期刊
BIOTECHNOLOGY ADVANCES
卷 29, 期 6, 页码 923-929出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biotechadv.2011.07.013
关键词
Recombinant therapeutic protein; Disulfide bond formation/scrambling; Biological activity; Stability
资金
- Natural Sciences and Engineering Research Council of Canada
Therapeutic proteins require correct disulfide bond formation for biological activity and stability. This makes their manufacturing and storage inherently challenging since disulfide bonds can be aberrantly formed and/or undergo significant structural changes. In this paper the mechanisms of disulfide bond formation and scrambling are reviewed, with a focus on their impact on the biological activity and storage stability of recombinant proteins. After assessing the research progress in detecting disulfide bond scrambling, strategies for preventing this phenomenon are proposed. (C) 2011 Elsevier Inc. All rights reserved.
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