Review
Oncology
Alberto M. Martelli, Camilla Evangelisti, Francesca Paganelli, Francesca Chiarini, James A. McCubrey
Summary: GSK-3 consists of two isoforms, alpha and beta, that are constitutively active but can be inactivated through phosphorylation by upstream kinases. It was initially considered a tumor suppressor, but it has also been found to have oncogenic properties in promoting pathways critical for cancer cell proliferation, survival, and drug-resistance.
Article
Clinical Neurology
Shuqiong Zheng, Jia Guo, Qianqian Xin, Hanga Galfalvy, Youran Ye, Na Yan, Rongrong Qian, J. John Mann, Enze Li, Xiang Xue, Honglei Yin
Summary: This study investigated the association of EPHX2 and P2X2 polymorphisms and mRNA expression with depression and suicidal behavior, as well as the mediating role of cognition in these associations. The results showed that cognitive function played a significant mediator role in the genetic effect on depression. The rs202059124 C allele was associated with increased depression risk, and P2X2 mRNA expression was related to depression. Furthermore, a haploblock (rs9331942 and rs2279590) was associated with suicide attempts. These findings suggest that EPHX2 and P2X2 genes are implicated in depression and suicidal behavior.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Hsuan-Yeh Pan, Mallika Valapala
Summary: Autophagy is a vital cellular mechanism that ensures cellular maintenance and survival. The GSK-3 signaling pathway regulates autophagy by modulating TFEB and other signaling molecules.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Ying Yang, Ting Huang, Hongli Zhang, Xuping Li, Shuotao Shi, Xiaoyu Tian, Ziwei Huang, Rong Zhang, Zhongqiu Liu, Yuanyuan Cheng
Summary: The study revealed that formononetin, a soy isoflavone, significantly improved depressive behaviors and cardiac function in patients with myocardial infarction (MI) by targeting GSK-3 beta to regulate macrophage/microglial polarization. Importantly, IL-6 and IL-17A produced after MI may cause neuroinflammation, which could be key factors for depression.
Article
Medicine, Research & Experimental
Chuanzheng Wang, Fei Cao, Jiahao Cao, Zhen Jiao, Yuting You, Yu Xiong, Wenxiu Zhao, Xiaomin Wang
Summary: CD58 is upregulated in HCC tissues and its overexpression is associated with poor prognosis in HCC patients. CD58 promotes proliferation and metastasis in HCC cells by activating the AKT/GSK-3β/β-catenin pathway, suggesting that CD58 may serve as a prognostic biomarker and therapeutic target for HCC.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Chemistry, Medicinal
Richard A. Hartz, Vijay T. Ahuja, Guanglin Luo, Ling Chen, Prasanna Sivaprakasam, Hong Xiao, Carol M. Krause, Wendy J. Clarke, Songmei Xu, John S. Tokarski, Kevin Kish, Hal Lewis, Nicolas Szapiel, Ramu Ravirala, Sayali Mutalik, Deepa Nakmode, Devang Shah, Catherine R. Burton, John E. Macor, Gene M. Dubowchik
Summary: Glycogen synthase kinase-3 (GSK-3) is a crucial regulator of cellular functions, implicated in diseases such as Alzheimer's disease, mood disorders, diabetes, and cancer. Its role in the production of abnormal tau protein in neurofibrillary tangles associated with Alzheimer's disease has been established. The synthesis and evaluation of pyrimidine-based GSK-3 inhibitors led to the identification of highly potent compounds that effectively lowered phosphorylated tau levels in a mouse model of Alzheimer's disease.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
E. P. Moreno-Jimenez, M. Flor-Garcia, A. Hernandez-Vivanco, J. Terreros-Roncal, C. B. Rodriguez-Moreno, N. Toni, P. Mendez, Maria Llorens-Martin
Summary: Adult hippocampal neurogenesis enhances brain plasticity and contributes to the cognitive reserve during aging. The molecular mechanisms regulating the maturation and synaptic integration of new neurons are not fully understood. In this study, the formation and maturation of inhibitory synapses during adult hippocampal neurogenesis were investigated using a novel retrovirus. The results suggest that GSK-3β plays a key role in inhibitory synapse formation and maturation during adult hippocampal neurogenesis.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Psychiatry
Honglei Yin, Jia Guo, Qianqian Xin, Shuqiong Zheng, Xiang Xue, Enze Li, Ting Liu, Na Yan, John Keilp, J. John Mann
Summary: Genetic factors may interact with childhood trauma to influence cognitive deficits related to suicide attempts and depression risk. Depressed individuals displayed longer reaction times, with suicide attempters showing longer reaction times for negative words. The protective effects of the rs211034 gene were eliminated in individuals exposed to childhood sexual abuse.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Cell Biology
Wenlong Hu, Jie Shen, Yu Tao, Dan Donga, Sicheng Lu, Liu Li, Dongdong Sun, Minmin Fan, Changliang Xu, Weixing Shen, Chengtao Yu, Haibo Cheng
Summary: This study found that CCDC85C inhibits the proliferation and migration of colorectal cancer cells by binding to GSK-3 beta and promoting ubiquitination and degradation of beta-catenin.
CELLULAR SIGNALLING
(2023)
Article
Neurosciences
Shaohui Wang, Yao Jiang, Yabo Liu, Qianhui Liu, Hongwei Sun, Mengjie Mei, Xiaomei Liao
Summary: This study demonstrates that ferroptosis promotes abnormal aggregation of tau protein and may serve as a promising therapeutic target for tauopathies.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Clinical Neurology
Rachel Hendricks, John G. Keilp, Mohammad Lesanpezeshki, Rina Muqkurtaj, Steven P. Ellis, Hanga Galfalvy, Ainsley K. Burke, Nadine Melhem, J. John Mann
Summary: This study examined the performance on the CD-RISC in individuals with familial risk for mood disorder and suicidal behavior. The study found that individuals with a history of suicide attempt had the lowest CD-RISC scores. However, CD-RISC scores were strongly correlated with other common risk factors for suicide attempt, such as hopelessness and subjective depression. Group differences in CD-RISC scores were eliminated when these risk factors were accounted for. Rating: 7 out of 10.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Genetics & Heredity
Cuifen Li, Manli Xie, Weiwei Wang, Yanyan Liu, Dan Liao, Jingwen Yin, Hao Huang
Summary: This study is the first and most comprehensive investigation of the association between ERs and depression in women, and the findings support the concept that ERs participate in the etiology of sex heterogeneity in depression.
FRONTIERS IN GENETICS
(2022)
Article
Clinical Neurology
Hui Wang, Liang Liang, Can Yang, Ling Xiao, Huiling Wang, Gaohua Wang, Zhixian Zhu
Summary: This study found that low-density lipoprotein receptor-related protein 1 (LRP1) in the hippocampus of rats is positively correlated with depressive-like behaviors. Administration of LRP1 improved depressive-like behaviors, while LRP1 knockdown alleviated the inhibition of synaptic plasticity induced by chronic unpredicted mild stress (CUMS). Furthermore, LRP1 knockdown increased synaptic plasticity through microtubule dynamics and activation of the Akt/GSK-3 beta signaling pathway. These findings suggest that LRP1 may serve as a potential therapeutic target for depression.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Computer Science, Interdisciplinary Applications
Muskan Garg
Summary: The increasing use of the internet for expressing personal thoughts and beliefs has made it easier for the social NLP research community to identify and validate the connections between social media posts and mental health status. Cross-sectional and longitudinal studies on social media data underscore the importance of real-time responsible AI models for mental health analysis. This comprehensive survey focuses on quantifying mental health on social media, classifying research directions in social computing, tracking advances in ML and DL models, and examining social well-being through personal writings on social media. The paper outlines various research directions for mental healthcare, including the handling of online social media data for stress, depression, and suicide detection. The key features of this manuscript include feature extraction and classification, recent advancements in AI models, publicly available dataset, and future research directions. The paper aims to introduce young researchers and academic practitioners to the field of computational intelligence for mental health analysis on social media, providing a quantitative synthesis and qualitative review of over 92 potential research articles. In addition, the paper releases a collection of existing work on suicide detection in an easily accessible and updatable repository.
ARCHIVES OF COMPUTATIONAL METHODS IN ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Yuko Nagao, Kikuko Amo-Shiinoki, Hiroko Nakabayashi, Masayuki Hatanaka, Manabu Kondo, Kimie Matsunaga, Masahiro Emoto, Shigeru Okuya, Yukio Tanizawa, Katsuya Tanabe
Summary: Endoplasmic reticulum stress is a key pathogenic factor in type 1 and 2 diabetes. Gsk-3 inhibition prevents proteasomal degradation of ATF4 and alleviates apoptosis by regulating phosphorylation of ATF4-S214. Mechanistically, Gsk-3 inhibition modulates transcription targets of ATF4 and facilitates dephosphorylation of eIF2 alpha under ER stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Carmine Tomasetti, Chiara Montemitro, Annastasia L. C. Fiengo, Cristina Santone, Laura Orsolini, Alessandro Valchera, Alessandro Carano, Maurizio Pompili, Gianluca Serafini, Giampaolo Perna, Federica Vellante, Giovanni Martinotti, Massimo D. Giannantonio, Yong-Ku Kim, Marco D. Nicola, Antonello Bellomo, Antonio Ventriglio, Michele Fornaro, Domenico D. Berardis
CURRENT PHARMACEUTICAL DESIGN
(2019)
Article
Clinical Neurology
Kyu-Man Han, Hee-Jung Jee, Hyonggin An, Cheolmin Shin, Ho-Kyoung Yoon, Young-Hoon Ko, Byung-Joo Ham, Yong-Ku Kim, Changsu Han
JOURNAL OF AFFECTIVE DISORDERS
(2019)
Article
Biochemistry & Molecular Biology
Eunsoo Won, Kyu-Man Han, Aram Kim, Min-Soo Lee, Yong-Ku Kim, Hun Soo Chang, Byung-Joo Ham
MOLECULAR & CELLULAR TOXICOLOGY
(2019)
Review
Clinical Neurology
Seoyoung Yoon, Yong-Ku Kim
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2019)
Editorial Material
Psychiatry
Yong-Ku Kim
PSYCHIATRY INVESTIGATION
(2019)
Article
Psychiatry
Ana C. Andreazza, Isabelle Laksono, Brisa S. Fernandes, Catherine Toben, Piotr Lewczuk, Peter Riederer, Sidney H. Kennedy, Dimitrios Kapogiannis, Florence Thibaut, Manfred Gerlach, Carla Gallo, Yong-Ku Kim, Edna Grunblatt, Lakshmi Yatham, Michael Berk, Bernhard T. Baune
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2019)
Article
Clinical Neurology
Jeong-Kyung Ko, Kyu-Man Han, Cheolmin Shin, Seung-Hoon Lee, Changsu Han, Yong-Ku Kim, Ho-Kyong Yoon, Young-Hoon Ko
JOURNAL OF AFFECTIVE DISORDERS
(2019)
Review
Clinical Neurology
Meysam Amidfar, Marie Woelfer, Gislaine Z. Reus, Joao Quevedo, Martin Walter, Yong-Ku Kim
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2019)
Review
Psychiatry
Seon-Cheol Park, Yong-Ku Kim
PSYCHIATRY INVESTIGATION
(2019)
Editorial Material
Psychiatry
Seon-Cheol Park, Yong-Ku Kim
PSYCHIATRY INVESTIGATION
(2019)
Editorial Material
Neurosciences
Youn Jung Lee, Yong-Ku Kim
CURRENT NEUROPHARMACOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Eunsoo Won, Yong-Ku Kim
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Biochemistry & Molecular Biology
Junhyung Kim, Yong-Ku Kim
Summary: Alzheimer's disease is the most common type of dementia, with depression being a risk factor for its development. While depression patients often recover without residual symptoms, late-life depression patients may show residual cognitive impairment. Understanding how risk factors impact the course of Alzheimer's disease is crucial for its management.
Review
Biochemistry & Molecular Biology
Lorenza Lucidi, Mauro Pettorruso, Federica Vellante, Francesco Di Carlo, Franca Ceci, Maria Chiara Santovito, Ilenia Di Muzio, Michele Fornaro, Antonio Ventriglio, Carmine Tomasetti, Alessandro Valchera, Alessandro Gentile, Yong-Ku Kim, Giovanni Martinotti, Silvia Fraticelli, Massimo Di Giannantonio, Domenico De Berardis
Summary: The gut microbiota plays a crucial role in maintaining homeostasis, growth, and digestive processes. It also influences the intercommunication system between the gut and the brain, potentially impacting the pathogenesis and clinical management of Bipolar Disorder. Current literature suggests a relationship between compositional alterations in the gut microbiota and BD, with potential benefits in treating BD symptoms through modifications in the microbiota composition. Further research is needed to explore the potential of correcting gut microbiota alterations as a novel strategy in BD management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Eunsoo Won, Kyoung-Sae Na, Yong-Ku Kim
Summary: Inflammatory conditions and disruptions in circadian rhythms, including alterations in the melatonin system, have been suggested as mechanisms underlying major depressive disorder. Melatonin, with its immunological and non-immunological actions, can suppress inflammation and influence neuroinflammation and neurotoxicity, leading to alterations in brain regions implicated in depression. Further research on the associations between melatonin, immune markers, and brain structure and function may help identify potential biomarkers for MDD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Nadia Deflorin, Ulrike Ehlert, Rita T. Amiel Castro
Summary: Changes in the gut microbiome of infants have been associated with maternal psychological symptoms during pregnancy. This study found that maternal prenatal depressive symptoms are associated with lower diversity of the infant's microbiome, while maternal saliva cortisol levels are linked to increased diversity and changes in specific bacterial groups. Further research is needed to understand the implications of these microbiota alterations for child health.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zheng Ma, Hui-Xia Zhou, Da-Chun Chen, Dong-Mei Wang, Xiang-Yang Zhang
Summary: The impaired glucose metabolism in drug-na & iuml;ve schizophrenia patients is strongly associated with suicidal behavior, suggesting that glucose metabolism abnormalities may be potential biomarkers of suicide in schizophrenia patients. Regular monitoring of glucose metabolism variables is essential for suicide prevention.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Katie M. Lavigne, Jiaxuan Deng, Delphine Raucher-Chene, Adele Hotte-Meunier, Chloe Voyer, Lisa Sarraf, Martin Lepage, Genevieve Sauve
Summary: Psychiatric disorders are characterized by cognitive deficits and cognitive biases, which are associated with specific symptoms. While cognitive biases are present across diagnoses, their severity varies.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Yong-Yu Yin, Jiao-Zhao Yan, Shi-Xin Lai, Qian-Qian Wei, Si-Rui Sun, Li-Ming Zhang, Yun-Feng Li
Summary: This study found that gamma oscillations are closely associated with depression and may serve as predictive biomarkers of depression. Chronic restraint stress and lipopolysaccharide induced significant depression-like behaviors in mice and reduced gamma oscillations in the medial prefrontal cortex. Administration of ketamine, scopolamine, or fluoxetine increased gamma oscillations and exhibited rapid-acting antidepressant effects.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Veronica Begni, Moira Marizzoni, Kerstin Camile Creutzberg, Diana Morena Silipo, Mariusz Papp, Annamaria Cattaneo, Marco Andrea Riva
Summary: Exposure to stressful experiences is a significant risk factor for mental disorders, and pharmacological interventions targeting stress-induced alterations can help restore brain function. Lurasidone, an antipsychotic drug, has been shown to normalize the impairments caused by stress exposure and could be a valuable treatment for stress-induced mental illnesses. However, the mechanisms underlying the therapeutic effects of lurasidone are not well understood. This study found that chronic lurasidone treatment counteracted some of the transcriptional changes induced by chronic mild stress exposure, providing new insights into the potential therapeutic effects of lurasidone.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Esther E. Palacios-Barrios, Kunal Patel, Jamie L. Hanson
Summary: This review examines the association between early life interpersonal stress (ELIS) and depression, as well as the underlying mechanisms. The research shows that ELIS affects how youth respond to social rewards, and similar impairments in social reward processing are observed in youth with depression. The authors propose a preliminary model that suggests neurobehavioral disruptions in social reward processing as a mediating factor in the connection between ELIS and depression.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Rui Li, Jiaming Tang, Yizhuo Wang, Ying Wang, Hua Yang, Hongen Wei
Summary: Restricted and repetitive behaviors (RRBs) are characteristic features of neuropsychiatric disorders. This study focused on repetitive self-grooming behavior and investigated the involvement of the Pax2 gene in its control. Through the use of Pax2 neuron-specific deletion mice, the study found that the deletion of Pax2 gene affects the expression of the Arc gene in the prefrontal cortex, leading to impaired synaptic plasticity and excitatory/inhibitory imbalance, thereby contributing to the occurrence of repetitive self-grooming behavior.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Sara Derosa, Paulina Misztak, Jessica Mingardi, Giulia Mazzini, Heidi Kaastrup Muller, Laura Musazzi
Summary: This study investigated the involvement of neurotrophic signaling pathways in stress vulnerability/resilience and fast antidepressant response/non-response to ketamine in a rat model of depression. The findings showed that stress and ketamine induced specific changes in these pathways in different brain areas and subcellular fractions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Georgia F. Caruana, Sean P. Carruthers, Michael Berk, Susan L. Rossell, Tamsyn E. Van Rheenen
Summary: Cognitive impairment is related to both white matter macrostructure and microstructure in bipolar disorder patients. However, there is inconsistency in the results of the studies examining this relationship. Some studies have found an association between higher fractional anisotropy in white matter and better complex attention skills and executive functioning in bipolar disorder patients, while others have found no associations. Further research with increased statistical power and standardized methods is needed.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Alberto Galimberti, Martin Tik, Giovanni Pellegrino, Anna-Lisa Schuler
Summary: This study provides a systematic review and meta-analysis on the effectiveness of repetitive transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) for post-traumatic brain injury (TBI) symptoms. The results show that non-invasive brain stimulation techniques have a small overall effect on TBI sequelae, with significant effects observed for anxiety and headache. However, larger randomized controlled trials with longer follow-ups, optimized stimulation parameters, and standardized methodology are needed to establish the efficacy of these techniques in addressing TBI sequelae.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Amanda J. Sales, Pedro H. Gobira, Joa F. C. Pedrazzi, Joao R. Silveia, Elaine Del Bel, Felipe V. Gomes, Francisco S. Guimaraes
Summary: The study found that doxycycline can inhibit metalloproteinase in the brain and attenuate the rewarding effects and locomotor sensitization of drug abuse. This suggests that doxycycline could be repurposed for the treatment of substance use disorders.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Alejandro Borrego-Ruiz, Juan J. Borrego
Summary: There is substantial evidence that the development of the nervous system is related to the composition and functions of the gut microbiome. The communication between the central nervous system (CNS) and the gut microbiota is bidirectional, with various routes such as immune, endocrine, and neural circuits. Dysbiosis of the gut microbiota has been associated with neuropsychiatric diseases and psychological disorders. Fecal microbiota transplantation (FMT) therapy has shown a causal-effect relationship between the gut microbiota and behavioral features. Interventions based on prebiotics, probiotics, or synbiotics have demonstrated their influence on neurological disorders through the synthesis of neuroactive compounds and regulation of inflammatory and endocrine processes. Further research is needed to explore the impact of gut microbiota dysbiosis on psychiatric and psychological disorders and the potential therapeutic role of microbiota-based interventions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zhinan Li, Zhuang Kang, Xiaowei Xia, Leijun Li, Junyan Wu, Jiamin Dai, Tong Liu, Cai Chen, Yong Qiu, Ming Chen, Yanxi Liu, Ziyi Zhang, Zili Han, Zhengjia Dai, Qinling Wei
Summary: This study found that patients with schizophrenia showed lower levels of resilience and cognitive functions compared to healthy controls, as well as abnormal global properties and nodal metrics in brain networks. Furthermore, characteristic path length might moderate the relationship between resilience and working memory in these patients.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
David H. Adamowicz, Tsung-Chin Wu, Rebecca Daly, Michael R. Irwin, Dilip Jeste, Xin M. Tu, Lisa T. Eyler, Ellen E. Lee
Summary: This study aimed to explore the relationship between executive functioning and inflammatory biomarkers in people with schizophrenia. The results showed that systemic inflammation did not predict long-term declines in executive functioning. This suggests the need for further research to better understand the relationship and mechanisms between inflammation and cognition in schizophrenia.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Nina Walter, Julian Wenzel, Shalaila S. Haas, Letizia Squarcina, Carolina Bonivento, Anne Ruef, Dominic Dwyer, Theresa Lichtenstein, Oeznur Bastruek, Alexandra Stainton, Linda A. Antonucci, Paolo Brambilla, Stephen J. Wood, Rachel Upthegrove, Stefan Borgwardt, Rebekka Lencer, Eva Meisenzahl, Raimo K. R. Salokangas, Christos Pantelis, Alessandro Bertolino, Nikolaos Koutsouleris, Joseph Kambeitz, Lana Kambeitz-Ilankovic
Summary: Clinical and neuroimaging data can be used to predict the potential of cognitive training to improve social functioning in recent onset psychosis patients. The use of multivariate pattern analysis and support vector machine classifier allows for the prediction of social functioning improvement based on baseline cognitive data. The findings suggest that cognitive data can provide a robust individual estimate of future social functioning for patients with recent onset psychosis.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
