Article
Environmental Sciences
Qi Liu, Guo-Long Zang, Quan Zhao
Summary: In this study, UiO-66-NH2 and UiO-66-NS were prepared for efficient removal of methyl orange. UiO-66-NS showed good adsorption performance and exhibited high stability under different environmental conditions.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Yanira Mendez, Aldrin V. Vasco, Galway Ivey, Ana Laura Dias, Peter Gierth, Barbara B. Sousa, Claudio D. Navo, Angel Torres-Mozas, Tiago Rodrigues, Gonzalo Jimenez-Oses, Goncalo J. L. Bernardes
Summary: A novel multicomponent approach combining the isonitrile-tetrazine (4+1) cycloaddition and the Ugi four-component reaction was developed to generate pyrazole amide derivatives. The scope of the reaction and the mechanistic insights of the 4H-pyrazol-4-imine tautomerization were provided. This multicomponent process expands the chemical space of pyrazole amide derivatives and offers a tool for peptide modification and stapling.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Materials Science, Paper & Wood
Pouya Ghamari Kargar, Milad Nayebi, Zahra Parhizi, Rajender S. Varma
Summary: An eco-friendly approach was used to generate Ni nanoparticles on a magnetized cellulose biopolymer, resulting in a core-shell type nanocomposite (Fe3O4@CNF@Ni). The nanocomposite was characterized using various advanced techniques and its catalytic performance was evaluated in the synthesis of biaryl derivatives. The results showed that the nanocomposite exhibited high stability and catalytic efficiency.
Article
Chemistry, Organic
Yogesh Thopate, Richa Singh, Sumit K. Rastogi, Arun K. Sinha
Summary: In this study, a multicomponent 5 step reaction was developed to synthesize stilbene/biaryl-quinolone hybrid molecules. The combination of Gould-Jacobs reaction and Heck reaction, along with the use of diphenyl ether as a reaction solvent, allowed for the convergence of five steps into one pot. This method not only generated C-C and C-N bonds, but also cleaved C-O and C-C bonds, demonstrating its potential in the synthesis of hybrid molecules.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Xiaofang Lei, Maria Thomaidi, Giasemi K. Angeli, Alexander Domling, Constantinos G. Neochoritis
Summary: The synthesis of fluorene and fluorenone through isocyanide-based multicomponent reactions (IMCRs) has led to the discovery of 23 unprecedented adducts, demonstrating the potential for further utilization in diverse and complex derivatives.
Article
Chemistry, Organic
Alexandre Quelhas, Houda Gazzeh, Thierry Roisnel, Yann Trolez, Jean-Claude Guillemin
Summary: Kinetically unstable vinyl, allenyl and propargyl isocyanides react faster in Passerini and Ugi reactions than they decompose, leading to functionalized amides that can be further used in reactions involving unsaturated substituents.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Physical
Jian Tian, Lulu Zhao, Chuan Yang, Chao Yang, Lin Guo, Wujiong Xia
Summary: Metal-free heterogeneous catalysis is a promising strategy for the synthesis of valuable imidazolidines. In this study, a photocatalytically active carbon nitride-based heterogeneous catalyst was prepared from melamine and glyoxal. This catalyst, denoted as 1.0 Ci-C3N4, showed visible light harvesting capacity and catalytic activity, enabling the four-component synthesis of spiro-imidazolidines under visible light irradiation. The catalyst exhibited a broad substrate scope, good functional group tolerance, and easy recovery and recycling, making it suitable for industrial manufacture.
Article
Chemistry, Applied
Mohammad Taghi Nazeri, Siamak Javanbakht, Mohadese Nabi, Ahmad Shaabani
Summary: In this study, pectin was used as a green support to construct an efficient heterogeneous catalytic system based on metal phthalocyanines. The catalytic activity of the copper phthalocyanine-conjugated pectin in the CO2 fixation reaction was investigated. Pectin successfully improved the catalytic properties of the Cu-PcTA.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Organic
Gavaskar Deivasigamani, Suresh Babu Adukamparai Rajukrishnan
Summary: This study presents a facile and efficient synthesis method for highly substituted trispiro heterocyclic systems in a single step, with the product structure confirmed through various analytical techniques.
SYNTHETIC COMMUNICATIONS
(2021)
Article
Chemistry, Organic
Mario Perez-Venegas, Teresa Arbeloa, Jorge Banuelos, Inigo Lopez-Arbeloa, Nancy E. Lozoya-Perez, Bernardo Franco, Hector M. Mora-Montes, Jose L. Belmonte-Vazquez, Claudia Bautista-Hernandez, Eduardo Pena-Cabrera, Eusebio Juaristi
Summary: Mechanochemistry is used to prepare valuable dyes, with the molecular structure and fluorescence interaction playing a key role in fluorescence response, demonstrating high brightness in cellular media. The novel dyes efficiently stain PBMCs and Candida albicans cells, and can monitor different stages of phagocytosis.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Artemiy Nichugovskiy, Varvara Maksimova, Ekaterina Trapeznikova, Elizaveta Eshtukova-Shcheglova, Igor Ivanov, Marianna Yakubovskaya, Kirill Kirsanov, Dmitry Cheshkov, Gian Cesare Tron, Mikhail Maslov
Summary: This study demonstrates a new method for the synthesis of lipophilic synthetic polyamines (LPAs) and evaluates their anticancer activity in different cancer cell lines. The results show that LPAs with piperazine fragments exhibit comparable anticancer activity to aliphatic LPAs, and the presence of a diglyceride fragment in LPAs appears to be a key factor for their high anticancer activity.
Article
Chemistry, Multidisciplinary
Aref Ghasemi-Ghahsareh, Javad Safaei-Ghomi, Hourieh Sadat Oboudatian
Summary: In this work, l-tryptophan functionalized silica-coated magnetic nanoparticles were prepared and evaluated as a recyclable magnetic nanocatalyst for the synthesis of spiro[indene-2,2'-naphthalene]-4'-carbonitrile derivatives. The obtained nanoparticles showed effective catalytic activity and provided products in moderate to excellent yields under reflux conditions. Various characterization techniques were used to investigate the structure of the nanoparticles.
Article
Chemistry, Multidisciplinary
Hui-Ling Fang, Jing Sun, Chao-Guo Yan
Summary: The three-component reaction of isoquinoline, dialkyl but-2-ynedioate, and 4-arylidene-5-methyl-2-phenylpyrazol-3-ones at room temperature yielded functionalized spiro[pyrazole-4,1'-pyrido[2,1-a]isoquinolines], with the cis/cis-diastereoisomer as the major product. A similar three-component reaction with quinoline resulted in both cis/cis- and cis/trans-isomeric spiro[pyrazole-4,4'-pyrido[1,2-a]quinolines] in comparable yields, involving in situ generation of Huisgen's 1,4-dipole, sequential Michael addition, and annulation reaction process.
Article
Chemistry, Physical
M. J. Madhura, A. S. Jeevan Chakravarthy, S. Hariprasad, V Gayathri
Summary: In this study, a polystyrene anchored palladium (II) complex of 2-acetylbenzimidazole was synthesized and characterized. The supported complex exhibited excellent catalytic activity and recyclability in the Suzuki-Miyaura cross-coupling reaction.
Article
Chemistry, Organic
Takashi Okitsu, Maho Itoh, Ayaka Inui, Emiko Muta, Ryota Nakamoto, Yuta Adachi, Akimori Wada, Manabu Hatano
Summary: In this study, we report a method for the iodocyclization of ene-ynamides, which allows for the rapid synthesis of polycyclic aromatic compounds. The reaction is completed within 3 seconds and yields high amounts of cyclized products.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Review
Chemistry, Multidisciplinary
Srinivas Lavanya Kumar Manda, Shashank Tripathi, Anirban Ghoshal, Mayur D. Ambule, Ajay Kumar Srivastava, Gautam Panda
CHEMISTRY-A EUROPEAN JOURNAL
(2020)
Article
Chemistry, Organic
Shashank Tripathi, Mayur D. Ambule, Ajay Kumar Srivastava
JOURNAL OF ORGANIC CHEMISTRY
(2020)
Review
Chemistry, Organic
Anirban Ghoshal, Mayur D. Ambule, Anamika Yadav, Ajay Kumar Srivastava
Summary: This mini-review discusses the advances in base-mediated post-Ugi transformations, focusing on the abstraction of an alpha proton adjacent to amide carbonyl in aldehyde-derived Ugi adducts under basic conditions for intramolecular and intermolecular cyclizations. The methodologies are classified based on the peptidyl anion trapping under various reaction conditions, highlighting their importance in synthetic and medicinal chemistry.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Infectious Diseases
Ravishankar Ramachandran, Vivek Bhosale, Himanshu Reddy, Virendra Atam, M. M. A. Faridi, Jalees Fatima, Vaibhav Shukla, Zaw A. Khan, Hana Khan, Vikram Singh, Mahendra Pal Singh Negi, Mukesh Srivastava, Ajay Kumar Srivastava, Chandra Bhushan Tripathi, Nayan Ghosh, Nilanjana Majumdar, Raj Kamal Tripathi, Srikanta Kumar Rath, Prabhat Ranjan Mishra, Sharad Sharma, Tapas K. Kundu
Summary: Umifenovir shows efficacy, safety and tolerability in non-severe COVID-19 adult patients. It meets the primary and secondary endpoint criteria and exhibits statistically significant efficacy in mild-asymptomatic patients. It is efficacious, safe and well-tolerated at the tested dosage of 800mg BID, maximum 14 days.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Biophysics
Nitesh Priyadarshi, Mayur D. Ambule, Shimayali Kaushal, Asheesh Kumar, Poonam Sagar, Ajay Kumar Srivastava, Nitin Kumar Singhal
Summary: Nanoglycoclusters, a type of functional nanomaterial, have various applications such as detection, imaging, and targeting of bacteria. By controlling the size of gold nanoparticles, the length of linker molecules, and the density of glycans, selective detection of specific bacteria and lectins can be achieved.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Organic
Anamika Yadav, Anubhav Yadav, Shashank Tripathi, Varun Dewaker, Ruchir Kant, Prem Narayan Yadav, Ajay Kumar Srivastava
Summary: Novel Pyrazolo[1,5-a]quinoxalin-4(5H)-one derivatives, acting as opioid receptor modulators, have been synthesized through a copper-catalyzed reaction. The synthesized compounds showed antagonistic effects on opioid receptors, and docking studies confirmed their binding with hKOR protein.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Sangh Priya Singh, Asheesh Kumar, Ruchir Kant, Ajay Kumar Srivastava
Summary: A convenient method for the synthesis of less explored pyrrolo[1,2-a]pyrazine-3,6(2H,4H)-diones from Ugi adducts is described. The method involves acid-mediated cyclization of Ugi adducts to form dihydropyrazinones followed by gold(I)-catalyzed regioselective annulation. By reacting various substituted dihydropyrazinones under optimized conditions, densely functionalized pyrrolo[1,2-a]pyrazine-3,6(2H,4H)-diones were obtained in good-to-excellent yields. It was also observed that some acetone-derived Ugi adducts produced 7-acyl-pyrroloimidazolones as byproducts during TFA-mediated cyclization.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Shashank Tripathi, Monty Kumar, Mayur D. Ambule, Ankit Saxena, Ruchir Kant, Sanjeev K. Shukla, Ajay Kumar Srivastava
Summary: Stereoselective difunctionalizations of alkynes were achieved to prepare (Z)-/(E)-fi-sulfonylacrylamides. The (Z)-fi-sulfonylacrylamides were generated via a one-pot process, while the (E)-fi-sulfonylacrylamides were prepared in a two-step synthesis.
Article
Chemistry, Organic
Mayur D. Ambule, Mandweep Bhumij, Asheesh Kumar, Ruchir Kant, Ajay Kumar Srivastava
Summary: Post-Ugi modifications provide an atom-economic approach to construct functionalized heterocycles. In this study, we demonstrated the synthesis of highly functionalized azaspiro tricyclic scaffolds through Ugi condensation, ipso-cyclization, and aza-Michael ring closures. We also investigated the substrate scope and limitations of aza-Michael cyclizations and developed new methods for the preparation of novel azaspiro tricyclic scaffolds.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Organic
Anamika Yadav, Surabhi Upadhyay, Ruchir Kant, Ajay Kumar Srivastava
Summary: A robust synthesis of phenanthridines has been achieved via Pd(II)-catalyzed domino C(sp(2))-H activation/N-arylation using oxime esters with aryl acyl peroxides in a highly regioselective manner. This method is compatible with various oxime esters derived from acetophenone and benzophenone, allowing modular construction of functionalized phenanthridines with wide electronic functionality tolerance.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Organic
Shashank Tripathi, Monty Kumar, Ayush Shivhare, Ruchir Kant, Milind M. Deshmukh, Ajay Kumar Srivastava
Summary: In this study, a palladium(II)-catalyzed regio- and stereoselective difunctionalization of alkynoic acids was successfully achieved using sodium sulfinates and isocyanides to synthesize (E)-ss-sulfonylacrylamides. The reaction showed good functional group tolerance and excellent regio- and stereoselectivity on aromatic, heteroaromatic, and aliphatic alkynoic acids. DFT calculations were performed to elucidate the reaction mechanism and the stereoselective formation of (E)-ss-sulfonylacrylamides.
Article
Chemistry, Organic
Anirban Ghoshal, Anamika Yadav, Ajay Kumar Srivastava
JOURNAL OF ORGANIC CHEMISTRY
(2020)
Article
Chemistry, Multidisciplinary
Sangh Priya Singh, Shashank Tripathi, Anamika Yadav, Ruchir Kant, Hemant Kumar Srivastava, Ajay Kumar Srivastava
CHEMICAL COMMUNICATIONS
(2020)
Article
Chemistry, Organic
Anamika Yadav, Mayur D. Ambule, Ruchir Kant, Ajay K. Srivastava
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2020)
Article
Chemistry, Multidisciplinary
Anirban Ghoshal, Mayur D. Ambule, Revoju Sravanthi, Mohit Taneja, Ajay Kumar Srivastava
NEW JOURNAL OF CHEMISTRY
(2019)
