) Junfeng Wang et al.   PROTEIN SCIENCE