An integrated approach to extreme thermostabilization and affinity maturation of an antibody

Transfer of engineered biophysical properties between different antibody formats and expression systems

(2012) J. V. Schaefer et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Disulfide bond formation and its impact on the biological activity and stability of recombinant therapeutic proteins produced by Escherichia coli expression system

(2011) Lin Zhang et al.   BIOTECHNOLOGY ADVANCES

Coupling mammalian cell surface display with somatic hypermutation for the discovery and maturation of human antibodies

(2011) P. M. Bowers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Improving the species cross-reactivity of an antibody using computational design

(2009) Christopher J. Farady et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The Role of Thiols and Disulfides on Protein Stability

(2009) Maulik Trivedi et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Engineered Human Antibody Constant Domains with Increased Stability

(2009) Rui Gong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Design of therapeutic proteins with enhanced stability

(2009) N. Chennamsetty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Precise determination of the diversity of a combinatorial antibody library gives insight into the human immunoglobulin repertoire

(2009) J. Glanville et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The influence of the framework core residues on the biophysical properties of immunoglobulin heavy chain variable domains

(2009) Annemarie Honegger et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Structural understanding of stabilization patterns in engineered bispecific Ig-like antibody molecules

(2009) Jacob L. Jordan et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Antibody production, design and use for biosensor-based applications

(2009) Paul J. Conroy et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The effect of additional disulfide bonds on the stability and folding of ribonuclease A

(2008) Pascal Pecher et al.   BIOPHYSICAL CHEMISTRY

Single-domain antibodies as building blocks for novel therapeutics

(2008) D SAERENS et al.   CURRENT OPINION IN PHARMACOLOGY

Backrub-Like Backbone Simulation Recapitulates Natural Protein Conformational Variability and Improves Mutant Side-Chain Prediction

(2008) Colin A. Smith et al.   JOURNAL OF MOLECULAR BIOLOGY

Conserved amino acid networks involved in antibody variable domain interactions

(2008) Norman Wang et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS