Increased CRF signalling in a ventral tegmental area-interpeduncular nucleus-medial habenula circuit induces anxiety during nicotine withdrawal

VTA CRF neurons mediate the aversive effects of nicotine withdrawal and promote intake escalation

(2014) Taryn E Grieder et al.   NATURE NEUROSCIENCE

Activation of GABAergic Neurons in the Interpeduncular Nucleus Triggers Physical Nicotine Withdrawal Symptoms

(2013) Rubing Zhao-Shea et al.   CURRENT BIOLOGY

Fear and Anxiety Regulation by Conserved Affective Circuits

(2013) Hitoshi Okamoto et al.   NEURON

Corticotropin Releasing Factor Signaling in the Central Amygdala is Recruited during Binge-Like Ethanol Consumption in C57BL/6J Mice

(2012) E. G. Lowery-Gionta et al.   JOURNAL OF NEUROSCIENCE

Co-activation of VTA DA and GABA neurons mediates nicotine reinforcement

(2012) S Tolu et al.   MOLECULAR PSYCHIATRY

The Development and Application of Optogenetics

(2011) Lief Fenno et al.   Annual Review of Neuroscience

The age of anxiety: role of animal models of anxiolytic action in drug discovery

(2011) John F Cryan et al.   BRITISH JOURNAL OF PHARMACOLOGY

Augmented Cocaine Seeking in Response to Stress or CRF Delivered into the Ventral Tegmental Area Following Long-Access Self-Administration Is Mediated by CRF Receptor Type 1 But Not CRF Receptor Type 2

(2011) J. M. Blacktop et al.   JOURNAL OF NEUROSCIENCE

Negative Reward Signals from the Lateral Habenula to Dopamine Neurons Are Mediated by Rostromedial Tegmental Nucleus in Primates

(2011) S. Hong et al.   JOURNAL OF NEUROSCIENCE

Habenular α5 nicotinic receptor subunit signalling controls nicotine intake

(2011) Christie D. Fowler et al.   NATURE

Habenula “Cholinergic” Neurons Corelease Glutamate and Acetylcholine and Activate Postsynaptic Neurons via Distinct Transmission Modes

(2011) Jing Ren et al.   NEURON

Aversion to Nicotine Is Regulated by the Balanced Activity of β4 and α5 Nicotinic Receptor Subunits in the Medial Habenula

(2011) Silke Frahm et al.   NEURON

The inhibitory influence of the lateral habenula on midbrain dopamine cells: Ultrastructural evidence for indirect mediation via the rostromedial mesopontine tegmental nucleus

(2010) Judith Joyce Balcita-Pedicino et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Activation of  4* nAChRs is Necessary and Sufficient for Varenicline-Induced Reduction of Alcohol Consumption

(2010) L. M. Hendrickson et al.   JOURNAL OF NEUROSCIENCE

Effects of Corticotropin-Releasing Factor Receptor-1 Antagonists on the Brain Stress System Responses to Morphine Withdrawal

(2010) J. Navarro-Zaragoza et al.   MOLECULAR PHARMACOLOGY

The habenula: from stress evasion to value-based decision-making

(2010) Okihide Hikosaka   NATURE REVIEWS NEUROSCIENCE

Distinct Tonic and Phasic Anticipatory Activity in Lateral Habenula and Dopamine Neurons

(2010) Ethan S. Bromberg-Martin et al.   NEURON

Multiple Timescales of Memory in Lateral Habenula and Dopamine Neurons

(2010) Ethan S. Bromberg-Martin et al.   NEURON

Effects of Drugs of Abuse on Putative Rostromedial Tegmental Neurons, Inhibitory Afferents to Midbrain Dopamine Cells

(2010) Salvatore Lecca et al.   NEUROPSYCHOPHARMACOLOGY

Convergent actions of orexin/hypocretin and CRF on dopamine neurons: Emerging players in addiction

(2009) Stephanie L. Borgland et al.   BRAIN RESEARCH

The role of CRF and CRF-related peptides in the dark side of addiction

(2009) George F. Koob   BRAIN RESEARCH

Afferents to the GABAergic tail of the ventral tegmental area in the rat

(2009) Jennifer Kaufling et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Nicotinic Receptors in the Habenulo-Interpeduncular System Are Necessary for Nicotine Withdrawal in Mice

(2009) R. Salas et al.   JOURNAL OF NEUROSCIENCE

Chronic Cocaine Enhances Corticotropin-Releasing Factor-Dependent Potentiation of Excitatory Transmission in Ventral Tegmental Area Dopamine Neurons

(2009) J. Hahn et al.   JOURNAL OF NEUROSCIENCE

N-methyl-D-aspartate receptors are involved in lithium-induced state-dependent learning in mice

(2009) M. Rezayat et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Stress-Induced Potentiation of Cocaine Reward: A Role for CRFR1 and CREB

(2009) Arati S Kreibich et al.   NEUROPSYCHOPHARMACOLOGY

Neurocircuitry of Addiction

(2009) George F Koob et al.   NEUROPSYCHOPHARMACOLOGY

Phasic Firing in Dopaminergic Neurons Is Sufficient for Behavioral Conditioning

(2009) H.-C. Tsai et al.   SCIENCE

Dopamine Enhances Fast Excitatory Synaptic Transmission in the Extended Amygdala by a CRF-R1-Dependent Process

(2008) T. L. Kash et al.   JOURNAL OF NEUROSCIENCE

Crucial Role of  4 and  6 Nicotinic Acetylcholine Receptor Subunits from Ventral Tegmental Area in Systemic Nicotine Self-Administration

(2008) S. Pons et al.   JOURNAL OF NEUROSCIENCE

Corticotropin-releasing factor 1 and 2 receptors in the dorsal raphé differentially affect serotonin release in the nucleus accumbens

(2007) Jodi L. Lukkes et al.   EUROPEAN JOURNAL OF PHARMACOLOGY